Kobusin (BioDeep_00000000949)
Secondary id: BioDeep_00000267720
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C21H22O6 (370.1416)
中文名称: 自旋七叶素
谱图信息:
最多检出来源 Mentha canadensis(plant) 33.33%
分子结构信息
SMILES: COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC5=C(C=C4)OCO5)OC
InChI: InChI=1S/C21H22O6/c1-22-16-5-3-12(7-18(16)23-2)20-14-9-25-21(15(14)10-24-20)13-4-6-17-19(8-13)27-11-26-17/h3-8,14-15,20-21H,9-11H2,1-2H3/t14-,15-,20+,21+/m0/s1
描述信息
Demethoxyaschantin is a member of the class of furofurans that is tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole carrying an additional 3,4-dimethoxyphenyl substituent at position 4. It has a role as a plant metabolite. It is a furofuran, a lignan, a dimethoxybenzene and a member of benzodioxoles.
Kobusin is a natural product found in Pandanus utilis, Pandanus boninensis, and other organisms with data available.
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2].
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2].
同义名列表
18 个代谢物同义名
(3abeta,6abeta)-1beta-(3,4-Dimethoxyphenyl)-4beta-(1,3-benzodioxole-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan; 5-[(3S,3aR,6S,6aR)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole; 5-[(1S,3aR,4S,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2H-1,3-benzodioxole; 5-((1S,3aR,4S,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl)benzo[d][1,3]dioxole; 1,3-BENZODIOXOLE, 5-((1S,3AR,4S,6AR)-4-(3,4-DIMETHOXYPHENYL)TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1-YL)-; 5-((1S,3AR,4S,6AR)-4-(3,4-DIMETHOXYPHENYL)TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1-YL)-1,3-BENZODIOXOLE; (+)-Demethoxyaschantin; (+)-METHYLPIPERITOL; Demethoxyaschantin; UNII-CUR4HUP6JQ; Methylpiperitol; (+)-Spinescin; MEGxp0_001295; ACon1_001273; (+)-Kobusin; CUR4HUP6JQ; Kobusin; (+)-Demethoxyaschantin
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:133905
- KEGG: C17844
- PubChem: 182278
- ChEMBL: CHEMBL462822
- MeSH: kobusin
- ChemIDplus: 0036150239
- CAS: 36150-23-9
- medchemexpress: HY-N5101
- PubChem: 163311848
- KNApSAcK: C00000643
- KNApSAcK: 133905
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
32 个相关的物种来源信息
- 282740 - Achillea holosericea: 10.1016/S0031-9422(01)00442-3
- 881587 - Aiouea trinervis:
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 143780 - Aristolochia elegans: 10.1016/J.BMC.2003.10.031
- 12948 - Aristolochia gigantea: 10.3390/MOLECULES15129462
- 325095 - Aristolochia littoralis: 10.1016/J.BMC.2003.10.031
- 72332 - Artemisia absinthium: 10.1016/0040-4020(80)88051-3
- 72386 - Artemisia arborescens: 10.1016/S0031-9422(96)00720-0
- 401901 - Artemisia gorgonum: 10.1016/J.JEP.2011.09.039
- 1344466 - Esenbeckia leiocarpa: 10.1002/CHIN.199005299
- 1659214 - Geranium platyanthum: 10.32861/JBR.66.57.61
- 345239 - Geranium thunbergii: 10.1007/BF02969300
- 1382326 - Leucophyllum ambiguum:
- 460783 - Machilus wangchiana: 10.1021/NP900504A
- 3402 - Magnolia: 10.1248/CPB.50.541
- 86725 - Magnolia biondii:
- 85856 - Magnolia denudata:
- 54733 - Magnolia stellata: 10.1016/S0031-9422(00)80091-6
- 1619493 - Melicope hayesii: 10.1016/S0031-9422(98)00720-1
- 1035881 - Pandanus boninensis: 10.1016/J.PHYTOCHEM.2005.08.019
- 240453 - Pandanus odoratissimus: 10.1016/S0031-9422(98)00390-2
- 1165086 - Pandanus odorifer: 10.1016/S0031-9422(98)00390-2
- 4726 - Pandanus tectorius: 10.1016/S0031-9422(98)00390-2
- 406422 - Phyllodium pulchellum: 10.1021/NP049599X
- 33090 - Plants: -
- 1331808 - Raulinoa echinata: 10.1002/1099-1565(200101/02)12:1<64::AID-PCA562>3.0.CO;2-3
- 43727 - Samadera bidwillii: 10.1016/S0031-9422(96)00708-X
- 4182 - Sesamum indicum: 10.1021/NP9702953
- 587682 - Teucrium viscidum: 10.3390/MOLECULES18011262
- 403526 - Virola flexuosa: 10.1016/S0031-9422(00)82577-7
- 67938 - Zanthoxylum armatum: 10.1016/J.JEP.2013.12.039
- 1475459 - Zanthoxylum culantrillo: 10.1016/S0031-9422(97)00747-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Paola García-Huertas, Francisco Olmo, Manuel Sánchez-Moreno, Jorge Dominguez, Rachid Chahboun, Omar Triana-Chávez. Activity in vitro and in vivo against Trypanosoma cruzi of a furofuran lignan isolated from Piper jericoense.
Experimental parasitology.
2018 Jun; 189(?):34-42. doi:
10.1016/j.exppara.2018.04.009. [PMID: 29656102] - Vinod Bhatt, Sushila Sharma, Neeraj Kumar, Upendra Sharma, Bikram Singh. Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2017 Jan; 132(?):46-55. doi:
10.1016/j.jpba.2016.09.035. [PMID: 27693952] - Ramesh Kumar Santhanam, Syahida Ahmad, Faridah Abas, Intan Safinar Ismail, Yaya Rukayadi, Muhammad Tayyab Akhtar, Khozirah Shaari. Bioactive Constituents of Zanthoxylum rhetsa Bark and Its Cytotoxic Potential against B16-F10 Melanoma Cancer and Normal Human Dermal Fibroblast (HDF) Cell Lines.
Molecules (Basel, Switzerland).
2016 May; 21(6):. doi:
10.3390/molecules21060652. [PMID: 27231889]
