Canadine (BioDeep_00000000840)

 

Secondary id: BioDeep_00000017214, BioDeep_00000172059

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(1S)-16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaene

化学式: C20H21NO4 (339.1471)
中文名称: 四氢小檗碱, (s)-四氢小檗碱
谱图信息: 最多检出来源 Viridiplantae(plant) 21.32%

分子结构信息

SMILES: COC1=C(C2=C(CC3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)OC
InChI: InChI=1S/C20H21NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3

描述信息

(S)-canadine is the (S)-enantiomer of canadine. It has a role as a plant metabolite. It is an an (S)-7,8,13,14-tetrahydroprotoberberine and a canadine. It is functionally related to a (S)-nandinine. It is an enantiomer of a (R)-canadine.
(S)-Canadine is a natural product found in Hydrastis canadensis, Corydalis turtschaninovii, and other organisms with data available.
The (S)-enantiomer of canadine.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.721
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.718
Tetrahydroberberine is an isoquinoline alkaloid isolated from Corydalis Corydalis, with uM-level affinity for D2 and 5-HT1A receptors.
Tetrahydroberberine is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach[1][2][3].
Tetrahydroberberine is an isoquinoline alkaloid isolated from Corydalis Corydalis, with uM-level affinity for D2 and 5-HT1A receptors.

同义名列表

30 个代谢物同义名

(1S)-16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaene; (13aS)-5, 8, 13, 13a-tetrahydro-9, 10-dimethoxy-6H-benzo[g] -1,3-benzodioxolo[5, 6-a]quinolizine; (13aS)-9,10-dimethoxy-5,8,13,13a-tetrahydro-2H,6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; 6H-BENZO(G)-1,3-BENZODIOXOLO(5,6-A)QUINOLIZINE, 5,8,13,13A-TETRAHYDRO-9,10-DIMETHOXY-, (13AS)-; 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-, (13aS)-; (13aS)-9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; 6H-Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-, (S)-; (13aS)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine; 5,6,13,13a-Tetrahydro-9,10-dimethoxy-2,3-(methylenedioxy)-8H-dibenzo(a,g)quinolizine; 9,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-benzo[g][1,3]benzodioxolo[5,6-a]quinolizine; 13a-alpha-BERBINE, 9,10-DIMETHOXY-2,3-(METHYLENEDIOXY)-; Canadine (Tetrahydroberberine); (S)-(-)-Tetrahydroberberine; (-)-Tetrahydroberberine; (S)-Tetrahydroberberine; CANADINE L-FORM [MI]; (S)-(-)-Canadine; .ALPHA.-CANADINE; UNII-Q97V5BUT9D; Canadine l-form; Canadine, (-)-; alpha-canadine; (-)-Canadine; (S)-Canadine; l-Canadine; Q97V5BUT9D; Canadine; Tetrahydroberberine; (13aS)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3- benzodioxolo[5,6-a]quinolizine; (S)-Canadine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

13 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(10)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

37 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, AKT1, CA1, CYP1A1, CYP2E1, ELANE, FBXO32, MAPK14, XDH
Peripheral membrane protein 3 CYP1A1, CYP1B1, CYP2E1
Endoplasmic reticulum membrane 4 CYP1A1, CYP1A2, CYP1B1, CYP2E1
Nucleus 5 AKT1, DDX53, FBXO32, MAGEA3, MAPK14
cytosol 7 AKT1, CA1, DDX53, ELANE, FBXO32, MAPK14, XDH
dendrite 2 DRD2, P2RY1
phagocytic vesicle 1 ELANE
nucleoplasm 4 AKT1, DDX53, FBXO32, MAPK14
Cell membrane 5 ABCB1, AKT1, DRD2, P2RY1, P2RY12
lamellipodium 1 AKT1
Multi-pass membrane protein 5 ABCB1, CACNA1I, DRD2, P2RY1, P2RY12
Golgi apparatus membrane 1 DRD2
Synapse 1 DRD2
cell cortex 1 AKT1
cell surface 4 ABCB1, ELANE, P2RY1, P2RY12
glutamatergic synapse 4 AKT1, DRD2, MAPK14, P2RY1
Golgi membrane 1 DRD2
mitochondrial inner membrane 2 CYP1A1, CYP2E1
postsynapse 1 AKT1
presynaptic membrane 1 DRD2
acrosomal vesicle 1 DRD2
plasma membrane 8 ABCB1, AKT1, BCHE, CACNA1I, DRD2, F2, P2RY1, P2RY12
synaptic vesicle membrane 1 DRD2
Membrane 5 ABCB1, AKT1, CACNA1I, CYP1B1, P2RY12
apical plasma membrane 2 ABCB1, P2RY1
axon 1 DRD2
basolateral plasma membrane 1 P2RY1
extracellular exosome 4 ABCB1, CA1, ELANE, F2
endoplasmic reticulum 1 MAGEA3
extracellular space 4 BCHE, ELANE, F2, XDH
mitochondrion 3 CYP1A1, CYP1B1, MAPK14
protein-containing complex 1 AKT1
intracellular membrane-bounded organelle 5 CYP1A1, CYP1A2, CYP1B1, CYP2E1, DDX53
Microsome membrane 4 CYP1A1, CYP1A2, CYP1B1, CYP2E1
postsynaptic density 1 P2RY1
Secreted 3 BCHE, F2, VIP
extracellular region 5 BCHE, ELANE, F2, MAPK14, VIP
ciliary membrane 1 DRD2
dendritic spine 1 DRD2
perikaryon 1 DRD2
Z disc 1 FBXO32
microtubule cytoskeleton 1 AKT1
nucleolus 1 DDX53
cell-cell junction 1 AKT1
vesicle 1 AKT1
postsynaptic membrane 2 DRD2, P2RY1
presynaptic active zone membrane 1 P2RY1
Apical cell membrane 1 ABCB1
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
spindle 1 AKT1
GABA-ergic synapse 1 DRD2
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 ELANE, F2
secretory granule 1 ELANE
lateral plasma membrane 1 DRD2
nuclear speck 1 MAPK14
neuron projection 1 VIP
ciliary basal body 1 AKT1
cilium 2 DRD2, P2RY1
spindle pole 1 MAPK14
blood microparticle 2 BCHE, F2
non-motile cilium 1 DRD2
sperm flagellum 1 DRD2
cell body 1 P2RY1
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 BCHE, F2
transcription repressor complex 1 ELANE
axon terminus 1 DRD2
voltage-gated calcium channel complex 1 CACNA1I
specific granule lumen 1 ELANE
endocytic vesicle 1 DRD2
azurophil granule lumen 1 ELANE
nuclear envelope lumen 1 BCHE
external side of apical plasma membrane 1 ABCB1
dopaminergic synapse 1 DRD2
Cytoplasmic vesicle, phagosome 1 ELANE
SCF ubiquitin ligase complex 1 FBXO32
cell body membrane 1 P2RY12
cell projection membrane 1 P2RY12
G protein-coupled receptor complex 1 DRD2


文献列表

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