Inositol 1,3,4-trisphosphate (BioDeep_00000004626)

 

Secondary id: BioDeep_00001868887

human metabolite Endogenous


代谢物信息卡片


(2,3,5-Trihydroxy-4,6-diphosphonooxycyclohexyl) dihydrogen phosphate

化学式: C6H15O15P3 (419.96238300000005)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 15.38%

分子结构信息

SMILES: C1(C(C(C(C(C1OP(=O)(O)O)O)OP(=O)(O)O)OP(=O)(O)O)O)O
InChI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)

描述信息

Inositol 1,3,4-trisphosphate (CAS: 98102-63-7), also known as Ins(1,3,4)P3 or I3S, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. Within humans, inositol 1,3,4-trisphosphate participates in several enzymatic reactions. In particular, inositol 1,3,4-trisphosphate can be converted into 1D-myo-inositol 1,3,4,6-tetrakisphosphate through the action of the enzyme inositol-tetrakisphosphate 1-kinase. In addition, inositol 1,3,4-trisphosphate can be converted into inositol 1,3,4,5-tetraphosphate through its interaction with the enzyme inositol-tetrakisphosphate 1-kinase. In humans, inositol 1,3,4-trisphosphate is involved in inositol metabolism. Inositol 1,3,4-trisphosphate is a specific regulator of cellular signalling.
A specific regulator of cellular signaling [HMDB]

同义名列表

15 个代谢物同义名

(2,3,5-Trihydroxy-4,6-diphosphonooxycyclohexyl) dihydrogen phosphate; (1S,3S,4S)-1,3,4-TRIPHOSPHO-myo-inositol; D-Myo-inositol 1,3,4-trisphosphoric acid; Inositol 1,3,4-trisphosphate, (D)-isomer; D-myo-Inositol 1,3,4-tris(phosphate); 1D-Myo-inositol 1,3,4-trisphosphate; Inositol 1,3,4-trisphosphoric acid; D-Myo-inositol 1,3,4-trisphosphate; Myo-inositol 1,3,4-trisphosphate; Inositol 1,3,4-trisphosphate; Inositol 1,3,4-triphosphate; Ins(1,3,4)P3; SCHEMBL98182; 1,3,4-Itp; I3S



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

35 个相关的代谢反应过程信息。

Reactome(16)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(18)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhen Guan, Jianhua Wang, Jin Guo, Fang Wang, Xiuwei Wang, Guannan Li, Qiu Xie, Xu Han, Bo Niu, Ting Zhang. The maternal ITPK1 gene polymorphism is associated with neural tube defects in a high-risk Chinese population. PloS one. 2014; 9(1):e86145. doi: 10.1371/journal.pone.0086145. [PMID: 24465924]
  • Musheng Bao, Shino Hanabuchi, Valeria Facchinetti, Qiumei Du, Laura Bover, Joel Plumas, Laurence Chaperot, Wei Cao, Jun Qin, Shao-Cong Sun, Yong-Jun Liu. CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. Journal of immunology (Baltimore, Md. : 1950). 2012 Jul; 189(2):786-92. doi: 10.4049/jimmunol.1200887. [PMID: 22706086]
  • Zhongjun Dong, Dominique Davidson, Luis Alberto Pérez-Quintero, Tomohiro Kurosaki, Wojciech Swat, André Veillette. The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity. 2012 Jun; 36(6):974-85. doi: 10.1016/j.immuni.2012.03.023. [PMID: 22683124]
  • Yuan Wang, Yu-Jia Chu, Hong-Wei Xue. Inositol polyphosphate 5-phosphatase-controlled Ins(1,4,5)P3/Ca2+ is crucial for maintaining pollen dormancy and regulating early germination of pollen. Development (Cambridge, England). 2012 Jun; 139(12):2221-33. doi: 10.1242/dev.081224. [PMID: 22573619]
  • H Plattner, I M Sehring, I K Mohamed, K Miranda, W De Souza, R Billington, A Genazzani, E-M Ladenburger. Calcium signaling in closely related protozoan groups (Alveolata): non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic Apicomplexa (Plasmodium, Toxoplasma). Cell calcium. 2012 May; 51(5):351-82. doi: 10.1016/j.ceca.2012.01.006. [PMID: 22387010]
  • Rudolf Zechner, Robert Zimmermann, Thomas O Eichmann, Sepp D Kohlwein, Guenter Haemmerle, Achim Lass, Frank Madeo. FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling. Cell metabolism. 2012 Mar; 15(3):279-91. doi: 10.1016/j.cmet.2011.12.018. [PMID: 22405066]
  • Takeshi Ijuin, Tadaomi Takenawa. Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP). The Journal of biological chemistry. 2012 Mar; 287(10):6991-9. doi: 10.1074/jbc.m111.335539. [PMID: 22247557]
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  • Gwenny M Fuhler, Robert Brooks, Bonnie Toms, Sonia Iyer, Elizabeth A Gengo, Mi-Young Park, Matthew Gumbleton, Dennis R Viernes, John D Chisholm, William G Kerr. Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer. Molecular medicine (Cambridge, Mass.). 2012 Feb; 18(?):65-75. doi: 10.2119/molmed.2011.00178. [PMID: 22033675]
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  • Elisa Mitiko Kawamoto, Carmen Vivar, Simonetta Camandola. Physiology and pathology of calcium signaling in the brain. Frontiers in pharmacology. 2012; 3(?):61. doi: 10.3389/fphar.2012.00061. [PMID: 22518105]
  • Nanthakumar Thirunarayanan, Bruce M Raaka, Marvin C Gershengorn. Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. Frontiers in endocrinology. 2012; 3(?):120. doi: 10.3389/fendo.2012.00120. [PMID: 23087672]
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  • Ji Hee Yun, Soo Jung Park, Ara Jo, Jihee Lee Kang, Ilo Jou, Jung Soo Park, Youn Hee Choi. Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes. Experimental & molecular medicine. 2011 Dec; 43(12):660-8. doi: 10.3858/emm.2011.43.12.075. [PMID: 21918362]
  • Mark G Waugh, Shane Minogue, Emma L Clayton, J Justin Hsuan. CDP-diacylglycerol phospholipid synthesis in detergent-soluble, non-raft, membrane microdomains of the endoplasmic reticulum. Journal of lipid research. 2011 Dec; 52(12):2148-2158. doi: 10.1194/jlr.m017814. [PMID: 21937673]
  • Kiyoko Uehara, Akira Uehara. P2Y1, P2Y6, and P2Y12 receptors in rat splenic sinus endothelial cells: an immunohistochemical and ultrastructural study. Histochemistry and cell biology. 2011 Nov; 136(5):557-67. doi: 10.1007/s00418-011-0859-2. [PMID: 21879346]
  • Michael D Allen, Susanne Neumann, Marvin C Gershengorn. Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011 Oct; 25(10):3687-94. doi: 10.1096/fj.11-188961. [PMID: 21705666]
  • Simone Patergnani, Jan M Suski, Chiara Agnoletto, Angela Bononi, Massimo Bonora, Elena De Marchi, Carlotta Giorgi, Saverio Marchi, Sonia Missiroli, Federica Poletti, Alessandro Rimessi, Jerzy Duszynski, Mariusz R Wieckowski, Paolo Pinton. Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell communication and signaling : CCS. 2011 Sep; 9(?):19. doi: 10.1186/1478-811x-9-19. [PMID: 21939514]
  • Yuval Kaye, Yael Golani, Yaniv Singer, Yehoram Leshem, Gil Cohen, Mustafa Ercetin, Glenda Gillaspy, Alex Levine. Inositol polyphosphate 5-phosphatase7 regulates the production of reactive oxygen species and salt tolerance in Arabidopsis. Plant physiology. 2011 Sep; 157(1):229-41. doi: 10.1104/pp.111.176883. [PMID: 21677096]
  • Parvin Rahman, Richard D Huysmans, Fenny Wiradjaja, Rajendra Gurung, Lisa M Ooms, David A Sheffield, Jennifer M Dyson, Meredith J Layton, Absorn Sriratana, Hidetoshi Takada, Tony Tiganis, Christina A Mitchell. Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton. The Journal of biological chemistry. 2011 Aug; 286(34):29758-70. doi: 10.1074/jbc.m111.263103. [PMID: 21712384]
  • Simon Kaja, Jill D Hilgenberg, Volodymyr Rybalchenko, Wanda E Medina-Ortiz, Elaine V Gregg, Peter Koulen. Polycystin-2 expression and function in adult mouse lacrimal acinar cells. Investigative ophthalmology & visual science. 2011 Jul; 52(8):5605-11. doi: 10.1167/iovs.10-7114. [PMID: 21508103]
  • Chaohong Liu, Heather Miller, King Lam Hui, Brian Grooman, Silvia Bolland, Arpita Upadhyaya, Wenxia Song. A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling. Journal of immunology (Baltimore, Md. : 1950). 2011 Jul; 187(1):230-9. doi: 10.4049/jimmunol.1100157. [PMID: 21622861]
  • Mhairi J Maxwell, Mubing Duan, Jane E Armes, Gary P Anderson, David M Tarlinton, Margaret L Hibbs. Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice. Journal of immunology (Baltimore, Md. : 1950). 2011 Jun; 186(12):7164-75. doi: 10.4049/jimmunol.1004185. [PMID: 21572033]
  • Attila Braun, Timo Vogtle, David Varga-Szabo, Bernhard Nieswandt. STIM and Orai in hemostasis and thrombosis. Frontiers in bioscience (Landmark edition). 2011 06; 16(6):2144-60. doi: 10.2741/3844. [PMID: 21622167]
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  • G Bhardwaj, C P Wells, R Albert, D B van Rossum, R L Patterson. Exploring phospholipase C-coupled Ca(2+) signalling networks using Boolean modelling. IET systems biology. 2011 May; 5(3):174-84. doi: 10.1049/iet-syb.2010.0019. [PMID: 21639591]
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  • Stephanie J Harris, Richard V Parry, John G Foster, Matthew D Blunt, Amu Wang, Federica Marelli-Berg, John Westwick, Stephen G Ward. Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility. Journal of immunology (Baltimore, Md. : 1950). 2011 Apr; 186(8):4936-45. doi: 10.4049/jimmunol.1002350. [PMID: 21402888]
  • Caglar Cekic, Carolyn R Casella, Duygu Sag, Frann Antignano, Joseph Kolb, Jill Suttles, Michael R Hughes, Gerald Krystal, Thomas C Mitchell. MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4. Journal of immunology (Baltimore, Md. : 1950). 2011 Apr; 186(7):3858-65. doi: 10.4049/jimmunol.1001034. [PMID: 21339365]
  • Cheng-Yuan Kao, Ferdinand C O Los, Danielle L Huffman, Shinichiro Wachi, Nicole Kloft, Matthias Husmann, Valbona Karabrahimi, Jean-Louis Schwartz, Audrey Bellier, Christine Ha, Youn Sagong, Hui Fan, Partho Ghosh, Mindy Hsieh, Chih-Shen Hsu, Li Chen, Raffi V Aroian. Global functional analyses of cellular responses to pore-forming toxins. PLoS pathogens. 2011 Mar; 7(3):e1001314. doi: 10.1371/journal.ppat.1001314. [PMID: 21408619]
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  • Etsushi Kuroda, Frann Antignano, Victor W Ho, Michael R Hughes, Jens Ruschmann, Vivian Lam, Toshiaki Kawakami, William G Kerr, Kelly M McNagny, Laura M Sly, Gerald Krystal. SHIP represses Th2 skewing by inhibiting IL-4 production from basophils. Journal of immunology (Baltimore, Md. : 1950). 2011 Jan; 186(1):323-32. doi: 10.4049/jimmunol.1002778. [PMID: 21131429]
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