3-oxo-C12 homoserine lactone (BioDeep_00000003952)

 

Secondary id: BioDeep_00001883591


代谢物信息卡片


N-3-oxo-dodecanoyl-L-homoserine lactone

化学式: C16H27NO4 (297.194)
中文名称: 3-氧代-N-[(3S)-四氢-2-氧代-3-呋喃基]十二酰胺
谱图信息: 最多检出来源 Homo sapiens(plant) 28%

分子结构信息

SMILES: CCCCCCCCCC(=O)CC(=O)NC1CCOC1=O
InChI: InChI=1S/C16H27NO4/c1-2-3-4-5-6-7-8-9-13(18)12-15(19)17-14-10-11-21-16(14)20/h14H,2-12H2,1H3,(H,17,19)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 211

同义名列表

4 个代谢物同义名

N-3-oxo-dodecanoyl-L-homoserine lactone; N-(3-Oxododecanoyl)homoserine lactone; 3-oxo-C12 homoserine lactone; N-(3-Oxododecanoyl)homoserine lactone



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AIMP2, AQP9, BGLAP, CASP3, CASP7, ELANE, MARVELD1, MARVELD2, PPARG, PTGS2, RUNX2, SP7
Peripheral membrane protein 2 PON2, PTGS2
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 8 AIMP2, CASP3, CASP7, MARVELD1, PPARA, PPARG, RUNX2, SP7
cytosol 6 AIMP2, CASP3, CASP7, ELANE, PPARG, RUNX2
dendrite 1 BGLAP
phagocytic vesicle 1 ELANE
nucleoplasm 5 CASP3, CASP7, PPARA, PPARG, RUNX2
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 4 AQP9, MARVELD1, MARVELD2, TNF
Multi-pass membrane protein 3 AQP9, MARVELD1, MARVELD2
cell cortex 1 AQP9
cell junction 1 MARVELD2
cell surface 2 ELANE, TNF
glutamatergic synapse 1 CASP3
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 2 AIMP2, CASP7
plasma membrane 6 AQP9, CXCR5, MARVELD1, MARVELD2, PON2, TNF
Membrane 7 AIMP2, AQP9, CXCR5, IBSP, MARVELD1, MARVELD2, PON2
apical plasma membrane 1 MARVELD2
basolateral plasma membrane 2 AQP9, MARVELD2
caveola 1 PTGS2
extracellular exosome 2 BMP3, ELANE
endoplasmic reticulum 1 PTGS2
extracellular space 8 BGLAP, BMP3, CASP7, CXCL8, ELANE, IBSP, IL10, TNF
perinuclear region of cytoplasm 1 PPARG
Cell junction, tight junction 1 MARVELD2
bicellular tight junction 1 MARVELD2
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 2 AQP9, PPARG
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Secreted 5 BGLAP, BMP3, CXCL8, IBSP, IL10
extracellular region 8 BGLAP, BMP3, CXCL8, ELANE, IBSP, IL10, PON2, TNF
transcription regulator complex 1 RUNX2
external side of plasma membrane 2 CXCR5, TNF
perikaryon 1 BGLAP
cytoplasmic vesicle 1 MARVELD2
cell-cell junction 1 AQP9
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 BGLAP, IBSP
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 MARVELD1
collagen-containing extracellular matrix 1 ELANE
secretory granule 1 ELANE
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
chromatin 4 PPARA, PPARG, RUNX2, SP7
phagocytic cup 1 TNF
cytoskeleton 1 MARVELD1
Secreted, extracellular space 1 CASP7
Basolateral cell membrane 1 AQP9
Lipid droplet 1 AQP9
Cytoplasmic vesicle membrane 1 AQP9
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 2 BGLAP, PTGS2
transcription repressor complex 1 ELANE
specific granule lumen 1 ELANE
Schmidt-Lanterman incisure 1 MARVELD2
tight junction 1 MARVELD2
azurophil granule lumen 1 ELANE
paranodal junction 1 MARVELD2
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
tricellular tight junction 1 MARVELD2
Cytoplasmic vesicle, phagosome 1 ELANE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Marta Woźniak-Karczewska, Kamila Myszka, Agata Sznajdrowska, Alicja Szulc, Agnieszka Zgoła-Grześkowiak, Łukasz Ławniczak, Philippe F-X Corvini, Łukasz Chrzanowski. Isolation of rhamnolipids-producing cultures from faeces: Influence of interspecies communication on the yield of rhamnolipid congeners. New biotechnology. 2017 May; 36(?):17-25. doi: 10.1016/j.nbt.2016.12.008. [PMID: 28043869]
  • Sung Yong Eum, Dima Jaraki, Luc Bertrand, Ibolya E András, Michal Toborek. Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases. American journal of physiology. Gastrointestinal and liver physiology. 2014 Jun; 306(11):G992-G1001. doi: 10.1152/ajpgi.00016.2014. [PMID: 24742991]
  • Bijay K Khajanchi, Michelle L Kirtley, Sheri M Brackman, Ashok K Chopra. Immunomodulatory and protective roles of quorum-sensing signaling molecules N-acyl homoserine lactones during infection of mice with Aeromonas hydrophila. Infection and immunity. 2011 Jul; 79(7):2646-57. doi: 10.1128/iai.00096-11. [PMID: 21536794]