AdoMet (BioDeep_00000003014)

Main id: BioDeep_00000018412

Secondary id: BioDeep_00000400213

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate

化学式: C15H22N6O5S (398.1372)
中文名称: S-腺苷-L-蛋氨酸, S-腺甘基蛋氨酸
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 15.13%

分子结构信息

SMILES: C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
InChI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27?/m0/s1

描述信息

[Spectral] S-Adenosyl-L-methionine (exact mass = 398.13724) and L-Histidine (exact mass = 155.06948) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
A - Alimentary tract and metabolism > A16 - Other alimentary tract and metabolism products > A16A - Other alimentary tract and metabolism products > A16AA - Amino acids and derivatives
Acquisition and generation of the data is financially supported in part by CREST/JST.
C26170 - Protective Agent > C275 - Antioxidant
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

25 个代谢物同义名

(2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate; (3S)-5-[(3-Amino-3-carboxypropyl)methylsulfonio]-5-deoxyadenosine; 5-Deoxyadenosine-5-L-methionine disulphate ditosylate; 5-Deoxyadenosine-5-L-methionine disulfate ditosylate; S-Adenosyl-L-methionine disulphate tosylate; S-Adenosyl-L-methionine disulfate tosylate; S-(5-Deoxyadenosin-5-yl)-L-methionine; S-(5′-Adenosyl)-L-methionine chloride; S-(5-Adenosyl)-L-methionine chloride; S-(5-Adenosyl)-L-methionine; 2-S-Adenosyl-L-methionine; S-Adenosyl-L-methionine; L-S-Adenosylmethionine; S-Adenosyl methionine; S-Adenosyl-methionine; S-Adenosylmethionine; Adenosylmethionine; Active methionine; Acylcarnitine; Ademetionine; Donamet; AdoMet; SAMe; S-Adenosylmethionine; S-Adenosyl-L-methionine



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(10)

PlantCyc(0)

代谢反应

39 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(27)

WikiPathways(4)

Plant Reactome(0)

INOH(7)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACADM, AHCY, CBS, GNMT, MTR, MYC, ODC1, PRMT1, TP53
Peripheral membrane protein 1 CPT2
Endoplasmic reticulum membrane 2 PEMT, PNMT
Mitochondrion membrane 2 PEMT, PNMT
Nucleus 9 ACADM, AHCY, BHMT, CBS, DNMT1, MAT2B, MYC, PRMT1, TP53
cytosol 14 AHCY, AMD1, AS3MT, BHMT, CBS, GNMT, MAT2B, MTHFR, MTR, ODC1, PEMT, PNMT, PRMT1, TP53
mitochondrial membrane 3 ACADM, PEMT, PNMT
centrosome 1 TP53
nucleoplasm 5 CPT2, DNMT1, MYC, PRMT1, TP53
Cell membrane 1 SLC38A5
Multi-pass membrane protein 3 PEMT, PNMT, SLC38A5
lysosomal membrane 1 PRMT1
mitochondrial inner membrane 1 CPT2
Cytoplasm, cytosol 3 AS3MT, BHMT, PRMT1
plasma membrane 1 SLC38A5
Membrane 4 MYC, PEMT, SLC38A5, TP53
axon 1 ACADM
extracellular exosome 3 AHCY, BHMT, MAT2B
Lysosome membrane 1 PRMT1
endoplasmic reticulum 4 AHCY, PEMT, PNMT, TP53
mitochondrion 7 ACADM, CPT2, DNMT1, GATC, PEMT, PNMT, TP53
protein-containing complex 2 MYC, TP53
intracellular membrane-bounded organelle 2 PEMT, PNMT
pericentric heterochromatin 1 DNMT1
Mitochondrion matrix 2 ACADM, TP53
mitochondrial matrix 2 ACADM, TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
nucleolus 3 CPT2, MYC, TP53
Mitochondrion inner membrane 1 CPT2
Matrix side 1 CPT2
Cytoplasm, cytoskeleton 1 TP53
Nucleus, PML body 1 TP53
PML body 1 TP53
chromatin 2 MYC, TP53
Nucleus, nucleolus 1 MYC
site of double-strand break 1 TP53
nuclear envelope 1 MYC
female germ cell nucleus 1 DNMT1
[Isoform 1]: Endoplasmic reticulum membrane 2 PEMT, PNMT
Nucleus, nucleoplasm 2 MYC, PRMT1
Melanosome 1 AHCY
germ cell nucleus 1 TP53
replication fork 2 DNMT1, TP53
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
RNA polymerase II transcription repressor complex 1 MYC
methylosome 1 PRMT1
[Isoform 1]: Nucleus 1 TP53
Rough endoplasmic reticulum 1 MYC
glutamyl-tRNA(Gln) amidotransferase complex 1 GATC
[Isoform 2]: Endoplasmic reticulum membrane 2 PEMT, PNMT
Myc-Max complex 1 MYC
methionine adenosyltransferase complex 1 MAT2B
nucleoplasmic reticulum 1 MYC


文献列表

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  • James T Carrillo, Dulal Borthakur. Characterization of a plant S-adenosylmethionine synthetase from Acacia koa. Plant physiology and biochemistry : PPB. 2024 May; 210(?):108618. doi: 10.1016/j.plaphy.2024.108618. [PMID: 38631157]
  • Yi Xiao, Chao Han, Xiaocong Li, Xinting Zhu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu, Fang Liu. S-Adenosylmethionine (SAM) diet promotes innate immunity via histone H3K4me3 complex. International immunopharmacology. 2024 Apr; 131(?):111837. doi: 10.1016/j.intimp.2024.111837. [PMID: 38471365]
  • Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S Nguyen, Johan Joo, Mukund P Tantak, Holly Moots, Otto Phanstiel. The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress. Biomolecules. 2024 Mar; 14(3):. doi: 10.3390/biom14030326. [PMID: 38540746]
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  • Hong-Chao Duan, Chi Zhang, Peizhe Song, Junbo Yang, Ye Wang, Guifang Jia. C2-methyladenosine in tRNA promotes protein translation by facilitating the decoding of tandem m2A-tRNA-dependent codons. Nature communications. 2024 Feb; 15(1):1025. doi: 10.1038/s41467-024-45166-6. [PMID: 38310199]
  • Stephen G Andrews, Anthony M Koehle, Devendra Paudel, Thomas Neuberger, A Catharine Ross, Vishal Singh, Teodoro Bottiglieri, Rita Castro. Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice. Nutrients. 2024 Jan; 16(3):. doi: 10.3390/nu16030330. [PMID: 38337615]
  • Huan He, Ziwei Wang, Xueke Peng, Luolong Qing, Yu Zhang, Shaojuan Fu, Juan Xu, Yuanyuan Li, Silong Zhang. Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis. Journal of medicinal chemistry. 2024 Jan; 67(1):543-554. doi: 10.1021/acs.jmedchem.3c01770. [PMID: 38166392]
  • Lucía Barbier-Torres, Jyoti Chhimwal, So Yeon Kim, Komal Ramani, Aaron Robinson, Heping Yang, Jenny Van Eyk, Suthat Liangpunsakul, Ekihiro Seki, José M Mato, Shelly C Lu. S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver. International journal of biological sciences. 2024; 20(4):1218-1237. doi: 10.7150/ijbs.90104. [PMID: 38385082]
  • Jianying Yue, Yan Lu, Zhenqi Sun, Yuqing Guo, David San León, Fabio Pasin, Mingmin Zhao. Methyltransferase-like (METTL) homologues participate in Nicotiana benthamiana antiviral responses. Plant signaling & behavior. 2023 12; 18(1):2214760. doi: 10.1080/15592324.2023.2214760. [PMID: 37210738]
  • Yue Liu, Lianjing Ge, Huimeng Tang, Jinhui Zheng, Jinxiang Hu, Jingru Wang, Xiaoyu Yang, Ruimin Zhang, Xiaoyun Wang, Xiuming Li, Yan Zhang, Qinghua Shi. cGMP functions as an important messenger involved in SlSAMS1-regulated salt stress tolerance in tomato. Plant physiology and biochemistry : PPB. 2023 Nov; 204(?):108097. doi: 10.1016/j.plaphy.2023.108097. [PMID: 37864930]
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  • Zhong-Ce Hu, Yun-Chao Tao, Jun-Chao Pan, Chui-Mu Zheng, Yuan-Shan Wang, Ya-Ping Xue, Zhi-Qiang Liu, Yu-Guo Zheng. Breeding of Saccharomyces cerevisiae with a High-Throughput Screening Strategy for Improvement of S-Adenosyl-L-Methionine Production. Applied biochemistry and biotechnology. 2023 Jul; ?(?):. doi: 10.1007/s12010-023-04622-7. [PMID: 37418127]
  • Meijing Li, Zheyan Mi, Jinhao Wang, Zhongce Hu, Haibin Qin, Yuanshan Wang, Yuguo Zheng. [Microbial production of S-adenosyl-l-methionine: a review]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2023 Jun; 39(6):2248-2264. doi: 10.13345/j.cjb.220959. [PMID: 37401593]
  • Timothy Salita, Yepy H Rustam, Vinzenz Hofferek, Michael Jackson, Isaac Tollestrup, Jeffrey P Sheridan, Vern L Schramm, Gary B Evans, Gavin E Reid, Andrew B Munkacsi. Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitor. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2023 Jun; ?(?):159346. doi: 10.1016/j.bbalip.2023.159346. [PMID: 37301365]
  • Han Li, Lu Wu, Fuping Ye, Dapeng Wang, Li Wang, Wenqi Li, Yuan Xu, Zhenyang Li, Jingshu Zhang, Suhua Wang, Aihua Zhang, Qizhan Liu. As3MT via consuming SAM is involved in arsenic-induced nonalcoholic fatty liver disease by blocking m6A-mediated miR-142-5p maturation. The Science of the total environment. 2023 Jun; 892(?):164746. doi: 10.1016/j.scitotenv.2023.164746. [PMID: 37301390]
  • Likang Zhao, Changkai Li, Meng Zhang, Honglian Li, Shengli Ding, Xi Zhao, Lianjuan Yang, Jia Liu, Qing X Li, Risong Na. Design, Synthesis, and Antifungal Activity of Polyacetylenic Alcohol Derivatives and Stereoisomers against Phytopathogenic Fungi. Journal of agricultural and food chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.jafc.3c00924. [PMID: 37261403]
  • Li Yang, Xingxing Wang, Fuyong Zhao, Xianliang Zhang, Wei Li, Junsen Huang, Xiaoyu Pei, Xiang Ren, Yangai Liu, Kunlun He, Fei Zhang, Xiongfeng Ma, Daigang Yang. Roles of S-Adenosylmethionine and Its Derivatives in Salt Tolerance of Cotton. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119517. [PMID: 37298464]
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  • Jun-Min Lee, Min-Ho Park, Bu-Soo Park, Min-Kyu Oh. Production of S-methyl-methionine using engineered Saccharomyces cerevisiae sake K6. Journal of industrial microbiology & biotechnology. 2023 Feb; 50(1):. doi: 10.1093/jimb/kuad026. [PMID: 37653437]
  • Tetsuya Hirabayashi, Mai Kawaguchi, Sayaka Harada, Misa Mouri, Rina Takamiya, Yoshimi Miki, Hiroyasu Sato, Yoshitaka Taketomi, Kohei Yokoyama, Tetsuyuki Kobayashi, Suzumi M Tokuoka, Yoshihiro Kita, Emiko Yoda, Shuntaro Hara, Kyohei Mikami, Yasumasa Nishito, Norihito Kikuchi, Rieko Nakata, Mari Kaneko, Hiroshi Kiyonari, Kohji Kasahara, Toshiki Aiba, Kazutaka Ikeda, Tomoyoshi Soga, Makoto Kurano, Yutaka Yatomi, Makoto Murakami. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups. Cell reports. 2023 Jan; 42(2):111940. doi: 10.1016/j.celrep.2022.111940. [PMID: 36719796]
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  • Siyue Kan, Jingwen Tan, Qing Cai, Lulu An, Zhiqin Gao, Hong Yang, Siyu Liu, Risong Na, Lianjuan Yang. Synergistic activity of the combination of falcarindiol and itraconazole in vitro against dermatophytes. Frontiers in cellular and infection microbiology. 2023; 13(?):1128000. doi: 10.3389/fcimb.2023.1128000. [PMID: 37207188]
  • Audrey Lashley, Ryan Miller, Stephanie Provenzano, Sara-Alexis Jarecki, Paul Erba, Vonny Salim. Functional Diversification and Structural Origins of Plant Natural Product Methyltransferases. Molecules (Basel, Switzerland). 2022 Dec; 28(1):. doi: 10.3390/molecules28010043. [PMID: 36615239]
  • Francisco J Arriaza-Gallardo, Sebastian Schaupp, Yu-Cong Zheng, Mohd Farid Abdul-Halim, Hui-Jie Pan, Jörg Kahnt, Georgia Angelidou, Nicole Paczia, Xile Hu, Kyle Costa, Seigo Shima. The Function of Two Radical-SAM Enzymes, HcgA and HcgG, in the Biosynthesis of the [Fe]-Hydrogenase Cofactor. Angewandte Chemie (International ed. in English). 2022 12; 61(50):e202213239. doi: 10.1002/anie.202213239. [PMID: 36264001]
  • Gokay Albayrak, Serdar Demir, Halil Koyu, Sura Baykan. Anticholinesterase Compounds from Endemic Prangos uechtritzii. Chemistry & biodiversity. 2022 Nov; 19(11):e202200557. doi: 10.1002/cbdv.202200557. [PMID: 36201258]
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  • Atsuko Kitano, Toshio Norikura, Isao Matsui-Yuasa, Hiromi Shimakawa, Makoto Kamezawa, Akiko Kojima-Yuasa. Black carrot extract protects against hepatic injury through epigenetic modifications. Journal of food biochemistry. 2022 10; 46(10):e14292. doi: 10.1111/jfbc.14292. [PMID: 35762419]
  • Qiang Luo, Jiezhen Mo, Hao Chen, Zetao Hu, Baihui Wang, Jiabing Wu, Ziyu Liang, Wenhao Xie, Kangxi Du, Maolin Peng, Yingping Li, Tianyang Li, Yangyi Zhang, Xiaoyan Shi, Wen-Hui Shen, Yang Shi, Aiwu Dong, Hailin Wang, Jinbiao Ma. Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4. Nature communications. 2022 09; 13(1):5636. doi: 10.1038/s41467-022-33277-x. [PMID: 36163360]
  • Amna Devi, Romit Seth, Mamta Masand, Gopal Singh, Ashlesha Holkar, Shikha Sharma, Ashok Singh, Ram Kumar Sharma. Spatial Genomic Resource Reveals Molecular Insights into Key Bioactive-Metabolite Biosynthesis in Endangered Angelica glauca Edgew. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911064. [PMID: 36232367]
  • Yeong-Biau Yu, Douglas O Adams, Shang Fa Yang. Reprint of: 1-Aminocyclopropanecarboxylate Synthase, a Key Enzyme in Ethylene Biosynthesis. Archives of biochemistry and biophysics. 2022 09; 726(?):109238. doi: 10.1016/j.abb.2022.109238. [PMID: 35680445]
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  • Pei-Wen Yang, Ju-Ying Jiao, Zhen Chen, Xiao-Yan Zhu, Chien-Shan Cheng. Keep a watchful eye on methionine adenosyltransferases, novel therapeutic opportunities for hepatobiliary and pancreatic tumours. Biochimica et biophysica acta. Reviews on cancer. 2022 09; 1877(5):188793. doi: 10.1016/j.bbcan.2022.188793. [PMID: 36089205]
  • Renata Orłowska, Jacek Zebrowski, Janusz Zimny, Piotr Androsiuk, Piotr Tomasz Bednarek. S-Adenosyl-L-Methionine and Cu(II) Impact Green Plant Regeneration Efficiency. Cells. 2022 08; 11(17):. doi: 10.3390/cells11172700. [PMID: 36078107]
  • Ayesha M Patel, Karl J Koebke, Timothy J Grunkemeyer, Colleen M Riordan, Youngsoo Kim, Ryan C Bailey, E Neil G Marsh. Purification of the full-length, membrane-associated form of the antiviral enzyme viperin utilizing nanodiscs. Scientific reports. 2022 07; 12(1):11909. doi: 10.1038/s41598-022-16233-z. [PMID: 35831548]
  • Yu Li, Wangdan Xiong, Feng He, Tianxiong Qi, Zhen Sun, Yuchen Liu, Shiqie Bai, Honglun Wang, Zhenying Wu, Chunxiang Fu. Down-regulation of PvSAMS impairs S-adenosyl-L-methionine and lignin biosynthesis, and improves cell wall digestibility in switchgrass. Journal of experimental botany. 2022 06; 73(12):4157-4169. doi: 10.1093/jxb/erac147. [PMID: 35383829]
  • Krisztina A Szigeti, Alexandra Kalmár, Orsolya Galamb, Gábor Valcz, Barbara K Barták, Zsófia B Nagy, Sára Zsigrai, Ildikó Felletár, Árpád V Patai, Tamás Micsik, Márton Papp, Eszter Márkus, Zsolt Tulassay, Peter Igaz, István Takács, Béla Molnár. Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content. BMC cancer. 2022 Jun; 22(1):605. doi: 10.1186/s12885-022-09659-1. [PMID: 35655145]
  • Fenglei Sun, Jun Ma, Penglong Wang, Yanlong Yang. Genome-Wide Identification of the SAMS Gene Family in Upland Cotton (Gossypium hirsutum L.) and Expression Analysis in Drought Stress Treatments. Genes. 2022 05; 13(5):. doi: 10.3390/genes13050860. [PMID: 35627245]
  • Takujiro Homma, Sho Kobayashi, Junichi Fujii. Methionine Deprivation Reveals the Pivotal Roles of Cell Cycle Progression in Ferroptosis That Is Induced by Cysteine Starvation. Cells. 2022 05; 11(10):. doi: 10.3390/cells11101603. [PMID: 35626640]
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  • Gokul G, Jogender Singh. Dithiothreitol causes toxicity in C. elegans by modulating the methionine-homocysteine cycle. eLife. 2022 04; 11(?):. doi: 10.7554/elife.76021. [PMID: 35438636]
  • Wen Fang, Yibing Zhu, Sen Yang, Xiaomeng Tong, Cunqi Ye. Reciprocal regulation of phosphatidylcholine synthesis and H3K36 methylation programs metabolic adaptation. Cell reports. 2022 04; 39(2):110672. doi: 10.1016/j.celrep.2022.110672. [PMID: 35417718]
  • Ferrol I Rome, Curtis C Hughey. Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction. Molecular metabolism. 2022 04; 58(?):101452. doi: 10.1016/j.molmet.2022.101452. [PMID: 35121169]
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