m-Cresol (BioDeep_00000004239)

 

Secondary id: BioDeep_00000405503, BioDeep_00000860201

human metabolite Endogenous blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


3-Cresol, calcium salt(1:2)

化学式: C7H8O (108.0575)
中文名称: 间甲酚
谱图信息: 最多检出来源 Homo sapiens(blood) 19.33%

分子结构信息

SMILES: c1(cccc(c1)C)O
InChI: InChI=1S/C7H8O/c1-6-3-2-4-7(8)5-6/h2-5,8H,1H3

描述信息

m-Cresol is an isomer of p-cresol and o-cresol. Cresols are organic compounds which are methylphenols. They are a widely occurring natural and manufactured group of aromatic organic compounds which are categorized as phenols (sometimes called phenolics). Depending on the temperature, cresols can be solid or liquid because they have melting points not far from room temperature. Like other types of phenols, they are slowly oxidized by long exposure to air and the impurities often give cresols a yellowish to brownish red tint. Cresols have an odor characteristic to that of other simple phenols, reminiscent to some of a "medicine" smell. Cresol solutions are used as household cleaners and disinfectants, perhaps most famously under the trade name Lysol. In the past, cresol solutions have been used as antiseptics in surgery, but they have been largely displaced in this role by less toxic compounds. Lysol was also advertised as a disinfecting vaginal douche in mid-twentieth century America. Cresols are found in many foods and in wood and tobacco smoke, crude oil, coal tar, and in brown mixtures such as creosote and cresylic acids, which are wood preservatives. Small organisms in soil and water produce cresols when they break down materials in the environment. Most exposures to cresols are at very low levels that are not harmful. When cresols are breathed, ingested, or applied to the skin at very high levels, they can be very harmful. Effects observed in people include irritation and burning of skin, eyes, mouth, and throat; abdominal pain and vomiting; heart damage; anemia; liver and kidney damage; facial paralysis; coma; and death. Breathing high levels of cresols for a short time results in irritation of the nose and throat. Aside from these effects, very little is known about the effects of breathing cresols, for example, at lower levels over longer times. Ingesting high levels results in kidney problems, mouth and throat burns, abdominal pain, vomiting, and effects on the blood and nervous system. Skin contact with high levels of cresols can burn the skin and damage the kidneys, liver, blood, brain, and lungs. m-Cresol is a microbial metabolite that can be found in Lysinibacillus.
Flavouring ingredient. 3-Methylphenol is found in asparagus, tea, and arabica coffee.

同义名列表

18 个代谢物同义名

3-Cresol, calcium salt(1:2); 1-Hydroxy-3-methylbenzene; 3-Cresol, sodium salt; m-Hydroxytoluene; 3-Hydroxytoluene; m-Cresylic acid; m-Methylphenol; 3-PHENYLPHENOL; 3-Methylphenol; m-Oxytoluene; Meta-cresol; Metacresol; m-Kresol; m-Toluol; m-cresol; 3-Cresol; 3-Cresol; m-Cresol



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

68 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ACMSD, CAT, NR0B1, PSMA1, TBX20, TYR
Peripheral membrane protein 2 ACHE, CYP1B1
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 5 ACHE, NR0B1, PSMA1, SNRNP27, TBX20
cytosol 6 ACMSD, AVP, CAT, GPT, MYL4, PSMA1
dendrite 2 AVP, C4A
centrosome 1 PSMA1
nucleoplasm 3 NR0B1, PSMA1, SNRNP27
Cell membrane 1 ACHE
Cell projection, axon 1 C4A
Golgi apparatus membrane 1 GCNT2
Synapse 2 ACHE, C4A
cell surface 1 ACHE
Golgi apparatus 3 ACHE, ATRN, GCNT2
Golgi membrane 2 GCNT2, INS
neuromuscular junction 1 ACHE
neuronal cell body 1 C4A
Lysosome 1 TYR
plasma membrane 4 ACHE, ATRN, C4A, IGHE
Membrane 6 ACHE, ACMSD, CAT, CYP1B1, GCNT2, NR0B1
axon 2 C4A, CCK
extracellular exosome 5 ATRN, C4A, CAT, GPT, PSMA1
extracellular space 8 ACHE, ATRN, AVP, C4A, CCK, IGHE, INS, PTH
perinuclear region of cytoplasm 2 ACHE, TYR
mitochondrion 2 CAT, CYP1B1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 4 CAT, CYP1B1, NR0B1, TYR
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 3 ATRN, IGHE, TYR
Secreted 5 ACHE, AVP, C4A, CCK, INS
extracellular region 8 ACHE, AVP, C4A, CAT, CCK, IGHE, INS, PTH
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
centriolar satellite 1 NR0B1
Melanosome membrane 1 TYR
Golgi-associated vesicle 1 TYR
Single-pass type II membrane protein 1 GCNT2
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 AVP
nuclear speck 1 NR0B1
chromatin 2 NR0B1, TBX20
IgE immunoglobulin complex 1 IGHE
blood microparticle 1 C4A
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 IGHE
[Isoform 3]: Secreted 1 ATRN
myosin II complex 1 MYL4
endosome lumen 1 INS
Cell projection, dendrite 1 C4A
Melanosome 1 TYR
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
proteasome complex 1 PSMA1
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 C4A, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 AVP
proteasome core complex 1 PSMA1
proteasome core complex, alpha-subunit complex 1 PSMA1
clathrin-coated endocytic vesicle membrane 1 AVP
A band 1 MYL4
synaptic cleft 1 ACHE
[Isoform 1]: Cell membrane 1 ATRN
U4/U6 x U5 tri-snRNP complex 1 SNRNP27
[Isoform 3]: Cell membrane 1 IGHE
ribosome 1 NR0B1
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Hugo Hartl, Wenshao Li, Thomas Danny Michl, Raveendra Anangi, Robert Speight, Krasimir Vasilev, Kostya Ken Ostrikov, Jennifer MacLeod. Antimicrobial adhesive films by plasma-enabled polymerisation of m-cresol. Scientific reports. 2022 05; 12(1):7560. doi: 10.1038/s41598-022-11400-8. [PMID: 35534598]
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  • Pichiah Saravanan, K Pakshirajan, Prabirkumar Saha. Batch growth kinetics of an indigenous mixed microbial culture utilizing m-cresol as the sole carbon source. Journal of hazardous materials. 2009 Feb; 162(1):476-81. doi: 10.1016/j.jhazmat.2008.05.069. [PMID: 18573608]
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