Tenofovir (BioDeep_00000002493)
Secondary id: BioDeep_00000397818
human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds
代谢物信息卡片
({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid
化学式: C9H14N5O4P (287.07833740000007)
中文名称: 替诺福韦
谱图信息:
最多检出来源 Homo sapiens(blood) 5.36%
分子结构信息
SMILES: CC(CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
InChI: InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)
描述信息
Tenofovir is only found in individuals that have used or taken this drug. Tenofovir, marketed by Gilead Sciences under the trade name Viread®, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. [Wikipedia]Tenofovir inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. Specifically, the drugs are analogues of the naturally occurring deoxynucleotides needed to synthesize the viral DNA and they compete with the natural deoxynucleotides for incorporation into the growing viral DNA chain. However, unlike the natural deoxynucleotides substrates, NRTIs and NtRTIs (nucleoside/tide reverse transcriptase inhibitors) lack a 3-hydroxyl group on the deoxyribose moiety. As a result, following incorporation of an NRTI or an NtRTI, the next incoming deoxynucleotide cannot form the next 5-3 phosphodiester bond needed to extend the DNA chain. Thus, when an NRTI or NtRTI is incorporated, viral DNA synthesis is halted, a process known as chain termination. All NRTIs and NtRTIs are classified as competitive substrate inhibitors.
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Tenofovir (GS 1278) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV)[1].
同义名列表
24 个代谢物同义名
({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid; 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098; 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer; 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer; (R)-9-(2-Phosphonylmethoxypropyl)adenine; 9-(2-Phosphonylmethoxypropyl)adenine; 9-(2-Phosphonomethoxypropyl)adenine; Disoproxil fumarate, tenofovir; Fumarate, tenofovir disoproxil; Tenofovir Disoproxil Fumarate; Disoproxil, tenofovir; Tenofovir disoproxil; Anhydrous tenofovir; 9-PMPA (tenofovir); Tenofovir (anh.); Anh. tenofovir; D,L-Tenofovir; Tenofovir; (R)-PMPA; Viread; PMPA; TDF; GS 1278; Tenofovir
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:63625
- ChEBI: CHEBI:63716
- KEGG: C17407
- PubChem: 464205
- PubChem: 64987
- HMDB: HMDB0014445
- DrugBank: DB14126
- ChEMBL: CHEMBL315593
- ChEMBL: CHEMBL483
- Wikipedia: Tenofovir
- MeSH: Tenofovir
- chemspider: 408154
- CAS: 1217720-14-3
- CAS: 107021-12-5
- CAS: 147127-20-6
- PMhub: MS000002797
- PubChem: 336445146
- PDB-CCD: TFO
- medchemexpress: HY-13910
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Tenofovir Metabolism Pathway:
Adenosine triphosphate + Tenofovir Monophosphate ⟶ Adenosine diphosphate + Tenofovir Diphosphate
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dathan M Byonanebye, Mark N Polizzotto, Fernando Maltez, Andri Rauch, Katharina Grabmeier-Pfistershammer, Ferdinand Wit, Stéphane De Wit, Antonella Castagna, Antonella d'Arminio Monforte, Cristina Mussini, Jan-Christian Wasmuth, Eric Fontas, Irene Abela, Mario Sarcletti, Loveleen Bansi-Matharu, Nadine Jaschinski, Lars Peters, Sean R Hosein, Vani Vannappagari, Cal Cohen, Emiliano Bissio, Amanda Mocroft, Matthew Law, Lene Ryom, Kathy Petoumenos. Associations between change in BMI and the risk of hypertension and dyslipidaemia in people receiving integrase strand-transfer inhibitors, tenofovir alafenamide, or both compared with other contemporary antiretroviral regimens: a multicentre, prospective observational study from the RESPOND consortium cohorts.
The lancet. HIV.
2024 May; 11(5):e321-e332. doi:
10.1016/s2352-3018(23)00328-4. [PMID: 38621392] - Jen-Yu Hsu, Hsin-Yun Sun, Ling-Ya Chen, Sui-Yuan Chang, Yu-Chung Chuang, Yu-Shan Huang, Yi-Ching Su, Wen-Chun Liu, Chien-Ching Hung. Weight and metabolic changes among virally suppressed people with HIV who switched to co-formulated bictegravir/emtricitabine/tenofovir alafenamide.
Journal of global antimicrobial resistance.
2024 Mar; 36(?):426-435. doi:
10.1016/j.jgar.2023.10.012. [PMID: 37923129] - Kexin Tong, Mingjing Chen, Danni Wang, Haifeng Dai, Jiayi Peng, Jia Zhang, Jiao Zhou, Yujiao Chang, Wenxiang Huang. Effects of first-line nucleot(s)ide analogues on lipid profiles in patients with chronic hepatitis B: a network meta-analysis.
European journal of clinical pharmacology.
2024 Mar; 80(3):335-354. doi:
10.1007/s00228-023-03616-y. [PMID: 38197944] - Chung-Jen Chen. Epstein-Barr virus reactivation and disease flare of systemic lupus erythematosus.
Taiwanese journal of obstetrics & gynecology.
2024 Mar; 63(2):161-164. doi:
10.1016/j.tjog.2024.01.008. [PMID: 38485308] - Chloe Orkin, Jean-Michel Molina, Pedro Cahn, Johannes Lombaard, Khuanchai Supparatpinyo, Sushma Kumar, Havilland Campbell, Hong Wan, Valerie Teal, Zhi Jin Xu, Ernest Asante-Appiah, Peter Sklar, Hedy Teppler, Rima Lahoulou. Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials.
The lancet. HIV.
2024 Feb; 11(2):e75-e85. doi:
10.1016/s2352-3018(23)00258-8. [PMID: 38141637] - Samuel Kesse, Yuhong Xu, Sanyuan Shi, Shanshan Jin, Shafi Ullah, Yongchao Dai, Miao He, Anjie Zheng, Fengwei Xu, Zixiu Du, Raphael N Alolga, Jinliang Peng. MDSC-targeted liposomal all-trans retinoic acid suppresses mMdscs and improves immunotherapy in HBV infection.
Expert opinion on drug delivery.
2024 Feb; 21(2):347-363. doi:
10.1080/17425247.2024.2317936. [PMID: 38406829] - Hyeyeon Hong, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi. Cardiovascular risk in chronic hepatitis B patients treated with tenofovir disoproxil fumarate or tenofovir alafenamide.
Clinical and molecular hepatology.
2024 Jan; 30(1):49-63. doi:
10.3350/cmh.2023.0328. [PMID: 37981763] - Scott K Fung, Calvin Q Pan, Grace Lai-Hung Wong, Wai-Kay Seto, Sang Hoon Ahn, Chi-Yi Chen, Hie-Won L Hann, Maciej S Jablkowski, Yoon Jun Kim, Cihan Yurdaydin, Cheng-Yuan Peng, Tuan Nguyen, Hiroshi Yatsuhashi, John F Flaherty, Leland J Yee, Frida Abramov, Hongyuan Wang, Dzhamal Abdurakhmanov, Young-Suk Lim, Maria Buti. Atherosclerotic cardiovascular disease risk profile of patients with chronic hepatitis B treated with tenofovir alafenamide or tenofovir disoproxil fumarate for 96 weeks.
Alimentary pharmacology & therapeutics.
2024 Jan; 59(2):217-229. doi:
10.1111/apt.17764. [PMID: 37905449] - Pin-Nan Cheng, I-Cher Feng, Jyh-Jou Chen, Hsing-Tao Kuo, Pei-Lun Lee, Ming-Lung Yu, Yen-Cheng Chiu, Hung-Chih Chiu, Shih-Chieh Chien, Pei-Jer Chen, Chun-Jen Liu. Body weight increase and metabolic derangements after tenofovir disoproxil fumarate switch to tenofovir alafenamide in patients with chronic hepatitis B.
Alimentary pharmacology & therapeutics.
2024 Jan; 59(2):230-238. doi:
10.1111/apt.17765. [PMID: 37845815] - Jiang Xiao, Guiju Gao, Yi Ding, Jialu Li, Chengyu Gao, Qiuhua Xu, Liang Wu, Hongyuan Liang, Liang Ni, Fang Wang, Yujiao Duan, Di Yang, Hongxin Zhao. Reasons, safety and efficacy analysis for conversion of HAART to TAF/FTC/BIC among HIV-infected patients.
Chinese medical journal.
2023 Dec; 136(24):2931-2937. doi:
10.1097/cm9.0000000000002939. [PMID: 38032036] - Lin Gan, Xiaoxin Xie, Yanhua Fu, Yebing Song, Chunli Song, Tingting Ren, Hai Long. Efficacy and safety of bictegravir/emtricitabine/tenofovir alafenamide fumarate for adult patients with human immunodeficiency virus-1 in China: a retrospective real-world cohort study.
Expert review of anti-infective therapy.
2023 Dec; ?(?):1-7. doi:
10.1080/14787210.2023.2292544. [PMID: 38058002] - Wen-Ting Peng, Chuan Jiang, Fei-Lan Yang, Nian-Qi Zhou, Ke-Yu Chen, Jin-Qing Liu, Shi-Fang Peng, Lei Fu. Tenofovir amibufenamide vs tenofovir alafenamide for treating chronic hepatitis B: A real-world study.
World journal of gastroenterology.
2023 Nov; 29(44):5907-5918. doi:
10.3748/wjg.v29.i44.5907. [PMID: 38111506] - Y Q Duan, P Hu. [Research progress on the effect of tenofovir disoproxil fumarate on blood lipid profile].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2023 Oct; 31(10):1103-1107. doi:
10.3760/cma.j.cn501113-20220407-00177. [PMID: 38016781] - A Yakut, M Aladag. The relationship between the use of nucleos(t)ide analogs and metabolic parameters in patients with chronic hepatitis B.
European review for medical and pharmacological sciences.
2023 Oct; 27(19):9315-9323. doi:
10.26355/eurrev_202310_33959. [PMID: 37843345] - Simone Perazzolo, Zachary Stephen, Masa Eguchi, Xiaolin Xu, Rachele Delle Fratte, Ann C Collier, Ann J Melvin, Rodney J Y Ho. A novel formulation enabled transformation of 3 HIV drugs tenofovir-lamivudine-dolutegravir (TLD) from short-acting to long-acting all-in-one injectable.
AIDS (London, England).
2023 Aug; ?(?):. doi:
10.1097/qad.0000000000003706. [PMID: 37650755] - C D Chang, C Dong, S X Zhao, X W Yuan, X X Zhang, D D Zhao, Y Dou, Y M Nan. [Real-world study on the efficacy and safety of first-line antiviral therapy for chronic hepatitis B].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2023 Aug; 31(8):855-861. doi:
10.3760/cma.j.cn501113-20230322-00124. [PMID: 37723068] - Leonardo Calza, Vincenzo Colangeli, Giulia Pensalfine, Lucia Appolloni, Salvatore Vitale, Isabella Bon, Pierluigi Viale. Doravirine/lamivudine/tenofovir disoproxil fumarate in virologically suppressed people living with HIV: A real-life experience.
International journal of STD & AIDS.
2023 Aug; ?(?):9564624231195084. doi:
10.1177/09564624231195084. [PMID: 37565832] - Eui Gwon Hwang, Eun-Ae Jung, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim. Risk of dyslipidemia in chronic hepatitis B patients taking tenofovir alafenamide: a systematic review and meta-analysis.
Hepatology international.
2023 Aug; 17(4):860-869. doi:
10.1007/s12072-023-10528-7. [PMID: 37099248] - Hadeer M Abouelezz, Dalia H El-Kashef, Rania R Abdеlaziz, Manar A Nader. Tenofovir alone or combined with doxorubicin abrogates DMBA-induced mammary cell carcinoma: An insight into its modulatory impact on oxidative/Notch/apoptotic signaling.
Life sciences.
2023 May; ?(?):121798. doi:
10.1016/j.lfs.2023.121798. [PMID: 37236603] - Xiu Chen, Jun Li, Liqiu Kou, Xiaolu Xie, Deqing Wei, Yaling Li. Efficacy and safety of long-acting cabotegravir versus oral tenofovir disoproxil fumarate-emtricitabine as HIV pre-exposure prophylaxis: A systematic review and meta-analysis.
Reviews in medical virology.
2023 May; ?(?):e2460. doi:
10.1002/rmv.2460. [PMID: 37198721] - Anna Brestovitsky, Mayumi Iwasaki, Jungnam Cho, Natthawut Adulyanukosol, Jerzy Paszkowski, Marco Catoni. Specific suppression of long terminal repeat retrotransposon mobilization in plants.
Plant physiology.
2023 04; 191(4):2245-2255. doi:
10.1093/plphys/kiac605. [PMID: 36583226] - Zhang Junli, H E Ying, Zhang Xia, F U Hongfang, H U Xiaoyu. Fuzheng Huayu preparation (/) combined with tenofovir disoproxil fumarate on hepatitis B: a systematic review and Meta-analysis.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 04; 43(2):221-230. doi:
10.19852/j.cnki.jtcm.20221108.005. [PMID: 36994510] - Angelica Perna, Maria A Carleo, Silvia Mascolo, Alessandra Guida, Marcella Contieri, Carmine Sellitto, Eleonora Hay, Paolo De Blasiis, Angela Lucariello, Germano Guerra, Alfonso Baldi, Antonio De Luca, Paolo Maggi, Vincenzo Esposito. Adipocyte differentiation of 3T3-L1 cells under tenofovir alafenamide, tenofovir disoproxil fumarate, and integrase strand transfer inhibitors selective challenge: an in-vitro model.
AIDS (London, England).
2023 03; 37(4):561-570. doi:
10.1097/qad.0000000000003455. [PMID: 36504092] - Won-Mook Choi, Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, W Ray Kim, Leland J Yee, Craig Brooks-Rooney, Tristan Curteis, Harriet Cant, Chien-Hung Chen, Chi-Yi Chen, Yi-Hsiang Huang, Young-Joo Jin, Dae Won Jun, Jin-Wook Kim, Neung Hwa Park, Cheng-Yuan Peng, Hyun Phil Shin, Jung Woo Shin, Yao-Hsu Yang, Young-Suk Lim. Hepatocellular carcinoma risk in patients with chronic hepatitis B receiving tenofovir- vs. entecavir-based regimens: Individual patient data meta-analysis.
Journal of hepatology.
2023 03; 78(3):534-542. doi:
10.1016/j.jhep.2022.12.007. [PMID: 36572349] - Javier Martínez-Sanz, Sergio Serrano-Villar, Alfonso Muriel, Lucio J García Fraile, Eva Orviz, Álvaro Mena de Cea, Antoni A Campins, Santiago Moreno. Metabolic-Related Outcomes After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Adults With Human Immunodeficiency Virus (HIV): A Multicenter Prospective Cohort Study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2023 02; 76(3):e652-e660. doi:
10.1093/cid/ciac621. [PMID: 35903910] - Charalampos D Moschopoulos, Konstantinos Protopapas, Konstantinos Thomas, Dimitra Kavatha, Antonios Papadopoulos, Anastasia Antoniadou. Switching from Tenofovir Disoproxil to Tenofovir Alafenamide Fumarate: Impact on Cardiovascular Risk and Lipid Profile in People Living with HIV, an Observational Study.
AIDS research and human retroviruses.
2023 02; 39(2):68-75. doi:
10.1089/aid.2022.0086. [PMID: 36401506] - Ryoko Sekiya, Takashi Muramatsu, Akito Ichiki, Yushi Chikasawa, Masato Bingo, Mihoko Yotsumoto, Takeshi Hagiwara, Kagehiro Amano, Ei Kinai. Young age is a key determinant of body weight gain after switching from tenofovir disoproxil fumarate to tenofovir alafenamide in Japanese people living with HIV.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2023 Feb; 29(2):171-178. doi:
10.1016/j.jiac.2022.10.014. [PMID: 37589078] - Franco Maggiolo, Giuliano Rizzardini, Jean-Michel Molina, Federico Pulido, Stephane De Wit, Linos Vandekerckhove, Juan Berenguer, Michelle L D'Antoni, Christiana Blair, Susan K Chuck, David Piontkowsky, Hal Martin, Richard Haubrich, Ian R McNicholl, Joel Gallant. Bictegravir/emtricitabine/tenofovir alafenamide in older individuals with HIV: Results of a 96-week, phase 3b, open-label, switch trial in virologically suppressed people ≥65 years of age.
HIV medicine.
2023 01; 24(1):27-36. doi:
10.1111/hiv.13319. [PMID: 35527425] - Adem Simsek, Oguz Karabay, Ertugrul Guclu, Hande Toptan. Comparison of Metabolic Effects of Three Different Treatment Combinations with Retrospective Real-life Data in People Living with HIV.
Current HIV research.
2023; 21(5):314-322. doi:
10.2174/011570162x266922231107094649. [PMID: 37990894] - Jing Wen Chen, Xiong Yue Cao, Xun Qi, Ji Ming Zhang. Effect of nucleos(t)ide analogues on blood lipid profiles in patients with chronic hepatitis B: A cross-sectional survey.
Medicine.
2022 Dec; 101(50):e31980. doi:
10.1097/md.0000000000031980. [PMID: 36550809] - Arif Sarowar, Carla S Coffin, Scott Fung, Alexander Wong, Karen Doucette, David Truong, Brian Conway, Sarah Haylock-Jacobs, Alnoor Ramji, Bettina E Hansen, Harry L A Janssen, Curtis Cooper. Brief Report: Effect of Antiretroviral Switch From Tenofovir Disoproxil fumarate to Tenofovir Alafenamide on Alanine Aminotransferase, Lipid Profiles, and Renal Function in HIV/HBV-Coinfected Individuals in a Nationwide Canadian Study.
Journal of acquired immune deficiency syndromes (1999).
2022 12; 91(4):368-372. doi:
10.1097/qai.0000000000003079. [PMID: 36288543] - M A Hamed, R E Akhigbe, A O Aremu, A F Odetayo. Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats.
Chemico-biological interactions.
2022 Dec; 368(?):110233. doi:
10.1016/j.cbi.2022.110233. [PMID: 36309141] - Qi Zhang, Jinlin Liang, Junhua Yin, Yiyue Jiang, Ning Yu, Xingmei Liao, Siru Zhao, Leyuan Wu, Rong Fan. Real-life impact of tenofovir disoproxil fumarate and entecavir therapy on lipid profile, glucose, and uric acid in chronic hepatitis B patients.
Journal of medical virology.
2022 11; 94(11):5465-5474. doi:
10.1002/jmv.27977. [PMID: 35794065] - Liqin Sun, Yun He, Liumei Xu, Fang Zhao, Yang Zhou, Lukun Zhang, Qiaoli Peng, Haitao Zhang, Qiuyue Zhang, Tingzhi Cao, Ying Song, Siyuan Wang, Man Rao, Xinyun Jia, Xiaoning Liu, Jing Zhou, Bin Ju, Hui Wang, Jiaye Liu. Higher Risk of Dyslipidemia With Coformulated Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide than Efavirenz, Lamivudine, and Tenofovir Disoproxil Fumarate Among Antiretroviral-Naive People Living With HIV in China.
Journal of acquired immune deficiency syndromes (1999).
2022 10; 91(S1):S8-S15. doi:
10.1097/qai.0000000000003040. [PMID: 36094509] - Z Gok Sargin, U Celik, I Dusunceli, Y Ustundag. Comparison of the side effects of antivirals in chronic hepatitis B patients: a single-center experience.
Acta gastro-enterologica Belgica.
2022 Oct; 85(4):587-592. doi:
10.51821/85.4.10634. [PMID: 36566368] - William Liu, Sarah Yu, Bingfang Yan. Effect of alcohol exposure on the efficacy and safety of tenofovir alafenamide fumarate, a major medicine against human immunodeficiency virus.
Biochemical pharmacology.
2022 10; 204(?):115224. doi:
10.1016/j.bcp.2022.115224. [PMID: 36007574] - Olayemi Osiyemi, Stéphane De Wit, Faïza Ajana, Fiona Bisshop, Joaquín Portilla, Jean Pierre Routy, Christoph Wyen, Mounir Ait-Khaled, Peter Leone, Keith A Pappa, Ruolan Wang, Jonathan Wright, Nisha George, Brian Wynne, Michael Aboud, Jean van Wyk, Kimberly Y Smith. Efficacy and Safety of Switching to Dolutegravir/Lamivudine Versus Continuing a Tenofovir Alafenamide-Based 3- or 4-Drug Regimen for Maintenance of Virologic Suppression in Adults Living With Human Immunodeficiency Virus Type 1: Results Through Week 144 From the Phase 3, Noninferiority TANGO Randomized Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 09; 75(6):975-986. doi:
10.1093/cid/ciac036. [PMID: 35079789] - Miriam T Levy, Angela Kashuba, Edward Gane. Plasma and breast milk pharmacokinetics of tenofovir alafenamide of mothers with chronic hepatitis B infection-Authors' reply.
Alimentary pharmacology & therapeutics.
2022 Aug; 56(3):548-549. doi:
10.1111/apt.17102. [PMID: 35804469] - Tahrima Kayes, Harry Crane, Allison Symonds, Julie Dumond, Mackenzie Cottrell, Julia Di Girolamo, Sicha Manandhar, Tien Huey Lim, Edward Gane, Angela Kashuba, Miriam T Levy. Plasma and breast milk pharmacokinetics of tenofovir alafenamide in mothers with chronic hepatitis B infection.
Alimentary pharmacology & therapeutics.
2022 Aug; 56(3):510-518. doi:
10.1111/apt.17040. [PMID: 35599363] - Mei-Hsuan Lee. Plasma and breast milk pharmacokinetics of tenofovir alafenamide in mothers with chronic hepatitis B infection.
Alimentary pharmacology & therapeutics.
2022 Aug; 56(3):546-547. doi:
10.1111/apt.17079. [PMID: 35804473] - Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan. The use of tenofovir in patients with COVID-19.
HIV medicine.
2022 Aug; 23(7):807-808. doi:
10.1111/hiv.13228. [PMID: 35023263] - Qianqian Zhang, Youmei Peng, Jiao Hou, Yanhong Chen, Bingjie Liu, Pinghu Zhang, Wenquan Yu, Junbiao Chang. An O-Benzyl Phosphonamidate Prodrug of Tenofovir for the Treatment of Hepatitis B Virus Infection.
Journal of medicinal chemistry.
2022 07; 65(13):9493-9505. doi:
10.1021/acs.jmedchem.2c00869. [PMID: 35776695] - Dvora Leah Joseph Davey, Kathryn Dovel, Susan Cleary, Nehaa Khadka, Nyiko Mashele, Miriam Silliman, Rufaro Mvududu, Dorothy C Nyemba, Thomas J Coates, Landon Myer. Stepped care to optimize pre-exposure prophylaxis (PrEP) effectiveness in pregnant and postpartum women (SCOPE-PP) in South Africa: a randomized control trial.
BMC public health.
2022 07; 22(1):1306. doi:
10.1186/s12889-022-13652-5. [PMID: 35799121] - Botond Lakatos, Justyna Kowalska, Sergii Antoniak, Deniz Gokengin, Josip Begovac, Anna Vassilenko, Piotr Wasilewski, Lukas Fleischhans, David Jilich, Raimonda Matulionyte, Kerstin Kase, Antonios Papadopoulus, Nino Rukhadze, Arjan Harxhi, Sam Hofman, Gordana Dragovic, Marta Vasyliev, Antonija Verhaz, Nina Yancheva, Cristiana Oprea. Retrospective evaluation of an observational cohort by the Central and Eastern Europe Network Group shows a high frequency of potential drug-drug interactions among HIV-positive patients receiving treatment for coronavirus disease 2019 (COVID-19).
HIV medicine.
2022 07; 23(6):693-700. doi:
10.1111/hiv.13214. [PMID: 34859557] - Jihye Lim, Won-Mook Choi, Ju Hyun Shim, Danbi Lee, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi. Efficacy and safety of tenofovir alafenamide versus tenofovir disoproxil fumarate in treatment-naïve chronic hepatitis B.
Liver international : official journal of the International Association for the Study of the Liver.
2022 07; 42(7):1517-1527. doi:
10.1111/liv.15261. [PMID: 35343041] - Terry A Marryshow, Josephine Muhairwe, Alice Tang, Maleliha Morake M Molulela, Riya Matta, Michael R Jordan. Determining the acceptability of point-of-care urine tenofovir testing and its performance in predicting HIV RNA suppression.
International journal of STD & AIDS.
2022 Jul; 33(8):777-783. doi:
10.1177/09564624221103043. [PMID: 35611960] - Weiqing Meng, Meiling Chen, Yangzi Song, Huan Zhang, Ruming Xie, Fujie Zhang. Prevalence and Risk Factors of Low Bone Mineral Density in HIV/AIDS Patients: A Chinese Cross-Sectional Study.
Journal of acquired immune deficiency syndromes (1999).
2022 07; 90(3):360-368. doi:
10.1097/qai.0000000000002958. [PMID: 35315797] - Joy Y Feng, Venice Du Pont, Darius Babusis, Calvin J Gordon, Egor P Tchesnokov, Jason K Perry, Vincent Duong, Arya Vijjapurapu, Xiaofeng Zhao, Julie Chan, Cal Cohen, Kavita Juneja, Tomas Cihlar, Matthias Götte, John P Bilello. The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2.
Molecules (Basel, Switzerland).
2022 Jun; 27(13):. doi:
10.3390/molecules27134212. [PMID: 35807457] - José L Blanco, Jhon Rojas, Elisa de Lazzari, Alexy Inciarte, Mar Subirana, Pilar Callau, María Martinez-Rebollar, Montserrat Laguno, Josep Mallolas, Lorena de la Mora, Berta Torres, Ana Gonzalez-Cordón, Esteban Martinez. Simplification from tenofovir disoproxil fumarate plus lamivudine or emtricitabine plus ritonavir-boosted protease inhibitor to ritonavir-boosted atazanavir plus lamivudine in virologically suppressed HIV-infected adults with osteopenia: a pilot study.
The Journal of antimicrobial chemotherapy.
2022 06; 77(7):1974-1979. doi:
10.1093/jac/dkac137. [PMID: 35512339] - Eiichi Ogawa, Makoto Nakamuta, Toshimasa Koyanagi, Aritsune Ooho, Norihiro Furusyo, Eiji Kajiwara, Kazufumi Dohmen, Akira Kawano, Takeaki Satoh, Kazuhiro Takahashi, Koichi Azuma, Nobuyuki Yamashita, Naoki Yamashita, Rie Sugimoto, Hiromasa Amagase, Masami Kuniyoshi, Yasunori Ichiki, Chie Morita, Masaki Kato, Shinji Shimoda, Hideyuki Nomura, Jun Hayashi. Switching to tenofovir alafenamide for nucleos(t)ide analogue-experienced patients with chronic hepatitis B: Week 144 results from a real-world, multicentre cohort study.
Alimentary pharmacology & therapeutics.
2022 Jun; ?(?):. doi:
10.1111/apt.17107. [PMID: 35735794] - Kai Juhani Kauppinen, Inka Aho, Jussi Sutinen. Switching from tenofovir alafenamide to tenofovir disoproxil fumarate improves lipid profile and protects from weight gain.
AIDS (London, England).
2022 Jun; ?(?):. doi:
10.1097/qad.0000000000003245. [PMID: 35727143] - Yanhang Gao, Fei Kong, Xinwen Song, Jia Shang, Lvfeng Yao, Jinyu Xia, Yanzhong Peng, Weidong Liu, Huanyu Gong, Mao Mu, Hesong Cui, Tao Han, Wen Chen, Xiaolu Wu, Yongfeng Yang, Xuebing Yan, Zhenjing Jin, Peng Wang, Qingjing Zhu, Liang Chen, Caiyan Zhao, Dengke Zhang, Weili Jin, Daidi Wang, Xiuhong Wen, Chunmei Liu, Jidong Jia, Qing Mao, Yanhua Ding, Xueyuan Jin, Zong Zhang, Qianguo Mao, Guangming Li, Junqi Niu. Pradefovir Treatment in Patients With Chronic Hepatitis B: Week 24 Results From a Multicenter, Double-Blind, Randomized, Noninferiority, Phase 2 Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 06; 74(11):1925-1932. doi:
10.1093/cid/ciab763. [PMID: 34487151] - Juhan Lee, Jae Geun Lee, Shin Hwang, Kwang-Woong Lee, Jong Man Kim, Je Ho Ryu, Bong-Wan Kim, Dong Lak Choi, Young Kyoung You, Dong-Sik Kim, Yang Won Nah, Koo Jeong Kang, Jai Young Cho, Hee Chul Yu, Geun Hong, Dongho Choi, Ju Ik Moon, Myoung Soo Kim. Renal safety of tenofovir disoproxil fumarate and entecavir in liver transplant patients: a nationwide Korean registry study.
Hepatology international.
2022 Jun; 16(3):537-544. doi:
10.1007/s12072-022-10320-z. [PMID: 35467324] - Lauren Jennings, Tracy Kellermann, Matthew Spinelli, Zukiswa Nkantsu, Dolphina Cogill, Marije van Schalkwyk, Eric Decloedt, Gert van Zyl, Catherine Orrell, Monica Gandhi. Drug Resistance, Rather than Low Tenofovir Levels in Blood or Urine, Is Associated with Tenofovir, Emtricitabine, and Efavirenz Failure in Resource-Limited Settings.
AIDS research and human retroviruses.
2022 06; 38(6):455-462. doi:
10.1089/aid.2021.0135. [PMID: 34779228] - Caroline R Garcia, Armin T Rad, Farnoosh Saeedinejad, Arvind Manojkumar, Deepa Roy, Hansapani Rodrigo, Sue Anne Chew, Ziyaur Rahman, Mu-Ping Nieh, Upal Roy. Effect of drug-to-lipid ratio on nanodisc-based tenofovir drug delivery to the brain for HIV-1 infection.
Nanomedicine (London, England).
2022 06; 17(13):959-978. doi:
10.2217/nnm-2022-0043. [PMID: 35642549] - Nicholas I Paton, Joseph Musaazi, Cissy Kityo, Stephen Walimbwa, Anne Hoppe, Apolo Balyegisawa, Jesca Asienzo, Arvind Kaimal, Grace Mirembe, Abbas Lugemwa, Gilbert Ategeka, Margaret Borok, Henry Mugerwa, Abraham Siika, Eva Laker A Odongpiny, Barbara Castelnuovo, Agnes Kiragga, Andrew Kambugu. Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial.
The lancet. HIV.
2022 06; 9(6):e381-e393. doi:
10.1016/s2352-3018(22)00092-3. [PMID: 35460601] - Susan H Eshleman, Jessica M Fogel, Estelle Piwowar-Manning, Gordon Chau, Vanessa Cummings, Yaw Agyei, Paul Richardson, Philip Sullivan, Casey D Haines, Lane R Bushman, Christos Petropoulos, Deborah Persaud, Ryan Kofron, Craig W Hendrix, Peter L Anderson, Jennifer Farrior, John Mellors, Adeola Adeyeye, Alex Rinehart, Marty St Clair, Susan Ford, James F Rooney, Carrie-Anne Mathew, Portia Hunidzarira, Elizabeth Spooner, Juliet Mpendo, Gonasagrie Nair, Myron S Cohen, James P Hughes, Mina Hosseinipour, Brett Hanscom, Sinead Delany-Moretlwe, Mark A Marzinke. Characterization of Human Immunodeficiency Virus (HIV) Infections in Women Who Received Injectable Cabotegravir or Tenofovir Disoproxil Fumarate/Emtricitabine for HIV Prevention: HPTN 084.
The Journal of infectious diseases.
2022 05; 225(10):1741-1749. doi:
10.1093/infdis/jiab576. [PMID: 35301540] - Jennifer Lagoutte-Renosi, Mylène Flammang, Didier Ducloux, Jamal Bamoulid, Pierre-Yves Royer, Quentin Lepiller, Anne-Laure Clairet, Siamak Davani, Patrice Muret. Bictegravir/emtricitabine/tenofovir alafenamide combination in the management of kidney transplant patients with HIV receiving immunosuppressants.
Journal of chemotherapy (Florence, Italy).
2022 May; 34(3):199-202. doi:
10.1080/1120009x.2021.1940436. [PMID: 34180378] - Yunia Mayanja, Onesmus Kamacooko, Jane Frances Lunkuse, Vincent Muturi-Kioi, Allan Buzibye, Denis Omali, Kundai Chinyenze, Monica Kuteesa, Pontiano Kaleebu, Matt A Price. Oral pre-exposure prophylaxis preference, uptake, adherence and continuation among adolescent girls and young women in Kampala, Uganda: a prospective cohort study.
Journal of the International AIDS Society.
2022 05; 25(5):e25909. doi:
10.1002/jia2.25909. [PMID: 35543110] - Chan-Young Jung, Hyung Woo Kim, Sang Hoon Ahn, Seung Up Kim, Beom Seok Kim. Higher risk of kidney function decline with entecavir than tenofovir alafenamide in patients with chronic hepatitis B.
Liver international : official journal of the International Association for the Study of the Liver.
2022 05; 42(5):1017-1026. doi:
10.1111/liv.15208. [PMID: 35220649] - Tristan Foucault, Lynda Handala, Gilles Paintaud, Catherine Gaudy-Graffin, Julien Marlet. Treatment of chronic hepatitis B: virological and pharmacological aspects.
Virologie (Montrouge, France).
2022 05; 26(3):228-239. doi:
10.1684/vir.2022.0927. [PMID: 35792839] - Lila Starbuck, Sarit A Golub, Augustus Klein, Alexander B Harris, Amiyah Guerra, Christopher Rincon, Asa E Radix. Brief Report: Transgender Women and Preexposure Prophylaxis Care: High Preexposure Prophylaxis Adherence in a Real-World Health Care Setting in New York City.
Journal of acquired immune deficiency syndromes (1999).
2022 05; 90(1):15-19. doi:
10.1097/qai.0000000000002915. [PMID: 35013087] - F D Wang, J Zhou, D M Zhang, M L Wang, Y C Tao, D B Wu, H Tang, E Q Chen. [A study of the effectiveness of nucleos(t)ide analogues in the treatment of HBeAg- positive chronic hepatitis B with normal alanine aminotransferase and high level of HBV DNA].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2022 Apr; 30(4):389-394. doi:
10.3760/cma.j.cn501113-20210705-00318. [PMID: 35545563] - Chan-Young Jung, Hyung Woo Kim, Sang Hoon Ahn, Seung Up Kim, Beom Seok Kim. Tenofovir is Associated With Higher Risk of Kidney Function Decline Than Entecavir in Patients With Chronic Hepatitis B.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2022 04; 20(4):956-958.e2. doi:
10.1016/j.cgh.2021.05.032. [PMID: 34029751] - Robin Schaefer, Pedro Henrique Amparo da Costa Leite, Ronaldo Silva, Quarraisha Abdool Karim, Christopher Akolo, Carlos F Cáceres, Inês Dourado, Kimberly Green, Anita Hettema, Elske Hoornenborg, Smarajit Jana, Bernhard Kerschberger, Hally Mahler, Sindy Matse, Hamish McManus, Jean-Michel Molina, Sushena Reza-Paul, Iskandar Azwa, Maryam Shahmanesh, Doug Taylor, Hamid Vega-Ramirez, Valdiléa G Veloso, Rachel Baggaley, Shona Dalal. Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data.
The lancet. HIV.
2022 04; 9(4):e242-e253. doi:
10.1016/s2352-3018(22)00004-2. [PMID: 35271825] - Lucy Campbell, Fowzia Ibrahim, Birgit Barbini, Amanda Samarawickrama, Chloe Orkin, Julie Fox, Laura Waters, Yvonne Gilleece, Shema Tariq, Frank A Post. Bone mineral density, kidney function and participant-reported outcome measures in women who switch from tenofovir disoproxil emtricitabine and a nonnucleoside reverse transcriptase inhibitor to abacavir, lamivudine and dolutegravir.
HIV medicine.
2022 04; 23(4):362-370. doi:
10.1111/hiv.13215. [PMID: 34866304] - E Sinakos, P Panas, N Fragkou, N Antoniadis, G Katsanos, E Tsakni, T Oikonomou, A Notopoulos, G Tsoulfas, I Goulis, E Akriviadis. Tenofovir alafenamide prophylaxis post-liver transplantation: a real-world study in patients with chronic kidney disease.
Acta gastro-enterologica Belgica.
2022 Apr; 85(2):331-337. doi:
10.51821/85.2.9577. [PMID: 35709777] - Young Eun Chon, Soo Young Park, Seung Up Kim, Han Pyo Hong, Jae Seung Lee, Hye Won Lee, Mi Na Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Beom Kyung Kim. Long-term renal safety between patients with chronic hepatitis B receiving tenofovir vs. entecavir therapy: A multicenter study.
Journal of viral hepatitis.
2022 04; 29(4):289-296. doi:
10.1111/jvh.13656. [PMID: 35152517] - Eiichi Ogawa, Makoto Nakamuta, Toshimasa Koyanagi, Aritsune Ooho, Norihiro Furusyo, Eiji Kajiwara, Kazufumi Dohmen, Akira Kawano, Takeaki Satoh, Kazuhiro Takahashi, Koichi Azuma, Nobuyuki Yamashita, Naoki Yamashita, Rie Sugimoto, Hiromasa Amagase, Masami Kuniyoshi, Yasunori Ichiki, Chie Morita, Masaki Kato, Shinji Shimoda, Hideyuki Nomura, Jun Hayashi. Sequential HBV treatment with tenofovir alafenamide for patients with chronic hepatitis B: week 96 results from a real-world, multicenter cohort study.
Hepatology international.
2022 Apr; 16(2):282-293. doi:
10.1007/s12072-021-10295-3. [PMID: 35075593] - Joonho Jeong, Jung Woo Shin, Seok Won Jung, Eun Ji Park, Neung Hwa Park. Tenofovir alafenamide treatment may not worsen the lipid profile of chronic hepatitis B patients: A propensity score-matched analysis.
Clinical and molecular hepatology.
2022 04; 28(2):254-264. doi:
10.3350/cmh.2021.0314. [PMID: 34959261] - Geoffroy Liegeon, Nicole Ngo-Giang-Huong, Nicolas Salvadori, Piyawan Bunpo, Ratchada Cressey, Jullapong Achalapong, Prateep Kanjanavikai, Orada Patamasingh Na Ayudhaya, Sinart Prommas, Thitiporn Siriwachirachai, Prapan Sabsanong, Jean Yves Mary, Gonzague Jourdain. Proximal tubular dysfunction in pregnant women receiving tenofovir disoproxil fumarate to prevent mother-to-child transmission of hepatitis B virus.
The Journal of antimicrobial chemotherapy.
2022 03; 77(4):1111-1118. doi:
10.1093/jac/dkab490. [PMID: 35045168] - Laura Labarthe, Thibaut Gelé, Hélène Gouget, Mariam-Sarah Benzemrane, Pauline Le Calvez, Nicolas Legrand, Olivier Lambotte, Roger Le Grand, Christine Bourgeois, Aurélie Barrail-Tran. Pharmacokinetics and tissue distribution of tenofovir, emtricitabine and dolutegravir in mice.
The Journal of antimicrobial chemotherapy.
2022 03; 77(4):1094-1101. doi:
10.1093/jac/dkab501. [PMID: 35022753] - Derin Sevenler, Xin Niu, Sandy Dossantos, Mehmet Toner, Tim R Cressey, Rebecca D Sandlin, Paul K Drain. Point-of-care semi-quantitative test for adherence to tenofovir alafenamide or tenofovir disoproxil fumarate.
The Journal of antimicrobial chemotherapy.
2022 03; 77(4):996-999. doi:
10.1093/jac/dkab487. [PMID: 35038336] - Zili Hu, Huilan Zeng, Jingyu Hou, Juncheng Wang, Li Xu, Yaojun Zhang, Minshan Chen, Zhongguo Zhou. Tenofovir vs. Entecavir on Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma after Radiofrequency Ablation.
Viruses.
2022 03; 14(4):. doi:
10.3390/v14040656. [PMID: 35458386] - Hsin-Yun Sun, Chien-Yu Cheng, Chi-Ying Lin, Chia-Jui Yang, Nan-Yao Lee, Bo-Huang Liou, Hung-Jen Tang, Yuang-Meng Liu, Chun-Yuan Lee, Tun-Chieh Chen, Yi-Chia Huang, Yuan-Ti Lee, Ming-Jui Tsai, Po-Liang Lu, Hung-Chin Tsai, Ning-Chi Wang, Tung-Che Hung, Shu-Hsing Cheng, Chien-Ching Hung. Real-world effectiveness of direct-acting antivirals in people living with human immunodeficiency virus and hepatitis C virus genotype 6 infections.
World journal of gastroenterology.
2022 Mar; 28(11):1172-1183. doi:
10.3748/wjg.v28.i11.1172. [PMID: 35431505] - Natalia Festinger, Kaja Spilarewicz-Stanek, Kamila Borowczyk, Dariusz Guziejewski, Sylwia Smarzewska. Highly Sensitive Determination of Tenofovir in Pharmaceutical Formulations and Patients Urine-Comparative Electroanalytical Studies Using Different Sensing Methods.
Molecules (Basel, Switzerland).
2022 Mar; 27(6):. doi:
10.3390/molecules27061992. [PMID: 35335355] - Xieer Liang, Qing Xie, Jia Shang, Hong Tang, Min Xu, Qinghua Meng, Jiming Zhang, Pujun Gao, Jifang Sheng, Hao Wang, Jidong Jia, Guiqiang Wang, Shunquan Wu, Jingna Ping, Jinlin Hou. Tenofovir disoproxil fumarate for multiple nucleos(t)ide analogues treatment failure hepatitis B: Is monotherapy enough?.
Journal of gastroenterology and hepatology.
2022 Mar; 37(3):471-479. doi:
10.1111/jgh.15757. [PMID: 34894002] - Md Masud Parvez, Said Kalkisim, Phuong Thi Thu Nguyen, Jin Ah Jung, Jeong-Kon Park, Jong-Lyul Ghim, Eun-Young Kim, Yong-Soon Cho, Melih O Babaoglu, Jae-Gook Shin. Para-aminosalicylic acid significantly reduced tenofovir exposure in human subjects: Mismatched findings from in vitro to in vivo translational research.
British journal of clinical pharmacology.
2022 03; 88(3):1159-1169. doi:
10.1111/bcp.15056. [PMID: 34432302] - Simone Perazzolo, Danny D Shen, Rodney J Y Ho. Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 2: Model for the Drug-combination Nanoparticles.
Journal of pharmaceutical sciences.
2022 03; 111(3):825-837. doi:
10.1016/j.xphs.2021.10.009. [PMID: 34673094] - Marta Librero Jiménez, María Ángeles López Garrido, María Carmen Fernández Cano. Letter to the editor: Reactivation of HBV triggered by SARS-CoV-2 in a patient with cirrhosis.
Hepatology (Baltimore, Md.).
2022 Mar; 75(3):765-766. doi:
10.1002/hep.32271. [PMID: 34888903] - Supawadee Suppadungsuk, Purim Janepiriyaprayoon, Somnuek Sungkanuparph. Recovery of renal function after early versus late switching of tenofovir disoproxil fumarate in people living with HIV with renal insufficiency.
International journal of STD & AIDS.
2022 03; 33(4):391-396. doi:
10.1177/09564624221076632. [PMID: 35143730] - Chih-Lang Lin, Yi-Lan Lin, Kung-Hao Liang, Li-Wei Chen, Cheng-Hung Chien, Ching-Chih Hu, Ting-Shuo Huang, Yu-Chiau Shyu, Chau-Ting Yeh, Rong-Nan Chien. Prognosis Comparison Between Chronic Hepatitis B Patients Receiving a Finite Course of Tenofovir and Entecavir Treatment: A Nationwide Cohort Study in Taiwan.
Clinical therapeutics.
2022 03; 44(3):403-417.e6. doi:
10.1016/j.clinthera.2022.01.010. [PMID: 35469645] - Julia M Migliorati, Xiao-Bo Zhong. Mutations in muscle-type creatine kinase impact HIV prevention.
Trends in pharmacological sciences.
2022 03; 43(3):165-167. doi:
10.1016/j.tips.2021.11.017. [PMID: 34887127] - Xiaoping Qian, Qi Chen, Yunhui Chen, Shiliang Ji, Ying Wang, Ye Sun, Huixin Qi, Kan Zhong, Jinfang Jiang, Xin Chen, Lifeng Huang, Yong Yang. A simple and fast LC-MS/MS method for the simultaneous determination of tenofovir alafenamide and tenofovir in human plasma.
Biomedical chromatography : BMC.
2022 Mar; 36(3):e5273. doi:
10.1002/bmc.5273. [PMID: 34725843] - Wenting Peng, Huimin Gu, Chuan Jiang, Jinqing Liu, Jian Zhang, Lei Fu. Comparison of tenofovir alafenamide and entecavir for hepatitis B virus-related acute-on-chronic liver failure.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2022 Feb; 47(2):194-201. doi:
10.11817/j.issn.1672-7347.2022.210578. [PMID: 35545409] - Karla Cristina Silva Petruccelli, Djane Clarys Baía-da-Silva, Fernando Val, Monica Santos Valões, Nadia Cubas-Vega, Alexandre Vilhena Silva-Neto, Vanderson Sampaio, Aline Alencar, Roberto Pecoits-Filho, Rodrigo Carvalho Moreira, Sandra Wagner Cardoso, Ronaldo I Moreira, Iuri Costa Leite, José Valdez Madruga, Esper G Kallas, Paulo R Alencastro, Brenda Hoagland, Beatriz Grinsztejn, Valdiléa Gonçalves Veloso Santos, Marcus Vinícius Guimarães Lacerda. Kidney function and daily emtricitabine/tenofovir disoproxil fumarate pre-exposure prophylaxis against HIV: results from the real-life multicentric demonstrative project PrEP Brazil.
AIDS research and therapy.
2022 02; 19(1):12. doi:
10.1186/s12981-022-00437-4. [PMID: 35209929] - Samukelisiwe Ngcobo, Refilwe P Molatlhegi, Farzana Osman, Sinaye Ngcapu, Natasha Samsunder, Nigel J Garrett, Salim S Abdool Karim, Quarraisha Abdool Karim, Lyle R McKinnon, Aida Sivro. Pre-infection plasma cytokines and chemokines as predictors of HIV disease progression.
Scientific reports.
2022 02; 12(1):2437. doi:
10.1038/s41598-022-06532-w. [PMID: 35165387] - Lung-Yi Mak, Joseph Hoang, Dae Won Jun, Chien-Hung Chen, Cheng-Yuan Peng, Ming-Lun Yeh, Sung Eun Kim, Daniel Q Huang, Jae Yoon Jeong, Eileen Yoon, Hyunwoo Oh, Pei-Chien Tsai, Chung-Feng Huang, Sang Bong Ahn, Huy Trinh, Qing Xie, Grace L H Wong, Masaru Enomoto, Jae-Jun Shim, Dong-Hyun Lee, Li Liu, Ritsuzo Kozuka, Yong Kyun Cho, Soung Won Jeong, Hyoung Su Kim, Lindsey Trinh, Allen Dao, Rui Huang, Rex Wan-Hin Hui, Vivien Tsui, Sabrina Quek, Htet Htet Toe Wai Khine, Eiichi Ogawa, Chia Yen Dai, Jee Fu Huang, Ramsey Cheung, Chao Wu, Wan-Long Chuang, Seng Gee Lim, Ming-Lung Yu, Man-Fung Yuen, Mindie H Nguyen. Longitudinal renal changes in chronic hepatitis B patients treated with entecavir versus TDF: a REAL-B study.
Hepatology international.
2022 Feb; 16(1):48-58. doi:
10.1007/s12072-021-10271-x. [PMID: 34822056] - A Geragotellis, S Patel, M Sonderup, N Wearne, Z Barday, L Sanglay, V Naicker, C W Spearman. Tenofovir alafenamide: An initial experience at Groote Schuur Hospital, Cape Town, South Africa.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
2022 Feb; 112(2):13505. doi:
NULL. [PMID: 35139993] - Louise A Ouattara, Andrea R Thurman, Terry A Jacot, Mackenzie Cottrell, Craig Sykes, Kimberly Blake, Xi Fang, Susan Ju, Nikolas C Vann, Jill Schwartz, Gustavo F Doncel. Genital Mucosal Drug Concentrations and anti-HIV Activity in Tenofovir-Based PrEP Products: Intravaginal Ring vs. Oral Administration.
Journal of acquired immune deficiency syndromes (1999).
2022 01; 89(1):87-97. doi:
10.1097/qai.0000000000002820. [PMID: 34878438] - Pimsiri Sripongpun, W Ray Kim, Ajitha Mannalithara, Allison Kwong, Tami Daugherty, Aparna Goel, Paul Y Kwo. Tenofovir Alafenamide Attenuates Effects of Diabetes and Body Mass on Serum Alanine Aminotransferase Activities in Patients With Chronic Hepatitis B.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2022 01; 20(1):230-232. doi:
10.1016/j.cgh.2020.11.047. [PMID: 33285291] - Yoshihito Uchida, Masamitsu Nakao, Shunsuke Yamada, Shohei Tsuji, Hayato Uemura, Jun-Ichi Kouyama, Kayoko Naiki, Kayoko Sugawara, Nobuaki Nakayama, Yukinori Imai, Tomoaki Tomiya, Satoshi Mochida. Superiority of tenofovir alafenamide fumarate over entecavir for serum HBsAg level reduction in patients with chronic HBV infection: A 144-week outcome study after switching of the nucleos(t)ide analog.
PloS one.
2022; 17(2):e0262764. doi:
10.1371/journal.pone.0262764. [PMID: 35180213] - Kazuharu Suzuki, Goki Suda, Yoshiya Yamamoto, Satoshi Abiko, Kenji Kinoshita, Shuichi Miyamoto, Ryo Sugiura, Megumi Kimura, Osamu Maehara, Ren Yamada, Takashi Kitagataya, Taku Shigesawa, Masatsugu Ohara, Naoki Kawagishi, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto. Effect of switching from tenofovir disoproxil fumarate to tenofovir alafenamide on lipid profiles in patients with hepatitis B.
PloS one.
2022; 17(1):e0261760. doi:
10.1371/journal.pone.0261760. [PMID: 35051189] - Carlos Eduardo Andrade Fioroti, Jesiree Iglésias Quadros Distenhreft, Bruna Bastos Paulino, Kamilla Lacchine, Danilo Rodrigues Ramos, Antonio Carlos Seguro, Weverton Machado Luchi. Tenofovir-induced renal and bone toxicity: report of two cases and literature review.
Revista do Instituto de Medicina Tropical de Sao Paulo.
2022; 64(?):e10. doi:
10.1590/s1678-9946202264010. [PMID: 35170711] - Fumitaka Suzuki, Yoshiyuki Suzuki, Yoshiyasu Karino, Yasuhito Tanaka, Masayuki Kurosaki, Hiroshi Yatsuhashi, Tomofumi Atarashi, Masanori Atsukawa, Tsunamasa Watanabe, Masaru Enomoto, Masatoshi Kudo, Naoto Maeda, Hiroshi Kohno, Kouji Joko, Kojiro Michitaka, Koichiro Miki, Kazuhiro Takahashi, Tatsuya Ide, Shigetoshi Fujiyama, Tomoko Kohno, Hiroshi Itoh, Sakiyo Tsukamoto, Yuko Suzuki, Yoshiaki Kawano, Wataru Sugiura, Hiromitsu Kumada. Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-positive chronic hepatitis B patients: a phase 4, prospective study.
BMC gastroenterology.
2021 Dec; 21(1):489. doi:
10.1186/s12876-021-02008-9. [PMID: 34930140] - Kensuke Abe, Taku Obara, Satomi Kamio, Asahi Kondo, Junji Imamura, Tatsuya Goto, Toshihiro Ito, Hiroshi Sato, Nobuyuki Takahashi. Renal function in Japanese HIV-1-positive patients who switch to tenofovir alafenamide fumarate after long-term tenofovir disoproxil fumarate: a single-center observational study.
AIDS research and therapy.
2021 12; 18(1):94. doi:
10.1186/s12981-021-00420-5. [PMID: 34876151] - Engie Salama, Lucas Hill, Nimish Patel, Brookie M Best, Jeremiah D Momper. Brief Report: Pharmacokinetics of Bictegravir and Tenofovir in Combination With Darunavir/Cobicistat in Treatment-Experienced Persons With HIV.
Journal of acquired immune deficiency syndromes (1999).
2021 12; 88(4):389-392. doi:
10.1097/qai.0000000000002765. [PMID: 34285156] - Mira Atef, Naglaa Zayed, Rabab Salama, Shereen Abdel Alem, Hanaa Yousof, Mohammad Saber, Mai Hamed, Ayman Yosry. Is urinary β2-microglobulin a reliable marker for assessment of renal tubular dysfunction in chronic hepatitis B patients receiving tenofovir therapy?.
European journal of gastroenterology & hepatology.
2021 12; 33(1S Suppl 1):e992-e998. doi:
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