AdoMet (BioDeep_00000003014)

natural product PANOMIX_OTCML-2023 Volatile Flavor Compounds

代谢物信息卡片

(2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate

化学式: C15H22N6O5S (398.1372322)
中文名称: S-腺苷-L-蛋氨酸, S-腺甘基蛋氨酸
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.08%

分子结构信息

SMILES: C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
InChI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27?/m0/s1

描述信息

[Spectral] S-Adenosyl-L-methionine (exact mass = 398.13724) and L-Histidine (exact mass = 155.06948) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
A - Alimentary tract and metabolism > A16 - Other alimentary tract and metabolism products > A16A - Other alimentary tract and metabolism products > A16AA - Amino acids and derivatives
Acquisition and generation of the data is financially supported in part by CREST/JST.
C26170 - Protective Agent > C275 - Antioxidant
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

25 个代谢物同义名

(2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate; (3S)-5-[(3-Amino-3-carboxypropyl)methylsulfonio]-5-deoxyadenosine; 5-Deoxyadenosine-5-L-methionine disulphate ditosylate; 5-Deoxyadenosine-5-L-methionine disulfate ditosylate; S-Adenosyl-L-methionine disulphate tosylate; S-Adenosyl-L-methionine disulfate tosylate; S-(5-Deoxyadenosin-5-yl)-L-methionine; S-(5′-Adenosyl)-L-methionine chloride; S-(5-Adenosyl)-L-methionine chloride; S-(5-Adenosyl)-L-methionine; 2-S-Adenosyl-L-methionine; S-Adenosyl-L-methionine; L-S-Adenosylmethionine; S-Adenosyl methionine; S-Adenosyl-methionine; S-Adenosylmethionine; Adenosylmethionine; Active methionine; Acylcarnitine; Ademetionine; Donamet; AdoMet; SAMe; S-Adenosylmethionine; S-Adenosyl-L-methionine

数据库引用编号

38 个数据库交叉引用编号

ChEBI: CHEBI:67040
KEGG: C00019
PubChem: 34755
PubChem: 5136
PubChem: 3321
Metlin: METLIN3289
DrugBank: DB00118
ChEMBL: CHEMBL1235831
ChEMBL: CHEMBL1088977
MeSH: S-Adenosylmethionine
MetaCyc: S-ADENOSYLMETHIONINE
KNApSAcK: C00007347
CAS: 91279-78-6
CAS: 78548-84-2
CAS: 29908-03-0
MoNA: PS013301
MoNA: PS013306
MoNA: PS013305
MoNA: KNA00188
MoNA: PS090903
MoNA: KNA00185
MoNA: KNA00372
MoNA: KNA00374
MoNA: PR100076
MoNA: KNA00187
MoNA: PS090901
MoNA: PS013302
MoNA: KNA00186
MoNA: KNA00375
MoNA: KNA00373
MoNA: PR100378
PMhub: MS000007720
ChEBI: CHEBI:15414
PDB-CCD: SAM
3DMET: B04620
NIKKAJI: J23.293I
KNApSAcK: 15414
LOTUS: LTS0093657

分类词条

氨基酸、肽和类似物

代谢反应

39 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(27)

choline biosynthesis I: H₂O + phosphoryl-choline ⟶ choline + phosphate
phosphatidylcholine biosynthesis II: S-adenosyl-L-methionine + phosphoryl-ethanolamine ⟶ S-adenosyl-L-homocysteine + H⁺ + N-methylethanolamine phosphate
phosphatidylcholine biosynthesis III: S-adenosyl-L-methionine + phosphoryl-ethanolamine ⟶ S-adenosyl-L-homocysteine + H⁺ + N-methylethanolamine phosphate
phosphatidylcholine biosynthesis IV: S-adenosyl-L-methionine + phosphoryl-ethanolamine ⟶ S-adenosyl-L-homocysteine + H⁺ + N-methylethanolamine phosphate
S-adenosylmethionine biosynthesis: ATP + H₂O + met ⟶ S-adenosyl-L-methionine + H⁺ + diphosphate + phosphate
ubiquinone-9 biosynthesis: 3-nonaprenyl-4-hydroxybenzoate ⟶ 2-nonaprenylphenol + CO₂
ovothiol A biosynthesis: cys + his ⟶ S-4-(histidyl)-cysteine sulfoxide
methionine salvage pathway: S-methyl-5'-thioadenosine + phosphate ⟶ 5-methylthioribose-1-phosphate + adenine
superpathway of polyamine biosynthesis I: H₂O + agmatine ⟶ putrescine + urea
spermidine biosynthesis I: S-adenosyl-L-methionine + H⁺ ⟶ S-adenosyl-L-methioninamine + CO₂
superpathway of polyamine biosynthesis II: N-carbamoylputrescine + H₂O + H⁺ ⟶ CO₂ + ammonia + putrescine
superpathway of polyamine biosynthesis I: H₂O + agmatine ⟶ putrescine + urea
superpathway of arginine and polyamine biosynthesis: N-acetyl-L-ornithine + H₂O ⟶ L-ornithine + acetate
spermidine biosynthesis I: S-adenosyl-L-methionine + H⁺ ⟶ S-adenosyl-L-methioninamine + CO₂
superpathway of sterol biosynthesis: 4-methyl-2-oxopentanoate + NAD⁺ + coenzyme A ⟶ CO₂ + NADH + isovaleryl-CoA
ergosterol biosynthesis: H⁺ + NADPH + O₂ + lanosterol ⟶ 4,4-dimethyl-5-α-cholesta-8,14,24-trien-3-β-ol + H₂O + NADP⁺ + formate
ergosterol biosynthesis: NADP⁺ + ergosterol ⟶ 5,7,22,24(28)-ergostatetraenol + H⁺ + NADPH
superpathway of phospholipid biosynthesis: an L-1-phosphatidyl-glycerol ⟶ a cardiolipin + glycerol
ester phospholipid biosynthesis: an L-1-phosphatidyl-glycerol ⟶ a cardiolipin + glycerol
heme biosynthesis from uroporphyrinogen-III II: H⁺ + uroporphyrinogen-III ⟶ CO₂ + coproporphyrinogen III
ubiquinol-8 biosynthesis (prokaryotic): 3-octaprenyl-4-hydroxybenzoate + H⁺ ⟶ 2-octaprenylphenol + CO₂
methionine biosynthesis: H₂O + L-cystathionine ⟶ H⁺ + L-homocysteine + ammonia + pyruvate
superpathway of lysine, threonine and methionine biosynthesis II: H₂O + L-cystathionine ⟶ H⁺ + L-homocysteine + ammonia + pyruvate
methionine biosynthesis II: H₂O + L-cystathionine ⟶ H⁺ + L-homocysteine + ammonia + pyruvate
S-adenosyl-L-methionine biosynthesis: ATP + H₂O + met ⟶ S-adenosyl-L-methionine + H⁺ + diphosphate + phosphate
aspartate superpathway: ATP + ammonia + nicotinate adenine dinucleotide ⟶ AMP + H⁺ + NAD⁺ + diphosphate
methionine and S-adenosylmethionine synthesis: ATP + H₂O + met ⟶ S-adenosyl-L-methionine + H⁺ + diphosphate + phosphate

WikiPathways(4)

Disorders of folate metabolism and transport: Folic acid ⟶ DHF
Methionine metabolism leading to sulfur amino acids and related disorders: Adenosine ⟶ AMP
Trans-sulfuration and one-carbon metabolism: Methionine ⟶ Decarboxylated SAM
MTHFR deficiency: Choline ⟶ Phosphocholine

Plant Reactome(0)

INOH(7)

Tryptophan degradation ( Tryptophan degradation ): L-Tryptophan + O2 ⟶ N-Formyl-L-kynurenine
Arginine and Proline metabolism ( Arginine and Proline metabolism ): ATP + Creatine ⟶ ADP + N-Phospho-creatine
Glycine and Serine metabolism ( Glycine and Serine metabolism ): Guanidino-acetic acid + S-Adenosyl-L-methionine ⟶ Creatine + S-Adenosyl-L-homocysteine
Tyrosine metabolism ( Tyrosine metabolism ): 4-Hydroxy-phenyl-acetaldehyde + H2O + NAD+ ⟶ 4-Hydroxy-phenyl-acetic acid + NADH
Nicotinate and Nicotinamide metabolism ( Nicotinate and Nicotinamide metabolism ): ATP + Deamido-NAD+ + H2O + L-Glutamine ⟶ AMP + L-Glutamic acid + NAD+ + Pyrophosphate
Histidine degradation ( Histidine degradation ): H2O + L-Carnosine ⟶ L-Histidine + beta-Alanine
Methionine and Cysteine metabolism ( Methionine and Cysteine metabolism ): H2O + L-Cystathionine ⟶ 2-Oxo-butanoic acid + L-Cysteine + NH3

PlantCyc(0)

COVID-19 Disease Map(1)

@COVID-19 Disease Map["name"]: L-Asparagine + NARS2 ⟶ NLcomp

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

55605 - Angelica acutiloba:
48101 - Angelica dahurica: 10.1021/NP050301S
52491 - Angelica decursiva:
85712 - Angelica gigas:
165353 - Angelica sinensis:
3702 - Arabidopsis thaliana: 10.1073/PNAS.1831512100
4039 - Daucus carota: 10.1016/J.PHYTOCHEM.2005.05.010
239644 - Halosciastrum melanotilingia:
9606 - Homo sapiens: 10.1007/S11306-016-1051-4
9606 - Homo sapiens: 10.1016/0006-3002(58)90199-9
228659 - Oplopanax elatus: 10.1021/NP900628J
182917 - Oplopanax horridus: 10.1021/NP900674D
3888 - Pisum sativum: 10.1016/S0031-9422(00)85670-8
569774 - 金线莲: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Qinhua Gan, Haifeng Zheng, Xinyu Li, Jing Li, Jingxue Ma, Yuji Zhang, Jiakun Han, Lin Zhang, Wenxu Zhou, Yandu Lu. Solving the Jigsaw puzzle of phytosterol diversity by a novel sterol methyltransferase from Zea mays. The Journal of steroid biochemistry and molecular biology. 2024 Jun; 240(?):106498. doi: 10.1016/j.jsbmb.2024.106498. [PMID: 38447903]
James T Carrillo, Dulal Borthakur. Characterization of a plant S-adenosylmethionine synthetase from Acacia koa. Plant physiology and biochemistry : PPB. 2024 May; 210(?):108618. doi: 10.1016/j.plaphy.2024.108618. [PMID: 38631157]
Yi Xiao, Chao Han, Xiaocong Li, Xinting Zhu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu, Fang Liu. S-Adenosylmethionine (SAM) diet promotes innate immunity via histone H3K4me3 complex. International immunopharmacology. 2024 Apr; 131(?):111837. doi: 10.1016/j.intimp.2024.111837. [PMID: 38471365]
Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S Nguyen, Johan Joo, Mukund P Tantak, Holly Moots, Otto Phanstiel. The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress. Biomolecules. 2024 Mar; 14(3):. doi: 10.3390/biom14030326. [PMID: 38540746]
Daniel Leclerc, Karen E Christensen, Alaina M Reagan, Vafa Keser, Yan Luan, Olga V Malysheva, Brandi Wasek, Teodoro Bottiglieri, Marie A Caudill, Gareth R Howell, Rima Rozen. Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner. Molecular nutrition & food research. 2024 Mar; 68(5):e2300355. doi: 10.1002/mnfr.202300355. [PMID: 38327171]
Hong-Chao Duan, Chi Zhang, Peizhe Song, Junbo Yang, Ye Wang, Guifang Jia. C2-methyladenosine in tRNA promotes protein translation by facilitating the decoding of tandem m2A-tRNA-dependent codons. Nature communications. 2024 Feb; 15(1):1025. doi: 10.1038/s41467-024-45166-6. [PMID: 38310199]
Stephen G Andrews, Anthony M Koehle, Devendra Paudel, Thomas Neuberger, A Catharine Ross, Vishal Singh, Teodoro Bottiglieri, Rita Castro. Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice. Nutrients. 2024 Jan; 16(3):. doi: 10.3390/nu16030330. [PMID: 38337615]
Huan He, Ziwei Wang, Xueke Peng, Luolong Qing, Yu Zhang, Shaojuan Fu, Juan Xu, Yuanyuan Li, Silong Zhang. Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis. Journal of medicinal chemistry. 2024 Jan; 67(1):543-554. doi: 10.1021/acs.jmedchem.3c01770. [PMID: 38166392]
Lucía Barbier-Torres, Jyoti Chhimwal, So Yeon Kim, Komal Ramani, Aaron Robinson, Heping Yang, Jenny Van Eyk, Suthat Liangpunsakul, Ekihiro Seki, José M Mato, Shelly C Lu. S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver. International journal of biological sciences. 2024; 20(4):1218-1237. doi: 10.7150/ijbs.90104. [PMID: 38385082]
Jianying Yue, Yan Lu, Zhenqi Sun, Yuqing Guo, David San León, Fabio Pasin, Mingmin Zhao. Methyltransferase-like (METTL) homologues participate in Nicotiana benthamiana antiviral responses. Plant signaling & behavior. 2023 12; 18(1):2214760. doi: 10.1080/15592324.2023.2214760. [PMID: 37210738]
Yue Liu, Lianjing Ge, Huimeng Tang, Jinhui Zheng, Jinxiang Hu, Jingru Wang, Xiaoyu Yang, Ruimin Zhang, Xiaoyun Wang, Xiuming Li, Yan Zhang, Qinghua Shi. cGMP functions as an important messenger involved in SlSAMS1-regulated salt stress tolerance in tomato. Plant physiology and biochemistry : PPB. 2023 Nov; 204(?):108097. doi: 10.1016/j.plaphy.2023.108097. [PMID: 37864930]
Mengjie An, Doudou Chang, Xiaoli Wang, Kaiyong Wang. Protective effects of polymer amendment on specific metabolites in soil and cotton leaves under cadmium contamination. Ecotoxicology and environmental safety. 2023 Sep; 264(?):115463. doi: 10.1016/j.ecoenv.2023.115463. [PMID: 37714036]
Wenli Hu, Shuang Hu, Shaozhuang Li, Qi Zhou, Zijing Xie, Xiaohua Hao, Sha Wu, Lianfu Tian, Dongping Li. AtSAMS regulates floral organ development by DNA methylation and ethylene signaling pathway. Plant science : an international journal of experimental plant biology. 2023 Sep; 334(?):111767. doi: 10.1016/j.plantsci.2023.111767. [PMID: 37302530]
Hua Li, Lele Zhang, Baocun Wu, Yang Li, Huijuan Wang, Huixin Teng, Dongwei Wei, Zhiliang Yuan, Zuli Yuan. Physiological and proteomic analyses reveal the important role of arbuscular mycorrhizal fungi on enhancing photosynthesis in wheat under cadmium stress. Ecotoxicology and environmental safety. 2023 Aug; 261(?):115105. doi: 10.1016/j.ecoenv.2023.115105. [PMID: 37285679]
Zhong-Ce Hu, Yun-Chao Tao, Jun-Chao Pan, Chui-Mu Zheng, Yuan-Shan Wang, Ya-Ping Xue, Zhi-Qiang Liu, Yu-Guo Zheng. Breeding of Saccharomyces cerevisiae with a High-Throughput Screening Strategy for Improvement of S-Adenosyl-L-Methionine Production. Applied biochemistry and biotechnology. 2023 Jul; ?(?):. doi: 10.1007/s12010-023-04622-7. [PMID: 37418127]
Meijing Li, Zheyan Mi, Jinhao Wang, Zhongce Hu, Haibin Qin, Yuanshan Wang, Yuguo Zheng. [Microbial production of S-adenosyl-l-methionine: a review]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2023 Jun; 39(6):2248-2264. doi: 10.13345/j.cjb.220959. [PMID: 37401593]
Timothy Salita, Yepy H Rustam, Vinzenz Hofferek, Michael Jackson, Isaac Tollestrup, Jeffrey P Sheridan, Vern L Schramm, Gary B Evans, Gavin E Reid, Andrew B Munkacsi. Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitor. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2023 Jun; ?(?):159346. doi: 10.1016/j.bbalip.2023.159346. [PMID: 37301365]
Han Li, Lu Wu, Fuping Ye, Dapeng Wang, Li Wang, Wenqi Li, Yuan Xu, Zhenyang Li, Jingshu Zhang, Suhua Wang, Aihua Zhang, Qizhan Liu. As3MT via consuming SAM is involved in arsenic-induced nonalcoholic fatty liver disease by blocking m6A-mediated miR-142-5p maturation. The Science of the total environment. 2023 Jun; 892(?):164746. doi: 10.1016/j.scitotenv.2023.164746. [PMID: 37301390]
Likang Zhao, Changkai Li, Meng Zhang, Honglian Li, Shengli Ding, Xi Zhao, Lianjuan Yang, Jia Liu, Qing X Li, Risong Na. Design, Synthesis, and Antifungal Activity of Polyacetylenic Alcohol Derivatives and Stereoisomers against Phytopathogenic Fungi. Journal of agricultural and food chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.jafc.3c00924. [PMID: 37261403]
Li Yang, Xingxing Wang, Fuyong Zhao, Xianliang Zhang, Wei Li, Junsen Huang, Xiaoyu Pei, Xiang Ren, Yangai Liu, Kunlun He, Fei Zhang, Xiongfeng Ma, Daigang Yang. Roles of S-Adenosylmethionine and Its Derivatives in Salt Tolerance of Cotton. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119517. [PMID: 37298464]
Pei-Yi Chu, Dev-Aur Chou, Po-Ming Chen, En-Pei Isabel Chiang. Translocation of Methionine Adenosyl Transferase MAT2A and Its Prognostic Relevance for Liver Hepatocellular Carcinoma. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24109103. [PMID: 37240447]
Jun-Min Lee, Min-Ho Park, Bu-Soo Park, Min-Kyu Oh. Production of S-methyl-methionine using engineered Saccharomyces cerevisiae sake K6. Journal of industrial microbiology & biotechnology. 2023 Feb; 50(1):. doi: 10.1093/jimb/kuad026. [PMID: 37653437]
Tetsuya Hirabayashi, Mai Kawaguchi, Sayaka Harada, Misa Mouri, Rina Takamiya, Yoshimi Miki, Hiroyasu Sato, Yoshitaka Taketomi, Kohei Yokoyama, Tetsuyuki Kobayashi, Suzumi M Tokuoka, Yoshihiro Kita, Emiko Yoda, Shuntaro Hara, Kyohei Mikami, Yasumasa Nishito, Norihito Kikuchi, Rieko Nakata, Mari Kaneko, Hiroshi Kiyonari, Kohji Kasahara, Toshiki Aiba, Kazutaka Ikeda, Tomoyoshi Soga, Makoto Kurano, Yutaka Yatomi, Makoto Murakami. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups. Cell reports. 2023 Jan; 42(2):111940. doi: 10.1016/j.celrep.2022.111940. [PMID: 36719796]
Alex Bare, Jaime Thomas, Daniel Etoroma, Soon Goo Lee. Functional analysis of phosphoethanolamine N-methyltransferase in plants and parasites: Essential S-adenosylmethionine-dependent methyltransferase in choline and phospholipid metabolism. Methods in enzymology. 2023; 680(?):101-137. doi: 10.1016/bs.mie.2022.08.028. [PMID: 36710008]
Siyue Kan, Jingwen Tan, Qing Cai, Lulu An, Zhiqin Gao, Hong Yang, Siyu Liu, Risong Na, Lianjuan Yang. Synergistic activity of the combination of falcarindiol and itraconazole in vitro against dermatophytes. Frontiers in cellular and infection microbiology. 2023; 13(?):1128000. doi: 10.3389/fcimb.2023.1128000. [PMID: 37207188]
Audrey Lashley, Ryan Miller, Stephanie Provenzano, Sara-Alexis Jarecki, Paul Erba, Vonny Salim. Functional Diversification and Structural Origins of Plant Natural Product Methyltransferases. Molecules (Basel, Switzerland). 2022 Dec; 28(1):. doi: 10.3390/molecules28010043. [PMID: 36615239]
Francisco J Arriaza-Gallardo, Sebastian Schaupp, Yu-Cong Zheng, Mohd Farid Abdul-Halim, Hui-Jie Pan, Jörg Kahnt, Georgia Angelidou, Nicole Paczia, Xile Hu, Kyle Costa, Seigo Shima. The Function of Two Radical-SAM Enzymes, HcgA and HcgG, in the Biosynthesis of the [Fe]-Hydrogenase Cofactor. Angewandte Chemie (International ed. in English). 2022 12; 61(50):e202213239. doi: 10.1002/anie.202213239. [PMID: 36264001]
Gokay Albayrak, Serdar Demir, Halil Koyu, Sura Baykan. Anticholinesterase Compounds from Endemic Prangos uechtritzii. Chemistry & biodiversity. 2022 Nov; 19(11):e202200557. doi: 10.1002/cbdv.202200557. [PMID: 36201258]
Gopal Peddinti, Hannu Hotti, Teemu H Teeri, Heiko Rischer. De novo transcriptome assembly of Conium maculatum L. to identify candidate genes for coniine biosynthesis. Scientific reports. 2022 10; 12(1):17562. doi: 10.1038/s41598-022-21728-w. [PMID: 36266299]
Atsuko Kitano, Toshio Norikura, Isao Matsui-Yuasa, Hiromi Shimakawa, Makoto Kamezawa, Akiko Kojima-Yuasa. Black carrot extract protects against hepatic injury through epigenetic modifications. Journal of food biochemistry. 2022 10; 46(10):e14292. doi: 10.1111/jfbc.14292. [PMID: 35762419]
Qiang Luo, Jiezhen Mo, Hao Chen, Zetao Hu, Baihui Wang, Jiabing Wu, Ziyu Liang, Wenhao Xie, Kangxi Du, Maolin Peng, Yingping Li, Tianyang Li, Yangyi Zhang, Xiaoyan Shi, Wen-Hui Shen, Yang Shi, Aiwu Dong, Hailin Wang, Jinbiao Ma. Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4. Nature communications. 2022 09; 13(1):5636. doi: 10.1038/s41467-022-33277-x. [PMID: 36163360]
Amna Devi, Romit Seth, Mamta Masand, Gopal Singh, Ashlesha Holkar, Shikha Sharma, Ashok Singh, Ram Kumar Sharma. Spatial Genomic Resource Reveals Molecular Insights into Key Bioactive-Metabolite Biosynthesis in Endangered Angelica glauca Edgew. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911064. [PMID: 36232367]
Yeong-Biau Yu, Douglas O Adams, Shang Fa Yang. Reprint of: 1-Aminocyclopropanecarboxylate Synthase, a Key Enzyme in Ethylene Biosynthesis. Archives of biochemistry and biophysics. 2022 09; 726(?):109238. doi: 10.1016/j.abb.2022.109238. [PMID: 35680445]
Cody T Lloyd, David F Iwig, Bo Wang, Matteo Cossu, William W Metcalf, Amie K Boal, Squire J Booker. Discovery, structure and mechanism of a tetraether lipid synthase. Nature. 2022 09; 609(7925):197-203. doi: 10.1038/s41586-022-05120-2. [PMID: 35882349]
Pei-Wen Yang, Ju-Ying Jiao, Zhen Chen, Xiao-Yan Zhu, Chien-Shan Cheng. Keep a watchful eye on methionine adenosyltransferases, novel therapeutic opportunities for hepatobiliary and pancreatic tumours. Biochimica et biophysica acta. Reviews on cancer. 2022 09; 1877(5):188793. doi: 10.1016/j.bbcan.2022.188793. [PMID: 36089205]
Renata Orłowska, Jacek Zebrowski, Janusz Zimny, Piotr Androsiuk, Piotr Tomasz Bednarek. S-Adenosyl-L-Methionine and Cu(II) Impact Green Plant Regeneration Efficiency. Cells. 2022 08; 11(17):. doi: 10.3390/cells11172700. [PMID: 36078107]
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Yu Li, Wangdan Xiong, Feng He, Tianxiong Qi, Zhen Sun, Yuchen Liu, Shiqie Bai, Honglun Wang, Zhenying Wu, Chunxiang Fu. Down-regulation of PvSAMS impairs S-adenosyl-L-methionine and lignin biosynthesis, and improves cell wall digestibility in switchgrass. Journal of experimental botany. 2022 06; 73(12):4157-4169. doi: 10.1093/jxb/erac147. [PMID: 35383829]
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