Tiglyl-CoA (BioDeep_00000005181)
Main id: BioDeep_00000630310
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C26H42N7O17P3S (849.1571)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC=C(C)C(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O
InChI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/b14-5+/t15-,18-,19-,20+,24-/m1/s1
描述信息
Tiglyl-CoA is a metabolite in the degradation of isoleucine to propionic acid pathway. A defect in the conversion of tiglyl-CoA to alpha-methyl-beta-hydroxybutyryl-CoA, results in episodic abdominal pain and acidosis in patients with Tiglic acidemia (OMIM 275190).
Tiglyl-CoA is a metabolite in the degradation of isoleucine to propionic acid pathway.
同义名列表
22 个代谢物同义名
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-2-methylbut-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid; trans-2-Methylbut-2-enoyl-coenzyme A; (e)-2-Methylbut-2-enoyl-coenzyme A; (e)-2-Methylcrotonoyl-coenzyme A; 2-Methylbut-2-enoyl-coenzyme A; trans-2-Methylbut-2-enoyl-CoA; 2-Methyl-crotonyl-coenzyme A; (e)-2-Methylbut-2-enoyl-CoA; Methylcrotonyl-coenzyme A; (e)-2-Methylcrotonoyl-CoA; 2-Methylbut-2-enoyl-CoA; 2-methylcrotonoyl-CoA; 2-Methyl-crotonyl-CoA; 2-Methylcrotanoyl-CoA; 2-Methylcrotonyl-CoA; Methylcrotonoyl-CoA; Methylcrotonyl-CoA; Tigloyl-coenzyme A; Tiglyl-coenzyme A; Tigloyl-CoA; Tiglyl-CoA; Q2816001
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:15478
- ChEBI: CHEBI:11614
- KEGG: C03345
- PubChem: 6443760
- PubChem: 1138
- HMDB: HMDB0002054
- Metlin: METLIN448
- Wikipedia: Tiglyl-CoA
- MetaCyc: CPD-1083
- foodb: FDB022819
- chemspider: 4947725
- CAS: 6247-62-7
- PMhub: MS000017904
- PubChem: 6188
- LipidMAPS: LMFA07050191
- 3DMET: B04891
- RefMet: Methylcrotonoyl-CoA
分类词条
相关代谢途径
代谢反应
48 个相关的代谢反应过程信息。
Reactome(36)
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
BioCyc(1)
- isoleucine degradation I:
2-methylacetoacetyl-CoA + coenzyme A ⟶ acetyl-CoA + propanoyl-CoA
Plant Reactome(0)
INOH(4)
- Valine,Leucine and Isoleucine degradation ( Valine,Leucine and Isoleucine degradation ):
2-Methyl-3-acetoacetyl-CoA + CoA ⟶ Acetyl-CoA + Propanoyl-CoA - (S)-3-Hydroxy-2-methyl-butanoyl-CoA = 2-Methylbut-2-enoyl-CoA + H2O ( Valine,Leucine and Isoleucine degradation ):
2-Methylbut-2-enoyl-CoA + H2O ⟶ (S)-3-Hydroxy-2-methyl-butanoyl-CoA - 2-Methyl-butanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor ( Valine,Leucine and Isoleucine degradation ):
2-Methyl-butanoyl-CoA + Acceptor ⟶ 2-Methylbut-2-enoyl-CoA + Reduced acceptor - 2-Methyl-butanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor ( Valine,Leucine and Isoleucine degradation ):
2-Methyl-butanoyl-CoA + Acceptor ⟶ 2-Methylbut-2-enoyl-CoA + Reduced acceptor
PlantCyc(6)
- lupanine biosynthesis:
cadaverine + pyruvate ⟶ 17-oxosparteine + H+ + H2O + ala - lupanine biosynthesis:
cadaverine + pyruvate ⟶ 17-oxosparteine + H+ + H2O + ala - lupanine biosynthesis:
(E)-2-methylcrotonoyl-CoA + 13-hydroxylupanine ⟶ 13-[(E)-2-methylcrotonoyl]oxylupanine + coenzyme A - lupanine biosynthesis:
cadaverine + pyruvate ⟶ 17-oxosparteine + H+ + H2O + ala - lupanine biosynthesis:
cadaverine + pyruvate ⟶ 17-oxosparteine + H+ + H2O + ala - lupanine biosynthesis:
cadaverine + pyruvate ⟶ 17-oxosparteine + H+ + H2O + ala
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kenichiro Yamada, Kaori Aiba, Yasuyuki Kitaura, Yusuke Kondo, Noriko Nomura, Yuji Nakamura, Daisuke Fukushi, Kei Murayama, Yoshiharu Shimomura, James Pitt, Seiji Yamaguchi, Kenji Yokochi, Nobuaki Wakamatsu. Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion.
Journal of medical genetics.
2015 Oct; 52(10):691-8. doi:
10.1136/jmedgenet-2015-103231. [PMID: 26251176] - Geng Ding, Ping Che, Hilal Ilarslan, Eve S Wurtele, Basil J Nikolau. Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination.
The Plant journal : for cell and molecular biology.
2012 May; 70(4):562-77. doi:
10.1111/j.1365-313x.2011.04893.x. [PMID: 22211474] - M Duran, L Bruinvis, D Ketting, J P Kamerling, S K Wadman, R B Schutgens. The identification of (E)-2-methylglutaconic acid, a new isoleucine metabolite, in the urine of patients with beta-ketothiolase deficiency, propionic acidaemia and methylmalonic acidaemia.
Biomedical mass spectrometry.
1982 Jan; 9(1):1-5. doi:
10.1002/bms.1200090102. [PMID: 7059658]
