2-Hydroxyfluorene (BioDeep_00000009907)

 

Secondary id: BioDeep_00001874063

human metabolite Endogenous


代谢物信息卡片


2-Hydroxy fluorene

化学式: C13H10O (182.0732)
中文名称: 2-羟基芴
谱图信息: 最多检出来源 Viridiplantae(plant) 9.5%

分子结构信息

SMILES: C1C2=CC=CC=C2C3=C1C=C(C=C3)O
InChI: InChI=1S/C13H10O/c14-11-5-6-13-10(8-11)7-9-3-1-2-4-12(9)13/h1-6,8,14H,7H2

描述信息

2-Hydroxyfluorene (2-OHF) is a metabolite of fluorene. Fluorene is one of the most abundant polycyclic aromatic hydrocarbons (PAHs) throughout the gas phase in the environment, especially in tobacco smoke condensate. 2-OHF is an effective biomarker for evaluating the exposure to PAHs from smoking. It has been found in urine [HMDB]
2-Hydroxyfluorene (2-OHF) is a metabolite of fluorene. Fluorene is one of the most abundant polycyclic aromatic hydrocarbons (PAHs) throughout the gas phase in the environment, especially in tobacco smoke condensate. 2-OHF is an effective biomarker for evaluating the exposure to PAHs from smoking. It has been found in urine.
CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4793; ORIGINAL_PRECURSOR_SCAN_NO 4790
CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4811; ORIGINAL_PRECURSOR_SCAN_NO 4806
CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4829; ORIGINAL_PRECURSOR_SCAN_NO 4826
CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4796; ORIGINAL_PRECURSOR_SCAN_NO 4793
CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4823; ORIGINAL_PRECURSOR_SCAN_NO 4821
CONFIDENCE standard compound; INTERNAL_ID 1094; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4758; ORIGINAL_PRECURSOR_SCAN_NO 4754

同义名列表

6 个代谢物同义名

2-Hydroxy fluorene; 2-Hydroxyfluorene; 9H-Fluoren-2-ol; Fluoren-2-ol; 2-Fluorenol; 2-Hydroxyfluorene



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AHRR, ALB, EGFR, ESR1, SYNE1, TSHB
Peripheral membrane protein 2 CYP1B1, ESR1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 CYP1B1, EGFR
Nucleus 8 ACR, AHRR, ALB, DNMT1, EGFR, ESR1, OGG1, SYNE1
cytosol 4 AHRR, ALB, ESR1, OGG1
centrosome 1 ALB
nucleoplasm 5 AHRR, DNMT1, ESR1, OGG1, SYNE1
Cell membrane 2 EGFR, ESR1
Cytoplasmic side 2 ESR1, SYNE1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 2 EGFR, TPO
glutamatergic synapse 2 EGFR, SYNE1
Golgi apparatus 3 ALB, ESR1, SYNE1
Golgi membrane 2 EGFR, INS
endosome 1 EGFR
plasma membrane 6 EGFR, ESR1, F2, F2RL3, IGHE, TPO
Membrane 6 CYP1B1, EGFR, ESR1, F2RL3, SYNE1, TPO
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 3 ALB, F2, SHBG
endoplasmic reticulum 1 ALB
extracellular space 11 ALB, AMH, CRP, CXCL8, EGFR, F2, IGHE, INS, TG, TPO, TSHB
perinuclear region of cytoplasm 2 EGFR, SYNE1
mitochondrion 3 CYP1B1, DNMT1, OGG1
protein-containing complex 5 ACR, ALB, EGFR, ESR1, OGG1
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 1 CYP1B1
pericentric heterochromatin 1 DNMT1
Single-pass type I membrane protein 3 EGFR, IGHE, TPO
Secreted 9 ALB, AMH, CRP, CXCL8, F2, INS, SHBG, TG, TSHB
extracellular region 12 ACR, ALB, AMH, CRP, CXCL8, F2, F2RL3, IGHE, INS, SHBG, TG, TSHB
mitochondrial matrix 1 OGG1
anchoring junction 1 ALB
transcription regulator complex 1 ESR1
nuclear membrane 2 EGFR, SYNE1
nucleolus 1 SYNE1
midbody 1 SYNE1
P-body 1 SYNE1
Golgi-associated vesicle 1 ACR
postsynaptic membrane 1 SYNE1
Membrane raft 1 EGFR
Cytoplasm, cytoskeleton 1 SYNE1
focal adhesion 1 EGFR
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 F2
nuclear speck 1 OGG1
Nucleus outer membrane 1 SYNE1
nuclear outer membrane 1 SYNE1
sarcomere 1 SYNE1
receptor complex 1 EGFR
ciliary basal body 1 ALB
chromatin 2 AHRR, ESR1
IgE immunoglobulin complex 1 IGHE
cytoskeleton 1 SYNE1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, F2
[Isoform 2]: Cell membrane 1 IGHE
nuclear envelope 1 SYNE1
endosome lumen 1 INS
female germ cell nucleus 1 DNMT1
aryl hydrocarbon receptor complex 1 AHRR
Nucleus, nucleoplasm 1 OGG1
Nucleus speckle 1 OGG1
euchromatin 1 ESR1
replication fork 1 DNMT1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 ALB, F2, INS
nuclear matrix 1 OGG1
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic endocytic zone 1 SYNE1
Single-pass type IV membrane protein 1 SYNE1
Nucleus matrix 1 OGG1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 ESR1
postsynaptic actin cytoskeleton 1 SYNE1
dendritic spine head 1 SYNE1
[Isoform 3]: Cell membrane 1 IGHE
meiotic nuclear membrane microtubule tethering complex 1 SYNE1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
acrosomal matrix 1 ACR
ciliary transition fiber 1 ALB
[Isoform GSRP-56]: Golgi apparatus 1 SYNE1


文献列表

  • Tae-Woo Lee, Dae Hwan Kim, Ji Young Ryu. Association between urinary polycyclic aromatic hydrocarbons and hypertension in the Korean population: data from the Second Korean National Environmental Health Survey (2012-2014). Scientific reports. 2020 10; 10(1):17142. doi: 10.1038/s41598-020-74353-w. [PMID: 33051516]
  • Yanli Liu, Hongjie Zhang, Huitao Zhang, Yingying Niu, Ye Fu, Jisheng Nie, Aimin Yang, Jinzhu Zhao, Jin Yang. Mediation effect of AhR expression between polycyclic aromatic hydrocarbons exposure and oxidative DNA damage among Chinese occupational workers. Environmental pollution (Barking, Essex : 1987). 2018 Dec; 243(Pt B):972-977. doi: 10.1016/j.envpol.2018.09.014. [PMID: 30248604]
  • B L Pan, H T Zhang, H J Zhang, W T Chen, J Yang. [Relationship between urinary polycyclic aromatic hydrocarbon metabolite and cell cycle of lymphocyte in coke oven workers]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2016 Nov; 34(11):814-818. doi: 10.3760/cma.j.issn.1001-9391.2016.11.004. [PMID: 28043266]
  • Omayma Alshaarawy, Hosam A Elbaz, Michael E Andrew. The association of urinary polycyclic aromatic hydrocarbon biomarkers and cardiovascular disease in the US population. Environment international. 2016 Apr; 89-90(?):174-8. doi: 10.1016/j.envint.2016.02.006. [PMID: 26878282]
  • Xiao Zhang, Huawei Duan, Feng Gao, Yuanyuan Li, Chuanfeng Huang, Yong Niu, Weimin Gao, Shanfa Yu, Yuxin Zheng. Increased micronucleus, nucleoplasmic bridge, and nuclear bud frequencies in the peripheral blood lymphocytes of diesel engine exhaust-exposed workers. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):408-17. doi: 10.1093/toxsci/kfu239. [PMID: 25370840]
  • Wen Q Yin, Li Wang, Rui R Li, Shu Y Cao, Yu T Ye, Lei Li. Personal exposure levels of PAHs in the general population in northern rural area of Jiangsu Province, China. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2014; 49(3):281-6. doi: 10.1080/10934529.2014.846604. [PMID: 24279619]
  • Gaston Knobel, Korina Calimag-Williams, Andres D Campiglia. Solid-phase extraction, sample stacking and capillary zone electrophoresis for the analysis of urinary polycyclic aromatic hydrocarbon metabolites. The Analyst. 2012 Dec; 137(23):5639-47. doi: 10.1039/c2an36265a. [PMID: 23086075]
  • Ruifang Fan, Dongli Wang, Chuanwei Mao, Shangkang Ou, Zhixia Lian, Shaoling Huang, Qiongshan Lin, Runhao Ding, Jianwen She. Preliminary study of children's exposure to PAHs and its association with 8-hydroxy-2'-deoxyguanosine in Guangzhou, China. Environment international. 2012 Jul; 42(?):53-8. doi: 10.1016/j.envint.2011.03.021. [PMID: 21511339]
  • Olorunfemi Adetona, Andreas Sjodin, Li Zheng, Lovisa C Romanoff, Manuel Aguilar-Villalobos, Larry L Needham, Daniel B Hall, Antonio Luis, Brandon E Cassidy, Christopher D Simpson, Luke P Naeher. Personal exposure to PM(2.5) and urinary hydroxy-PAH levels in bus drivers exposed to traffic exhaust, in Trujillo, Peru. Journal of occupational and environmental hygiene. 2012; 9(4):217-29. doi: 10.1080/15459624.2012.666142. [PMID: 22455670]
  • Korina Calimag-Williams, Hector C Goicoechea, Andres D Campiglia. Room-temperature fluorescence spectroscopy of monohydroxy metabolites of polycyclic aromatic hydrocarbons on octadecyl extraction membranes. Talanta. 2011 Sep; 85(4):1805-11. doi: 10.1016/j.talanta.2011.07.009. [PMID: 21872023]
  • Horacio Riojas-Rodriguez, Astrid Schilmann, Adriana Teresa Marron-Mares, Omar Masera, Zheng Li, Lovisa Romanoff, Andreas Sjödin, Leonora Rojas-Bracho, Larry L Needham, Isabelle Romieu. Impact of the improved patsari biomass stove on urinary polycyclic aromatic hydrocarbon biomarkers and carbon monoxide exposures in rural Mexican women. Environmental health perspectives. 2011 Sep; 119(9):1301-7. doi: 10.1289/ehp.1002927. [PMID: 21622083]
  • Xue Han, Niya Zhou, Zhihong Cui, Mingfu Ma, Lianbing Li, Min Cai, Yafei Li, Hui Lin, Ying Li, Lin Ao, Jinyi Liu, Jia Cao. Association between urinary polycyclic aromatic hydrocarbon metabolites and sperm DNA damage: a population study in Chongqing, China. Environmental health perspectives. 2011 May; 119(5):652-7. doi: 10.1289/ehp.1002340. [PMID: 21147605]
  • Xiaohui Xu, Robert L Cook, Vito A Ilacqua, Haidong Kan, Evelyn O Talbott, Greg Kearney. Studying associations between urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and cardiovascular diseases in the United States. The Science of the total environment. 2010 Oct; 408(21):4943-8. doi: 10.1016/j.scitotenv.2010.07.034. [PMID: 20701951]
  • Rong-Hui Kang, Yong-Sheng Wang, Hong-Mei Yang, Gui-Rong Li, Xuan Tan, Jin-Hua Xue, Jin-Quan Zhang, Yu-Kun Yuan, Lin-Fei Shi, Xi-Lin Xiao. Rapid simultaneous analysis of 1-hydroxypyrene, 2-hydroxyfluorene, 9-hydroxyphenanthrene, 1- and 2-naphthol in urine by first derivative synchronous fluorescence spectrometry using Tween-20 as a sensitizer. Analytica chimica acta. 2010 Jan; 658(2):180-6. doi: 10.1016/j.aca.2009.11.015. [PMID: 20103092]
  • Yan Han, Yankai Xia, Pengfei Zhu, Shanlei Qiao, Rencheng Zhao, Nianzu Jin, Shoulin Wang, Ling Song, Guangbo Fu, Xinru Wang. Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males. The Science of the total environment. 2010 Jan; 408(4):768-73. doi: 10.1016/j.scitotenv.2009.11.021. [PMID: 19942255]
  • Pengfei Zhu, Zenghui Bian, Yankai Xia, Yan Han, Shanlei Qiao, Rencheng Zhao, Nianzu Jin, Shoulin Wang, Yuzhu Peng, Xinru Wang. Relationship between urinary metabolites of polycyclic aromatic hydrocarbons and thyroid hormone levels in Chinese non-occupational exposure adult males. Chemosphere. 2009 Nov; 77(7):883-8. doi: 10.1016/j.chemosphere.2009.08.054. [PMID: 19766290]
  • Huiyong Wang, Walter B Wilson, Andres D Campiglia. Using gold nanoparticles to improve the recovery and the limits of detection for the analysis of monohydroxy-polycyclic aromatic hydrocarbons in urine samples. Journal of chromatography. A. 2009 Jul; 1216(31):5793-9. doi: 10.1016/j.chroma.2009.06.015. [PMID: 19559440]
  • M Mattarozzi, M Musci, M Careri, A Mangia, S Fustinoni, L Campo, F Bianchi. A novel headspace solid-phase microextraction method using in situ derivatization and a diethoxydiphenylsilane fibre for the gas chromatography-mass spectrometry determination of urinary hydroxy polycyclic aromatic hydrocarbons. Journal of chromatography. A. 2009 Jul; 1216(30):5634-9. doi: 10.1016/j.chroma.2009.05.072. [PMID: 19523642]
  • Heinz-Werner Hagedorn, Gerhard Scherer, Johannes Engl, Kirsten Riedel, Francis Cheung, Graham Errington, Jim Shepperd, Mike McEwan. Urinary excretion of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in nonsmokers and in smokers of cigarettes with different ISO tar yields. Journal of analytical toxicology. 2009 Jul; 33(6):301-9. doi: 10.1093/jat/33.6.301. [PMID: 19653933]
  • Yankai Xia, Yan Han, Pengfei Zhu, Shoulin Wang, Aihua Gu, Li Wang, Chuncheng Lu, Guangbo Fu, Ling Song, Xinru Wang. Relation between urinary metabolites of polycyclic aromatic hydrocarbons and human semen quality. Environmental science & technology. 2009 Jun; 43(12):4567-73. doi: 10.1021/es9000642. [PMID: 19603678]
  • Yankai Xia, Pengfei Zhu, Yan Han, Chuncheng Lu, Shoulin Wang, Aihua Gu, Guangbo Fu, Renzhen Zhao, Ling Song, Xinru Wang. Urinary metabolites of polycyclic aromatic hydrocarbons in relation to idiopathic male infertility. Human reproduction (Oxford, England). 2009 May; 24(5):1067-74. doi: 10.1093/humrep/dep006. [PMID: 19202139]
  • Plernpit Suwan-ampai, Ana Navas-Acien, Paul T Strickland, Jacqueline Agnew. Involuntary tobacco smoke exposure and urinary levels of polycyclic aromatic hydrocarbons in the United States, 1999 to 2002. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2009 Mar; 18(3):884-93. doi: 10.1158/1055-9965.epi-08-0939. [PMID: 19258471]
  • Laura Campo, Federica Rossella, Silvia Fustinoni. Development of a gas chromatography/mass spectrometry method to quantify several urinary monohydroxy metabolites of polycyclic aromatic hydrocarbons in occupationally exposed subjects. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Nov; 875(2):531-40. doi: 10.1016/j.jchromb.2008.10.017. [PMID: 18952507]
  • M Buratti, L Campo, S Fustinoni, P E Cirla, I Martinotti, D Cavallo, V Foa. Urinary hydroxylated metabolites of polycyclic aromatic hydrocarbons as biomarkers of exposure in asphalt workers. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2007 May; 12(3):221-39. doi: 10.1080/13547500601100110. [PMID: 17453738]
  • Yu Wang, Wenbing Zhang, Yulian Dong, Ruifang Fan, Guoying Sheng, Jiamo Fu. Quantification of several monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urine by high-performance liquid chromatography with fluorescence detection. Analytical and bioanalytical chemistry. 2005 Nov; 383(5):804-9. doi: 10.1007/s00216-005-0066-x. [PMID: 16184365]
  • Akira Toriba, Thaneeya Chetiyanukornkul, Ryoichi Kizu, Kazuichi Hayakawa. Quantification of 2-hydroxyfluorene in human urine by column-switching high performance liquid chromatography with fluorescence detection. The Analyst. 2003 Jun; 128(6):605-10. doi: 10.1039/b212738e. [PMID: 12866875]