Capillarisin (BioDeep_00000000656)

 

Secondary id: BioDeep_00000398479, BioDeep_00001867536

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one

化学式: C16H12O7 (316.0583)
中文名称: 茵陈色原酮
谱图信息: 最多检出来源 Homo sapiens(blood) 43.44%

分子结构信息

SMILES: COC1=C(C2=C(C=C1O)OC(=CC2=O)OC3=CC=C(C=C3)O)O
InChI: InChI=1S/C16H12O7/c1-21-16-11(19)6-12-14(15(16)20)10(18)7-13(23-12)22-9-4-2-8(17)3-5-9/h2-7,17,19-20H,1H3

描述信息

Capillarisin is a member of coumarins.
Capillarisin is a natural product found in Artemisia capillaris with data available.

同义名列表

9 个代谢物同义名

5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one; 5,7-dihydroxy-2-(4-hydroxy-phenoxy)-6-methoxychromone; 2-(p-Hydroxyphenoxy)-6-methoxy-5,7-dihydroxychromone; capillarisine; Capillarisin; AC1NQYDG; Capillarisin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKR1B1, AKT1, BIRC5, CCND1, DDIT3, MAPK14, MAPK8, NFKB1, PTGS2, STAT3
Peripheral membrane protein 2 GORASP1, PTGS2
Endoplasmic reticulum membrane 2 HMOX1, PTGS2
Nucleus 10 AKT1, BIRC5, CCND1, DDIT3, HMOX1, JUND, MAPK14, MAPK8, NFKB1, STAT3
cytosol 11 AKR1B1, AKT1, BIRC5, CCND1, DDIT3, GPT, HMOX1, MAPK14, MAPK8, NFKB1, STAT3
centrosome 1 CCND1
nucleoplasm 10 AKR1B1, AKT1, BIRC5, CCND1, HMOX1, JUND, MAPK14, MAPK8, NFKB1, STAT3
RNA polymerase II transcription regulator complex 3 DDIT3, JUND, STAT3
Cell membrane 2 AKT1, TNF
Cytoplasmic side 2 GORASP1, HMOX1
lamellipodium 1 AKT1
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 2 AKT1, MAPK14
Golgi apparatus 1 GORASP1
Golgi membrane 1 GORASP1
neuronal cell body 1 TNF
postsynapse 1 AKT1
plasma membrane 4 AKT1, IGHE, STAT3, TNF
Membrane 2 AKT1, HMOX1
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 2 AKR1B1, GPT
endoplasmic reticulum 2 HMOX1, PTGS2
extracellular space 7 AKR1B1, HMOX1, IGHE, IL17A, IL5, IL6, TNF
perinuclear region of cytoplasm 1 HMOX1
bicellular tight junction 1 CCND1
mitochondrion 3 AKR1B1, MAPK14, NFKB1
protein-containing complex 3 AKT1, BIRC5, PTGS2
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 IGHE
Secreted 3 IL17A, IL5, IL6
extracellular region 8 DNAH9, IGHE, IL17A, IL5, IL6, MAPK14, NFKB1, TNF
mitochondrial outer membrane 1 HMOX1
transcription regulator complex 4 DDIT3, JUND, NFKB1, STAT3
motile cilium 1 DNAH9
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
external side of plasma membrane 2 IL17A, TNF
microtubule cytoskeleton 2 AKT1, BIRC5
midbody 1 BIRC5
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
Cytoplasm, cytoskeleton, spindle 1 BIRC5
microtubule 2 BIRC5, DNAH9
spindle 2 AKT1, BIRC5
cis-Golgi network 1 GORASP1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
axoneme 1 DNAH9
nuclear speck 1 MAPK14
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 DDIT3
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 4 DDIT3, JUND, NFKB1, STAT3
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
Chromosome 1 BIRC5
centriole 1 BIRC5
spindle pole 1 MAPK14
nuclear chromosome 1 BIRC5
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
[Isoform 2]: Cell membrane 1 IGHE
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 MAPK14, NFKB1
endoplasmic reticulum lumen 2 IL6, PTGS2
transcription repressor complex 2 CCND1, JUND
specific granule lumen 1 NFKB1
kinetochore 1 BIRC5
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
chromosome, centromeric region 1 BIRC5
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
protein-DNA complex 1 DDIT3
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
basal dendrite 1 MAPK8
[Isoform 3]: Cell membrane 1 IGHE
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
interleukin-6 receptor complex 1 IL6
cyclin D1-CDK4 complex 1 CCND1
CHOP-C/EBP complex 1 DDIT3
CHOP-ATF3 complex 1 DDIT3
CHOP-ATF4 complex 1 DDIT3
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
cyclin D1-CDK6 complex 1 CCND1
outer dynein arm 1 DNAH9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
distal portion of axoneme 1 DNAH9


文献列表

  • Guangyao Peng, Xiaoping Long. Capillarisin exerts antiasthmatic activity in neonatal rats via modulating the matrix remodeling. Pakistan journal of pharmaceutical sciences. 2020 Jul; 33(4(Supplementary)):1907-1915. doi: . [PMID: 33612476]
  • Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
  • Ke-Hung Tsui, Ying-Ling Chang, Pei-Shan Yang, Chen-Pang Hou, Yu-Hsiang Lin, Bing-Wei Lin, Tsui-Hsia Feng, Horng-Heng Juang. The inhibitory effects of capillarisin on cell proliferation and invasion of prostate carcinoma cells. Cell proliferation. 2018 Apr; 51(2):e12429. doi: 10.1111/cpr.12429. [PMID: 29271007]
  • Ke-Hung Tsui, Ying-Ling Chang, Tsui-Hsia Feng, Chen-Pang Hou, Yu-Hsiang Lin, Pei-Shan Yang, Bing-Wei Lee, Horng-Heng Juang. Capillarisin blocks prostate-specific antigen expression on activation of androgen receptor in prostate carcinoma cells. The Prostate. 2018 03; 78(4):242-249. doi: 10.1002/pros.23463. [PMID: 29164633]
  • Minjee Kim, Jaemoo Chun, Hyun Ah Jung, Jae Sue Choi, Yeong Shik Kim. Capillarisin attenuates exercise-induced muscle damage through MAPK and NF-κB signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017 Aug; 32(?):30-36. doi: 10.1016/j.phymed.2017.04.007. [PMID: 28732805]
  • Salman Khan, Omer Shehzad, Jaemoo Chun, Ran Joo Choi, Saitbyul Park, Md Nurul Islam, Jae Sue Choi, Yeong Shik Kim. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. Journal of ethnopharmacology. 2014 Mar; 152(3):478-86. doi: 10.1016/j.jep.2014.01.028. [PMID: 24495472]
  • Suckbae Han, Jong Hyun Lee, Chulwon Kim, Dongwoo Nam, Won-Seok Chung, Seok-Geun Lee, Kyoo Seok Ahn, Somi K Cho, Moonjae Cho, Kwang Seok Ahn. Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-κB activation. Immunopharmacology and immunotoxicology. 2013 Feb; 35(1):34-42. doi: 10.3109/08923973.2012.736522. [PMID: 23131135]
  • Salman Khan, Ran Joo Choi, Omer Shehzad, Hyun Pyo Kim, Md Nurul Islam, Jae Sue Choi, Yeong Shik Kim. Molecular mechanism of capillarisin-mediated inhibition of MyD88/TIRAP inflammatory signaling in in vitro and in vivo experimental models. Journal of ethnopharmacology. 2013 Jan; 145(2):626-37. doi: 10.1016/j.jep.2012.12.001. [PMID: 23237934]
  • Hye Kyung Kim, Bo Ram Choi, Yun Ok Bak, Chen Zhao, Sung Won Lee, Ju-Hong Jeon, Insuk So, Jong Kwan Park. The role of capillarisin from Artemisia capillaris on penile erection. Phytotherapy research : PTR. 2012 Jun; 26(6):800-5. doi: 10.1002/ptr.3635. [PMID: 22072532]
  • Akihito Mase, Bunsho Makino, Naoko Tsuchiya, Masahiro Yamamoto, Yoshio Kase, Shuuichi Takeda, Takaaki Hasegawa. Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis. Journal of ethnopharmacology. 2010 Feb; 127(3):742-9. doi: 10.1016/j.jep.2009.11.029. [PMID: 19962433]
  • Tzung-Yan Lee, Fang-Yu Chen, Hen-Hong Chang, Han-Chieh Lin. The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes. Molecular and cellular biochemistry. 2009 May; 325(1-2):53-9. doi: 10.1007/s11010-008-0019-8. [PMID: 19132499]
  • Haitao Lv, Hui Sun, Xijun Wang, Wenjun Sun, Guozheng Jiao, Dixin Zhou, Li Zhao, Hongxin Cao, Guangmei Zhang. Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation. Journal of separation science. 2008 Mar; 31(4):659-66. doi: 10.1002/jssc.200700596. [PMID: 18264991]
  • C Y Chu, T H Tseng, J M Hwang, F P Chou, C J Wang. Protective effects of capillarisin on tert-butylhydroperoxide-induced oxidative damage in rat primary hepatocytes. Archives of toxicology. 1999 Jun; 73(4-5):263-8. doi: 10.1007/s002040050615. [PMID: 10463392]
  • X J Wang, H Sun, Z S Liu. [Quantitative analysis of 6,7-dimethylesculetin and capillarisine in Artemisia capillaris Thunb. and prescriptions containing the crude drug]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1994 Nov; 19(11):667-70, 702. doi: . [PMID: 7893384]
  • T Ikenaga, M Hizako, M Tajima, K Nakashima. Production of choleretic substances in the capitulum, leaf and stem of Artemisia capillaris during the plant growth cycle. Biological & pharmaceutical bulletin. 1994 Jan; 17(1):150-1. doi: 10.1248/bpb.17.150. [PMID: 8148806]
  • T Komiya, M Tsukui, H Oshio. Letter: Capillarisin, a constituent from Artemisiae capillaris herba. Chemical & pharmaceutical bulletin. 1975 Jun; 23(6):1387-9. doi: 10.1248/cpb.23.1387. [PMID: 1182880]