Chloral hydrate (BioDeep_00000006376)
Secondary id: BioDeep_00001867623
human metabolite Chemicals and Drugs
代谢物信息卡片
1,1,1-Trichloro-2,2-dihydroxyethane
化学式: C2H3Cl3O2 (163.91986280000003)
中文名称: 三氯乙醛水合物
谱图信息:
最多检出来源 Macaca mulatta(otcml) 1.38%
分子结构信息
SMILES: C(C(Cl)(Cl)Cl)(O)O
InChI: InChI=1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H
描述信息
Chloral hydrate is a sedative and hypnotic drug as well as a chemical reagent and precursor. The name chloral hydrate indicates that it is formed from chloral (trichloroacetaldehyde) by the addition of one molecule of water. Its chemical formula is C2H3Cl3O2. It was discovered through the chlorination of ethanol in 1832 by Justus von Liebig in Gießen. Its sedative properties were first published in 1869 and subsequently, because of its easy synthesis, its use was widespread. (Wikipedia)
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CC - Aldehydes and derivatives
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2199 - Adjuvant Analgesic
同义名列表
17 个代谢物同义名
1,1,1-Trichloro-2,2-dihydroxyethane; Trichloroacetaldehyde hydric acid; 2,2,2-trichloroethane-1,1-diol; 2,2,2-Trichloro-1,1-ethanediol; 1,1,1-Trichloro-2,2-ethanediol; Trichloroacetaldehyde hydrate; Trichloracetaldehyd-hydrat; Chloral monohydric acid; Aquachloral supprettes; Chloral hydric acid; Chloral monohydrate; Hydrate, chloral; chloral hydrate; Knockout drops; Chloralhydrat; Somnote; Noctec
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:28142
- KEGG: C06899
- KEGGdrug: D00265
- PubChem: 2707
- HMDB: HMDB0060451
- Metlin: METLIN1642
- DrugBank: DB01563
- ChEMBL: CHEMBL455917
- Wikipedia: Chloral hydrate
- MeSH: Chloral Hydrate
- MetaCyc: CPD0-1476
- CAS: 302-17-0
- PMhub: MS000019404
- PubChem: 9116
- NIKKAJI: J1.517B
- RefMet: Chloral hydrate
分类词条
相关代谢途径
Reactome(0)
BioCyc(3)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jinfeng Zhao, Shiyu Yan, Xue Ma, Yanqing Song, Yao Pan. Nrf2 regulates the activation of THP-1 cells induced by chloral hydrate.
Ecotoxicology and environmental safety.
2023 Mar; 256(?):114841. doi:
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Water research.
2022 Oct; 225(?):119106. doi:
10.1016/j.watres.2022.119106. [PMID: 36152442] - Amanda J Stolarz, Bijay P Chhetri, Michael J Borrelli, Samir V Jenkins, Azemat Jamshidi-Parsian, Joshua H Phillips, Daniel Fologea, Jay Gandy, Robert J Griffin. Liposome Formulation for Tumor-Targeted Drug Delivery Using Radiation Therapy.
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Journal of experimental botany.
2011 Nov; 62(15):5509-19. doi:
10.1093/jxb/err228. [PMID: 21841172] - Daisuke Tamaoki, Ichirou Karahara, Takumi Nishiuchi, Tatsuya Wakasugi, Kyoji Yamada, Seiichiro Kamisaka. Involvement of auxin dynamics in hypergravity-induced promotion of lignin-related gene expression in Arabidopsis inflorescence stems.
Journal of experimental botany.
2011 Nov; 62(15):5463-9. doi:
10.1093/jxb/err224. [PMID: 21841171] - Shifeng Zhu, Rae-Dong Jeong, Srivathsa C Venugopal, Ludmila Lapchyk, DuRoy Navarre, Aardra Kachroo, Pradeep Kachroo. SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus.
PLoS pathogens.
2011 Nov; 7(11):e1002318. doi:
10.1371/journal.ppat.1002318. [PMID: 22072959] - Chiara Fuccio, Riccardo Schiavina, Paolo Castellucci, Domenico Rubello, Giuseppe Martorana, Monica Celli, Claudio Malizia, Marta Barios Profitos, Maria Cristina Marzola, Vincenzina Pettinato, Stefano Fanti. Androgen deprivation therapy influences the uptake of 11C-choline in patients with recurrent prostate cancer: the preliminary results of a sequential PET/CT study.
European journal of nuclear medicine and molecular imaging.
2011 Nov; 38(11):1985-9. doi:
10.1007/s00259-011-1867-0. [PMID: 21732105] - Sun Mi Park, Jin Hee Shin, Gyeong Joon Moon, Sung Ig Cho, Yong Beom Lee, Byoung Joo Gwag. Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice.
BMC neuroscience.
2011 Oct; 12(?):106. doi:
10.1186/1471-2202-12-106. [PMID: 22029666] - Andrew B Nowakowski, David H Petering. Reactions of the fluorescent sensor, Zinquin, with the zinc-proteome: adduct formation and ligand substitution.
Inorganic chemistry.
2011 Oct; 50(20):10124-33. doi:
10.1021/ic201076w. [PMID: 21905645] - Kun Li, Yunpeng Diao, Houli Zhang, Shouyu Wang, Zhen Zhang, Bo Yu, Shanshan Huang, Hong Yang. Tannin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound healing in rats.
BMC complementary and alternative medicine.
2011 Oct; 11(?):86. doi:
10.1186/1472-6882-11-86. [PMID: 21982053] - Chika Tateda, Kanako Watanabe, Tomonobu Kusano, Yoshihiro Takahashi. Molecular and genetic characterization of the gene family encoding the voltage-dependent anion channel in Arabidopsis.
Journal of experimental botany.
2011 Oct; 62(14):4773-85. doi:
10.1093/jxb/err113. [PMID: 21705391] - Xiao-San Huang, Tao Luo, Xing-Zheng Fu, Qi-Jun Fan, Ji-Hong Liu. Cloning and molecular characterization of a mitogen-activated protein kinase gene from Poncirus trifoliata whose ectopic expression confers dehydration/drought tolerance in transgenic tobacco.
Journal of experimental botany.
2011 Oct; 62(14):5191-206. doi:
10.1093/jxb/err229. [PMID: 21778184] - Alex T Chow, Anthony T O'Geen, Randy A Dahlgren, Francisco J Díaz, Kin-Hang Wong, Po-Keung Wong. Reactivity of litter leachates from California oak woodlands in the formation of disinfection by-products.
Journal of environmental quality.
2011 Sep; 40(5):1607-16. doi:
10.2134/jeq2010.0488. [PMID: 21869524] - Hiromitsu Kawata, Shinichi Arai, Toshito Nakagawa, Nobuyuki Ishikura, Ayako Nishimoto, Hitoshi Yoshino, Takuya Shiraishi, Kazutaka Tachibana, Ryo Nakamura, Haruhiko Sato. Biological properties of androgen receptor pure antagonist for treatment of castration-resistant prostate cancer: optimization from lead compound to CH5137291.
The Prostate.
2011 Sep; 71(12):1344-56. doi:
10.1002/pros.21351. [PMID: 21308717] - Tadeusz M Zielonka, Urszula Demkow, Dorota Michalowska-Mitczuk, Malgorzata Filewska, Beata Bialas, Katarzyna Zycinska, Michael H Obrowski, Jan Kus, Ewa Skopinska-Rozewska. Angiogenic activity of sera from pulmonary tuberculosis patients in relation to IL-12p40 and TNFα serum levels.
Lung.
2011 Aug; 189(4):351-7. doi:
10.1007/s00408-011-9291-6. [PMID: 21603999] - Neta Shlezinger, Anna Minz, Yonatan Gur, Ido Hatam, Yasin F Dagdas, Nicholas J Talbot, Amir Sharon. Anti-apoptotic machinery protects the necrotrophic fungus Botrytis cinerea from host-induced apoptotic-like cell death during plant infection.
PLoS pathogens.
2011 Aug; 7(8):e1002185. doi:
10.1371/journal.ppat.1002185. [PMID: 21876671] - Pannaga Krishnamurthy, Kosala Ranathunge, Shraddha Nayak, Lukas Schreiber, M K Mathew. Root apoplastic barriers block Na+ transport to shoots in rice (Oryza sativa L.).
Journal of experimental botany.
2011 Aug; 62(12):4215-28. doi:
10.1093/jxb/err135. [PMID: 21558150] - Floriane L'Haridon, Angélique Besson-Bard, Matteo Binda, Mario Serrano, Eliane Abou-Mansour, Francine Balet, Henk-Jan Schoonbeek, Stephane Hess, Ricardo Mir, José Léon, Olivier Lamotte, Jean-Pierre Métraux. A permeable cuticle is associated with the release of reactive oxygen species and induction of innate immunity.
PLoS pathogens.
2011 Jul; 7(7):e1002148. doi:
10.1371/journal.ppat.1002148. [PMID: 21829351] - Xi Chen, Shihui Xing, Yanqing Feng, Songlin Chen, Zhong Pei, Chuhuai Wang, Xiuling Liang. Early stage transplantation of bone marrow cells markedly ameliorates copper metabolism and restores liver function in a mouse model of Wilson disease.
BMC gastroenterology.
2011 Jun; 11(?):75. doi:
10.1186/1471-230x-11-75. [PMID: 21676234] - Antoine Peraldi, Giovanni Beccari, Andrew Steed, Paul Nicholson. Brachypodium distachyon: a new pathosystem to study Fusarium head blight and other Fusarium diseases of wheat.
BMC plant biology.
2011 Jun; 11(?):100. doi:
10.1186/1471-2229-11-100. [PMID: 21639892] - Olatz Pampliega, María Domercq, Federico N Soria, Pablo Villoslada, Alfredo Rodríguez-Antigüedad, Carlos Matute. Increased expression of cystine/glutamate antiporter in multiple sclerosis.
Journal of neuroinflammation.
2011 Jun; 8(?):63. doi:
10.1186/1742-2094-8-63. [PMID: 21639880] - Philip Wolff, Isabelle Weinhofer, Jonathan Seguin, Pawel Roszak, Christian Beisel, Mark T A Donoghue, Charles Spillane, Magnus Nordborg, Marc Rehmsmeier, Claudia Köhler. High-resolution analysis of parent-of-origin allelic expression in the Arabidopsis Endosperm.
PLoS genetics.
2011 Jun; 7(6):e1002126. doi:
10.1371/journal.pgen.1002126. [PMID: 21698132] - Alan Wayne Jones. Early drug discovery and the rise of pharmaceutical chemistry.
Drug testing and analysis.
2011 Jun; 3(6):337-44. doi:
10.1002/dta.301. [PMID: 21698778] - Norio Nonomura, Hitoshi Takayama, Masashi Nakayama, Yasutomo Nakai, Atsunari Kawashima, Masatoshi Mukai, Akira Nagahara, Katsuyuki Aozasa, Akira Tsujimura. Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer.
BJU international.
2011 Jun; 107(12):1918-22. doi:
10.1111/j.1464-410x.2010.09804.x. [PMID: 21044246] - Juan Zhang, Rachel D Grindstaff, Sheau-Fung Thai, Sandra A Murray, Michael Kohan, Carl F Blackman. Chloral hydrate decreases gap junction communication in rat liver epithelial cells.
Cell biology and toxicology.
2011 Jun; 27(3):207-16. doi:
10.1007/s10565-011-9182-x. [PMID: 21243523] - Kai Yang, Dong Qiang, Sarah Delaney, Rhea Mehta, W R Bruce, Peter J O'Brien. Differences in glyoxal and methylglyoxal metabolism determine cellular susceptibility to protein carbonylation and cytotoxicity.
Chemico-biological interactions.
2011 May; 191(1-3):322-9. doi:
10.1016/j.cbi.2011.02.012. [PMID: 21334317] - Pablo Carbonell-Bejerano, Cristina Urbez, Antonio Granell, Juan Carbonell, Miguel A Perez-Amador. Ethylene is involved in pistil fate by modulating the onset of ovule senescence and the GA-mediated fruit set in Arabidopsis.
BMC plant biology.
2011 May; 11(?):84. doi:
10.1186/1471-2229-11-84. [PMID: 21575215] - Yen-Ta Chen, Cheuk-Kwan Sun, Yu-Chun Lin, Li-Teh Chang, Yung-Lung Chen, Tzu-Hsien Tsai, Sheng-Ying Chung, Sarah Chua, Ying-Hsien Kao, Chia-Hong Yen, Pei-Lin Shao, Kuan-Cheng Chang, Steve Leu, Hon-Kan Yip. Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction.
Journal of translational medicine.
2011 May; 9(?):51. doi:
10.1186/1479-5876-9-51. [PMID: 21545725] - Moritaka Nakamura, Masatsugu Toyota, Masao Tasaka, Miyo Terao Morita. An Arabidopsis E3 ligase, SHOOT GRAVITROPISM9, modulates the interaction between statoliths and F-actin in gravity sensing.
The Plant cell.
2011 May; 23(5):1830-48. doi:
10.1105/tpc.110.079442. [PMID: 21602290] - Arne Solberg, Olav A Haugen, Trond Viset, Anders Bergh, Ilker Tasdemir, Göran Ahlgren, Anders Widmark, Anders Angelsen. Residual prostate cancer in patients treated with endocrine therapy with or without radical radiotherapy: a side study of the SPCG-7 randomized trial.
International journal of radiation oncology, biology, physics.
2011 May; 80(1):55-61. doi:
10.1016/j.ijrobp.2010.01.072. [PMID: 20598453] - Daoquan Xiang, Prakash Venglat, Chabane Tibiche, Hui Yang, Eddy Risseeuw, Yongguo Cao, Vivijan Babic, Mathieu Cloutier, Wilf Keller, Edwin Wang, Gopalan Selvaraj, Raju Datla. Genome-wide analysis reveals gene expression and metabolic network dynamics during embryo development in Arabidopsis.
Plant physiology.
2011 May; 156(1):346-56. doi:
10.1104/pp.110.171702. [PMID: 21402797] - Crystal Sloan, Joseph Tuinei, Katherine Nemetz, Jonathan Frandsen, Jamie Soto, Noah Wride, Tomoki Sempokuya, Luis Alegria, Heiko Bugger, E Dale Abel. Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice.
Diabetes.
2011 May; 60(5):1424-34. doi:
10.2337/db10-1106. [PMID: 21441440] - Xianhuo Wang, Xingmei Duan, Guangli Yang, Xiaoyan Zhang, Linyu Deng, Hao Zheng, Chongyang Deng, Jiaolin Wen, Ning Wang, Cheng Peng, Xia Zhao, Yuquan Wei, Lijuan Chen. Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model.
PloS one.
2011 Apr; 6(4):e18490. doi:
10.1371/journal.pone.0018490. [PMID: 21559510] - Prakash Venglat, Daoquan Xiang, Shuqing Qiu, Sandra L Stone, Chabane Tibiche, Dustin Cram, Michelle Alting-Mees, Jacek Nowak, Sylvie Cloutier, Michael Deyholos, Faouzi Bekkaoui, Andrew Sharpe, Edwin Wang, Gordon Rowland, Gopalan Selvaraj, Raju Datla. Gene expression analysis of flax seed development.
BMC plant biology.
2011 Apr; 11(?):74. doi:
10.1186/1471-2229-11-74. [PMID: 21529361] - Yvan Kraepiel, Jacques Pédron, Oriane Patrit, Elizabeth Simond-Côte, Victor Hermand, Frédérique Van Gijsegem. Analysis of the plant bos1 mutant highlights necrosis as an efficient defence mechanism during D. dadantii/Arabidospis thaliana interaction.
PloS one.
2011 Apr; 6(4):e18991. doi:
10.1371/journal.pone.0018991. [PMID: 21533045] - Maria Dolores Gomez, Cristina Urbez, Miguel A Perez-Amador, Juan Carbonell. Characterization of constricted fruit (ctf) mutant uncovers a role for AtMYB117/LOF1 in ovule and fruit development in Arabidopsis thaliana.
PloS one.
2011 Apr; 6(4):e18760. doi:
10.1371/journal.pone.0018760. [PMID: 21533201] - Matthew R Willmann, Andrew J Mehalick, Rachel L Packer, Pablo D Jenik. MicroRNAs regulate the timing of embryo maturation in Arabidopsis.
Plant physiology.
2011 Apr; 155(4):1871-84. doi:
10.1104/pp.110.171355. [PMID: 21330492] - Lata Jayaram, Sanjeev Chunilal, Sandy Pickering, Richard E Ruffin, Peter D Zalewski. Sputum zinc concentration and clinical outcome in older asthmatics.
Respirology (Carlton, Vic.).
2011 Apr; 16(3):459-66. doi:
10.1111/j.1440-1843.2011.01932.x. [PMID: 21261783] - Hironori Fujita, Koichi Toyokura, Kiyotaka Okada, Masayoshi Kawaguchi. Reaction-diffusion pattern in shoot apical meristem of plants.
PloS one.
2011 Mar; 6(3):e18243. doi:
10.1371/journal.pone.0018243. [PMID: 21479227] - Yun Wang, Lei Jing, Xiao-Min Zhao, Ji-Ju Han, Zuo-Li Xia, Shu-Cun Qin, Ya-Ping Wu, Xue-Jun Sun. Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model.
Respiratory research.
2011 Mar; 12(?):26. doi:
10.1186/1465-9921-12-26. [PMID: 21375753] - Fei Xiao, Zhiying Huang, Houkai Li, Junjie Yu, Chunxia Wang, Shanghai Chen, Qingshu Meng, Ying Cheng, Xiang Gao, Jia Li, Yong Liu, Feifan Guo. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways.
Diabetes.
2011 Mar; 60(3):746-56. doi:
10.2337/db10-1246. [PMID: 21282364] - David Schwarz, Damaris Bloom, Rocío Castro, Oné R Pagán, C A Jiménez-Rivera. Parthenolide Blocks Cocaine's Effect on Spontaneous Firing Activity of Dopaminergic Neurons in the Ventral Tegmental Area.
Current neuropharmacology.
2011 Mar; 9(1):17-20. doi:
10.2174/157015911795017010. [PMID: 21886554] - Steffen Fischer, Christian Wiese, Eva Grosse Maestrup, Achim Hiller, Winnie Deuther-Conrad, Matthias Scheunemann, Dirk Schepmann, Jörg Steinbach, Bernhard Wünsch, Peter Brust. Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine.
European journal of nuclear medicine and molecular imaging.
2011 Mar; 38(3):540-51. doi:
10.1007/s00259-010-1658-z. [PMID: 21072511] - Yongil Yang, Dale T Karlson. Overexpression of AtCSP4 affects late stages of embryo development in Arabidopsis.
Journal of experimental botany.
2011 Mar; 62(6):2079-91. doi:
10.1093/jxb/erq400. [PMID: 21282328] - Hanna Paatela, Veera Vihma, Matti Jauhiainen, Eero Mervaala, Matti J Tikkanen. Dehydroepiandrosterone fatty acyl esters in high density lipoprotein: interaction with human vascular endothelial cells and vascular responses ex vivo.
Steroids.
2011 Mar; 76(4):376-80. doi:
10.1016/j.steroids.2010.12.007. [PMID: 21168430] - Peter W Stacpoole. The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?.
Environmental health perspectives.
2011 Feb; 119(2):155-8. doi:
10.1289/ehp.1002554. [PMID: 20920954]