2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane (BioDeep_00000002785)

 

Secondary id: BioDeep_00001871330

human metabolite


代谢物信息卡片


2-(4-{2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl}phenoxymethyl)oxirane

化学式: C21H24O4 (340.1675)
中文名称: 双酚A二缩水甘油醚, 2,2-双-(4-甘胺氧苯)丙烷
谱图信息: 最多检出来源 Viridiplantae(plant) 21.43%

分子结构信息

SMILES: CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4
InChI: InChI=1S/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3

描述信息

Potential food contaminant arising from its use in epoxy resin coatings for cans, concrete vats and tanks, etc.
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 5810
D009676 - Noxae > D002273 - Carcinogens

同义名列表

69 个代谢物同义名

2-(4-{2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl}phenoxymethyl)oxirane; 2,2-[(1-Methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane, 9ci; 2,2-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane; 4, 4-Dihydroxydiphenyldimethylmethane diglycidyl ether; 4,4-Dihydroxydiphenyldimethylmethane diglycidyl ether; P,P-dihydroxydiphenyldimethylmethane diglycidyl ether; Diglycidyl ether OF 2, 2-bis(4-hydroxyphenyl)propane; Bis(4-hydroxyphenyl)dimethylmethane diglycidyl ether; Diglycidyl ether OF 2, 2-bis(P-hydroxyphenyl)propane; Diglycidyl ether OF 2,2-bis(P-hydroxyphenyl)propane; Diglycidyl ether OF 2,2-bis(4-hydroxyphenyl)propane; 2, 2-Bis(P-hydroxyphenyl)propane, diglycidyl ether; 4,4-Isopropylidenebis(1-(2,3-epoxypropoxy)benzene); 4,4-Isopropylidenebis[1-(2,3-epoxypropoxy)benzene]; 2,2-Bis(4-hydroxyphenyl)propane, diglycidyl ether; 4,4-Bis(2, 3-epoxypropoxy)diphenyldimethylmethane; 2, 2-Bis(4-hydroxyphenyl)propane diglycidyl ether; 2,2-Bis(P-hydroxyphenyl)propane, diglycidyl ether; 2, 2-Bis(P-hydroxyphenyl)propane diglycidyl ether; 2,2-Bis(4-hydroxyphenyl)propane diglycidyl ether; 4,4-Bis(2,3-epoxypropoxy)diphenyldimethylmethane; 2,2-Bis(P-hydroxyphenyl)propane diglycidyl ether; Diglycidyl ether OF 4, 4-isopropylidenediphenol; Diglycidyl ether OF 4,4-isopropylidenediphenol; Propane, 2,2-bis (P-(2,3-epoxypropoxy)phenyl); 4, 4-Isopropylidenediphenol diglycidyl ether; 2,2-Bis[4-(2,3-epoxypropyloxy)phenyl]propane; 2,2-Bis(4-(2,3-epoxypropyloxy)phenyl)propane; 4,4-Isopropylidenediphenol diglycidyl ether; 2,2-Bis(P-(2,3-epoxypropoxy)phenyl)-propane; 2,2-Bis[4-(2,3-epoxypropoxy)phenyl]-propane; 2,2-Bis(4-(2,3-epoxypropoxy)phenyl)-propane; 2,2-Bis[(P-2,3-epoxypropoxy)phenyl]-propane; 2,2-Bis[P-(2,3-epoxypropoxy)phenyl]-propane; 2,2-Bis[P-(2,3-epoxypropoxy)phenyl]propane; 2,2-Bis(4-(2,3-epoxypropoxy)phenyl)propane; 2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane; 2,2-Bis(P-(2,3-epoxypropoxy)phenyl)propane; Bis(4-glycidyloxyphenyl)dimethylmethane; Bis(4-glycidyloxyphenyl)dimethyamethane; Bis[4-(2,3-epoxypropoxy)phenyl]propane; 2,2-[Bis(4-glycidyloxyphenyl)]propane; 2,2-Bis[4-(glycidyloxy)phenyl]propane; 2, 2-Bis(4-glycidyloxyphenyl)propane; 2, 2-Bis(P-glycidyloxyphenyl)propane; 2,2-Bis(P-glycidyloxyphenyl)propane; 2,2-Bis(4-glycidyloxyphenyl)propane; 2,2-Bis(phenyl-4-glycidoxy)propane; Diglycidyl diphenylolpropane ether; Diglycidyl ether OF bisphenol a; Isphenol a, diglycidyl ether; BISPHENOL A DIGLYCIDYL ETHER; Diglycidyl bisphenol a ether; Diomethane diglycidyl ether; Diglycidyl bisphenol a; Dian-bis-glycidylether; Dian diglycidyl ether; Araldite gy 250; Oligomer 340; Epophen el 5; Epi-rez 510; Epi-rez 508; Epoxide a; Dgebpa; DGEBA; Bpdge; BADGE; Bisphenol A diglycidyl ether; bisphenol A diglycidyl ether



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ADIG, BCL2, CAT, NES, PPARG, PTGS2
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 3 BCL2, CYP19A1, PTGS2
Nucleus 6 ADIG, BCL2, JUND, MPO, PPARA, PPARG
cytosol 3 BCL2, CAT, PPARG
nucleoplasm 4 JUND, MPO, PPARA, PPARG
RNA polymerase II transcription regulator complex 2 JUND, PPARG
Cell membrane 2 TNF, UNC5B
Multi-pass membrane protein 2 CATSPER1, CYP19A1
cell surface 2 ADIPOQ, TNF
Golgi membrane 1 INS
neuronal cell body 1 TNF
Lysosome 1 MPO
plasma membrane 4 CATSPER1, IGHE, TNF, UNC5B
Membrane 4 ADIG, BCL2, CAT, CYP19A1
caveola 1 PTGS2
extracellular exosome 3 BMP3, CAT, MPO
endoplasmic reticulum 4 ADIPOQ, BCL2, CYP19A1, PTGS2
extracellular space 9 ADIPOQ, BMP3, CXCL8, IGHE, IL10, IL6, INS, MPO, TNF
perinuclear region of cytoplasm 1 PPARG
mitochondrion 2 BCL2, CAT
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 3 CAT, MPO, PPARG
Microsome membrane 2 CYP19A1, PTGS2
Single-pass type I membrane protein 2 IGHE, UNC5B
Secreted 7 ADIG, ADIPOQ, BMP3, CXCL8, IL10, IL6, INS
extracellular region 11 ADIG, ADIPOQ, BMP3, CAT, CXCL8, IGHE, IL10, IL6, INS, MPO, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 ADIG, BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
transcription regulator complex 1 JUND
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 TNF, UNC5B
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 1 CAT
collagen trimer 1 ADIPOQ
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ADIPOQ
secretory granule 1 MPO
intermediate filament 1 NES
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
chromatin 3 JUND, PPARA, PPARG
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
[Isoform 2]: Cell membrane 1 IGHE
sperm flagellum 1 CATSPER1
endosome lumen 1 INS
Lipid droplet 1 ADIG
Cell projection, cilium, flagellum membrane 1 CATSPER1
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 NES
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
transcription repressor complex 1 JUND
transport vesicle 1 INS
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
phagocytic vesicle lumen 1 MPO
sperm principal piece 1 CATSPER1
[Isoform 3]: Cell membrane 1 IGHE
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
CatSper complex 1 CATSPER1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Tongtong Zhang, Jihuai Tan, Shaochuan Li. Functional cellulose-derived epoxy cross-linked with BADGE resin to construct high-performance epoxy composites. International journal of biological macromolecules. 2024 Apr; 265(Pt 2):130569. doi: 10.1016/j.ijbiomac.2024.130569. [PMID: 38553394]
  • Runhui Yang, Jiali Duan, Hong Li, Ying Sun, Bing Shao, Yumin Niu. Bisphenol-diglycidyl ethers in paired urine and serum samples from children and adolescents: Partitioning, clearance and exposure assessment. Environmental pollution (Barking, Essex : 1987). 2022 Aug; 306(?):119351. doi: 10.1016/j.envpol.2022.119351. [PMID: 35489536]
  • Tajpreet Kaur, Damanpreet Singh, Devendra Pathak, Amrit P Singh, Balbir Singh. Umbelliferone attenuates glycerol-induced myoglobinuric acute kidney injury through peroxisome proliferator-activated receptor-γ agonism in rats. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22892. doi: 10.1002/jbt.22892. [PMID: 34409680]
  • Anila Bello, Yalong Xue, Dhimiter Bello. Urinary biomonitoring of occupational exposures to Bisphenol A Diglycidyl Ether (BADGE) - based epoxy resins among construction painters in metal structure coating. Environment international. 2021 11; 156(?):106632. doi: 10.1016/j.envint.2021.106632. [PMID: 34020298]
  • Anna Marqueño, Elisabet Pérez-Albaladejo, Nancy D Denslow, John A Bowden, Cinta Porte. Untargeted lipidomics reveals the toxicity of bisphenol A bis(3-chloro-2- hydroxypropyl) ether and bisphenols A and F in zebrafish liver cells. Ecotoxicology and environmental safety. 2021 Aug; 219(?):112311. doi: 10.1016/j.ecoenv.2021.112311. [PMID: 33993092]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Elisabet Pérez-Albaladejo, Alejandra Solís, Ilaria Bani, Cinta Porte. PLHC-1 topminnow liver cells: An alternative model to investigate the toxicity of plastic additives in the aquatic environment. Ecotoxicology and environmental safety. 2021 Jan; 208(?):111746. doi: 10.1016/j.ecoenv.2020.111746. [PMID: 33396072]
  • Ans Punt, Aafke Aartse, Toine F H Bovee, Arjen Gerssen, Stefan P J van Leeuwen, Ron L A P Hoogenboom, Ad A C M Peijnenburg. Quantitative in vitro-to-in vivo extrapolation (QIVIVE) of estrogenic and anti-androgenic potencies of BPA and BADGE analogues. Archives of toxicology. 2019 07; 93(7):1941-1953. doi: 10.1007/s00204-019-02479-6. [PMID: 31111190]
  • Hyo-Kyung Bae, Bae-Dong Jung, Seunghyung Lee, Choon-Keun Park, Boo-Keun Yang, Hee-Tae Cheong. Correlation of spontaneous adipocyte generation with osteogenic differentiation of porcine skin-derived stem cells. Journal of veterinary science. 2019 Jan; 20(1):16-26. doi: 10.4142/jvs.2019.20.1.16. [PMID: 30481989]
  • Anna Marqueño, Elisabet Pérez-Albaladejo, Cintia Flores, Encarnación Moyano, Cinta Porte. Toxic effects of bisphenol A diglycidyl ether and derivatives in human placental cells. Environmental pollution (Barking, Essex : 1987). 2019 Jan; 244(?):513-521. doi: 10.1016/j.envpol.2018.10.045. [PMID: 30366299]
  • Mayumi Tsuji, Chihaya Koriyama, Yasuhiro Ishihara, Christoph F A Vogel, Toshihiro Kawamoto. Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children. European journal of medical research. 2018 Dec; 23(1):61. doi: 10.1186/s40001-018-0358-1. [PMID: 30587237]
  • Sho Akai, Shingo Oda, Tsuyoshi Yokoi. Establishment of a novel mouse model for pioglitazone-induced skeletal muscle injury. Toxicology. 2017 05; 382(?):1-9. doi: 10.1016/j.tox.2017.03.001. [PMID: 28263783]
  • Guanwu Li, Zheng Xu, Lingmi Hou, Xuefeng Li, Xin Li, Wei Yuan, Maki Polat, Shixin Chang. Differential effects of bisphenol A diglicydyl ether on bone quality and marrow adiposity in ovary-intact and ovariectomized rats. American journal of physiology. Endocrinology and metabolism. 2016 12; 311(6):E922-E927. doi: 10.1152/ajpendo.00267.2016. [PMID: 27756728]
  • Amrit Pal Singh, Nirmal Singh, Preet Mohinder Singh Bedi. Estrogen attenuates renal IRI through PPAR-γ agonism in rats. The Journal of surgical research. 2016 06; 203(2):324-30. doi: 10.1016/j.jss.2016.02.038. [PMID: 27363640]
  • Vinita Mohey, Manjinder Singh, Nikkita Puri, Tajpreet Kaur, Devendra Pathak, Amrit Pal Singh. Sildenafil obviates ischemia-reperfusion injury-induced acute kidney injury through peroxisome proliferator-activated receptor γ agonism in rats. The Journal of surgical research. 2016 Mar; 201(1):69-75. doi: 10.1016/j.jss.2015.09.035. [PMID: 26850186]
  • Kazuya Sato, Xingmin Feng, Jichun Chen, Jungang Li, Pawel Muranski, Marie J Desierto, Keyvan Keyvanfar, Daniela Malide, Sachiko Kajigaya, Neal S Young. PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function. Haematologica. 2016 Jan; 101(1):57-67. doi: 10.3324/haematol.2014.121632. [PMID: 26589913]
  • Toshihiro Kawamoto, Mayumi Tsuji, Toyohi Isse. Comparison of IgG against plastic resin in workers with and without chemical dermatitis. BMC public health. 2015 Sep; 15(?):930. doi: 10.1186/s12889-015-2302-4. [PMID: 26390923]
  • Margherita Fattore, Giacomo Russo, Francesco Barbato, Lucia Grumetto, Stefania Albrizio. Monitoring of bisphenols in canned tuna from Italian markets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2015 Sep; 83(?):68-75. doi: 10.1016/j.fct.2015.05.010. [PMID: 26070504]
  • Tanveer Singh, Rajesh Kumar Goel. Neuroprotective effect of Allium cepa L. in aluminium chloride induced neurotoxicity. Neurotoxicology. 2015 Jul; 49(?):1-7. doi: 10.1016/j.neuro.2015.04.007. [PMID: 25940660]
  • Lei Wang, Jingchuan Xue, Kurunthachalam Kannan. Widespread occurrence and accumulation of bisphenol A diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their derivatives in human blood and adipose fat. Environmental science & technology. 2015 Mar; 49(5):3150-7. doi: 10.1021/acs.est.5b00096. [PMID: 25679329]
  • Yan Chang, Charlene Nguyen, Vikram Rajesh Paranjpe, Frank Gilliland, Junfeng Jim Zhang. Analysis of bisphenol A diglycidyl ether (BADGE) and its hydrolytic metabolites in biological specimens by high-performance liquid chromatography and tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Aug; 965(?):33-8. doi: 10.1016/j.jchromb.2014.06.005. [PMID: 24980807]
  • Jaswinder Pal Singh, Amrit Pal Singh, Rajbir Bhatti. Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats. The Journal of surgical research. 2014 Apr; 187(2):631-9. doi: 10.1016/j.jss.2013.11.1088. [PMID: 24433871]
  • Alexandros G Asimakopoulos, Nikolaos S Thomaidis, Kurunthachalam Kannan. Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. The Science of the total environment. 2014 Feb; 470-471(?):1243-9. doi: 10.1016/j.scitotenv.2013.10.089. [PMID: 24246946]
  • Hany M El-Bassossy, Shaymaa M Abo-Warda, Ahmed Fahmy. Chrysin and luteolin alleviate vascular complications associated with insulin resistance mainly through PPAR-γ activation. The American journal of Chinese medicine. 2014; 42(5):1153-67. doi: 10.1142/s0192415x14500724. [PMID: 25169908]
  • Akanksha Kapil, Jaswinder Pal Singh, Tajpreet Kaur, Balbir Singh, Amrit Pal Singh. Involvement of peroxisome proliferator-activated receptor gamma in vitamin D-mediated protection against acute kidney injury in rats. The Journal of surgical research. 2013 Dec; 185(2):774-83. doi: 10.1016/j.jss.2013.07.017. [PMID: 24011919]
  • Pan Hu, Xin Chen, Rick J Whitener, Eric T Boder, Jeremy O Jones, Aleksey Porollo, Jiangang Chen, Ling Zhao. Effects of parabens on adipocyte differentiation. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Jan; 131(1):56-70. doi: 10.1093/toxsci/kfs262. [PMID: 22956630]
  • Mona F Mahmoud, Shimaa M El Shazly. Pioglitazone protects against cisplatin induced nephrotoxicity in rats and potentiates its anticancer activity against human renal adenocarcinoma cell lines. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Jan; 51(?):114-22. doi: 10.1016/j.fct.2012.09.006. [PMID: 22989705]
  • Lei Wang, Yinghong Wu, Wei Zhang, Kurunthachalam Kannan. Widespread occurrence and distribution of bisphenol A diglycidyl ether (BADGE) and its derivatives in human urine from the United States and China. Environmental science & technology. 2012 Dec; 46(23):12968-76. doi: 10.1021/es304050f. [PMID: 23145811]
  • Albert Kingman, Jeffrey Hyman, Scott A Masten, Beby Jayaram, Cynthia Smith, Frederick Eichmiller, Michael C Arnold, Paul A Wong, James M Schaeffer, Sheetal Solanki, William J Dunn. Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations. Journal of the American Dental Association (1939). 2012 Dec; 143(12):1292-302. doi: 10.14219/jada.archive.2012.0090. [PMID: 23204083]
  • Muna S Nahar, Amr S Soliman, Justin A Colacino, Antonia M Calafat, Kristen Battige, Ahmed Hablas, Ibrahim A Seifeldin, Dana C Dolinoy, Laura S Rozek. Urinary bisphenol A concentrations in girls from rural and urban Egypt: a pilot study. Environmental health : a global access science source. 2012 Apr; 11(?):20. doi: 10.1186/1476-069x-11-20. [PMID: 22472083]
  • Amrit Pal Singh, Amteshwar Jaggi Singh, Nirmal Singh. Pharmacological investigations of Punica granatum in glycerol-induced acute renal failure in rats. Indian journal of pharmacology. 2011 Sep; 43(5):551-6. doi: 10.4103/0253-7613.84971. [PMID: 22021999]
  • K Celinski, T Dworzanski, A Korolczuk, R Piasecki, M Slomka, A Madro, R Fornal. Effects of peroxisome proliferator-activated receptors-gamma ligands on dextran sodium sulphate-induced colitis in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2011 Jun; 62(3):347-56. doi: . [PMID: 21893696]
  • D Weismann, D M Erion, I Ignatova-Todorava, Y Nagai, R Stark, J J Hsiao, C Flannery, A L Birkenfeld, T May, M Kahn, D Zhang, X X Yu, S F Murray, S Bhanot, B P Monia, G W Cline, G I Shulman, V T Samuel. Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance. Diabetologia. 2011 Apr; 54(4):935-44. doi: 10.1007/s00125-010-1984-5. [PMID: 21190014]
  • T Dworzanski, K Celinski, A Korolczuk, M Slomka, S Radej, G Czechowska, A Madro, H Cichoz-Lach. Influence of the peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, rosiglitazone and antagonist, biphenol-A-diglicydyl ether (BADGE) on the course of inflammation in the experimental model of colitis in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2010 Dec; 61(6):683-93. doi: . [PMID: 21224499]
  • Masaki Wakutsu, Nobuyo Tsunoda, Sachiko Shiba, Etsuko Muraki, Keizo Kasono. Peroxisome proliferator-activated receptors (PPARs)-independent functions of fish oil on glucose and lipid metabolism in diet-induced obese mice. Lipids in health and disease. 2010 Sep; 9(?):101. doi: 10.1186/1476-511x-9-101. [PMID: 20846400]
  • Harikesh Kalonia, Puneet Kumar, Anil Kumar. Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: possible role of peroxisome proliferator activated receptor-Upsilon (PPARUpsilon) in Huntington's disease. Pharmacology, biochemistry, and behavior. 2010 Aug; 96(2):115-24. doi: 10.1016/j.pbb.2010.04.018. [PMID: 20450929]
  • Yulan Liu, Junxia Shi, Jing Lu, Guoquan Meng, Huiling Zhu, Yongqing Hou, Yulong Yin, Shengjun Zhao, Binying Ding. Activation of peroxisome proliferator-activated receptor-gamma potentiates pro-inflammatory cytokine production, and adrenal and somatotropic changes of weaned pigs after Escherichia coli lipopolysaccharide challenge. Innate immunity. 2009 Jun; 15(3):169-78. doi: 10.1177/1753425908102014. [PMID: 19474210]
  • L-F Liu, A Purushotham, A A Wendel, K Koba, J DeIuliis, K Lee, M A Belury. Regulation of adipose triglyceride lipase by rosiglitazone. Diabetes, obesity & metabolism. 2009 Feb; 11(2):131-42. doi: 10.1111/j.1463-1326.2008.00916.x. [PMID: 18643838]
  • Kazuto Takahashi, Shinya Yamaguchi, Tatsuhiro Shimoyama, Hiroyuki Seki, Kaoru Miyokawa, Hidenori Katsuta, Toshiaki Tanaka, Katsuhiko Yoshimoto, Hideki Ohno, Shinya Nagamatsu, Hitoshi Ishida. JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro. American journal of physiology. Endocrinology and metabolism. 2008 May; 294(5):E898-909. doi: 10.1152/ajpendo.00131.2007. [PMID: 18303122]
  • Un-jun Hyoung, Yun-jung Yang, Su-kyoung Kwon, Jae-hyoung Yoo, Soon-chul Myoung, Sae-chul Kim, Yeon-pyo Hong. Developmental toxicity by exposure to bisphenol A diglycidyl ether during gestation and lactation period in Sprague-Dawley male rats. Journal of preventive medicine and public health = Yebang Uihakhoe chi. 2007 Mar; 40(2):155-61. doi: 10.3961/jpmph.2007.40.2.155. [PMID: 17426428]
  • Graciela Ramilo, Iago Valverde, Jorge Lago, Juan M Vieites, Ana G Cabado. Cytotoxic effects of BADGE (bisphenol A diglycidyl ether) and BFDGE (bisphenol F diglycidyl ether) on Caco-2 cells in vitro. Archives of toxicology. 2006 Nov; 80(11):748-55. doi: 10.1007/s00204-006-0121-1. [PMID: 16783546]
  • Ki Young Kim, Sung Soo Kim, Hyae Gyeong Cheon. Differential anti-proliferative actions of peroxisome proliferator-activated receptor-gamma agonists in MCF-7 breast cancer cells. Biochemical pharmacology. 2006 Aug; 72(5):530-40. doi: 10.1016/j.bcp.2006.05.009. [PMID: 16806087]
  • Ariela Benigni, Carla Zoja, Susanna Tomasoni, Marco Campana, Daniela Corna, Cristina Zanchi, Elena Gagliardini, Elvira Garofano, Daniela Rottoli, Takahito Ito, Giuseppe Remuzzi. Transcriptional regulation of nephrin gene by peroxisome proliferator-activated receptor-gamma agonist: molecular mechanism of the antiproteinuric effect of pioglitazone. Journal of the American Society of Nephrology : JASN. 2006 Jun; 17(6):1624-32. doi: 10.1681/asn.2005090983. [PMID: 16687628]
  • Susanne Neschen, Katsutaro Morino, Jörg C Rossbacher, Rebecca L Pongratz, Gary W Cline, Saki Sono, Matthew Gillum, Gerald I Shulman. Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice. Diabetes. 2006 Apr; 55(4):924-8. doi: 10.2337/diabetes.55.04.06.db05-0985. [PMID: 16567512]
  • Tadaatsu Imaizumi, Koji Yamashita, Kageaki Taima, Akira Ishikawa, Hidemi Yoshida, Kei Satoh. Effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of retinoic acid-inducible gene-I in endothelial cells stimulated with lipopolysaccharide. Prostaglandins & other lipid mediators. 2005 Dec; 78(1-4):46-54. doi: 10.1016/j.prostaglandins.2005.02.006. [PMID: 16303604]
  • Hang Li, Xiong Z Ruan, Stephen H Powis, Ray Fernando, Wint Y Mon, David C Wheeler, John F Moorhead, Zac Varghese. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. Kidney international. 2005 Mar; 67(3):867-74. doi: 10.1111/j.1523-1755.2005.00151.x. [PMID: 15698426]
  • Salvatore Cuzzocrea, Barbara Pisano, Laura Dugo, Angela Ianaro, Pasquale Maffia, Nimesh S A Patel, Rosanna Di Paola, Armando Ialenti, Tiziana Genovese, Prabal K Chatterjee, Massimo Di Rosa, Achille P Caputi, Christoph Thiemermann. Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation. European journal of pharmacology. 2004 Jan; 483(1):79-93. doi: 10.1016/j.ejphar.2003.10.056. [PMID: 14709329]
  • Salvatore Cuzzocrea, Barbara Pisano, Laura Dugo, Angela Ianaro, Nimesh S A Patel, Rosanna Di Paola, Tiziana Genovese, Prabal K Chatterjee, Massimo Di Rosa, Achille P Caputi, Christoph Thiemermann. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. British journal of pharmacology. 2003 Sep; 140(2):366-76. doi: 10.1038/sj.bjp.0705419. [PMID: 12970094]
  • T Hanaoka, N Kawamura, K Hara, S Tsugane. Urinary bisphenol A and plasma hormone concentrations in male workers exposed to bisphenol A diglycidyl ether and mixed organic solvents. Occupational and environmental medicine. 2002 Sep; 59(9):625-8. doi: 10.1136/oem.59.9.625. [PMID: 12205237]
  • C Brede, I Skjevrak, H Herikstad, E Anensen, R Austvoll, T Hemmingsen. Improved sample extraction and clean-up for the GC-MS determination of BADGE and BFDGE in vegetable oil. Food additives and contaminants. 2002 May; 19(5):483-91. doi: 10.1080/02652030110088293. [PMID: 12028648]
  • Sebastian Fehlberg, Stefan Trautwein, Alexandra Göke, Rüdiger Göke. Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners. The Biochemical journal. 2002 Mar; 362(Pt 3):573-8. doi: 10.1042/0264-6021:3620573. [PMID: 11879183]
  • Elida González, Alicia Jawerbaum, Débora Sinner, Carolina Pustovrh, Verónica White, Evangelina Capobianco, Carme Xaus, Carmen Peralta, Joan Roselló-Catafau. Streptozotocin-pancreatic damage in the rat: modulatory effect of 15-deoxy delta12,14-prostaglandin j(2) on nitridergic and prostanoid pathway. Nitric oxide : biology and chemistry. 2002 Mar; 6(2):214-20. doi: 10.1006/niox.2001.0405. [PMID: 11890746]
  • C Simoneau, A Theobald, P Roncari, P Hannaert, E Anklam. Time-temperature study of the kinetics of migration of BADGE (bisphenol-A-diglycidyl-ether) into a fatty medium. Food additives and contaminants. 2002; 19 Suppl(?):73-8. doi: 10.1080/02652030110104843. [PMID: 11962717]
  • K Inoue, A Yamaguchi, M Wada, Y Yoshimura, T Makino, H Nakazaw. Quantitative detection of bisphenol A and bisphenol A diglycidyl ether metabolites in human plasma by liquid chromatography-electrospray mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 2001 Dec; 765(2):121-6. doi: 10.1016/s0378-4347(01)00393-0. [PMID: 11767304]
  • A Pontén, M Bruze. Contact allergy to epoxy resin based on diglycidyl ether of bisphenol F. Contact dermatitis. 2001 Feb; 44(2):98-9. doi: 10.1034/j.1600-0536.2001.4402092.x. [PMID: 11205414]
  • U Berger, M Oehme, L Girardin. Quantification of derivatives of bisphenol A diglycidyl ether (BADGE) and novolac glycidyl ether (NOGE) migrated from can coatings into tuna by HPLC/fluorescence and MS detection. Fresenius' journal of analytical chemistry. 2001 Jan; 369(2):115-23. doi: 10.1007/s002160000668. [PMID: 11225353]
  • L Kanerva, R Jolanki, T Estlander, M Henriks-Eckerman, M Tuomi, K Tarvainen. Airborne occupational allergic contact dermatitis from triglycidyl-p-aminophenol and tetraglycidyl-4,4'-methylene dianiline in preimpregnated epoxy products in the aircraft industry. Dermatology (Basel, Switzerland). 2000; 201(1):29-33. doi: 10.1159/000018424. [PMID: 10971055]
  • L Kanerva. Occupational allergic contact dermatitis from epoxy resin in a dental nurse with primary sensitization during cyclosporine treatment. Acta dermato-venereologica. 1996 Jan; 76(1):89-90. doi: 10.2340/00015555768990. [PMID: 8721515]
  • L Kanerva, R Jolanki, O Tupasela, L Halmepuro, H Keskinen, T Estlander, M L Sysilampi. Immediate and delayed allergy from epoxy resins based on diglycidyl ether of bisphenol A. Scandinavian journal of work, environment & health. 1991 Jun; 17(3):208-15. doi: 10.5271/sjweh.1718. [PMID: 1829851]
  • G C Peristianis, S M Doak, P N Cole, R W Hend. Two-year carcinogenicity study on three aromatic epoxy resins applied cutaneously to CF1 mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1988 Jul; 26(7):611-24. doi: 10.1016/0278-6915(88)90232-3. [PMID: 2972595]
  • I J Climie, D H Hutson, G Stoydin. Metabolism of the epoxy resin component 2,2-bis[4-(2,3-epoxypropoxy)phenyl]propane, the diglycidyl ether of bisphenol A (DGEBPA) in the mouse. Part II. Identification of metabolites in urine and faeces following a single oral dose of 14C-DGEBPA. Xenobiotica; the fate of foreign compounds in biological systems. 1981 Jun; 11(6):401-24. doi: 10.3109/00498258109045851. [PMID: 7293231]
  • I J Climie, D H Hutson, G Stoydin. Metabolism of the epoxy resin component 2,2-bis[4](2,3]epoxypropoxy)phenyl]propane, the diglycidyl ether of bisphenol A (DGEBPA) in the mouse. Part I. A comparison of the fate of a single dermal application and of a single oral dose of 14C-DGEBPA. Xenobiotica; the fate of foreign compounds in biological systems. 1981 Jun; 11(6):391-9. doi: 10.3109/00498258109045850. [PMID: 7293230]
  • L Accatino, F R Simon. Identification and characterization of a bile acid receptor in isolated liver surface membranes. The Journal of clinical investigation. 1976 Feb; 57(2):496-508. doi: 10.1172/jci108302. [PMID: 3520]