2-Chlorobenzoic acid (BioDeep_00000001205)

 

Secondary id: BioDeep_00001867996

human metabolite blood metabolite


代谢物信息卡片


2-Chlorobenzoic acid, copper (2+) salt

化学式: C7H5ClO2 (155.9978)
中文名称: 邻氯苯甲酸
谱图信息: 最多检出来源 Homo sapiens(blood) 43.87%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(=O)O)Cl
InChI: InChI=1S/C7H5ClO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, AKR7A2, CHM, CYP1A1, CYP2C19, PSMB5, TUBB2B
Peripheral membrane protein 3 COQ10A, CYP1A1, PLOD2
Endoplasmic reticulum membrane 3 CYP1A1, CYP2C19, PLOD2
Nucleus 4 CHM, PSMB5, STAG2, TUBB2B
cytosol 7 AKR7A2, CHM, CLC, HBB, PSMB5, STAG2, TGFBR2
dendrite 1 ACVRL1
centrosome 1 PSMB5
nucleoplasm 2 PSMB5, STAG2
Cell membrane 5 ABCB1, ACVRL1, OR2W1, TGFBR2, TNF
Cytoplasmic granule 1 CLC
Multi-pass membrane protein 2 ABCB1, OR2W1
cell surface 3 ABCB1, ACVRL1, TNF
Golgi apparatus 2 AKR7A2, ATRN
mitochondrial inner membrane 2 COQ10A, CYP1A1
neuronal cell body 2 ACVRL1, TNF
Cytoplasm, cytosol 2 CHM, CLC
plasma membrane 8 ABCB1, ACVRL1, ATRN, CSF2, CYP2C19, OR2W1, TGFBR2, TNF
Membrane 5 ABCB1, ACVRL1, HBB, STAG2, TGFBR2
apical plasma membrane 1 ABCB1
caveola 1 TGFBR2
extracellular exosome 6 ABCB1, AKR7A2, ATRN, HBB, PLOD2, PSMB5
Lumenal side 1 PLOD2
endoplasmic reticulum 1 PLOD2
extracellular space 6 ATRN, CLC, CSF2, HBB, TGFBR2, TNF
Schaffer collateral - CA1 synapse 1 TUBB2B
mitochondrion 3 AKR7A2, COQ10A, CYP1A1
intracellular membrane-bounded organelle 3 CSF2, CYP1A1, CYP2C19
Microsome membrane 1 CYP1A1
Single-pass type I membrane protein 3 ACVRL1, ATRN, TGFBR2
Secreted 2 CLC, CSF2
extracellular region 5 CLC, CSF2, HBB, TGFBR2, TNF
[Isoform 2]: Secreted 1 ATRN
external side of plasma membrane 2 TGFBR2, TNF
microtubule cytoskeleton 1 TUBB2B
nucleolus 1 STAG2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Mitochondrion inner membrane 2 COQ10A, CYP1A1
Matrix side 1 COQ10A
Membrane raft 2 TGFBR2, TNF
Cytoplasm, cytoskeleton 1 TUBB2B
microtubule 1 TUBB2B
collagen-containing extracellular matrix 1 CLC
receptor complex 1 TGFBR2
chromatin 1 STAG2
phagocytic cup 1 TNF
mitotic spindle 1 TUBB2B
Chromosome 1 STAG2
blood microparticle 1 HBB
proteasome core complex, beta-subunit complex 1 PSMB5
[Isoform 3]: Secreted 2 ATRN, TGFBR2
intercellular bridge 1 TUBB2B
fibrillar center 1 STAG2
Chromosome, centromere 1 STAG2
ficolin-1-rich granule lumen 1 HBB
proteasome complex 1 PSMB5
nuclear matrix 1 STAG2
tertiary granule lumen 1 HBB
mitotic spindle pole 1 STAG2
rough endoplasmic reticulum membrane 1 PLOD2
chromosome, centromeric region 1 STAG2
proteasome core complex 1 PSMB5
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 1 ATRN
Rough endoplasmic reticulum 1 PLOD2
cohesin complex 1 STAG2
mitotic cohesin complex 1 STAG2
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
CRLF-CLCF1 complex 1 CLC
hemoglobin complex 1 HBB
endocytic vesicle lumen 1 HBB
haptoglobin-hemoglobin complex 1 HBB
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
BMP receptor complex 1 ACVRL1
Rab-protein geranylgeranyltransferase complex 1 CHM
CNTFR-CLCF1 complex 1 CLC
transforming growth factor beta ligand-receptor complex 1 TGFBR2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Sufang Fan, Xiupin Wang, Peiwu Li, Qi Zhang, Wen Zhang. Simultaneous determination of 13 phytohormones in oilseed rape tissues by liquid chromatography-electrospray tandem mass spectrometry and the evaluation of the matrix effect. Journal of separation science. 2011 Mar; 34(6):640-50. doi: 10.1002/jssc.201000541. [PMID: 21312330]
  • Samuel G Dennison, Parnell O'Brien, Saumya Gopalkrishnan, Benjamin C Stark. Enhancement of aerobic degradation of benzoate and 2-chlorobenzoate by adapted activated sludge. Microbiological research. 2010 Oct; 165(8):687-94. doi: 10.1016/j.micres.2009.11.007. [PMID: 20006479]
  • Hagai Yasuor, Wei Zou, Vladimir V Tolstikov, Ronald S Tjeerdema, Albert J Fischer. Differential oxidative metabolism and 5-ketoclomazone accumulation are involved in Echinochloa phyllopogon resistance to clomazone. Plant physiology. 2010 May; 153(1):319-26. doi: 10.1104/pp.110.153296. [PMID: 20207709]
  • Xuemei Liu, Kieran J Germaine, David Ryan, David N Dowling. Genetically modified Pseudomonas biosensing biodegraders to detect PCB and chlorobenzoate bioavailability and biodegradation in contaminated soils. Bioengineered bugs. 2010 May; 1(3):198-206. doi: 10.4161/bbug.1.3.12443. [PMID: 21326926]
  • Kennan Kellaris Salinero, Keith Keller, William S Feil, Helene Feil, Stephan Trong, Genevieve Di Bartolo, Alla Lapidus. Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation. BMC genomics. 2009 Aug; 10(?):351. doi: 10.1186/1471-2164-10-351. [PMID: 19650930]
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  • Rao N V S Mamidi, Geert Mannens, Pieter Annaert, Jan Hendrickx, Ivo Goris, Mark Bockx, Cor G M Janssen, Mark Kao, Michael F Kelley, Willem Meuldermans. Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs. Drug metabolism and disposition: the biological fate of chemicals. 2007 Apr; 35(4):566-75. doi: 10.1124/dmd.106.012336. [PMID: 17220243]
  • Francisco Peixoto, Joaquim A F Vicente, Vítor M C Madeira. Comparative effects of herbicide dicamba and related compound on plant mitochondrial bioenergetics. Journal of biochemical and molecular toxicology. 2003; 17(3):185-92. doi: 10.1002/jbt.10077. [PMID: 12815615]
  • C A Blackledge, E A Partridge, I D Wilson, J K Nicholson. The metabolism and excretion of [14c] 2- and 4-chlorobenzoic acids in the rat. Journal of pharmaceutical and biomedical analysis. 2000 Jul; 22(6):1023-8. doi: 10.1016/s0731-7085(00)00295-8. [PMID: 10857571]
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