Inositol cyclic phosphate (BioDeep_00000005472)

 

Secondary id: BioDeep_00001869688

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(3aR,4R,5S,6S,7R,7aS)-2,4,5,6,7-pentahydroxy-hexahydro-2H-1,3,2λ⁵-benzodioxaphosphol-2-one

化学式: C6H11O8P (242.0192)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 9.63%

分子结构信息

SMILES: C1(C(C(C2C(C1O)OP(=O)(O2)O)O)O)O
InChI: InChI=1S/C6H11O8P/c7-1-2(8)4(10)6-5(3(1)9)13-15(11,12)14-6/h1-10H,(H,11,12)/t1-,2-,3+,4+,5-,6+/m0/s1



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ANPEP, DLK1, ITPR3, PLA2G12A, PLCG1, TNK1
Peripheral membrane protein 2 ACHE, TNK1
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 2 ACHE, PDIA3
cytosol 1 PLCG1
phagocytic vesicle 1 PDIA3
nucleoplasm 2 DAGLB, ITPR3
Cell membrane 3 ACHE, ANPEP, DAGLB
lamellipodium 1 PLCG1
ruffle membrane 1 PLCG1
Multi-pass membrane protein 2 DAGLB, ITPR3
Synapse 1 ACHE
cell surface 2 ACHE, PDIA3
glutamatergic synapse 1 PLCG1
Golgi apparatus 1 ACHE
Golgi membrane 1 INS
lysosomal membrane 2 ANPEP, DAGLB
neuromuscular junction 1 ACHE
neuronal cell body 1 ITPR3
plasma membrane 8 ACHE, ANPEP, DAGLB, F2, ITPR3, KNG1, PLCG1, TNK1
Membrane 5 ACHE, DAGLB, DLK1, ITPR3, TNK1
axon 1 CCK
brush border 1 ITPR3
extracellular exosome 4 ANPEP, F2, KNG1, PDIA3
endoplasmic reticulum 2 ITPR3, PDIA3
extracellular space 8 ACHE, ANPEP, CCK, DLK1, F2, INS, KNG1, PDIA3
perinuclear region of cytoplasm 1 ACHE
Schaffer collateral - CA1 synapse 1 PLCG1
Secreted 5 ACHE, CCK, F2, INS, PLA2G12A
extracellular region 6 ACHE, CCK, F2, INS, KNG1, PLA2G12A
Single-pass membrane protein 1 DLK1
Extracellular side 1 ACHE
external side of plasma membrane 1 ANPEP
nucleolus 1 ITPR3
apical part of cell 1 ITPR3
cell-cell junction 1 PLCG1
Single-pass type II membrane protein 1 ANPEP
Cell projection, lamellipodium 1 PLCG1
focal adhesion 1 PDIA3
basement membrane 1 ACHE
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 2 F2, KNG1
nuclear outer membrane 1 ITPR3
Cell projection, ruffle 1 PLCG1
ruffle 1 PLCG1
receptor complex 1 ITPR3
cell projection 1 PLCG1
COP9 signalosome 1 PLCG1
Secreted, extracellular space 1 KNG1
blood microparticle 2 F2, KNG1
Lipid-anchor, GPI-anchor 1 ACHE
Recycling endosome membrane 1 PDIA3
endosome lumen 1 INS
Melanosome 1 PDIA3
side of membrane 1 ACHE
secretory granule lumen 1 INS
secretory granule membrane 2 ANPEP, ITPR3
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 4 F2, INS, KNG1, PDIA3
platelet alpha granule lumen 1 KNG1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum-Golgi intermediate compartment 1 ANPEP
platelet dense tubular network membrane 1 ITPR3
synaptic cleft 1 ACHE
MHC class I peptide loading complex 1 PDIA3
Tapasin-ERp57 complex 1 PDIA3
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
transport vesicle membrane 1 ITPR3
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Jianwen Feng, Mary F Roberts, Guillaume Drin, Suzanne Scarlata. Dissection of the steps of phospholipase C beta 2 activity that are enhanced by G beta gamma subunits. Biochemistry. 2005 Feb; 44(7):2577-84. doi: 10.1021/bi0482607. [PMID: 15709770]
  • Sung Wook Park, Kyong Choi, Hwanghee Blaise Lee, Sung Kwang Park, Anthony J Turner, Nigel M Hooper, Haeng Soon Park. Glycosyl-phosphatidylinositol (GPI)-anchored renal dipeptidase is released by a phospholipase C in vivo. Kidney & blood pressure research. 2002; 25(1):7-12. doi: 10.1159/000049429. [PMID: 11834871]
  • M C Sekar, E D Scott, V Sambandam, R E Berry. Demonstration of the presence of cyclic inositol phosphohydrolase in human urine. Biochemical and molecular medicine. 1997 Oct; 62(1):95-100. doi: 10.1006/bmme.1997.2629. [PMID: 9367804]
  • M Ryan, M P Smith, T K Vinod, W L Lau, J F Keana, O H Griffith. Synthesis, structure-activity relationships, and the effect of polyethylene glycol on inhibitors of phosphatidylinositol-specific phospholipase C from Bacillus cereus. Journal of medicinal chemistry. 1996 Oct; 39(22):4366-76. doi: 10.1021/jm960434y. [PMID: 8893831]
  • G T Galasko, Y Bao, S J Broomfield, N M Hooper, A J Turner, J Larner. Circulating factors and insulin resistance. I. A novel myoinositol 1,2-cyclic phosphate phosphoglycan insulin antagonist from human plasma is elevated in noninsulin-dependent diabetes mellitus. The Journal of clinical endocrinology and metabolism. 1995 Aug; 80(8):2419-29. doi: 10.1210/jcem.80.8.7629237. [PMID: 7629237]
  • S J Broomfield, N M Hooper. Characterization of an antibody to the cross-reacting determinant of the glycosyl-phosphatidylinositol anchor of human membrane dipeptidase. Biochimica et biophysica acta. 1993 Feb; 1145(2):212-8. doi: 10.1016/0005-2736(93)90291-7. [PMID: 7679286]
  • N M Hooper, S J Broomfield, A J Turner. Characterization of antibodies to the glycosyl-phosphatidylinositol membrane anchors of mammalian proteins. The Biochemical journal. 1991 Jan; 273(Pt 2)(?):301-6. doi: 10.1042/bj2730301. [PMID: 1703760]
  • S Shak, M A Davitz, M L Wolinsky, V Nussenzweig, M J Turner, A Gurnett. Partial characterization of the cross-reacting determinant, a carbohydrate epitope shared by decay accelerating factor and the variant surface glycoprotein of the African Trypanosoma brucei. Journal of immunology (Baltimore, Md. : 1950). 1988 Mar; 140(6):2046-50. doi: . [PMID: 2450138]
  • T M Connolly, D B Wilson, T E Bross, P W Majerus. Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts. The Journal of biological chemistry. 1986 Jan; 261(1):122-6. doi: . [PMID: 3001044]
  • S Husted, T Hjort. Sperm antibodies in serum and seminal plasma. International journal of fertility. 1975; 20(2):97-105. doi: NULL. [PMID: 3485]