9-Hydroxyfluorene (BioDeep_00000006291)
Secondary id: BioDeep_00001868053
human metabolite
代谢物信息卡片
化学式: C13H10O (182.0732)
中文名称: 9-芴醇
谱图信息:
最多检出来源 Homo sapiens(otcml) 5.35%
分子结构信息
SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)O
InChI: InChI=1S/C13H10O/c14-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)13/h1-8,13-14H
描述信息
This compound belongs to the family of Fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 μM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo[1].
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:16904
- KEGG: C06711
- PubChem: 74318
- HMDB: HMDB0059803
- Metlin: METLIN44733
- ChEMBL: CHEMBL571548
- Wikipedia: Fluorenol
- MetaCyc: 9FLUORENOL
- CAS: 1689-64-1
- PMhub: MS000019313
- PubChem: 8936
- 3DMET: B01030
- NIKKAJI: J7.758E
- RefMet: Fluoren-9-ol
- medchemexpress: HY-W016388
- KNApSAcK: 16904
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- fluorene degradation II:
H+ + NADH + O2 + fluorene ⟶ 9-fluorenol + H2O + NAD+ - fluorene degradation I:
H+ + NADH + O2 + fluorene ⟶ 9-fluorenol + H2O + NAD+
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 1245468 - Alepocephalus rostratus: 10.1021/ES304345S
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Limin Cao, Dongming Wang, Yuhan Wen, Heng He, Ailian Chen, Dan Hu, Aijun Tan, Tingming Shi, Kejing Zhu, Jixuan Ma, Yun Zhou, Weihong Chen. Effects of environmental and lifestyle exposures on urinary levels of polycyclic aromatic hydrocarbon metabolites: A cross-sectional study of urban adults in China.
Chemosphere.
2020 Feb; 240(?):124898. doi:
10.1016/j.chemosphere.2019.124898. [PMID: 31557644] - Gideon St Helen, Maciej L Goniewicz, Delia Dempsey, Margaret Wilson, Peyton Jacob, Neal L Benowitz. Exposure and kinetics of polycyclic aromatic hydrocarbons (PAHs) in cigarette smokers.
Chemical research in toxicology.
2012 Apr; 25(4):952-64. doi:
10.1021/tx300043k. [PMID: 22428611] - Elizabeth Nethery, Amanda J Wheeler, Mandy Fisher, Andreas Sjödin, Zheng Li, Lovisa C Romanoff, Warren Foster, Tye E Arbuckle. Urinary polycyclic aromatic hydrocarbons as a biomarker of exposure to PAHs in air: a pilot study among pregnant women.
Journal of exposure science & environmental epidemiology.
2012 Jan; 22(1):70-81. doi:
10.1038/jes.2011.32. [PMID: 21915154] - Kristie M June, David Hammond, Andreas Sjödin, Zheng Li, Lovisa Romanoff, Richard J O'Connor. Cigarette ignition propensity, smoking behavior, and toxicant exposure: A natural experiment in Canada.
Tobacco induced diseases.
2011 Dec; 9(1):13. doi:
10.1186/1617-9625-9-13. [PMID: 22189009] - Rachel L Miller, Robin Garfinkel, Cynthia Lendor, Lori Hoepner, Zheng Li, Lovisa Romanoff, Andreas Sjodin, Larry Needham, Frederica P Perera, Robin M Whyatt. Polycyclic aromatic hydrocarbon metabolite levels and pediatric allergy and asthma in an inner-city cohort.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2010 Mar; 21(2 Pt 1):260-7. doi:
10.1111/j.1399-3038.2009.00980.x. [PMID: 20003063] - Laura Campo, Federica Rossella, Sofia Pavanello, Danuta Mielzynska, Ewa Siwinska, Lucyna Kapka, Pier Alberto Bertazzi, Silvia Fustinoni. Urinary profiles to assess polycyclic aromatic hydrocarbons exposure in coke-oven workers.
Toxicology letters.
2010 Jan; 192(1):72-8. doi:
10.1016/j.toxlet.2008.12.018. [PMID: 20143505] - Charles J Everett, Dana E King, Marty S Player, Eric M Matheson, Robert E Post, Arch G Mainous. Association of urinary polycyclic aromatic hydrocarbons and serum C-reactive protein.
Environmental research.
2010 Jan; 110(1):79-82. doi:
10.1016/j.envres.2009.09.010. [PMID: 19836015] - F Rossella, L Campo, S Pavanello, L Kapka, E Siwinska, S Fustinoni. Urinary polycyclic aromatic hydrocarbons and monohydroxy metabolites as biomarkers of exposure in coke oven workers.
Occupational and environmental medicine.
2009 Aug; 66(8):509-16. doi:
10.1136/oem.2008.042796. [PMID: 19221113] - M Mattarozzi, M Musci, M Careri, A Mangia, S Fustinoni, L Campo, F Bianchi. A novel headspace solid-phase microextraction method using in situ derivatization and a diethoxydiphenylsilane fibre for the gas chromatography-mass spectrometry determination of urinary hydroxy polycyclic aromatic hydrocarbons.
Journal of chromatography. A.
2009 Jul; 1216(30):5634-9. doi:
10.1016/j.chroma.2009.05.072. [PMID: 19523642] - Plernpit Suwan-ampai, Ana Navas-Acien, Paul T Strickland, Jacqueline Agnew. Involuntary tobacco smoke exposure and urinary levels of polycyclic aromatic hydrocarbons in the United States, 1999 to 2002.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2009 Mar; 18(3):884-93. doi:
10.1158/1055-9965.epi-08-0939. [PMID: 19258471] - Laura Campo, Federica Rossella, Silvia Fustinoni. Development of a gas chromatography/mass spectrometry method to quantify several urinary monohydroxy metabolites of polycyclic aromatic hydrocarbons in occupationally exposed subjects.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Nov; 875(2):531-40. doi:
10.1016/j.jchromb.2008.10.017. [PMID: 18952507]
