Triflumuron (BioDeep_00000002504)

 

Secondary id: BioDeep_00000397821

human metabolite blood metabolite


代谢物信息卡片


3-[(2-chlorophenyl)(hydroxy)methylidene]-1-[4-(trifluoromethoxy)phenyl]urea

化学式: C15H10ClF3N2O3 (358.0332)
中文名称: 甲醇中杀铃脲溶液
谱图信息: 最多检出来源 Escherichia coli(natural_products) 100%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(=O)NC(=O)NC2=CC=C(C=C2)OC(F)(F)F)Cl
InChI: InChI=1S/C15H10ClF3N2O3/c16-12-4-2-1-3-11(12)13(22)21-14(23)20-9-5-7-10(8-6-9)24-15(17,18)19/h1-8H,(H2,20,21,22,23)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 617; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5237; ORIGINAL_PRECURSOR_SCAN_NO 5232
CONFIDENCE standard compound; INTERNAL_ID 617; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5229; ORIGINAL_PRECURSOR_SCAN_NO 5227
CONFIDENCE standard compound; INTERNAL_ID 617; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5230; ORIGINAL_PRECURSOR_SCAN_NO 5226
CONFIDENCE standard compound; INTERNAL_ID 617; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5242; ORIGINAL_PRECURSOR_SCAN_NO 5241
CONFIDENCE standard compound; INTERNAL_ID 617; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5203; ORIGINAL_PRECURSOR_SCAN_NO 5199
CONFIDENCE standard compound; INTERNAL_ID 617; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5232; ORIGINAL_PRECURSOR_SCAN_NO 5230
D010575 - Pesticides > D002629 - Chemosterilants
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals

同义名列表

13 个代谢物同义名

3-[(2-chlorophenyl)(hydroxy)methylidene]-1-[4-(trifluoromethoxy)phenyl]urea; 2-Chloro-N-({[4-(trifluoromethoxy)phenyl]amino}carbonyl)benzamide; 2-chloro-N-(4-(Trifluoromethoxy)phenylaminocarbonyl)benzamide; 1-(O-Chlorobenzoyl)-3-(p-(trifluoromethoxy)phenyl)urea; 1-(4-Trifluoromethoxyphenyl)-3-(2-chlorobenzoyl)urea; BAY-sir 8514; BAY sir 8514; BAY-sir-8514; Triflumuron; BAY VI 7533; Trifluron; Alsystin; Triflumuron



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, ARHGAP45, BCL2, CAT, CDH1, MX1
Peripheral membrane protein 1 MX1
Endoplasmic reticulum membrane 2 BCL2, MX1
Nucleus 4 ALB, BCL2, CDH1, MX1
cytosol 7 ALB, AP1AR, ARHGAP45, BCL2, CAT, CDH1, MX1
trans-Golgi network 1 CDH1
centrosome 1 ALB
nucleoplasm 1 CDH1
Cell membrane 1 CDH1
lamellipodium 1 CDH1
ruffle membrane 1 ARHGAP45
Multi-pass membrane protein 1 SLC45A2
cell junction 1 CDH1
glutamatergic synapse 1 CDH1
Golgi apparatus 3 ALB, AP1AR, CDH1
postsynapse 1 CDH1
endosome 2 AP1AR, CDH1
plasma membrane 4 ARHGAP45, BTC, CDH1, FN1
Membrane 7 ARHGAP45, BCL2, BTC, CAT, CDH1, MX1, SLC45A2
apical plasma membrane 1 FN1
extracellular exosome 4 ALB, CAT, CDH1, FN1
endoplasmic reticulum 2 ALB, BCL2
extracellular space 3 ALB, BTC, FN1
perinuclear region of cytoplasm 2 CDH1, MX1
adherens junction 1 CDH1
mitochondrion 2 BCL2, CAT
protein-containing complex 3 ALB, BCL2, CAT
intracellular membrane-bounded organelle 1 CAT
Single-pass type I membrane protein 1 CDH1
Secreted 2 ALB, FN1
extracellular region 6 ALB, ARHGAP45, BTC, CAT, CDH1, FN1
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CDH1, MX1
Secreted, extracellular space, extracellular matrix 1 FN1
actin cytoskeleton 1 CDH1
Melanosome membrane 1 SLC45A2
Early endosome 1 AP1AR
Cell projection, ruffle membrane 1 ARHGAP45
Cytoplasm, perinuclear region 1 MX1
pore complex 1 BCL2
focal adhesion 1 CAT
microtubule 1 MX1
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
extracellular matrix 1 FN1
Peroxisome 1 CAT
basement membrane 1 FN1
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 FN1
lateral plasma membrane 1 CDH1
Late endosome 1 AP1AR
ciliary basal body 1 ALB
centriole 1 ALB
Golgi apparatus, trans-Golgi network 1 CDH1
spindle pole 1 ALB
blood microparticle 2 ALB, FN1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 ARHGAP45, CAT
endoplasmic reticulum lumen 2 ALB, FN1
platelet alpha granule lumen 2 ALB, FN1
transport vesicle 1 AP1AR
azurophil granule lumen 1 ARHGAP45
anaphase-promoting complex 1 CDH1
[Isoform 2]: Cytoplasm 1 MX1
clathrin-coated endocytic vesicle membrane 1 BTC
endoplasmic reticulum-Golgi intermediate compartment 1 FN1
[Isoform 2]: Nucleus 1 CDH1
apical junction complex 1 CDH1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
fibrinogen complex 1 FN1
catalase complex 1 CAT
BAD-BCL-2 complex 1 BCL2
ciliary transition fiber 1 ALB


文献列表

  • Antonio Masetti, Anna Rathé, Nicola Robertson, Diane Anderson, Jim Walker, Edison Pasqualini, Laura Depalo. Effects of three chitin synthesis inhibitors on egg masses, nymphs and adults of Halyomorpha halys (Hemiptera: Pentatomidae). Pest management science. 2023 Mar; ?(?):. doi: 10.1002/ps.7465. [PMID: 36944039]
  • Rim Timoumi, Ines Amara, Intidhar Ben Salem, Salwa Abid-Essefi. Triflumuron induces cytotoxic effects on hepatic and renal human cell lines. Journal of biochemical and molecular toxicology. 2020 Aug; 34(8):e22504. doi: 10.1002/jbt.22504. [PMID: 32227688]
  • Rim Timoumi, Ines Amara, Yossra Ayed, Intidhar Ben Salem, Salwa Abid-Essefi. Triflumuron induces genotoxicity in both mice bone marrow cells and human Colon cancer cell line. Toxicology mechanisms and methods. 2020 Jul; 30(6):438-449. doi: 10.1080/15376516.2020.1758981. [PMID: 32312157]
  • Rim Timoumi, Intidhar Ben Salem, Ines Amara, Emna Annabi, Salwa Abid-Essefi. Protective effects of fennel essential oil against oxidative stress and genotoxicity induced by the insecticide triflumuron in human colon carcinoma cells. Environmental science and pollution research international. 2020 Mar; 27(8):7957-7966. doi: 10.1007/s11356-019-07395-x. [PMID: 31893363]
  • Rim Timoumi, Ines Amara, Fadwa Neffati, Mohamed Fadhel Najjar, Emna El Golli-Bennour, Hassen Bacha, Salwa Abid-Essefi. Acute triflumuron exposure induces oxidative stress responses in liver and kidney of Balb/C mice. Environmental science and pollution research international. 2019 Feb; 26(4):3723-3730. doi: 10.1007/s11356-018-3908-8. [PMID: 30539393]
  • Nikita Bakanov, Matthias V Wieczorek, Ralf Schulz. Retention of plant protection products (PPPs) by aquatic plants in flow-through systems. Chemosphere. 2019 Feb; 216(?):587-594. doi: 10.1016/j.chemosphere.2018.10.186. [PMID: 30390589]
  • Ricardo Alcántara-de la Cruz, José Cola Zanuncio, Mabio Chrisley Lacerda, Carlos Frederico Wilcken, Flávio Lemes Fernandes, Wagner de Souza Tavares, Marcus Alvarenga Soares, Carlos Sigueyuki Sediyama. Side-effects of pesticides on the generalist endoparasitoid Palmistichus elaeisis (Hymenoptera: Eulophidae). Scientific reports. 2017 08; 7(1):10064. doi: 10.1038/s41598-017-10462-3. [PMID: 28855720]
  • M M Parrilla Vázquez, P Parrilla Vázquez, M Martínez Galera, A Uclés Moreno. Comparison of two ionic liquid dispersive liquid-liquid microextraction approaches for the determination of benzoylurea insecticides in wastewater using liquid chromatography-quadrupole-linear ion trap-mass spectrometry: evaluation of green parameters. Journal of chromatography. A. 2014 Aug; 1356(?):1-9. doi: 10.1016/j.chroma.2014.06.032. [PMID: 24993054]
  • Mingrong Qian, Liqin Wu, Hu Zhang, Mingfei Xu, Rui Li, Xiangyun Wang, Caixia Sun. Determination of 16 insect growth regulators in edible Chinese traditional herbs by liquid chromatography electrospray tandem mass spectrometry. Analytical and bioanalytical chemistry. 2012 Mar; 402(7):2451-62. doi: 10.1007/s00216-011-5699-3. [PMID: 22271101]
  • Roberto M Goulart, Haroldo X L Volpe, Alessandra M Vacari, Robson T Thuler, Sergio A De Bortoli. Insecticide selectivity to two species of Trichogramma in three different hosts, as determined by IOBC/WPRS methodology. Pest management science. 2012 Feb; 68(2):240-4. doi: 10.1002/ps.2251. [PMID: 21858909]
  • Yuanmu Fan, Shaotang Huang, Xuejun Yu, Xiaojun Gu, Yajun Qiu, Shubing Chen, Keteng Fang, Jun Chen. [Determination of diflubenzuron and triflumuron residues in greasy wool by accelerated solvent extraction technique and high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2009 Jul; 27(4):463-6. doi: . [PMID: 19938504]
  • R Karimzadeh, M J Hejazi, F Rahimzadeh Khoei, M Moghaddam. Laboratory evaluation of five chitin synthesis inhibitors against the colorado potato beetle, Leptinotarsa decemlineata. Journal of insect science (Online). 2007; 7(?):1-6. doi: 10.1673/031.007.5001. [PMID: 20345285]
  • Cristina S Bastos, Raul P de Almeida, Fábio A Suinaga. Selectivity of pesticides used on cotton (Gossypium hirsutum) to Trichogramma pretiosum reared on two laboratory-reared hosts. Pest management science. 2006 Jan; 62(1):91-8. doi: 10.1002/ps.1140. [PMID: 16308868]
  • A Huerta, P Medina, G Smagghe, P Castañera, E Viñuela. Topical toxicity of two acetonic fractions of Trichilia havanensis Jacq. and four insecticides to larvae and adults of Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae). Communications in agricultural and applied biological sciences. 2003; 68(4 Pt A):277-86. doi: ". [PMID: 15149120]
  • A Balinova. Multiresidue determination of pesticides in plants by high-performance liquid chromatography following gel permeation chromatographic clean-up. Journal of chromatography. A. 1998 Oct; 823(1-2):11-6. doi: 10.1016/s0021-9673(98)00478-6. [PMID: 9818389]
  • T Fukase, M Kamon, H Itagaki. A simulated field experiment with triflumuron, a benzoylphenylurea, on larvae of the house fly Musca domestica in chicken feces. Nihon juigaku zasshi. The Japanese journal of veterinary science. 1988 Feb; 50(1):93-7. doi: 10.1292/jvms1939.50.93. [PMID: 3361738]
  • P J Waller, E Lacey. The effect of triflumuron (SIR8514) on the free-living stages of sheep nematodes. Veterinary parasitology. 1986 Jun; 21(2):119-26. doi: 10.1016/0304-4017(86)90152-4. [PMID: 3739204]
  • R W Miller, Y Wong, O P Thomas. Feeding BAY Vi 7533 to hens. Poultry science. 1984 Sep; 63(9):1748-51. doi: 10.3382/ps.0631748. [PMID: 6483739]