12-Hydroxydodecanoic acid (BioDeep_00000001277)
Secondary id: BioDeep_00000031780, BioDeep_00000405505, BioDeep_00000412720, BioDeep_00000419328
human metabolite PANOMIX_OTCML-2023 Endogenous natural product BioNovoGene_Lab2019
描述信息
12-hydroxydodecanoic acid is the substrate of the human glutathione-dependent formaldehyde dehydrogenase (EC1.1.1.1). The enzyme that catalyzes the conversion of alcohols to aldehydes is a zinc-containing dimeric enzyme responsible for the oxidation of long-chain alcohols and omega-hydroxy fatty acids. (OMIM). The human glutathione-dependent formaldehyde dehydrogenase is unique among the structurally studied members of the alcohol dehydrogenase family in that it follows a random bi kinetic mechanism forming a binary complex, and a ternary complex with NAD+. (PMID 12196016).
12-hydroxydodecanoic acid is the substrate of the human glutathione-dependent formaldehyde dehydrogenase (EC1.1.1.1) . The enzyme that catalyzes the conversion of alcohols to aldehydes is a zinc-containing dimeric enzyme responsible for the oxidation of long-chain alcohols and omega-hydroxy fatty acids. (OMIM)
12-Hydroxydodecanoic acid is an endogenous metabolite.
同义名列表
31 个代谢物同义名
ω-Hydroxydodecanoic acid; Omega hydroxy dodecanoic acid; Omega-Hydroxydodecanoic acid; ω-Hydroxydodecanoate; 2-hydroxy-dodecanoic acid; 12-Hydroxydodecanoic acid; Omega hydroxy dodecanoate; Omega-hydroxy lauric acid; Omega-hydroxylauric acid; Omega-hydroxydodecanoate; Omega-OH dodecanoic acid; hydroxy dodecanoic acid; Omega-hydroxy laic acid; 12-hydroxy lauric acid; 12-Hydroxylauric acid; 2-Hydroxy-dodecanoate; 12-Hydroxydodecanoate; 12-Hydroxy laic acid; Omega-OH lauric acid; Omega-OH dodecanoate; hydroxy dodecanoate; Omega-hydroxy laate; Omega-OH laic acid; 12-Hydroxylaurate; 12-Hydroxy laate; Omega-OH laate; Sabinate; ω Sabinic acid; 12-Hydroxydodecanoic acid; 12-Hydroxydodecanoic acid
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:39567
- KEGG: C08317
- PubChem: 79034
- HMDB: HMDB0002059
- Metlin: METLIN6465
- DrugBank: DB03704
- ChEMBL: CHEMBL55068
- MetaCyc: CPD-12282
- KNApSAcK: C00001219
- foodb: FDB022822
- chemspider: 71366
- CAS: 27925-01-5
- CAS: 505-95-3
- PMhub: MS000000251
- PubChem: 10515
- LipidMAPS: LMFA01050039
- PDB-CCD: 12H
- 3DMET: B02161
- NIKKAJI: J182.260H
- RefMet: 12-Hydroxy lauric acid
- medchemexpress: HY-128743
- LOTUS: LTS0039167
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-601
- KNApSAcK: 39567
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
56 个相关的代谢反应过程信息。
Reactome(55)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Fatty acids:
ARA + H+ + Oxygen + TPNH ⟶ 12-HETE + H2O + TPN
BioCyc(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
16 个相关的物种来源信息
- 33682 - Euglenozoa: LTS0039167
- 2759 - Eukaryota: LTS0039167
- 9606 - Homo sapiens: -
- 5653 - Kinetoplastea: LTS0039167
- 3318 - Pinaceae: LTS0039167
- 58019 - Pinopsida: LTS0039167
- 3337 - Pinus: LTS0039167
- 3347 - Pinus radiata: 10.1016/0031-9422(82)83099-9
- 3347 - Pinus radiata: LTS0039167
- 35493 - Streptophyta: LTS0039167
- 58023 - Tracheophyta: LTS0039167
- 5690 - Trypanosoma: LTS0039167
- 5691 - Trypanosoma brucei: 10.1128/AAC.00044-13
- 5691 - Trypanosoma brucei: LTS0039167
- 5654 - Trypanosomatidae: LTS0039167
- 33090 - Viridiplantae: LTS0039167
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Meryem Köse, Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Elisabetta De Filippo, Katharina Sylvester, Trond Ulven, Ivar von Kügelgen, Christa E Müller. An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights.
Journal of medicinal chemistry.
2020 03; 63(5):2391-2410. doi:
10.1021/acs.jmedchem.9b01339. [PMID: 31721581] - Satoshi Yamaori, Noriyuki Araki, Mio Shionoiri, Kurumi Ikehata, Shinobu Kamijo, Shigeru Ohmori, Kazuhito Watanabe. A Specific Probe Substrate for Evaluation of CYP4A11 Activity in Human Tissue Microsomes and a Highly Selective CYP4A11 Inhibitor: Luciferin-4A and Epalrestat.
The Journal of pharmacology and experimental therapeutics.
2018 09; 366(3):446-457. doi:
10.1124/jpet.118.249557. [PMID: 29976573] - Myeongjin Yi, Jae-Gook Shin, Su-Jun Lee. Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma.
Toxicology and applied pharmacology.
2017 09; 330(?):100-106. doi:
10.1016/j.taap.2017.07.009. [PMID: 28729181] - Inge Van Bogaert, Steve Fleurackers, Simon Van Kerrebroeck, Dirk Develter, Wim Soetaert. Production of new-to-nature sophorolipids by cultivating the yeast Candida bombicola on unconventional hydrophobic substrates.
Biotechnology and bioengineering.
2011 Apr; 108(4):734-41. doi:
10.1002/bit.23004. [PMID: 21404247] - Hiromasa Imaishi, Mariana Petkova-Andonova. Molecular cloning of CYP76B9, a cytochrome P450 from Petunia hybrida, catalyzing the omega-hydroxylation of capric acid and lauric acid.
Bioscience, biotechnology, and biochemistry.
2007 Jan; 71(1):104-13. doi:
10.1271/bbb.60396. [PMID: 17213671] - Alexander N Grechkin, Lucia S Mukhtarova, Mats Hamberg. Detection of an enol intermediate in the hydroperoxide lyase chain cleavage reaction.
FEBS letters.
2003 Aug; 549(1-3):31-4. doi:
10.1016/s0014-5793(03)00758-0. [PMID: 12914919] - Michael Zemaitis, Samuel Poloyac, Reginald Frye. Identification of omega hydroxy fatty acids in biological samples as their pentafluoropropyl derivatives by gas chromatography/mass spectrometry with positive and negative ion detection.
Rapid communications in mass spectrometry : RCM.
2002; 16(15):1411-5. doi:
10.1002/rcm.733. [PMID: 12125016] - Y H Yang, J L Wang, C L Miranda, D R Buhler. CYP2M1: cloning, sequencing, and expression of a new cytochrome P450 from rainbow trout liver with fatty acid (omega-6)-hydroxylation activity.
Archives of biochemistry and biophysics.
1998 Apr; 352(2):271-80. doi:
10.1006/abbi.1998.0607. [PMID: 9587416] - . .
.
. doi:
. [PMID: 9531510]
