Quinoline-4-carboxylic acid (BioDeep_00000003089)

 

Secondary id: BioDeep_00000405717

human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


Quinoline-4-carboxylic acid

化学式: C10H7NO2 (173.0477)
中文名称: 4-喹啉羧酸, 喹啉-4-羧酸
谱图信息: 最多检出来源 Homo sapiens(blood) 16.06%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=CC=N2)C(=O)O
InChI: InChI=1S/C10H7NO2/c12-10(13)8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H,12,13)



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 EGFR, MSMP, PREP
Peripheral membrane protein 1 HSD17B6
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 1 EGFR
Nucleus 3 DLD, EGFR, PREP
cytosol 2 DHODH, PREP
nucleoplasm 1 DHODH
Cell membrane 1 EGFR
ruffle membrane 1 EGFR
Early endosome membrane 2 EGFR, HSD17B6
Multi-pass membrane protein 1 ABCC2
cell junction 1 EGFR
cell surface 2 ABCC2, EGFR
glutamatergic synapse 1 EGFR
Golgi membrane 1 EGFR
mitochondrial inner membrane 1 DHODH
acrosomal vesicle 1 DLD
endosome 1 EGFR
plasma membrane 2 ABCC2, EGFR
Membrane 4 ABCC2, DHODH, EGFR, PREP
apical plasma membrane 2 ABCC2, EGFR
basolateral plasma membrane 1 EGFR
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 2 EGFR, MSMP
perinuclear region of cytoplasm 1 EGFR
intercellular canaliculus 1 ABCC2
mitochondrion 3 DHODH, DLD, PREP
protein-containing complex 1 EGFR
intracellular membrane-bounded organelle 1 HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 1 EGFR
Secreted 1 MSMP
Single-pass membrane protein 1 DHODH
Mitochondrion matrix 2 DLD, PREP
mitochondrial matrix 2 DLD, PREP
motile cilium 1 DLD
nuclear membrane 1 EGFR
Apical cell membrane 1 ABCC2
Mitochondrion inner membrane 1 DHODH
Membrane raft 1 EGFR
focal adhesion 1 EGFR
intracellular vesicle 1 EGFR
receptor complex 1 EGFR
Cytoplasmic vesicle, secretory vesicle, acrosome 1 DLD
Cell projection, cilium, flagellum 1 DLD
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
pyruvate dehydrogenase complex 1 DLD
oxoglutarate dehydrogenase complex 1 DLD
clathrin-coated endocytic vesicle membrane 1 EGFR
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
acetyltransferase complex 1 DLD
acrosomal matrix 1 DLD
branched-chain alpha-ketoacid dehydrogenase complex 1 DLD
oxoadipate dehydrogenase complex 1 DLD


文献列表

  • Yi Hu, Emme C K Lin, Lan M Pham, Julia Cajica, Christopher M Amantea, Eric Okerberg, Heidi E Brown, Allister Fraser, Lingling Du, Yasushi Kohno, Junichi Ishiyama, John W Kozarich, Kevin R Shreder. Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA₂. Bioorganic & medicinal chemistry letters. 2013 Mar; 23(5):1553-6. doi: 10.1016/j.bmcl.2012.11.048. [PMID: 23333209]
  • J Strigácová, D Hudecová, L Varecka, A Lásiková, D Végh. Some biological properties of new quinoline-4-carboxylic acid and quinoline-4-carboxamide derivatives. Folia microbiologica. 2000; 45(4):305-9. doi: 10.1007/bf02817551. [PMID: 11347250]
  • V FABER, M IVERSEN. Variation in serum hyaluronidase-inhibitor during treatment with 3-hydroxy-2-phenyl-cinchoninic acid. Acta medica Scandinavica. 1952 Sep; 143(6):436-41. doi: 10.1111/j.0954-6820.1952.tb19156.x. [PMID: 12976035]
  • C G ZUBROD, E H DEARBORN, E K MARSHALL. Effect of 3-hydroxy-2-phenylcinchoninic acid on renal secretion of phenyl red and penicillin. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1950 Aug; 74(4):671-4. doi: 10.3181/00379727-74-18011. [PMID: 14781145]