Linezolid (BioDeep_00000002017)
Secondary id: BioDeep_00000397847
human metabolite blood metabolite Chemicals and Drugs Antibiotics
代谢物信息卡片
N-{[(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
化学式: C16H20FN3O4 (337.1438)
中文名称: 利奈唑胺
谱图信息:
最多检出来源 Homo sapiens(blood) 41.81%
分子结构信息
SMILES: CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCOCC3)F
InChI: InChI=1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)
描述信息
Linezolid is only found in individuals that have used or taken this drug. It is a synthetic antibiotic, the first of the oxazolidinone class, used for the treatment of infections caused by multi-resistant bacteria including streptococcus and methicillin-resistant Staphylococcus aureus (MRSA). Linezolid is a synthetic antibacterial agent of the oxazolidinone class of antibiotics. It has in vitro activity against aerobic Gram positive bacteria, certain Gram negative bacteria and anaerobic microorganisms. It selectively inhibits bacterial protein synthesis through binding to sites on the bacterial ribosome and prevents the formation of a functional 70S-initiation complex. Specifically, linezolid binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, which is an essential component of the bacterial translation process. The results of time-kill studies have shown linezolid to be bacteriostatic against enterococci and staphylococci. For streptococci, linezolid was found to be bactericidal for the majority of strains. Linezolid is also a reversible, nonselective inhibitor of monoamine oxidase. Therefore, linezolid has the potential for interaction with adrenergic and serotonergic agents.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D023303 - Oxazolidinones
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
8 个代谢物同义名
N-{[(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide; N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide; N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide; N-((3-(3-Fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide; Linezolide; Linezolid; Zyvox; Linezolid
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:181548
- ChEBI: CHEBI:63607
- KEGG: C08146
- KEGGdrug: D00947
- PubChem: 441401
- PubChem: 3929
- HMDB: HMDB0014739
- Metlin: METLIN66834
- DrugBank: DB00601
- ChEMBL: CHEMBL191283
- ChEMBL: CHEMBL126
- Wikipedia: Linezolid
- MeSH: Linezolid
- chemspider: 390139
- CAS: 165800-03-3
- CAS: 224323-50-6
- PMhub: MS000001671
- PubChem: 10346
- PDB-CCD: ZLD
- NIKKAJI: J709.722K
- RefMet: Linezolid
- KNApSAcK: 181548
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qiang Xu, Yanlei Sang, Anna Gao, Lu Li. The effects of drug-drug interaction on linezolid pharmacokinetics: A systematic review.
European journal of clinical pharmacology.
2024 Jun; 80(6):785-795. doi:
10.1007/s00228-024-03652-2. [PMID: 38421436] - Masahiro Toyokawa, Noboru Ohana, Daiki Tanno, Minako Imai, Yukiko Takano, Kazutaka Ohashi, Tomonari Yamashita, Kyoichi Saito, Hiroki Takahashi, Hiroki Shimura. In vitro activity of tedizolid against 43 species of Nocardia species.
Scientific reports.
2024 03; 14(1):5342. doi:
10.1038/s41598-024-55916-7. [PMID: 38438563] - Eiseul Kim, Seung-Min Yang, Hyo-Sun Kwak, Bo-Youn Moon, Suk-Kyung Lim, Hae-Yeong Kim. Genomic characteristics of cfr and fexA carrying Staphylococcus aureus isolated from pig carcasses in Korea.
Veterinary research.
2024 Feb; 55(1):21. doi:
10.1186/s13567-024-01278-x. [PMID: 38365748] - Reem Khaled Wassif, Seham A Elkheshen, Rehab Nabil Shamma, Mohammed S Amer, Rehab Elhelw, Maha El-Kayal. Injectable systems of chitosan in situ forming composite gel incorporating linezolid-loaded biodegradable nanoparticles for long-term treatment of bone infections.
Drug delivery and translational research.
2023 Aug; ?(?):. doi:
10.1007/s13346-023-01384-x. [PMID: 37542190] - Jing Yang, Hong-Tao Ren, Jie Wang, Ai-Ying Dong, Yu-Lan Chen, Di-Xia Hu, Hao Wang, Hong-Meng Ji, Hai-Nan Wen, Ying Chen, Dong-Yan Shi. Clinical characteristics, susceptibility profiles, and treatment of nocardiosis: a multicenter retrospective study in 2015-2021.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2023 May; 130(?):136-143. doi:
10.1016/j.ijid.2023.02.023. [PMID: 36871785] - Ming Wei, Peng Wang, Tianmeng Li, Qiangyi Wang, Mingze Su, Li Gu, Shuai Wang. Antimicrobial and antibiofilm effects of essential fatty acids against clinically isolated vancomycin-resistant Enterococcus faecium.
Frontiers in cellular and infection microbiology.
2023; 13(?):1266674. doi:
10.3389/fcimb.2023.1266674. [PMID: 37842001] - Murugan Thulasi Meenu, Grace Kaul, Abdul Akhir, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Developing the Natural Prenylflavone Artocarpin from Artocarpus hirsutus as a Potential Lead Targeting Pathogenic, Multidrug-Resistant Staphylococcus aureus, Persisters and Biofilms with No Detectable Resistance.
Journal of natural products.
2022 10; 85(10):2413-2423. doi:
10.1021/acs.jnatprod.2c00621. [PMID: 36222797] - Kristina Klobucar, Emily Jardine, Maya A Farha, Marc R MacKinnon, Meghan Fragis, Brenda Nkonge, Timsy Bhando, Louis Borrillo, Caressa N Tsai, Jarrod W Johnson, Brian K Coombes, Jakob Magolan, Eric D Brown. Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.
ACS infectious diseases.
2022 10; 8(10):2187-2197. doi:
10.1021/acsinfecdis.2c00357. [PMID: 36098580] - Ting Huang, Mao Zeng, Huiyao Fu, Kelei Zhao, Tao Song, Yidong Guo, Jingyu Zhou, Longfei Zhai, Chaolan Liu, Balakrishnan Prithiviraj, Xinrong Wang, Yiwen Chu. A novel antibiotic combination of linezolid and polymyxin B octapeptide PBOP against clinical Pseudomonas aeruginosa strains.
Annals of clinical microbiology and antimicrobials.
2022 Aug; 21(1):38. doi:
10.1186/s12941-022-00531-5. [PMID: 36038932] - Rasha M El-Gaml, Noha M El-Khodary, Rania R Abozahra, Ayman A El-Tayar, Soha M El-Masry. Applying pharmacokinetic/pharmacodynamic measurements for linezolid in critically ill patients: optimizing efficacy and reducing resistance occurrence.
European journal of clinical pharmacology.
2022 Aug; 78(8):1301-1310. doi:
10.1007/s00228-022-03340-z. [PMID: 35610318] - Zhengan Wang, Chao Gu, Lu Sun, Feng Zhao, Ying Fu, Lingfang Di, Junxiong Zhang, Hemu Zhuang, Shengnan Jiang, Haiping Wang, Feiteng Zhu, Yiyi Chen, Mengzhen Chen, Xia Ling, Yan Chen, Yunsong Yu. Development of a novel core genome MLST scheme for tracing multidrug resistant Staphylococcus capitis.
Nature communications.
2022 07; 13(1):4254. doi:
10.1038/s41467-022-31908-x. [PMID: 35869070] - Changde Wu, Xiwen Zhang, Jianfeng Xie, Qing Li, Jie He, Linlin Hu, Haofei Wang, Airan Liu, Jingyuan Xu, Congshan Yang, Yi Yang, Haibo Qiu, Yingzi Huang. Pharmacokinetic/Pharmacodynamic Parameters of Linezolid in the Epithelial Lining Fluid of Patients With Sepsis.
Journal of clinical pharmacology.
2022 07; 62(7):891-897. doi:
10.1002/jcph.2031. [PMID: 35049077] - Carlos Rodríguez-Lucas, Javier Fernández, Xenia Vázquez, María de Toro, Víctor Ladero, Carlos Fuster, Rosaura Rodicio, María Rosario Rodicio. Detection of the optrA Gene Among Polyclonal Linezolid-Susceptible Isolates of Enterococcus faecalis Recovered from Community Patients.
Microbial drug resistance (Larchmont, N.Y.).
2022 Jul; 28(7):773-779. doi:
10.1089/mdr.2021.0402. [PMID: 35727074] - Catherine Berry, Philipp du Cros, Katherine Fielding, Suzanne Gajewski, Emil Kazounis, Timothy D McHugh, Corinne Merle, Ilaria Motta, David A J Moore, Bern-Thomas Nyang'wa. TB-PRACTECAL: study protocol for a randomised, controlled, open-label, phase II-III trial to evaluate the safety and efficacy of regimens containing bedaquiline and pretomanid for the treatment of adult patients with pulmonary multidrug-resistant tuberculosis.
Trials.
2022 Jun; 23(1):484. doi:
10.1186/s13063-022-06331-8. [PMID: 35698158] - Wenqiang Zhou, Wenjuan Nie, Qingfeng Wang, Wenhui Shi, Yang Yang, Qi Li, Hui Zhu, Zhongquan Liu, Yangming Ding, Yu Lu, Naihui Chu. Linezolid Pharmacokinetics/Pharmacodynamics-Based Optimal Dosing for Multidrug-Resistant Tuberculosis.
International journal of antimicrobial agents.
2022 Jun; 59(6):106589. doi:
10.1016/j.ijantimicag.2022.106589. [PMID: 35405268] - Richard M Tehan, Rheannon R Blount, Ryan L Goold, Daphne R Mattos, Nicolas R Spatafora, Javier F Tabima, Romina Gazis, Chengshu Wang, Jane E Ishmael, Joseph W Spatafora, Kerry L McPhail. Tolypocladamide H and the Proposed Tolypocladamide NRPS in Tolypocladium Species.
Journal of natural products.
2022 05; 85(5):1363-1373. doi:
10.1021/acs.jnatprod.2c00153. [PMID: 35500108] - Shahbaz Ahmad, Farooq Ali, Sadaf Anwar Qureshi, Bibi Uzma, Qismat Shakeela, Muhammad Shehryar Sabir, Sajjad Ahmad, Ijazul Haq, Atia Rasheed, Shehzad Ahmed, Muhammad Farooq. The evaluation of antibiotic susceptibility pattern and associated risk factors of UTI in tertiary care hospital of Peshawar.
Pakistan journal of pharmaceutical sciences.
2022 May; 35(3(Special)):897-903. doi:
NULL. [PMID: 35791585] - Sebastian G Wicha, Andrea Mair, Ute Chiriac, Otto R Frey, Thomas Fuchs, Max Gaasch, Stefan Hagel, Daniel C Richter, Jason A Roberts, Anka C Röhr, Markus A Weigand, Alexander Brinkmann. Population pharmacokinetics and toxicodynamics of continuously infused linezolid in critically ill patients.
International journal of antimicrobial agents.
2022 May; 59(5):106572. doi:
10.1016/j.ijantimicag.2022.106572. [PMID: 35307562] - Katarzyna Pauter, Małgorzata Szultka-Młyńska, Michał Szumski, Anna Król-Górniak, Paweł Pomastowski, Bogusław Buszewski. CE-DAD-MS/MS in the simultaneous determination and identification of selected antibiotic drugs and their metabolites in human urine samples.
Electrophoresis.
2022 May; 43(9-10):978-989. doi:
10.1002/elps.202100190. [PMID: 34624141] - Francesca Sivori, Ilaria Cavallo, Daniela Kovacs, Maria Guembe, Isabella Sperduti, Mauro Truglio, Martina Pasqua, Grazia Prignano, Arianna Mastrofrancesco, Luigi Toma, Fulvia Pimpinelli, Aldo Morrone, Fabrizio Ensoli, Enea Gino Di Domenico. Role of Extracellular DNA in Dalbavancin Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms in Patients with Skin and Soft Tissue Infections.
Microbiology spectrum.
2022 04; 10(2):e0035122. doi:
10.1128/spectrum.00351-22. [PMID: 35416701] - Alexandra Lehman, Barbara A Santevecchi, Kelly L Maguigan, Nicholas Laconi, Tyler J Loftus, Alicia M Mohr, Bethany R Shoulders. Impact of Empiric Linezolid for Necrotizing Soft Tissue Infections on Duration of Methicillin-Resistant Staphylococcus aureus-Active Therapy.
Surgical infections.
2022 Apr; 23(3):313-317. doi:
10.1089/sur.2021.329. [PMID: 35133888] - Qiuya Lu, Xiaoshuang He, Jie Fang, Kaifeng Shi, Fengmei Hu, Xiaolan Bian, Xuefeng Wang. Simultaneous determination of linezolid and voriconazole serum concentrations using liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2022 Apr; 212(?):114659. doi:
10.1016/j.jpba.2022.114659. [PMID: 35182831] - Can Chen, Yiwei Li, Jingdi Yu, Shenxian Qian. Linezolid-induced thrombocytopenia in patients with acute myeloid leukemia: a matched case-control study.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.
2022 Mar; 24(3):540-545. doi:
10.1007/s12094-021-02711-9. [PMID: 34716540] - Thomas Köhler, Elke Schwier, Carmen Kirchner, Günther Winde, Dietrich Henzler, Claas Eickmeyer. Hemoadsorption with CytoSorb® and the early course of linezolid plasma concentration during septic shock.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs.
2022 Mar; 25(1):86-90. doi:
10.1007/s10047-021-01274-4. [PMID: 34047868] - Fei Jiang, Ziyan Kong, Ke Liu, Chen Cheng, Tingting Jiang, Ping Ma, Rongpeng Li. Phenotypic and genotypic characterisation of linezolid-resistant coagulase-negative staphylococci possessing cfr-carrying plasmid.
Journal of global antimicrobial resistance.
2022 03; 28(?):226-232. doi:
10.1016/j.jgar.2022.01.008. [PMID: 35041999] - Changcheng Shi, Junbo Xia, Jian Ye, Yaping Xie, Weizhong Jin, Wei Zhang, Liusheng Wang, Xuping Ding, Nengming Lin, Limin Wang. Effect of renal function on the risk of thrombocytopaenia in patients receiving linezolid therapy: A systematic review and meta-analysis.
British journal of clinical pharmacology.
2022 02; 88(2):464-475. doi:
10.1111/bcp.14965. [PMID: 34192814] - Yuki Sato, Yoh Takekuma, Takayuki Daisho, Hitoshi Kashiwagi, Shungo Imai, Mitsuru Sugawara. Development of a Method of Liquid Chromatography Coupled with Tandem Mass Spectrometry for Simultaneous Determination of Linezolid and Tedizolid in Human Plasma.
Biological & pharmaceutical bulletin.
2022; 45(4):421-428. doi:
10.1248/bpb.b21-00798. [PMID: 35370266] - Rawan Alraish, Sebastian G Wicha, Otto R Frey, Anka C Roehr, Johann Pratschke, Martin Stockmann, Tilo Wuensch, Magnus Kaffarnik. Liver function, quantified by the LiMAx test, as a predictor for the clinical outcome of critically ill patients treated with linezolid.
Technology and health care : official journal of the European Society for Engineering and Medicine.
2022; 30(2):309-321. doi:
10.3233/thc-191847. [PMID: 34180433] - Chien-Chou Chen, Wei-Ting Liu, Shih-Hua Lin. Lactic acidosis associated with standard dose linezolid in a kidney recipient with impaired renal function.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.
2022 Jan; 26(1):101701. doi:
10.1016/j.bjid.2021.101701. [PMID: 34942159] - Mahmoud Tareq Abdelwahab, Sean Wasserman, James C M Brust, Keertan Dheda, Lubbe Wiesner, Neel R Gandhi, Robin M Warren, Frederick A Sirgel, Graeme Meintjes, Gary Maartens, Paolo Denti. Linezolid Population Pharmacokinetics in South African Adults with Drug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
2021 11; 65(12):e0138121. doi:
10.1128/aac.01381-21. [PMID: 34543098] - Murugan Thulasi Meenu, Grace Kaul, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Cudraflavone C from Artocarpus hirsutus as a Promising Inhibitor of Pathogenic, Multidrug-Resistant S. aureus, Persisters, and Biofilms: A New Insight into a Rational Explanation of Traditional Wisdom.
Journal of natural products.
2021 10; 84(10):2700-2708. doi:
10.1021/acs.jnatprod.1c00578. [PMID: 34546736] - Maral Aminpour, Williams Ernesto Miranda Delgado, Soren Wacker, Sergey Noskov, Michael Houghton, D Lorne J Tyrrell, Jack A Tuszynski. Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19.
BMC pharmacology & toxicology.
2021 10; 22(1):61. doi:
10.1186/s40360-021-00519-5. [PMID: 34674775] - Maroussia Roelens, Giovanni Battista Migliori, Liudmila Rozanova, Janne Estill, Jonathon R Campbell, J Peter Cegielski, Simon Tiberi, Domingo Palmero, Greg J Fox, Lorenzo Guglielmetti, Giovanni Sotgiu, James C M Brust, Didi Bang, Christian Lienhardt, Christoph Lange, Dick Menzies, Olivia Keiser, Mario Raviglione. Evidence-based Definition for Extensively Drug-Resistant Tuberculosis.
American journal of respiratory and critical care medicine.
2021 09; 204(6):713-722. doi:
10.1164/rccm.202009-3527oc. [PMID: 34107231] - Nelson H Morgon, Giulia S Grandini, Maurício I Yoguim, Caio M Porto, Lucas C Santana, Srijit Biswas, Aguinaldo R de Souza. Potential activity of Linezolid against SARS-CoV-2 using electronic and molecular docking study.
Journal of molecular modeling.
2021 Jul; 27(8):222. doi:
10.1007/s00894-021-04828-8. [PMID: 34236527] - Sarah Van Vooren, Alain G Verstraete. A sensitive and high-throughput quantitative liquid chromatography high-resolution mass spectrometry method for therapeutic drug monitoring of 10 β-lactam antibiotics, linezolid and two β-lactamase inhibitors in human plasma.
Biomedical chromatography : BMC.
2021 Jul; 35(7):e5092. doi:
10.1002/bmc.5092. [PMID: 33590498] - Stefania Cheli, Marta Fusi, Annalisa De Silvestri, Igor Bonini, Emilio Clementi, Dario Cattaneo, Cristina Montrasio, Sara Baldelli. In linezolid underexposure, pharmacogenetics matters: The role of CYP3A5.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111631. doi:
10.1016/j.biopha.2021.111631. [PMID: 33940510] - Seyed Majid Mousavi Movahed, Hamed Akhavizadegan, Fatemeh Dolatkhani, Seyed Aria Nejadghaderi, Faezeh Aghajani, Monireh Faghir Gangi, Zahra Ghazi, Hoomaan Ghasemi. Different incidences of acute kidney injury (AKI) and outcomes in COVID-19 patients with and without non-azithromycin antibiotics: A retrospective study.
Journal of medical virology.
2021 Jul; 93(7):4411-4419. doi:
10.1002/jmv.26992. [PMID: 33792956] - Ying Dai, Shuying Jiang, Xiaoou Chen, Lu Han, Chunhong Zhang, Xuben Yu, Xiuhua Zhang. Analysis of the risk factors of linezolid-related haematological toxicity in Chinese patients.
Journal of clinical pharmacy and therapeutics.
2021 Jun; 46(3):807-813. doi:
10.1111/jcpt.13359. [PMID: 33555057] - Anthony J Renzoni, Gary D Peksa, Joshua M DeMott. Emergency department methicillin-resistant Staphylococcus aureus nare screen effect on pneumonia treatment duration.
The American journal of emergency medicine.
2021 06; 44(?):68-71. doi:
10.1016/j.ajem.2021.01.066. [PMID: 33581603] - P Fernández, L Moreno, G Yagüe, E Andreu, R Jara, M Segovia. Colonization by multidrug-resistant microorganisms in ICU patients during the COVID-19 pandemic.
Medicina intensiva.
2021 Jun; 45(5):313-315. doi:
10.1016/j.medine.2021.04.006. [PMID: 34059221] - Kshitij Shankhdhar. Diabetic Foot Amputation Prevention During COVID-19.
Advances in skin & wound care.
2021 May; 34(5):1-4. doi:
10.1097/01.asw.0000741532.29113.78. [PMID: 33852467] - Kathrin Rothe, Susanne Feihl, Jochen Schneider, Fabian Wallnöfer, Milena Wurst, Marina Lukas, Matthias Treiber, Tobias Lahmer, Markus Heim, Michael Dommasch, Birgit Waschulzik, Alexander Zink, Christiane Querbach, Dirk H Busch, Roland M Schmid, Gerhard Schneider, Christoph D Spinner. Rates of bacterial co-infections and antimicrobial use in COVID-19 patients: a retrospective cohort study in light of antibiotic stewardship.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2021 Apr; 40(4):859-869. doi:
10.1007/s10096-020-04063-8. [PMID: 33140176] - Ryota Tanaka, Yosuke Suzuki, Yuko Morinaga, Motoshi Iwao, Yukie Takumi, Kazuhiko Hashinaga, Ryosuke Tatsuta, Kazufumi Hiramatsu, Jun-Ichi Kadota, Hiroki Itoh. A retrospective test for a possible relationship between linezolid-induced thrombocytopenia and hyponatraemia.
Journal of clinical pharmacy and therapeutics.
2021 Apr; 46(2):343-351. doi:
10.1111/jcpt.13287. [PMID: 33016566] - Makoto Kai, Ryota Tanaka, Yosuke Suzuki, Koji Goto, Yoshifumi Ohchi, Norihisa Yasuda, Ryosuke Tatsuta, Takaaki Kitano, Hiroki Itoh. Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS/MS method.
Clinical biochemistry.
2021 Apr; 90(?):40-49. doi:
10.1016/j.clinbiochem.2021.01.012. [PMID: 33539809] - Vahid Damanpak Moghadam, Zohre Momenimovahed, Maryam Ghorbani, Javad Khodadadi. Linezolid a potential treatment for COVID-19 coinfections.
Brazilian journal of anesthesiology (Elsevier).
2021 Mar; 71(2):198. doi:
10.1016/j.bjane.2020.12.019. [PMID: 33619414] - Ryota Tanaka, Makoto Kai, Koji Goto, Yoshifumi Ohchi, Norihisa Yasuda, Ryosuke Tatsuta, Takaaki Kitano, Hiroki Itoh. High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2021 Feb; 194(?):113764. doi:
10.1016/j.jpba.2020.113764. [PMID: 33298382] - Fabrizio Di Maida, Lorenzo Viola, Luca Lambertini, Andrea Mari, Jessica Mencarini, Beatrice Borchi, Marco Carini, Lorenzo Zammarchi, Andrea Minervini. A rare urinary JC virus reactivation after long-term therapy with rituximab.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Feb; 103(?):447-449. doi:
10.1016/j.ijid.2020.11.194. [PMID: 33278620] - Milo Gatti, Emanuel Raschi, Fabrizio De Ponti. Serotonin syndrome by drug interactions with linezolid: clues from pharmacovigilance-pharmacokinetic/pharmacodynamic analysis.
European journal of clinical pharmacology.
2021 Feb; 77(2):233-239. doi:
10.1007/s00228-020-02990-1. [PMID: 32901348] - Carmen Elena Cervantes, Steven Menez, Jose M Monroy Trujillo, Mohamad Hanouneh. Clinical Approach to a Patient With an Acid-Base Disturbance.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 02; 77(2):A9-A11. doi:
10.1053/j.ajkd.2020.06.022. [PMID: 33485519] - Shu'an Wen, Tingting Zhang, Xia Yu, Weijie Dong, Tinglong Lan, Jun Fan, Yi Xue, Fen Wang, Lingling Dong, Shibing Qin, Hairong Huang. Bone penetration of linezolid in osteoarticular tuberculosis patients of China.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Feb; 103(?):364-369. doi:
10.1016/j.ijid.2020.11.203. [PMID: 33278623] - Yoshifumi Nishi, Chika Ogami, Yasuhiro Tsuji, Hitoshi Kawasuji, Harumi Yamada, Shin Kawai, Ippei Sakamaki, Hideto To, Yoshihiro Yamamoto. Evaluation of the relationship between linezolid exposure and hyponatremia.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2021 Feb; 27(2):165-171. doi:
10.1016/j.jiac.2020.08.017. [PMID: 32933858] - Lichao Fan, Huan Liu, Na Li, Chang Liu, Ye Gu, Yongyu Liu, Yu Chen. Medical treatment of 55 patients with COVID-19 from seven cities in northeast China who fully recovered: A single-center, retrospective, observational study.
Medicine.
2021 Jan; 100(2):e23923. doi:
10.1097/md.0000000000023923. [PMID: 33466134] - Jae Hyoung Im, Jin-Soo Lee, Moon-Hyun Chung, Hea Yoon Kwon, Man-Jong Lee, Ji Hyeon Baek. Effect of a serum lactate monitoring recommendation policy on patients treated with linezolid.
Medicine.
2021 Jan; 100(1):e23790. doi:
10.1097/md.0000000000023790. [PMID: 33429740] - Yingying Wang, Xuemei Ye, Qin Lan, Xiaofang Ke, Lufeng Hu, Lichuan Hu. UPLC-MS/MS Determination of Linezolid and Heme in Plasma of Infected Patients and Correlation Analysis.
BioMed research international.
2021; 2021(?):6679076. doi:
10.1155/2021/6679076. [PMID: 34337043] - Chih-Ning Cheng, Chien-Chih Wu, Ching-Hua Kuo, Chi-Chuan Wang, Jann-Tay Wang, Ya-Ting Lin, Ren-Shiang Jhang, Shu-Wen Lin. Impact of high plasma concentrations of linezolid in Taiwanese adult patients- therapeutic drug monitoring in improving adverse drug reactions.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2021 Jan; 120(1 Pt 2):466-475. doi:
10.1016/j.jfma.2020.06.011. [PMID: 32600864] - Xipei Wang, Yifan Wang, Fen Yao, Shenglong Chen, Yating Hou, Zhijie Zheng, Jinbiao Luo, Binghui Qiu, Zhanfu Li, Yirong Wang, Zheng Wu, Jinhua Lan, Chunbo Chen. Pharmacokinetics of Linezolid Dose Adjustment for Creatinine Clearance in Critically Ill Patients: A Multicenter, Prospective, Open-Label, Observational Study.
Drug design, development and therapy.
2021; 15(?):2129-2141. doi:
10.2147/dddt.s303497. [PMID: 34040351] - D Fage, G Deprez, B Fontaine, F Wolff, F Cotton. Simultaneous determination of 8 beta-lactams and linezolid by an ultra-performance liquid chromatography method with UV detection and cross-validation with a commercial immunoassay for the quantification of linezolid.
Talanta.
2021 Jan; 221(?):121641. doi:
10.1016/j.talanta.2020.121641. [PMID: 33076161] - Erni Juwita Nelwan, Rahajeng N Tunjungputri, Narottama Tunjung, Djoko Widodo. Hospital-acquired Skin and Skin-structure Infection in COVID-19 Infected Patient with Prolonged Hospitalization.
Acta medica Indonesiana.
2021 Jan; 53(1):105-107. doi:
NULL. [PMID: 33818413] - Wenjun Zhao, Lingti Kong, Chenchen Wu, Xiaofei Wu. Prolonged infusion of linezolid is associated with improved pharmacokinetic/pharmacodynamic (PK/PD) profiles in patients with external ventricular drains.
European journal of clinical pharmacology.
2021 Jan; 77(1):79-86. doi:
10.1007/s00228-020-02978-x. [PMID: 32812063] - D Battaglini, A Motos, G Li Bassi, H Yang, F Pagliara, M Yang, E Aguilera Xiol, A Meli, J Bobi, G Frigola, T Senussi, F Idone, C Travierso, C Chiurazzi, L Fernandez-Barat, M Rigol, J Ramirez, P Pelosi, D Chiumello, M Antonelli, D P Nicolau, J Bringue, A Artigas, L Guerrero, D Soy, A Torres. Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant Staphylococcus aureus Pneumonia.
Antimicrobial agents and chemotherapy.
2020 12; 65(1):. doi:
10.1128/aac.01009-20. [PMID: 33046500] - Soonsil Hyun, Yoonhwa Choi, Doyeon Jo, Seolah Choo, Tae Woo Park, Su-Jin Park, Seoyeon Kim, Seonju Lee, Sohyun Park, Sun Mi Jin, Dae Hee Cheon, Wanki Yoo, Rekha Arya, Yong Pil Chong, Kyeong Kyu Kim, Yang Soo Kim, Yan Lee, Jaehoon Yu. Proline Hinged Amphipathic α-Helical Peptide Sensitizes Gram-Negative Bacteria to Various Gram-Positive Antibiotics.
Journal of medicinal chemistry.
2020 12; 63(23):14937-14950. doi:
10.1021/acs.jmedchem.0c01506. [PMID: 33205989] - Vratislav Smolka, Marie Rohanova, Barbora Ludikova, Zbynek Novak, Martin Zapalka, Dagmar Pospisilova, Jana Volejnikova. Severe linezolid-induced lactic acidosis in a child with acute lymphoblastic leukemia: A case report.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2020 Dec; 26(12):1316-1318. doi:
10.1016/j.jiac.2020.07.018. [PMID: 32859497] - Dennis Kühn, Carlos Metz, Frederik Seiler, Holger Wehrfritz, Sophie Roth, Mohammad Alqudrah, André Becker, Hendrik Bracht, Stefan Wagenpfeil, Mathias Hoffmann, Robert Bals, Ulrich Hübner, Jürgen Geisel, Philipp M Lepper, Sören L Becker. Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study.
Critical care (London, England).
2020 11; 24(1):664. doi:
10.1186/s13054-020-03397-1. [PMID: 33239110] - Zhi Xu. 1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
European journal of medicinal chemistry.
2020 Nov; 206(?):112686. doi:
10.1016/j.ejmech.2020.112686. [PMID: 32795773] - Jing Ren, Yao Zheng, Hui Du, Shan Wang, Linna Liu, Wanshi Duan, Zeping Zhang, Lijun Heng, Qi Yang. Antibiotic-induced black hairy tongue: two case reports and a review of the literature.
The Journal of international medical research.
2020 Oct; 48(10):300060520961279. doi:
10.1177/0300060520961279. [PMID: 33044871] - Naohide Kuriyama, Kana Matsumoto, Kunihiko Morita, Yasuyo Shimomura, Yoshitaka Hara, Daisuke Hasegawa, Tomoyuki Nakamura, Chizuru Yamashita, Yu Kato, Hidefumi Komura, Osamu Nishida. Nafamostat mesilate inhibits linezolid metabolism via its antioxidant effects.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2020 Oct; 24(5):499-502. doi:
10.1111/1744-9987.13545. [PMID: 32524735] - L Ehmann, P Simon, D Busse, D Petroff, C Dorn, W Huisinga, A Dietrich, M Zeitlinger, H Wrigge, C Kloft. Risk of target non-attainment in obese compared to non-obese patients in calculated linezolid therapy.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2020 Sep; 26(9):1222-1228. doi:
10.1016/j.cmi.2020.04.009. [PMID: 32311473] - Nilusha Weerasooriya, Tharanga Fernando, Pasan Serasinghe, Buddhika Alahakoon, Chirath Madurapperuma, Ananda Jayanaga. Staphylococcal endocarditis in a quadricuspid aortic valve following uncomplicated dengue infection: a case report.
BMC infectious diseases.
2020 Aug; 20(1):583. doi:
10.1186/s12879-020-05315-w. [PMID: 32762676] - Claire Duployez, Rémi Le Guern, Claire Tinez, Anne-Laure Lejeune, Laurent Robriquet, Sophie Six, Caroline Loïez, Frédéric Wallet. Panton-Valentine Leukocidin-Secreting Staphylococcus aureus Pneumonia Complicating COVID-19.
Emerging infectious diseases.
2020 Aug; 26(8):1939-1941. doi:
10.3201/eid2608.201413. [PMID: 32298228] - Manshi Li, Fuhuo Yang, Yihan Lu, Weifeng Huang. Identification of Enterococcus faecalis in a patient with urinary-tract infection based on metagenomic next-generation sequencing: a case report.
BMC infectious diseases.
2020 Jul; 20(1):467. doi:
10.1186/s12879-020-05179-0. [PMID: 32615925] - Linjie Dou, Dandan Meng, Yalin Dong, Lihong Chen, Xinyan Han, Di Fan, Haiyan Dong. Dosage regimen and toxicity risk assessment of linezolid in sepsis patients.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Jul; 96(?):105-111. doi:
10.1016/j.ijid.2020.03.054. [PMID: 32251797] - Yanping Guan, Xiaoxia Yu, Ying Wang, Qinhai Li, Dan Liang, Hua Zhu, Chuxiong Chen, Boyu Dong, Jiebin Ou, Kaifeng Qiu, Junyan Wu. Developing an isotope dilution UHPLC-MS/MS method to quantify linezolid in human plasma: application to therapeutic drug monitoring.
Bioanalysis.
2020 Jul; 12(14):991-1001. doi:
10.4155/bio-2020-0098. [PMID: 32697609] - Cinzia Auriti, Fiammetta Piersigilli, Iliana Bersani, Sara Cairoli, Paolina Giuseppina Amante, Daniela Longo, Bianca Maria Goffredo. Staphylococcal meningitis therapy with linezolid in a young infant: efficacy, CSF levels and side effects.
Italian journal of pediatrics.
2020 Jun; 46(1):90. doi:
10.1186/s13052-020-00854-z. [PMID: 32600437] - Huan Xia, Jinying Gao, Ming Xiu, Dan Li. Community-acquired pneumonia caused by methicillin-resistant Staphylococcus aureus in a Chinese adult: A case report.
Medicine.
2020 Jun; 99(26):e20914. doi:
10.1097/md.0000000000020914. [PMID: 32590802] - Yuan Li, Weijie Dong, Tinglong Lan, Jun Fan, Shibing Qin, Ai Guo. Distribution of Linezolid in Tuberculosis Lesions in Patients with Spinal Multidrug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.00450-20. [PMID: 32366717] - Hao Chen, Yan Du, Quan Xia, Yan Li, Shuai Song, Xiaohui Huang. Role of linezolid combination therapy for serious infections: review of the current evidence.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2020 Jun; 39(6):1043-1052. doi:
10.1007/s10096-019-03801-x. [PMID: 31898798] - Pengbo Guo, Bettina A Buttaro, Hui Yi Xue, Ngoc T Tran, Ho Lun Wong. Lipid-polymer hybrid nanoparticles carrying linezolid improve treatment of methicillin-resistant Staphylococcus aureus (MRSA) harbored inside bone cells and biofilms.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2020 Jun; 151(?):189-198. doi:
10.1016/j.ejpb.2020.04.010. [PMID: 32335285] - Peter Nikolos, Justin Osorio, Kerry Mohrien, Christina Rose. Pharmacokinetics of linezolid for methicillin-resistant Staphylococcus aureus pneumonia in an adult receiving extracorporeal membrane oxygenation.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2020 05; 77(11):877-881. doi:
10.1093/ajhp/zxaa066. [PMID: 32426841] - Nitin Gupta, Rohit Kumar, Sayantan Banerjee, Gagandeep Singh, Sundeep Malla, Yogiraj Ray, Prashant Ramteke, Netto George, Parul Kodan, Anivita Aggarwal, Prabhat Kumar, Pankaj Jorwal, Manish Soneja, Ashutosh Biswas. Brain abscess in patients with chronic kidney disease: A case-based approach to management in resource-limited settings.
Drug discoveries & therapeutics.
2020 May; 14(2):93-97. doi:
10.5582/ddt.2019.01062. [PMID: 32321877] - Ernane Souza, Ryan L Crass, Jeremy Felton, Kengo Hanaya, Manjunath P Pai. Accumulation of Major Linezolid Metabolites in Patients with Renal Impairment.
Antimicrobial agents and chemotherapy.
2020 04; 64(5):. doi:
10.1128/aac.00027-20. [PMID: 32152085] - Helena Barrasa, Amaia Soraluce, Elena Usón, Javier Sainz, Alejandro Martín, José Ángel Sánchez-Izquierdo, Javier Maynar, Alicia Rodríguez-Gascón, Arantxazu Isla. Impact of augmented renal clearance on the pharmacokinetics of linezolid: Advantages of continuous infusion from a pharmacokinetic/pharmacodynamic perspective.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Apr; 93(?):329-338. doi:
10.1016/j.ijid.2020.02.044. [PMID: 32112965] - Andreas H Diacon, Veronique R De Jager, Rodney Dawson, Kim Narunsky, Naadira Vanker, Divan A Burger, Daniel Everitt, Frances Pappas, Jerry Nedelman, Carl M Mendel. Fourteen-Day Bactericidal Activity, Safety, and Pharmacokinetics of Linezolid in Adults with Drug-Sensitive Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
2020 03; 64(4):. doi:
10.1128/aac.02012-19. [PMID: 31988102] - Marc A Boudreau, Derong Ding, Jayda E Meisel, Jeshina Janardhanan, Edward Spink, Zhihong Peng, Yuanyuan Qian, Takao Yamaguchi, Sebastian A Testero, Peter I O'Daniel, Erika Leemans, Elena Lastochkin, Wei Song, Valerie A Schroeder, William R Wolter, Mark A Suckow, Shahriar Mobashery, Mayland Chang. Structure-Activity Relationship for the Oxadiazole Class of Antibacterials.
ACS medicinal chemistry letters.
2020 Mar; 11(3):322-326. doi:
10.1021/acsmedchemlett.9b00379. [PMID: 32184964] - Pengtao Bao, Zengzhen Zhang, Weiguo Zhao, Ying Jiang, Di Wang. Isolation and whole-genome sequencing of a new type of linezolid-resistant Enterococcus faecalis from two cases of infective endocarditis following renal transplantation.
Journal of global antimicrobial resistance.
2020 03; 20(?):346-347. doi:
10.1016/j.jgar.2020.01.019. [PMID: 32061876] - Sean Wasserman, Shu Huo, Karina Ky, Ysabella Noelle Malig, Ali Esmail, Keertan Dheda, Peter Bacchetti, Roy Gerona, Gary Maartens, Monica Gandhi, John Metcalfe. Correlation of Linezolid Hair Concentrations with Plasma Exposure in Patients with Drug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.02145-19. [PMID: 31932382] - Ernane Souza, Jeremy Felton, Ryan L Crass, Kengo Hanaya, Manjunath P Pai. Development of a sensitive LC-MS/MS method for quantification of linezolid and its primary metabolites in human serum.
Journal of pharmaceutical and biomedical analysis.
2020 Jan; 178(?):112968. doi:
10.1016/j.jpba.2019.112968. [PMID: 31727360] - Yomna Hosny, Nader S Abutaleb, Mariam Omara, Marwa Alhashimi, Mohamed M Elsebaei, Heba S Elzahabi, Mohamed N Seleem, Abdelrahman S Mayhoub. Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness.
European journal of medicinal chemistry.
2020 Jan; 185(?):111830. doi:
10.1016/j.ejmech.2019.111830. [PMID: 31718945] - Toshihisa Hiraiwa, Kazuhiro Moriyama, Kana Matsumoto, Yasuyo Shimomura, Yu Kato, Chizuru Yamashita, Yoshitaka Hara, Takahiro Kawaji, Yasuyoshi Kurimoto, Tomoyuki Nakamura, Naohide Kuriyama, Junpei Shibata, Hidefumi Komura, Kunihiko Morita, Osamu Nishida. In vitro Evaluation of Linezolid and Doripenem Clearance with Different Hemofilters.
Blood purification.
2020; 49(3):295-301. doi:
10.1159/000504039. [PMID: 31995801] - Chika Ogami, Yasuhiro Tsuji, Hideto To, Yoshihiro Yamamoto. Pharmacokinetics, toxicity and clinical efficacy of linezolid in Japanese pediatric patients.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2019 Dec; 25(12):979-986. doi:
10.1016/j.jiac.2019.05.025. [PMID: 31208925] - Sonia Luque, Rosana Muñoz-Bermudez, Daniel Echeverría-Esnal, Luisa Sorli, Nuria Campillo, Javier Martínez-Casanova, Elena González-Colominas, Francisco Álvarez-Lerma, Juan Pablo Horcajada, Santiago Grau, Jason A Roberts. Linezolid Dosing in Patients With Liver Cirrhosis: Standard Dosing Risk Toxicity.
Therapeutic drug monitoring.
2019 12; 41(6):732-739. doi:
10.1097/ftd.0000000000000665. [PMID: 31259884] - Mohamed M Elsebaei, Nader S Abutaleb, Abdulrahman A Mahgoub, Daoyi Li, Mohamed Hagras, Haroon Mohammad, Mohamed N Seleem, Abdelrahman S Mayhoub. Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
European journal of medicinal chemistry.
2019 Nov; 182(?):111593. doi:
10.1016/j.ejmech.2019.111593. [PMID: 31446245] - Hanbin Li, David H Salinger, Daniel Everitt, Mengchun Li, Angelo Del Parigi, Carl Mendel, Jerry R Nedelman. Long-Term Effects on QT Prolongation of Pretomanid Alone and in Combinations in Patients with Tuberculosis.
Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.00445-19. [PMID: 31358590] - Shan Wang, Yun Li, Feng Xue, Jian Liu, Weiwei Yang, Jia Zhang, Martin Glenschek-Sieberth, Yuan Lyu. Comparative in vitro potency and kill curve activity of tedizolid and linezolid against Gram-positive bacteria isolated from Chinese hospitalized patients in 2013-2016.
Journal of chemotherapy (Florence, Italy).
2019 Oct; 31(6):313-319. doi:
10.1080/1120009x.2019.1623968. [PMID: 31215343] - Dexiao Kong, Xia Liu, Xiaomei Li, Jianting Hu, Xiaoyan Li, Juan Xiao, Yibo Dai, Mingming He, Xiaoli Liu, Yang Jiang, Ruodi Cui, Lihong Zhang, Juandong Wang, Ai Li, Fang Wang, Yuan Zhang, Juan Xiao, Wei Wang, Chengyun Zheng. Mesenchymal stem cells significantly improved treatment effects of Linezolid on severe pneumonia in a rabbit model.
Bioscience reports.
2019 09; 39(9):. doi:
10.1042/bsr20182455. [PMID: 31484796] - Patrice Nordmann, Angel Rodríguez-Villodres, Laurent Poirel. A selective culture medium for screening linezolid-resistant gram-positive bacteria.
Diagnostic microbiology and infectious disease.
2019 Sep; 95(1):1-4. doi:
10.1016/j.diagmicrobio.2019.03.006. [PMID: 30981556] - Lei Yin, Yixuan Feng, Jin Tong, Zhiqiong Guo, Yuyao Zhang, Qi Zhang, Yantong Sun, J Paul Fawcett, Jingkai Gu. Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study.
Analytical and bioanalytical chemistry.
2019 Aug; 411(20):5139-5148. doi:
10.1007/s00216-019-01891-2. [PMID: 31179528] - Laia Fernández-Barat, Ana Motos, Mauro Panigada, Francisco Álvarez-Lerma, Lucía Viña, Ruben Lopez-Aladid, Adrian Ceccato, Gianluigi Li Bassi, David P Nicolau, Yuli Lopez, Laura Muñoz, Laura Guerrero, Dolors Soy, Trinidad Israel, Pedro Castro, Antoni Torres. Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients.
Critical care (London, England).
2019 07; 23(1):251. doi:
10.1186/s13054-019-2523-5. [PMID: 31291978] - Wanqing Zhou, Shuo Gao, Hongjing Xu, Zhifeng Zhang, Fei Chen, Han Shen, Chunni Zhang. Distribution of the optrA gene in Enterococcus isolates at a tertiary care hospital in China.
Journal of global antimicrobial resistance.
2019 06; 17(?):180-186. doi:
10.1016/j.jgar.2019.01.001. [PMID: 30641287] - Henrik Hasman, Philip T L C Clausen, Hülya Kaya, Frank Hansen, Jenny Dahl Knudsen, Mikala Wang, Barbara Juliane Holzknecht, Jurgita Samulioniené, Bent L Røder, Niels Frimodt-Møller, Ole Lund, Anette M Hammerum. LRE-Finder, a Web tool for detection of the 23S rRNA mutations and the optrA, cfr, cfr(B) and poxtA genes encoding linezolid resistance in enterococci from whole-genome sequences.
The Journal of antimicrobial chemotherapy.
2019 06; 74(6):1473-1476. doi:
10.1093/jac/dkz092. [PMID: 30863844]
