But-2-enoic acid (BioDeep_00000002203)

Main id: BioDeep_00000628810

Secondary id: BioDeep_00000416042, BioDeep_00000860728

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


beta-Methylacrylic acid

化学式: C4H6O2 (86.0368)
中文名称: 2-丁烯酸, 巴豆酸
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 32.3%

分子结构信息

SMILES: C/C=C/C(=O)O
InChI: InChI=1S/C4H6O2/c1-2-3-4(5)6/h2-3H,1H3,(H,5,6)

描述信息

But-2-enoic acid, also known as (2E)-2-butenoate or alpha-crotonic acid, belongs to the class of organic compounds known as straight chain organic acids. These are organic acids with a straight aliphatic chain. But-2-enoic acid is a very hydrophobic molecule, practically insoluble in water, and relatively neutral.
Food flavour component
KEIO_ID C093
NSC 8751 is an endogenous metabolite.
NSC 8751 is an endogenous metabolite.

同义名列表

58 个代谢物同义名

beta-Methylacrylic acid; beta-Methacrylic acid; 3-Methyl-acrylic acid; trans-2-butenoic acid; (2E)-But-2-enoic acid; Β-methylacrylic acid; b-Methylacrylic acid; 3-Methylacrylic acid; (e)-But-2-enoic acid; (2E)-2-Butenoic acid; alpha-Crotonic acid; alpha-Butenoic acid; trans-Crotonic acid; Solid crotonic acid; (e)-2-Butenoic acid; beta-Methylacrylate; b-Methacrylic acid; Β-methacrylic acid; Kyselina krotonova; (2E)-But-2-enoate; beta-Methacrylate; trans-2-Butenoate; (e)-Crotonic acid; (e)-But-2-enoate; (2E)-2-Butenoate; b-Methylacrylate; Β-methylacrylate; 3-Methylacrylate; 2E-butenoic acid; but-2-enoic acid; alpha-Butenoate; a-Butenoic acid; alpha-Crotonate; trans-Crotonate; 2-Butenoic acid; (e)-2-Butenoate; Α-crotonic acid; Α-butenoic acid; a-Crotonic acid; Β-methacrylate; b-Methacrylate; Crotonic acid; (e)-Crotonate; Butenoic acid; But-2-enoate; a-Butenoate; Α-butenoate; Α-crotonate; 2-Butenoate; a-Crotonate; Crotonate; Butenoate; BEO; 2-Butenoic acid; NSC 8751; 2-Butenoate; 2-Butenoic acid; Crotonic acid



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

7 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(7)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CA2, CAT, CRYZ, FADD, HDAC9, OCM, PLA2G12A
Peripheral membrane protein 1 HSD17B6
Endoplasmic reticulum membrane 1 TAAR1
Nucleus 6 BRDT, CS, FOXD2, HDAC9, PLCZ1, SIRT3
cytosol 6 CA2, CAT, CROT, CRYZ, FADD, PLCZ1
nucleoplasm 4 HDAC9, NRG1, PLCZ1, SIRT3
Cell membrane 4 CA2, NRG1, TAAR1, TNFSF12
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 TAAR1
glutamatergic synapse 1 NRG1
mitochondrial inner membrane 1 ATP5ME
plasma membrane 5 CA2, FADD, NRG1, TAAR1, TNFSF12
Membrane 4 CAT, CS, NRG1, TNFSF12
apical plasma membrane 1 NRG1
extracellular exosome 4 CA2, CAT, CRYZ, CS
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HSD17B6, SUMF1
extracellular space 2 NRG1, TNFSF12
perinuclear region of cytoplasm 2 PLCZ1, TNFSF12
mitochondrion 6 ATP5ME, CAT, CRYZ, CS, GCDH, SIRT3
protein-containing complex 2 CAT, SIRT3
intracellular membrane-bounded organelle 3 CAT, CROT, HSD17B6
Microsome membrane 1 HSD17B6
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 NRG1
Secreted 3 NRG1, PLA2G12A, TNFSF12
extracellular region 4 CAT, NRG1, PLA2G12A, TNFSF12
cytoplasmic side of plasma membrane 1 FADD
Mitochondrion matrix 3 CS, GCDH, SIRT3
mitochondrial matrix 4 CAT, CS, GCDH, SIRT3
transcription regulator complex 1 HDAC9
nucleolus 1 PLCZ1
apical part of cell 1 CA2
Single-pass type II membrane protein 1 TNFSF12
Cytoplasm, perinuclear region 1 PLCZ1
focal adhesion 1 CAT
Peroxisome 2 CAT, CROT
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, CROT
peroxisomal membrane 1 CAT
chromatin 1 FOXD2
Endomembrane system 1 TAAR1
cell body 1 FADD
myelin sheath 1 CA2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 SUMF1
histone methyltransferase complex 1 HDAC9
histone deacetylase complex 1 HDAC9
CD95 death-inducing signaling complex 1 FADD
death-inducing signaling complex 1 FADD
ripoptosome 1 FADD
proton-transporting ATP synthase complex 1 ATP5ME
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
catalase complex 1 CAT
sperm head 1 PLCZ1


文献列表

  • Yibo Dong, Chao Chen. Comprehensive Profiling of Paper Mulberry (Broussonetia papyrifera) Crotonylome Reveals the Significance of Lysine Crotonylation in Young Leaves. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031173. [PMID: 35163093]
  • Xing Liu, Entezar Mehrabi Nasab, Seyyed Shamsadin Athari. Anti-inflammatory effect of N-(trifluoromethylphenyl)- 2-cyano-3-hydroxy-crotonic acid amide and gluconic acid on allergic rhinitis and asthma controlling. Allergologia et immunopathologia. 2022; 50(6):71-75. doi: 10.15586/aei.v50i6.612. [PMID: 36335448]
  • Hirohisa Tsuda. Generation of poly-β-hydroxybutyrate from externally provided acetate in rice root. Plant physiology and biochemistry : PPB. 2012 Jan; 50(1):35-43. doi: 10.1016/j.plaphy.2011.09.019. [PMID: 22099517]
  • Oktavia Hendrawati, Herman J Woerdenbag, Paul J A Michiels, Herald G Aantjes, Annie van Dam, Oliver Kayser. Identification of lignans and related compounds in Anthriscus sylvestris by LC-ESI-MS/MS and LC-SPE-NMR. Phytochemistry. 2011 Dec; 72(17):2172-9. doi: 10.1016/j.phytochem.2011.08.009. [PMID: 21889175]
  • Haibo Yu, Huibin Yang, Dongliang Cui, Liang Lv, Bin Li. Synthesis and herbicidal activity of diphenyl ether derivatives containing unsaturated carboxylates. Journal of agricultural and food chemistry. 2011 Nov; 59(21):11718-26. doi: 10.1021/jf2039444. [PMID: 21958315]
  • Karen Bohmert-Tatarev, Susan McAvoy, Sean Daughtry, Oliver P Peoples, Kristi D Snell. High levels of bioplastic are produced in fertile transplastomic tobacco plants engineered with a synthetic operon for the production of polyhydroxybutyrate. Plant physiology. 2011 Apr; 155(4):1690-708. doi: 10.1104/pp.110.169581. [PMID: 21325565]
  • N B Tavakalyan, A G Karapetyan, A S Pogosyan, A K Abrahamyan, A Corti, A Pompella, A Mihranyan. Influence of unsaturated carbonic acids on hemocompatibility and cytotoxicity of poly-vinylacetate based co-polymers. Journal of materials science. Materials in medicine. 2010 May; 21(5):1693-702. doi: 10.1007/s10856-010-4020-x. [PMID: 20162328]
  • Masanori Matsuura, Yoko Saikawa, Kosei Inui, Koichi Nakae, Masayuki Igarashi, Kimiko Hashimoto, Masaya Nakata. Identification of the toxic trigger in mushroom poisoning. Nature chemical biology. 2009 Jul; 5(7):465-7. doi: 10.1038/nchembio.179. [PMID: 19465932]
  • Alfons J M Stams, Jacco Huisman, Pedro A Garcia Encina, Gerard Muyzer. Citric acid wastewater as electron donor for biological sulfate reduction. Applied microbiology and biotechnology. 2009 Jul; 83(5):957-63. doi: 10.1007/s00253-009-1995-7. [PMID: 19399495]
  • Xu Zhang, Zhanyong Li, X X Zhu. Biomimetic mineralization induced by fibrils of polymers derived from a bile acid. Biomacromolecules. 2008 Sep; 9(9):2309-14. doi: 10.1021/bm800204t. [PMID: 18698846]
  • Hao Chen, Janet L Taylor, Suzanne R Abrams. Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations. Bioorganic & medicinal chemistry letters. 2007 Apr; 17(7):1979-83. doi: 10.1016/j.bmcl.2007.01.021. [PMID: 17300931]
  • Michael Fahrbach, Jan Kuever, Ruth Meinke, Peter Kämpfer, Juliane Hollender. Denitratisoma oestradiolicum gen. nov., sp. nov., a 17beta-oestradiol-degrading, denitrifying betaproteobacterium. International journal of systematic and evolutionary microbiology. 2006 Jul; 56(Pt 7):1547-1552. doi: 10.1099/ijs.0.63672-0. [PMID: 16825628]
  • Mehlika Pulat, Ayhan Ekmekci, Belma Aslim. The release of bovine serum albumin from polyurethane based hydrophilic and hydrophobic disks and microbiological interactions. Bio-medical materials and engineering. 2006; 16(2):147-56. doi: . [PMID: 16477123]
  • Izabela Jasicka-Misiak, Piotr P Wieczorek, Paweł Kafarski. Crotonic acid as a bioactive factor in carrot seeds (Daucus carota L.). Phytochemistry. 2005 Jun; 66(12):1485-91. doi: 10.1016/j.phytochem.2005.04.005. [PMID: 15960983]
  • Hartwig Schmidt, Fathulla Tadjimukhamedov, Isabelle V Mohrenz, Geoffrey B Smith, Gary A Eiceman. Microfabricated differential mobility spectrometry with pyrolysis gas chromatography for chemical characterization of bacteria. Analytical chemistry. 2004 Sep; 76(17):5208-17. doi: 10.1021/ac0497611. [PMID: 15373463]
  • Christopher L Sprague, Adnan A Elfarra. Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene. Drug metabolism and disposition: the biological fate of chemicals. 2003 Aug; 31(8):986-92. doi: 10.1124/dmd.31.8.986. [PMID: 12867486]
  • Yan-li Tang, Yan-ru Deng, Han-qing Wang. [Chemical components of essential oils from the herb of Ligularia virgaurea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2003 Jul; 28(7):627-9. doi: . [PMID: 15139106]
  • Tahar Mechichi, Erko Stackebrandt, Georg Fuchs. Alicycliphilus denitrificans gen. nov., sp. nov., a cyclohexanol-degrading, nitrate-reducing beta-proteobacterium. International journal of systematic and evolutionary microbiology. 2003 Jan; 53(Pt 1):147-152. doi: 10.1099/ijs.0.02276-0. [PMID: 12661531]