Penicillin V (BioDeep_00000002974)

 

Secondary id: BioDeep_00001867851

human metabolite blood metabolite


代谢物信息卡片


(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

化学式: C16H18N2O5S (350.0936)
中文名称: 青霉素V
谱图信息: 最多检出来源 Mentha canadensis(plant) 22.16%

分子结构信息

SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)COC3=CC=CC=C3)C(=O)O)C
InChI: InChI=1S/C16H18N2O5S/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1

描述信息

Penicillin V is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CE - Beta-lactamase sensitive penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

50 个代谢物同义名

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-DIMETHYL-7-oxo-6-(2-phenoxyacetamido)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylIC ACID; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R,6R)-3,3-DIMETHYL-7-oxo-6-(2-phenoxyacetamido)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylate; Phenoxymethylpenicillinic acid potassium salt; 6-Phenoxyacetamidopenicillanic acid; Phenoxymethylpenicillin potassium; Phenoxymethylenepenicillinic acid; 6-Phenoxyacetamidopenicillanate; Phenoxymethylpenicillinic acid; Phenoxymethylenepenicillinate; Phenoximethylpenicillinum; Phenoxymethylpenicillinum; Penicillin, phenoxymethyl; Penicillin phenoxymethyl; Phenoxymethylpenicilline; Phenoxymethyl penicillin; Potassium, penicillin V; Phenoxymethylpenicillin; Phenoxomethylpenicillin; Fenossimetilpenicillina; Berromycin, penicillin; Penicillin V potassium; Fenoxymethylpenicillin; Penicillin berromycin; Beromycin, penicillin; Fenoximetilpenicilina; Sodium, penicillin V; Penicillin beromycin; V Sodium, penicillin; Penicillin V sodium; Penicillin VK; Penicillin V; Penicillin-V; Vegacillin; V-Cillin K; V Cillin K; Beromycin; Fenoxypen; VCillin K; Apocillin; Oracillin; Fenospen; V-Cillin; Betapen; Pen VK; PCV; PV; Penicillin V



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, CYP3A4, HMGB1, MRTFA, PC, TYR
Peripheral membrane protein 3 CYP1B1, HK1, HMGB1
Endoplasmic reticulum membrane 3 CD59, CYP1B1, CYP3A4
Nucleus 3 ALB, HMGB1, MRTFA
cytosol 4 ALB, HK1, MRTFA, PC
centrosome 1 ALB
nucleoplasm 2 HMGB1, MRTFA
Cell membrane 3 CD59, HMGB1, TNF
cell surface 4 CD59, HMGB1, TNF, TNR
glutamatergic synapse 2 MRTFA, TNR
Golgi apparatus 1 ALB
Golgi membrane 2 CD59, INS
neuronal cell body 1 TNF
postsynapse 1 MRTFA
Cytoplasm, cytosol 1 HK1
Lysosome 1 TYR
Presynapse 1 MRTFA
endosome 1 HMGB1
plasma membrane 5 CD59, HMGB1, IGHE, INSRR, TNF
Membrane 4 CD59, CYP1B1, CYP3A4, INSRR
axon 1 INSRR
extracellular exosome 3 ALB, CD59, SERPING1
endoplasmic reticulum 2 ALB, HMGB1
extracellular space 11 ALB, CD59, COL2A1, CRP, HMGB1, IGHE, IL4, INS, SERPING1, TNF, TNR
perinuclear region of cytoplasm 1 TYR
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 3 CYP1B1, HK1, PC
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 3 CYP1B1, CYP3A4, TYR
Microsome membrane 2 CYP1B1, CYP3A4
Single-pass type I membrane protein 3 IGHE, INSRR, TYR
Secreted 6 ALB, COL2A1, CRP, HMGB1, IL4, INS
extracellular region 10 ALB, COL2A1, CRP, HMGB1, IGHE, IL4, INS, SERPING1, TNF, TNR
Mitochondrion outer membrane 1 HK1
mitochondrial outer membrane 1 HK1
Mitochondrion matrix 1 PC
mitochondrial matrix 1 PC
Extracellular side 1 HMGB1
anchoring junction 1 ALB
external side of plasma membrane 2 CD59, TNF
Secreted, extracellular space, extracellular matrix 2 COL2A1, TNR
actin cytoskeleton 1 MYOZ3
Z disc 1 MYOZ3
Melanosome membrane 1 TYR
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 CD59
Membrane raft 3 HK1, TNF, TNR
focal adhesion 1 CD59
basement membrane 1 COL2A1
collagen trimer 1 COL2A1
collagen-containing extracellular matrix 3 COL2A1, SERPING1, TNR
receptor complex 1 INSRR
ciliary basal body 1 ALB
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
Chromosome 1 HMGB1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, SERPING1
Lipid-anchor, GPI-anchor 1 CD59
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 1 INS
specific granule membrane 1 CD59
tertiary granule membrane 1 CD59
Melanosome 1 TYR
side of membrane 1 CD59
Cytoplasm, myofibril, sarcomere, Z line 1 MYOZ3
ficolin-1-rich granule lumen 1 HMGB1
secretory granule lumen 2 HMGB1, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, COL2A1, INS, SERPING1
transcription repressor complex 1 HMGB1
platelet alpha granule lumen 2 ALB, SERPING1
transport vesicle 2 CD59, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 CD59, INS
perineuronal net 1 TNR
ER to Golgi transport vesicle membrane 1 CD59
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
condensed chromosome 1 HMGB1
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
collagen type II trimer 1 COL2A1
collagen type XI trimer 1 COL2A1
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
insulin receptor complex 1 INSRR
tenascin complex 1 TNR
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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