Morphine-6-glucuronide (BioDeep_00000002925)

 

Secondary id: BioDeep_00001871391

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-{[(1S,5R,13R,14S,17R)-10-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraen-14-yl]oxy}oxane-2-carboxylic acid

化学式: C23H27NO9 (461.1686)
中文名称: 吗啡-6-Β-D-葡糖苷酸
谱图信息: 最多检出来源 Homo sapiens(blood) 26.66%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Morphine-6-glucuronide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/morphine-6-glucuronide (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000002925). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)OC6C(C(C(C(O6)C(=O)O)O)O)O
InChI: InChI=1S/C23H27NO9/c1-24-7-6-23-10-3-5-13(31-22-17(28)15(26)16(27)19(33-22)21(29)30)20(23)32-18-12(25)4-2-9(14(18)23)8-11(10)24/h2-5,10-11,13,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,13-,15-,16-,17+,19-,20-,22+,23-/m0/s1

描述信息

Morphine-6-glucuronide (M6G) is a major active metabolite of morphine, and as such is the molecule responsible for much of the pain-relieving effects of morphine (and thus heroin). M6G is formed from morphine by the enzyme UDP-Glucuronosyltransferase-2B7 (UGT2B7). M6G can accumulate to toxic levels in kidney failure.
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist > C1657 - Opiate

同义名列表

7 个代谢物同义名

(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-{[(1S,5R,13R,14S,17R)-10-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraen-14-yl]oxy}oxane-2-carboxylic acid; M-6-G TRIFLUOROACETATE-HYDRATE; Morphine 6-glucuronide(minor); Morphine-6beta-glucuronide; Morphine 6-glucuronide; Morphine-6-glucuronide; Morphine-6-glucuronide



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(1)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, ALB, CYP2D6, CYP3A4, PEBP1, PGP, TLR4
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 4 CYP2D6, CYP3A4, UGT1A1, UGT2B7
Nucleus 2 ALB, PEBP1
cytosol 3 ALB, PEBP1, SLC2A1
dendrite 1 OPRM1
centrosome 1 ALB
Cell membrane 6 ABCB1, OPRD1, OPRM1, SLC2A1, SLCO1C1, TLR4
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 6 ABCB1, ABCC3, OPRD1, OPRM1, SLC2A1, SLCO1C1
Golgi apparatus membrane 1 B3GAT2
Synapse 1 OPRM1
cell surface 2 ABCB1, TLR4
Golgi apparatus 2 ALB, OPRM1
Golgi membrane 3 B3GAT2, INS, SLC2A1
presynaptic membrane 1 OPRD1
sarcolemma 1 SLC2A1
Lysosome 1 SGSH
Presynapse 1 SLC2A1
endosome 1 OPRM1
plasma membrane 9 ABCB1, ABCC3, GCG, OPRD1, OPRM1, SLC2A1, SLCO1C1, TLR4, UGT1A1
synaptic vesicle membrane 1 OPRD1
Membrane 11 ABCB1, ABCC3, B3GAT2, CYP2D6, CYP3A4, OPRD1, OPRM1, SLC2A1, TLR4, UGT1A1, UGT2B7
apical plasma membrane 2 ABCB1, SLC2A1
axon 1 OPRM1
basolateral plasma membrane 3 ABCC3, SLC2A1, SLCO1C1
caveola 1 SLC2A1
extracellular exosome 5 ABCB1, ALB, PEBP1, SGSH, SLC2A1
endoplasmic reticulum 4 ALB, CYP2D6, OPRM1, UGT1A1
extracellular space 4 ALB, GCG, IL6, INS
lysosomal lumen 1 SGSH
perinuclear region of cytoplasm 2 TLR4, UGT1A1
intercalated disc 1 SLC2A1
mitochondrion 1 CYP2D6
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 2 CYP2D6, CYP3A4
Microsome membrane 2 CYP2D6, CYP3A4
Single-pass type I membrane protein 1 TLR4
Secreted 4 ALB, GCG, IL6, INS
extracellular region 4 ALB, GCG, IL6, INS
Single-pass membrane protein 3 CYP2D6, UGT1A1, UGT2B7
anchoring junction 1 ALB
photoreceptor inner segment 1 SLC2A1
external side of plasma membrane 1 TLR4
perikaryon 1 OPRM1
Z disc 1 SLC2A1
midbody 1 SLC2A1
Early endosome 1 TLR4
Single-pass type II membrane protein 1 B3GAT2
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 UGT1A1
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 2 OPRD1, OPRM1
ciliary basal body 1 ALB
phagocytic cup 1 TLR4
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, SLC2A1
Basolateral cell membrane 1 ABCC3
endosome lumen 1 INS
female germ cell nucleus 1 SLC2A1
Cell projection, dendrite 1 OPRM1
Melanosome 1 SLC2A1
basal plasma membrane 1 ABCC3
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, GCG, IL6, INS
cortical actin cytoskeleton 1 SLC2A1
platelet alpha granule lumen 1 ALB
axon terminus 1 OPRD1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 1 OPRD1
Basal cell membrane 1 ABCC3
external side of apical plasma membrane 1 ABCB1
female pronucleus 1 SLC2A1
dendrite membrane 1 OPRD1
[Glucagon-like peptide 1]: Secreted 1 GCG
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 UGT1A1
glucose transporter complex 1 SLC2A1
cytochrome complex 1 UGT1A1
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1
ciliary transition fiber 1 ALB


文献列表

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