Inositol 1,3,4-trisphosphate (BioDeep_00000004626)

 

Secondary id: BioDeep_00001868887

human metabolite Endogenous


代谢物信息卡片


(2,3,5-Trihydroxy-4,6-diphosphonooxycyclohexyl) dihydrogen phosphate

化学式: C6H15O15P3 (419.9624)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(otcml) 37.86%

分子结构信息

SMILES: C1(C(C(C(C(C1OP(=O)(O)O)O)OP(=O)(O)O)OP(=O)(O)O)O)O
InChI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)

描述信息

Inositol 1,3,4-trisphosphate (CAS: 98102-63-7), also known as Ins(1,3,4)P3 or I3S, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. Within humans, inositol 1,3,4-trisphosphate participates in several enzymatic reactions. In particular, inositol 1,3,4-trisphosphate can be converted into 1D-myo-inositol 1,3,4,6-tetrakisphosphate through the action of the enzyme inositol-tetrakisphosphate 1-kinase. In addition, inositol 1,3,4-trisphosphate can be converted into inositol 1,3,4,5-tetraphosphate through its interaction with the enzyme inositol-tetrakisphosphate 1-kinase. In humans, inositol 1,3,4-trisphosphate is involved in inositol metabolism. Inositol 1,3,4-trisphosphate is a specific regulator of cellular signalling.
A specific regulator of cellular signaling [HMDB]

同义名列表

15 个代谢物同义名

(2,3,5-Trihydroxy-4,6-diphosphonooxycyclohexyl) dihydrogen phosphate; (1S,3S,4S)-1,3,4-TRIPHOSPHO-myo-inositol; D-Myo-inositol 1,3,4-trisphosphoric acid; Inositol 1,3,4-trisphosphate, (D)-isomer; D-myo-Inositol 1,3,4-tris(phosphate); 1D-Myo-inositol 1,3,4-trisphosphate; Inositol 1,3,4-trisphosphoric acid; D-Myo-inositol 1,3,4-trisphosphate; Myo-inositol 1,3,4-trisphosphate; Inositol 1,3,4-trisphosphate; Inositol 1,3,4-triphosphate; Ins(1,3,4)P3; SCHEMBL98182; 1,3,4-Itp; I3S



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

35 个相关的代谢反应过程信息。

Reactome(16)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(18)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 EDN1, GTPBP4, IKBKG, ITPR3, PRKX
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 5 GTPBP4, IKBKG, MYB, PLCZ1, PRKX
cytosol 7 GTPBP4, IKBKG, INPP1, ITPK1, MYB, PLCZ1, PRKCQ
dendrite 1 P2RY1
nucleoplasm 6 GTPBP4, IKBKG, ITPR3, MYB, PLCZ1, PRKX
RNA polymerase II transcription regulator complex 1 MYB
Cell membrane 3 GPRC5A, OXTR, P2RY1
Multi-pass membrane protein 4 GPRC5A, ITPR3, OXTR, P2RY1
Synapse 1 TAC1
cell surface 1 P2RY1
glutamatergic synapse 1 P2RY1
Golgi membrane 1 INS
lysosomal membrane 1 EGF
neuronal cell body 2 ITPR3, TAC1
plasma membrane 10 EGF, F2, GPRC5A, GPRIN2, IGHE, ITPR3, KNG1, OXTR, P2RY1, PRKCQ
Membrane 5 EGF, GTPBP4, ITPR3, MYB, OXTR
apical plasma membrane 3 ITPK1, OXTR, P2RY1
axon 1 TAC1
basolateral plasma membrane 1 P2RY1
brush border 1 ITPR3
extracellular exosome 4 EGF, F2, GPRC5A, KNG1
endoplasmic reticulum 1 ITPR3
extracellular space 7 EDN1, EGF, F2, IGHE, INS, KNG1, TAC1
perinuclear region of cytoplasm 2 GTPBP4, PLCZ1
adherens junction 1 OXTR
protein-containing complex 1 IKBKG
intracellular membrane-bounded organelle 1 GPRC5A
postsynaptic density 1 P2RY1
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 IGHE
Secreted 3 EDN1, F2, INS
extracellular region 7 EDN1, EGF, F2, IGHE, INS, KNG1, TAC1
basal part of cell 1 EDN1
centriolar satellite 1 PRKCQ
nuclear membrane 1 GTPBP4
nucleolus 4 GPRC5A, GTPBP4, ITPR3, PLCZ1
apical part of cell 1 ITPR3
vesicle 1 GPRC5A
postsynaptic membrane 1 P2RY1
presynaptic active zone membrane 1 P2RY1
Cytoplasm, perinuclear region 1 PLCZ1
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 2 F2, KNG1
nuclear outer membrane 1 ITPR3
receptor complex 2 GPRC5A, ITPR3
cilium 1 P2RY1
IgE immunoglobulin complex 1 IGHE
mitotic spindle 1 IKBKG
Secreted, extracellular space 1 KNG1
Nucleus, nucleolus 1 GTPBP4
spindle pole 1 IKBKG
blood microparticle 2 F2, KNG1
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 1 INS
microvillus 1 OXTR
Cytoplasmic vesicle membrane 1 GPRC5A
cell body 1 P2RY1
ubiquitin ligase complex 1 IKBKG
secretory granule lumen 1 INS
secretory granule membrane 1 ITPR3
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 F2, INS, KNG1
nuclear matrix 1 MYB
platelet alpha granule lumen 2 EGF, KNG1
transport vesicle 2 EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
IkappaB kinase complex 1 IKBKG
clathrin-coated endocytic vesicle membrane 1 EGF
platelet dense tubular network membrane 1 ITPR3
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
[Isoform 3]: Cell membrane 1 IGHE
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
transport vesicle membrane 1 ITPR3
rough endoplasmic reticulum lumen 1 EDN1
sperm head 1 PLCZ1
Weibel-Palade body 1 EDN1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3


文献列表

  • Zhen Guan, Jianhua Wang, Jin Guo, Fang Wang, Xiuwei Wang, Guannan Li, Qiu Xie, Xu Han, Bo Niu, Ting Zhang. The maternal ITPK1 gene polymorphism is associated with neural tube defects in a high-risk Chinese population. PloS one. 2014; 9(1):e86145. doi: 10.1371/journal.pone.0086145. [PMID: 24465924]
  • Musheng Bao, Shino Hanabuchi, Valeria Facchinetti, Qiumei Du, Laura Bover, Joel Plumas, Laurence Chaperot, Wei Cao, Jun Qin, Shao-Cong Sun, Yong-Jun Liu. CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. Journal of immunology (Baltimore, Md. : 1950). 2012 Jul; 189(2):786-92. doi: 10.4049/jimmunol.1200887. [PMID: 22706086]
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