1-Butanol (BioDeep_00000004268)

 

Secondary id: BioDeep_00000608201, BioDeep_00000861864

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


Alcohol, N-butyl

化学式: C4H10O (74.0732)
中文名称: 正丁醇, 丁醇, 1-丁醇
谱图信息: 最多检出来源 Viridiplantae(plant) 19.41%

分子结构信息

SMILES: CCCCO
InChI: InChI=1S/C4H10O/c1-2-3-4-5/h5H,2-4H2,1H3

描述信息

1-butanol, also known as 1-butyl alcohol or 1-hydroxybutane, is a member of the class of compounds known as primary alcohols. Primary alcohols are compounds comprising the primary alcohol functional group, with the general structure RCOH (R=alkyl, aryl). Thus, 1-butanol is considered to be a fatty alcohol lipid molecule. 1-butanol is soluble (in water) and an extremely weak acidic compound (based on its pKa). 1-butanol can be found in a number of food items such as sugar apple, kumquat, cherry tomato, and angelica, which makes 1-butanol a potential biomarker for the consumption of these food products. 1-butanol can be found primarily in blood, feces, and saliva, as well as throughout most human tissues. 1-butanol exists in all eukaryotes, ranging from yeast to humans. Moreover, 1-butanol is found to be associated with diabetes mellitus type 2. The largest use of n-butanol is as an industrial intermediate, particularly for the manufacture of butyl acetate (itself an artificial flavorant and industrial solvent). It is a petrochemical, manufactured from propylene and usually used close to the point of manufacture. Estimated production figures for 1997 are: United States 784,000 tonnes; Western Europe 575,000 tonnes; Japan 225,000 tonnes .
1-Butanol, which is also known as n-butanol or 1-butanol or butyl alcohol (sometimes also called biobutanol when produced biologically), is an alcohol with a 4 carbon structure and the molecular formula of C4H10O. It is primarily used as a solvent, as an intermediate in chemical synthesis, and as a fuel. There are four isomeric structures for butanol. The straight chain isomer with the alcohol at an internal carbon is sec-butanol or 2-butanol. The branched isomer with the alcohol at a terminal carbon is isobutanol, and the branched isomer with the alcohol at the internal carbon is tert-butanol. 1-Butanol is produced in small amounts by gut microbial fermenetation through the butanoate metabolic pathway. It has been found in Bacillus, Clostridium, Escherichia, Lactobacillus, Pseudomonas, Saccharomyces, Synechococcus and Thermoanaerobacterium.

同义名列表

22 个代谢物同义名

Alcohol, N-butyl; N-Butyl alcohol; 1-Hydroxybutane; Propyl carbinol; Butyl hydroxide; Methylolpropane; 1-Butyl alcohol; N Butyl alcohol; Alcohol, butyl; N-Butylalkohol; Propylcarbinol; Butyl alcohol; N-Butan-1-ol; Butan-1-ol; 1-butanol; N-Butanol; N Butanol; 1 Butanol; Hemostyp; Butanol; BuOH; 1-Butanol



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(1)

代谢反应

137 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(13)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(124)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AKT1, BCL2, CASP3, CASP9, CAT, MAPK14, NOS2, PTGS2, RELA
Peripheral membrane protein 2 ACHE, PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 9 ACHE, AKT1, BCL2, CASP3, CASP9, MAPK14, MPO, NOS2, RELA
cytosol 10 AKT1, BCL2, CASP3, CASP9, CAT, GPT, LIPE, MAPK14, NOS2, RELA
nucleoplasm 6 AKT1, CASP3, MAPK14, MPO, NOS2, RELA
Cell membrane 3 ACHE, AKT1, LIPE
lamellipodium 1 AKT1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 1 ACHE
glutamatergic synapse 4 AKT1, CASP3, MAPK14, RELA
Golgi apparatus 1 ACHE
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 1 CASP3
postsynapse 1 AKT1
Cytoplasm, cytosol 2 LIPE, NOS2
Lysosome 2 GAA, MPO
plasma membrane 5 ACHE, AKT1, GAA, IFNLR1, NOS2
Membrane 7 ACHE, AKT1, BCL2, CAT, GAA, IFNLR1, LIPE
caveola 2 LIPE, PTGS2
extracellular exosome 4 CAT, GAA, GPT, MPO
Lysosome membrane 1 GAA
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 7 ACHE, CXCL8, IL10, IL2, IL4, INS, MPO
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 ACHE, NOS2
mitochondrion 4 BCL2, CASP9, CAT, MAPK14
protein-containing complex 5 AKT1, BCL2, CASP9, CAT, PTGS2
intracellular membrane-bounded organelle 3 CAT, GAA, MPO
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 IFNLR1
Secreted 7 ACHE, CXCL8, GAA, IL10, IL2, IL4, INS
extracellular region 10 ACHE, CAT, CXCL8, GAA, IL10, IL2, IL4, INS, MAPK14, MPO
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
transcription regulator complex 1 RELA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
microtubule cytoskeleton 1 AKT1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
cell-cell junction 1 AKT1
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 NOS2
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 AKT1
Peroxisome 2 CAT, NOS2
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 MPO
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 1 RELA
spindle pole 1 MAPK14
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
side of membrane 1 ACHE
myelin sheath 1 BCL2
azurophil granule 1 MPO
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
apoptosome 1 CASP9
phagocytic vesicle lumen 1 MPO
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
NF-kappaB p50/p65 complex 1 RELA
[Isoform H]: Cell membrane 1 ACHE
NF-kappaB complex 1 RELA
caspase complex 1 CASP9
interleukin-28 receptor complex 1 IFNLR1


文献列表

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