Cyclizine (BioDeep_00000002344)
Secondary id: BioDeep_00000411071
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C18H22N2 (266.1782892)
中文名称: 苯甲嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCN(C(c2ccccc2)c2ccccc2)CC1
InChI: InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
描述信息
Cyclizine is only found in individuals that have used or taken this drug. It is a histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)Vomiting (emesis) is essentially a protective mechanism for removing irritant or otherwise harmful substances from the upper GI tract. Emesis or vomiting is controlled by the vomiting centre in the medulla region of the brain, an important part of which is the chemotrigger zone (CTZ). The vomiting centre possesses neurons which are rich in muscarinic cholinergic and histamine containing synapses. These types of neurons are especially involved in transmission from the vestibular apparatus to the vomiting centre. Motion sickness principally involves overstimulation of these pathways due to various sensory stimuli. Hence the action of cyclizine which acts to block the histamine receptors in the vomiting centre and thus reduce activity along these pathways. Furthermore since cyclizine possesses anti-cholinergic properties as well, the muscarinic receptors are similarly blocked.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AE - Piperazine derivatives
CONFIDENCE standard compound; INTERNAL_ID 1; HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
同义名列表
15 个代谢物同义名
(N-Benzhydryl)(n-methyl)diethylenediamine; (+-)-1-Diphenylmethyl-4-methylpiperazine; 1-(Diphenylmethyl)-4-methylpiperazine; N-Methyl-n-benzhydrylpiperazine; N-Benzhydryl-n-methylpiperazine; 1-Benzhydryl-4-methylpiperazin; Hydrochloride, cyclizine; Cyclizine Hydrochloride; Cyclizine chloride; HCL, Cyclizine; Cyclizine HCL; Cyclizinum; Ciclizina; CYCLIZINE; Marezine
数据库引用编号
82 个数据库交叉引用编号
- ChEBI: CHEBI:3994
- KEGG: C06930
- KEGGdrug: D81845
- KEGGdrug: D03621
- PubChem: 6726
- HMDB: HMDB0015307
- Metlin: METLIN44219
- DrugBank: DB01176
- ChEMBL: CHEMBL648
- Wikipedia: Cyclizine
- MeSH: Cyclizine
- chemspider: 6470
- CAS: 82-92-8
- MoNA: HB000432
- MoNA: HB000450
- MoNA: HB000437
- MoNA: HB002773
- MoNA: HB000411
- MoNA: HB000447
- MoNA: HB000425
- MoNA: HB000444
- MoNA: HB000452
- MoNA: HB000449
- MoNA: HB000403
- MoNA: HB000406
- MoNA: HB000430
- MoNA: HB000405
- MoNA: HB000408
- MoNA: HB000410
- MoNA: HB000402
- MoNA: HB000422
- MoNA: HB000419
- MoNA: HB000454
- MoNA: HB000460
- MoNA: HB000438
- MoNA: HB000409
- MoNA: HB000418
- MoNA: HB000404
- MoNA: HB000416
- MoNA: HB000426
- MoNA: HB000451
- MoNA: HB000436
- MoNA: HB000423
- MoNA: HB000424
- MoNA: HB000443
- MoNA: HB000439
- MoNA: HB000415
- MoNA: HB000434
- MoNA: HB000453
- MoNA: HB000458
- MoNA: HB000448
- MoNA: HB000455
- MoNA: HB000435
- MoNA: HB000420
- MoNA: HB000401
- MoNA: HB000413
- MoNA: HB000428
- MoNA: HB002774
- MoNA: HB002770
- MoNA: HB000429
- MoNA: HB000446
- MoNA: HB002772
- MoNA: HB000442
- MoNA: HB000431
- MoNA: HB000456
- MoNA: HB002771
- MoNA: HB000445
- MoNA: HB000427
- MoNA: HB000459
- MoNA: HB000407
- MoNA: HB000414
- MoNA: HB000441
- MoNA: HB000433
- MoNA: HB000457
- MoNA: HB000412
- MoNA: HB000417
- MoNA: HB000440
- MoNA: HB000421
- PMhub: MS000002395
- PubChem: 9147
- NIKKAJI: J4.621C
- RefMet: Cyclizine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Michel Y Fares, Nada S Abdelwahab, Ghada M El-Sayed, Maha A Hegazy, Maha M Abdelrahman. Spectrofluorimetric Approach for Quantification of Cyclizine in the Presence of its Toxic Impurities in Human Plasma; in silico Study and ADMET Calculations.
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Molecular pharmacology.
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. [PMID: 31515284] - Danyi Lu, Dong Dong, Qian Xie, Zhijie Li, Baojian Wu. Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter.
Drug metabolism and disposition: the biological fate of chemicals.
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Journal of medicinal chemistry.
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Journal of analytical toxicology.
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The Analyst.
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