Phosphonoacetate (BioDeep_00000001405)

 

Secondary id: BioDeep_00000405582, BioDeep_00000405992

human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


Disodium phosphonoacetate monohydrate

化学式: C2H5O5P (139.9875)
中文名称: 磷酰基乙酸, 膦酸乙酸
谱图信息: 最多检出来源 Homo sapiens(plant) 9.96%

分子结构信息

SMILES: C(C(=O)O)P(=O)(O)O
InChI: InChI=1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)

描述信息

Phosphonoacetate, also known as fosfonet or phosphonacetic acid, belongs to the class of organic compounds known as organic phosphonic acids. These are organic compounds containing phosphonic acid. Phosphonoacetate exists in all living organisms, ranging from bacteria to humans.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AD - Phosphonic acid derivatives
A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [HMDB]
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
KEIO_ID P082
Phosphonoacetic acid is an endogenous metabolite. Phosphonoacetic acid also has anti-orthopoxvirus activity[1].

同义名列表

25 个代谢物同义名

Disodium phosphonoacetate monohydrate; Disodium carboxymethylphosphonate; Carboxymethanephosphonic acid; Phosphonoacetate, disodium; Carboxymethanephosphonate; Disodium phosphonoacetate; Acetic acid,2-phosphono-; 2-phosphonoacetic acid; Acid, phosphonoacetic; Phosphonoacetic acid; Acid, phosphonacetic; Phosphonacetic acid; Fosfonoacetic acid; Sodium, fosfonet; Phosphonoacetate; Phosphonacetate; Fosfonet sodium; Fosfonoacetate; Lopac-P-6909; Fosfonet; PAE; PPA; Phosphonoacetate; Phosphonoacetate; Phosphonoacetic acid



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 GLI3, HPGDS, IFI16, NFKB2, PC, PML, POLB, PRKX, RPSA, TSC2
Peripheral membrane protein 2 PML, TSC2
Endoplasmic reticulum membrane 3 CD4, PML, TYRO3
Nucleus 11 EXO1, GLI3, IFI16, NFKB2, PML, POLB, PRKX, RPSA, SSBP1, TSC2, TYRO3
cytosol 9 GLI3, HPGDS, IFI16, NFKB2, NGF, PC, PML, RPSA, TSC2
dendrite 1 NGF
nuclear body 1 EXO1
nucleoplasm 9 EXO1, GLI3, HPGDS, IFI16, NFKB2, PML, POLB, PRKX, RPSA
Cell membrane 4 CD4, FCER1G, RPSA, TYRO3
Cytoplasmic side 1 PML
Early endosome membrane 1 PML
Multi-pass membrane protein 2 ABHD16A, LIM2
cell junction 1 LIM2
cell surface 2 FCER1G, TYRO3
Golgi apparatus 1 TSC2
lysosomal membrane 1 TSC2
synaptic vesicle 1 NGF
Cytoplasm, cytosol 1 TSC2
Lysosome 1 TSC2
plasma membrane 7 CD4, EXO1, FCER1G, IFNLR1, LIM2, RPSA, TYRO3
Membrane 7 ABHD16A, IFI16, IFNLR1, LIM2, RPSA, TSC2, TYRO3
axon 1 NGF
extracellular exosome 2 RPSA, SSBP1
Lysosome membrane 1 TSC2
extracellular space 1 NGF
perinuclear region of cytoplasm 1 TSC2
mitochondrion 2 PC, SSBP1
protein-containing complex 1 POLB
intracellular membrane-bounded organelle 2 GLI3, HPGDS
postsynaptic density 1 TSC2
Single-pass type I membrane protein 4 CD4, FCER1G, IFNLR1, TYRO3
Secreted 1 NGF
extracellular region 1 NGF
Mitochondrion matrix 1 PC
mitochondrial matrix 2 PC, SSBP1
nuclear membrane 1 PML
external side of plasma membrane 2 CD4, FCER1G
nucleolus 3 GLI3, IFI16, PML
Early endosome 1 CD4
vesicle 1 LIM2
Membrane raft 1 CD4
microtubule 1 POLB
mitochondrial nucleoid 1 SSBP1
Nucleus, PML body 1 PML
PML body 1 PML
axoneme 1 GLI3
ciliary tip 1 GLI3
nuclear speck 2 GLI3, IFI16
receptor complex 1 TYRO3
ciliary base 1 GLI3
cilium 1 GLI3
chromatin 1 NFKB2
chromosome, telomeric region 1 PML
nuclear envelope 1 TYRO3
endosome lumen 1 NGF
tertiary granule membrane 1 FCER1G
Golgi lumen 1 NGF
endoplasmic reticulum lumen 1 CD4
nuclear matrix 1 PML
transcription repressor complex 1 GLI3
clathrin-coated endocytic vesicle membrane 1 CD4
ficolin-1-rich granule membrane 1 FCER1G
spindle microtubule 1 POLB
cytosolic ribosome 1 RPSA
T cell receptor complex 1 CD4
GLI-SUFU complex 1 GLI3
Fc-gamma receptor III complex 1 FCER1G
cytosolic small ribosomal subunit 1 RPSA
Bcl3/NF-kappaB2 complex 1 NFKB2
Mitochondrion matrix, mitochondrion nucleoid 1 SSBP1
Fc-epsilon receptor I complex 1 FCER1G
TSC1-TSC2 complex 1 TSC2
small ribosomal subunit 1 RPSA
interleukin-28 receptor complex 1 IFNLR1
[Isoform IFI16-beta]: Cytoplasm 1 IFI16


文献列表

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