Rimonabant (BioDeep_00000009827)
Secondary id: BioDeep_00000858382
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride
化学式: C22H21Cl3N4O (462.0781)
中文名称: 利莫纳班
谱图信息:
最多检出来源 Homo sapiens(blood) 80.42%
分子结构信息
SMILES: CC1=C(N(N=C1C(=O)NN1CCCCC1)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(Cl)C=C1
InChI: InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
描述信息
Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States. This decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression.
A - Alimentary tract and metabolism > A08 - Antiobesity preparations, excl. diet products > A08A - Antiobesity preparations, excl. diet products
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators
D018377 - Neurotransmitter Agents > D063385 - Cannabinoid Receptor Modulators > D063387 - Cannabinoid Receptor Antagonists
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D019440 - Anti-Obesity Agents
Same as: D05731
同义名列表
15 个代谢物同义名
N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride; 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide; N-(1-Piperidinyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxamide; 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide; Rimonabant hydrochloride; Rimonabantum; SR 141716A; Rimonabant; SR141716a; SR 141716; SR141716; Acomplia; Zimulti; a 281; SR 141716
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:34967
- KEGG: C14319
- PubChem: 104850
- HMDB: HMDB0015623
- Metlin: METLIN63002
- DrugBank: DB06155
- ChEMBL: CHEMBL111
- Wikipedia: Rimonabant
- MeSH: Rimonabant
- KNApSAcK: C00053749
- chemspider: 94641
- CAS: 168273-06-1
- PMhub: MS000023646
- PubChem: 17395319
- PDB-CCD: AY6
- NIKKAJI: J649.754C
- KNApSAcK: 34967
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Abigail L Brewer, Claire E Felter, Anna R Sternitzky, Sade M Spencer. Somatic and anxiety-like behaviors in male and female rats during withdrawal from the non-selective cannabinoid agonist WIN 55,212-2.
Pharmacology, biochemistry, and behavior.
2024 Jan; ?(?):173707. doi:
10.1016/j.pbb.2024.173707. [PMID: 38244864] - Lucas Fajardo, Phelipe Sanchez, Jérôme Salles, Jean Paul Rigaudière, Véronique Patrac, Sylvie Caspar-Bauguil, Camille Bergoglgio, Cédric Moro, Stéphane Walrand, Olivier Le Bacquer. Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function.
American journal of physiology. Endocrinology and metabolism.
2023 02; 324(2):E176-E184. doi:
10.1152/ajpendo.00258.2022. [PMID: 36629822] - S O Vanegas, A M Reck, C E Rodriguez, J A Marusich, O Yassin, G Sotzing, J L Wiley, S G Kinsey. Assessment of dependence potential and abuse liability of Δ8-tetrahydrocannabinol in mice.
Drug and alcohol dependence.
2022 11; 240(?):109640. doi:
10.1016/j.drugalcdep.2022.109640. [PMID: 36179506] - Pengyun Li, Qiaohong Lin, Shiyang Sun, Ning Yang, Yu Xia, Shengjie Cao, Wenjuan Zhang, Qian Li, Haoxin Guo, Maoxiang Zhu, Yilong Wang, Zhibing Zheng, Song Li. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism.
Cell death & disease.
2022 09; 13(9):808. doi:
10.1038/s41419-022-05242-5. [PMID: 36130940] - Christian V Cabanlong, Lauren N Russell, William E Fantegrossi, Paul L Prather. Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors.
Toxicological sciences : an official journal of the Society of Toxicology.
2022 04; 187(1):175-185. doi:
10.1093/toxsci/kfac024. [PMID: 35201352] - Erkan Kilinc, Seyit Ankarali, Ibrahim Ethem Torun, Yasar Dagistan. Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine.
The European journal of neuroscience.
2022 02; 55(4):1015-1031. doi:
10.1111/ejn.14897. [PMID: 32639078] - Nora Helmrich, Martin Roderfeld, Anne Baier, Anita Windhorst, Diran Herebian, Ertan Mayatepek, Christian Dierkes, Matthias Ocker, Dieter Glebe, Bruno Christ, Yuri Churin, Karuna Irungbam, Elke Roeb. Pharmacologic Antagonization of Cannabinoid Receptor 1 Improves Cholestasis in Abcb4-/- Mice.
Cellular and molecular gastroenterology and hepatology.
2022; 13(4):1041-1055. doi:
10.1016/j.jcmgh.2021.12.013. [PMID: 34954190] - Nicolas Hoertel, Marina Sánchez-Rico, Céline Cougoule, Erich Gulbins, Johannes Kornhuber, Alexander Carpinteiro, Katrin Anne Becker, Angela M Reiersen, Eric J Lenze, David Seftel, Cédric Lemogne, Frédéric Limosin. Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms.
Molecular psychiatry.
2021 12; 26(12):7098-7099. doi:
10.1038/s41380-021-01254-3. [PMID: 34385600] - Juliette Salles, Fabienne Briand-Mésange, Stéphanie Trudel, Jérôme Ausseil, Jean-Pierre Salles, Hugues Chap. Can antidepressants unlock prescription of rimonabant in the fight against COVID-19?.
Molecular psychiatry.
2021 12; 26(12):7091-7092. doi:
10.1038/s41380-021-01221-y. [PMID: 34282263] - Samar Rezq, Reham Hassan, Mona F Mahmoud. Rimonabant ameliorates hepatic ischemia/reperfusion injury in rats: Involvement of autophagy via modulating ERK- and PI3K/AKT-mTOR pathways.
International immunopharmacology.
2021 Nov; 100(?):108140. doi:
10.1016/j.intimp.2021.108140. [PMID: 34536742] - M L Eckard, S G Kinsey. Gabapentin attenuates somatic signs of precipitated THC withdrawal in mice.
Neuropharmacology.
2021 06; 190(?):108554. doi:
10.1016/j.neuropharm.2021.108554. [PMID: 33845073] - Li Zhao, Tao Liu, Zhan-Jun Dou, Mei-Ting Wang, Zi-Xuan Hu, Bei Wang. CB1 receptor antagonist rimonabant protects against chronic intermittent hypoxia-induced renal injury in rats.
BMC nephrology.
2021 04; 22(1):153. doi:
10.1186/s12882-021-02362-6. [PMID: 33902473] - Olivier Le Bacquer, Kassandra Lanchais, Kristell Combe, Loïc Van Den Berghe, Stéphane Walrand. Acute rimonabant treatment promotes protein synthesis in C2C12 myotubes through a CB1-independent mechanism.
Journal of cellular physiology.
2021 04; 236(4):2669-2683. doi:
10.1002/jcp.30034. [PMID: 32885412] - Alba Huerga-Gómez, Tania Aguado, Aníbal Sánchez-de la Torre, Ana Bernal-Chico, Carlos Matute, Susana Mato, Manuel Guzmán, Ismael Galve-Roperh, Javier Palazuelos. Δ9 -Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo.
Glia.
2021 03; 69(3):532-545. doi:
10.1002/glia.23911. [PMID: 32956517] - Joseph K Ritter, Ashfaq Ahmad, Shobha Mummalaneni, Zdravka Daneva, Sara K Dempsey, Ningjun Li, Pin-Lan Li, Vijay Lyall. Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na+-K+-ATPase in Mouse Kidney Thick Ascending Limb Tubules.
The Journal of pharmacology and experimental therapeutics.
2021 01; 376(1):1-11. doi:
10.1124/jpet.120.000163. [PMID: 33087396] - Yue-Mei Zhang, Michael Greco, Tonya Le Blanc, Wensheng Lang, Jack Kauffman, John Masucci, William V Murray, Keith Demarest, Mark Joseph Macielag. Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB1R Inverse Agonists.
ACS medicinal chemistry letters.
2020 Dec; 11(12):2504-2509. doi:
10.1021/acsmedchemlett.0c00495. [PMID: 33335674] - Zhan-Jun Dou, Xiao-Ling Gao, Yan-Li Jia, Jie Chen, Jiao-Jiao Yang, Yan Chen, Shu-Jie Wu, Tao Liu, Mei-Ting Wang, Chong Yang, Na Zhang, Bei Wang. CB1 receptor antagonist rimonabant protects against chronic intermittent hypoxia-induced bone metabolism disorder and destruction in rats.
Sleep & breathing = Schlaf & Atmung.
2020 Dec; 24(4):1441-1449. doi:
10.1007/s11325-019-02009-9. [PMID: 31898189] - Inmaculada Ruz-Maldonado, Bo Liu, Patricio Atanes, Attilio Pingitore, Guo Cai Huang, Pratik Choudhary, Shanta J Persaud. The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.
Cellular and molecular life sciences : CMLS.
2020 Nov; 77(22):4709-4723. doi:
10.1007/s00018-019-03433-6. [PMID: 31925452] - Fabienne Briand-Mésange, Stéphanie Trudel, Juliette Salles, Jérôme Ausseil, Jean-Pierre Salles, Hugues Chap. Possible Role of Adipose Tissue and the Endocannabinoid System in Coronavirus Disease 2019 Pathogenesis: Can Rimonabant Return?.
Obesity (Silver Spring, Md.).
2020 09; 28(9):1580-1581. doi:
10.1002/oby.22916. [PMID: 32463562] - Belén Palomares, Martín Garrido-Rodriguez, Claudia Gonzalo-Consuegra, María Gómez-Cañas, Suwipa Saen-Oon, Robert Soliva, Juan A Collado, Javier Fernández-Ruiz, Gaetano Morello, Marco A Calzado, Giovanni Appendino, Eduardo Muñoz. Δ9 -Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARγ and CB1 receptors.
British journal of pharmacology.
2020 09; 177(17):4034-4054. doi:
10.1111/bph.15155. [PMID: 32510591] - Jérémie Joffre, Che-Chung Yeh, Erika Wong, Mayuri Thete, Fengyun Xu, Ivana Zlatanova, Elliot Lloyd, Lester Kobzik, Matthieu Legrand, Judith Hellman. Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury.
Journal of immunology (Baltimore, Md. : 1950).
2020 06; 204(12):3339-3350. doi:
10.4049/jimmunol.2000213. [PMID: 32385136] - Kaveh Shahveisi, Vahid Farnia, Habibolah Khazaie, Hamed Ghazvini, Masoumeh Nozari, Mehdi Khodamoradi. Novel object recognition memory in REM sleep-deprived rats: Role of the cannabinoid CB1 receptor.
Behavioural brain research.
2020 03; 381(?):112311. doi:
10.1016/j.bbr.2019.112311. [PMID: 31711896] - Karuna Irungbam, Yuri Churin, Tomomitsu Matono, Jakob Weglage, Matthias Ocker, Dieter Glebe, Martin Hardt, Alica Koeppel, Martin Roderfeld, Elke Roeb. Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2.
Laboratory investigation; a journal of technical methods and pathology.
2020 03; 100(3):454-465. doi:
10.1038/s41374-019-0327-5. [PMID: 31570772] - Günter A Müller, Andreas W Herling, Susanne Wied, Timo D Müller. CB1 Receptor-Dependent and Independent Induction of Lipolysis in Primary Rat Adipocytes by the Inverse Agonist Rimonabant (SR141716A).
Molecules (Basel, Switzerland).
2020 Feb; 25(4):. doi:
10.3390/molecules25040896. [PMID: 32085406] - G A Müller, S Wied, A W Herling. Analysis of Direct Effects of the CB1 Receptor Antagonist Rimonabant on Fatty Acid Oxidation and Glycogenolysis in Liver and Muscle Cells in vitro.
Biochemistry. Biokhimiia.
2019 Aug; 84(8):954-962. doi:
10.1134/s000629791908011x. [PMID: 31522677] - Ester Aso, Víctor Fernández-Dueñas, Marc López-Cano, Jaume Taura, Masahiko Watanabe, Isidre Ferrer, Rafael Luján, Francisco Ciruela. Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus: Cannabidiol Blunts Δ9-Tetrahydrocannabinol-Induced Cognitive Impairment.
Molecular neurobiology.
2019 Aug; 56(8):5382-5391. doi:
10.1007/s12035-018-1456-3. [PMID: 30610611] - Liqing Chen, Yan Yan, Tinggui Chen, Liwei Zhang, Xiaoxia Gao, Chenhui Du, Huizhi Du. Forsythiaside prevents β-amyloid-induced hippocampal slice injury by upregulating 2-arachidonoylglycerol via cannabinoid receptor 1-dependent NF-κB pathway.
Neurochemistry international.
2019 05; 125(?):57-66. doi:
10.1016/j.neuint.2019.02.008. [PMID: 30769029] - Julieta Lazarte, Robert A Hegele. Cannabis effects on lipoproteins.
Current opinion in lipidology.
2019 04; 30(2):140-146. doi:
10.1097/mol.0000000000000575. [PMID: 30649023] - M C G Leite-Avalca, F T Staats, D Verona, P de Souza, M C Almeida, J E Silva-Santos, A R Zampronio. Cannabinoid CB1 Receptor Antagonist Rimonabant Decreases Levels of Markers of Organ Dysfunction and Alters Vascular Reactivity in Aortic Vessels in Late Sepsis in Rats.
Inflammation.
2019 Apr; 42(2):618-627. doi:
10.1007/s10753-018-0919-z. [PMID: 30556096] - Ji Hye Han, Hanho Shin, Ju-Young Park, Jun Gi Rho, Dong Hwee Son, Ki Woo Kim, Je Kyung Seong, Sung-Hwa Yoon, Wook Kim. A novel peripheral cannabinoid 1 receptor antagonist, AJ5012, improves metabolic outcomes and suppresses adipose tissue inflammation in obese mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 03; 33(3):4314-4326. doi:
10.1096/fj.201801152rr. [PMID: 30566396] - Bojan Jorgačević, Danijela Vučević, Milena Vesković, Dušan Mladenović, Dušan Vukićević, Rada Ješić Vukićević, Vera Todorović, Tatjana Radosavljević. The effect of cannabinoid receptor 1 blockade on adipokine and proinflammatory cytokine concentration in adipose and hepatic tissue in mice with nonalcoholic fatty liver disease.
Canadian journal of physiology and pharmacology.
2019 Feb; 97(2):120-129. doi:
10.1139/cjpp-2018-0607. [PMID: 30673308] - Caitlin A D Jagla, Caitlin E Scott, Yaliang Tang, Changjiang Qiao, Gabriel E Mateo-Semidey, Guillermo A Yudowski, Dai Lu, Debra A Kendall. Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin-Dependent Responses.
Molecular pharmacology.
2019 01; 95(1):1-10. doi:
10.1124/mol.118.112854. [PMID: 30322873] - Yue-Mei Zhang, Michael N Greco, Mark J Macielag, Christopher A Teleha, Renee L DesJarlais, Yuting Tang, George Ho, Cuifen Hou, Cailin Chen, Shuyuan Zhao, Jack Kauffman, Raul Camacho, Jenson Qi, William Murray, Keith Demarest, James Leonard. 6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity.
Journal of medicinal chemistry.
2018 11; 61(22):10276-10298. doi:
10.1021/acs.jmedchem.8b01467. [PMID: 30339387] - Abhigyan Ravula, Hardik Chandasana, Barry Setlow, Marcelo Febo, Adriaan W Bruijnzeel, Hartmut Derendorf. Simultaneous quantification of cannabinoids tetrahydrocannabinol, cannabidiol and CB1 receptor antagonist in rat plasma: An application to characterize pharmacokinetics after passive cannabis smoke inhalation and co-administration of rimonabant.
Journal of pharmaceutical and biomedical analysis.
2018 Oct; 160(?):119-125. doi:
10.1016/j.jpba.2018.07.004. [PMID: 30077950] - L W Wei, Z Q Yuan, M D Zhao, C W Gu, J H Han, L Fu. Inhibition of Cannabinoid Receptor 1 Can Influence the Lipid Metabolism in Mice with Diet-Induced Obesity.
Biochemistry. Biokhimiia.
2018 Oct; 83(10):1279-1287. doi:
10.1134/s0006297918100127. [PMID: 30472964] - Kristen R Trexler, Sara R Nass, Molly S Crowe, Joshua D Gross, Margaret S Jones, Austin W McKitrick, David P Siderovski, Steven G Kinsey. Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice.
Drug and alcohol dependence.
2018 Oct; 191(?):14-24. doi:
10.1016/j.drugalcdep.2018.05.029. [PMID: 30071445] - Ji H Han, Hanho Shin, Jun G Rho, Jung-Eun Kim, Dong H Son, Juhwan Yoon, Yong J Lee, Jung-Hyuck Park, Byung J Song, Chang-Sik Choi, Seul G Yoon, Il Y Kim, Eun K Lee, Je K Seong, Ki W Kim, Wook Kim. Peripheral cannabinoid 1 receptor blockade mitigates adipose tissue inflammation via NLRP3 inflammasome in mouse models of obesity.
Diabetes, obesity & metabolism.
2018 09; 20(9):2179-2189. doi:
10.1111/dom.13350. [PMID: 29740969] - George S Amato, Amruta Manke, Vineetha Vasukuttan, Robert W Wiethe, Rodney W Snyder, Scott P Runyon, Rangan Maitra. Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists.
Bioorganic & medicinal chemistry.
2018 08; 26(15):4518-4531. doi:
10.1016/j.bmc.2018.07.043. [PMID: 30077609] - Eduardo Hernández-Vázquez, Sandra Young-Peralta, Litzia Cerón-Romero, Sara García-Jiménez, Samuel Estrada-Soto. Acute and subacute antidiabetic studies of ENP-9, a new 1,5-diarylpyrazole derivative.
The Journal of pharmacy and pharmacology.
2018 Aug; 70(8):1031-1039. doi:
10.1111/jphp.12933. [PMID: 29774523] - João P Silva, Helena Carmo, Félix Carvalho. The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis.
Toxicology letters.
2018 May; 287(?):59-69. doi:
10.1016/j.toxlet.2018.01.023. [PMID: 29410032] - Thomas F Gamage, Charlotte E Farquhar, Timothy W Lefever, Julie A Marusich, Richard C Kevin, Iain S McGregor, Jenny L Wiley, Brian F Thomas. Molecular and Behavioral Pharmacological Characterization of Abused Synthetic Cannabinoids MMB- and MDMB-FUBINACA, MN-18, NNEI, CUMYL-PICA, and 5-Fluoro-CUMYL-PICA.
The Journal of pharmacology and experimental therapeutics.
2018 05; 365(2):437-446. doi:
10.1124/jpet.117.246983. [PMID: 29549157] - Alessandra Porcu, Miriam Melis, Rostislav Turecek, Celine Ullrich, Ignazia Mocci, Bernhard Bettler, Gian Luigi Gessa, M Paola Castelli. Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a Gαi/o protein inhibitor.
Neuropharmacology.
2018 05; 133(?):107-120. doi:
10.1016/j.neuropharm.2018.01.024. [PMID: 29407764] - Eugene Chang, Dae-Hee Kim, Hyekyung Yang, Da Hyun Lee, Soo Han Bae, Cheol-Young Park. CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes.
PloS one.
2018; 13(10):e0206152. doi:
10.1371/journal.pone.0206152. [PMID: 30365523] - Molly S Crowe, Catheryn D Wilson, Emma Leishman, Paul L Prather, Heather B Bradshaw, Matthew L Banks, Steven G Kinsey. The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.
British journal of pharmacology.
2017 Dec; 174(23):4523-4539. doi:
10.1111/bph.14055. [PMID: 28963716] - Noha I Hussien, Hanan I El-Kerdasy, Mohammad El-Tantawy Ibrahim. Protective effect of rimonabant, a canabinoid receptor 1 antagonist, on nonalcoholic fatty liver disease in a rat model through modulation of the hepatic expression of activin A and follistatin.
Canadian journal of physiology and pharmacology.
2017 Dec; 95(12):1433-1441. doi:
10.1139/cjpp-2017-0070. [PMID: 28759733] - Pegah Mehrpouya-Bahrami, Kumaraswamy Naidu Chitrala, Mitra S Ganewatta, Chuanbing Tang, E Angela Murphy, Reilly T Enos, Kandy T Velazquez, Jamie McCellan, Mitzi Nagarkatti, Prakash Nagarkatti. Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity.
Scientific reports.
2017 11; 7(1):15645. doi:
10.1038/s41598-017-15154-6. [PMID: 29142285] - Cintia Folgueira, Silvia Barja-Fernandez, Laura Prado, Omar Al-Massadi, Cecilia Castelao, Veronica Pena-Leon, Patricia Gonzalez-Saenz, Javier Baltar, Ivan Baamonde, Rosaura Leis, Carlos Dieguez, Uberto Pagotto, Felipe F Casanueva, Sulay A Tovar, Ruben Nogueiras, Luisa M Seoane. Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway.
World journal of gastroenterology.
2017 Sep; 23(35):6403-6411. doi:
10.3748/wjg.v23.i35.6403. [PMID: 29085189] - Alison J Dawson, Eric S Kilpatrick, Anne-Marie Coady, Abeer M M Elshewehy, Youssra Dakroury, Lina Ahmed, Stephen L Atkin, Thozhukat Sathyapalan. Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss.
BMC endocrine disorders.
2017 Jul; 17(1):41. doi:
10.1186/s12902-017-0194-2. [PMID: 28705172] - T W Grim, A J Morales, B F Thomas, J L Wiley, G W Endres, S S Negus, A H Lichtman. Apparent CB1 Receptor Rimonabant Affinity Estimates: Combination with THC and Synthetic Cannabinoids in the Mouse In Vivo Triad Model.
The Journal of pharmacology and experimental therapeutics.
2017 07; 362(1):210-218. doi:
10.1124/jpet.117.240192. [PMID: 28442584] - Duy-Khanh Dang, Eun-Joo Shin, Anh-Thu Mai, Choon-Gon Jang, Seung-Yeol Nah, Ji Hoon Jeong, Catherine Ledent, Tsuneyuki Yamamoto, Toshitaka Nabeshima, Emmanuel S Onaivi, Hyoung-Chun Kim. Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice.
Free radical biology & medicine.
2017 07; 108(?):204-224. doi:
10.1016/j.freeradbiomed.2017.03.033. [PMID: 28363605] - Bojan Jorgačević, Danijela Vučević, Ivana Đuričić, Slađana Šobajić, Dušan Mladenović, Milena Vesković, Rada Ješić Vukićević, Tatjana Radosavljević. The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease.
Chemistry and physics of lipids.
2017 04; 204(?):85-93. doi:
10.1016/j.chemphyslip.2017.03.009. [PMID: 28363784] - Yousuf M Al Suleimani, Ahmed S Al Mahruqi. The endogenous lipid N-arachidonoyl glycine is hypotensive and nitric oxide-cGMP-dependent vasorelaxant.
European journal of pharmacology.
2017 Jan; 794(?):209-215. doi:
10.1016/j.ejphar.2016.11.040. [PMID: 27890711] - Prusothman Yoganantharjah, Avinesh R Byreddy, Daniel Fraher, Munish Puri, Yann Gibert. Rapid quantification of neutral lipids and triglycerides during zebrafish embryogenesis.
The International journal of developmental biology.
2017; 61(1-2):105-111. doi:
10.1387/ijdb.160209yg. [PMID: 28287241] - Annelies Cannaert, Jolien Storme, Florian Franz, Volker Auwärter, Christophe P Stove. Detection and Activity Profiling of Synthetic Cannabinoids and Their Metabolites with a Newly Developed Bioassay.
Analytical chemistry.
2016 12; 88(23):11476-11485. doi:
10.1021/acs.analchem.6b02600. [PMID: 27779402] - Lawrence C Blume, Sandra Leone-Kabler, Deborah J Luessen, Glen S Marrs, Erica Lyons, Caroline E Bass, Rong Chen, Dana E Selley, Allyn C Howlett. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner.
Journal of neurochemistry.
2016 11; 139(3):396-407. doi:
10.1111/jnc.13767. [PMID: 27513693] - Eduardo Hernández-Vázquez, Sandybel Salgado-Barrera, Juan José Ramírez-Espinosa, Samuel Estrada-Soto, Francisco Hernández-Luis. Synthesis and molecular docking of N'-arylidene-5-(4-chlorophenyl)-1-(3,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbohydrazides as novel hypoglycemic and antioxidant dual agents.
Bioorganic & medicinal chemistry.
2016 05; 24(10):2298-306. doi:
10.1016/j.bmc.2016.04.007. [PMID: 27079123] - Elisabetta Esposito, Markus Drechsler, Rita Cortesi, Claudio Nastruzzi. Encapsulation of cannabinoid drugs in nanostructured lipid carriers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2016 May; 102(?):87-91. doi:
10.1016/j.ejpb.2016.03.005. [PMID: 26952905] - Miguel Moreno-Martet, Ana Feliú, Francisco Espejo-Porras, Miriam Mecha, Francisco J Carrillo-Salinas, Javier Fernández-Ruiz, Carmen Guaza, Eva de Lago. The disease-modifying effects of a Sativex-like combination of phytocannabinoids in mice with experimental autoimmune encephalomyelitis are preferentially due to Δ9-tetrahydrocannabinol acting through CB1 receptors.
Multiple sclerosis and related disorders.
2015 Nov; 4(6):505-11. doi:
10.1016/j.msard.2015.08.001. [PMID: 26590655] - Xiaoya Wang, Qin Yu, Hongmei Yue, Shuang Zeng, Fenfen Cui. Effect of Intermittent Hypoxia and Rimonabant on Glucose Metabolism in Rats: Involvement of Expression of GLUT4 in Skeletal Muscle.
Medical science monitor : international medical journal of experimental and clinical research.
2015 Oct; 21(?):3252-60. doi:
10.12659/msm.896039. [PMID: 26503060] - Morvarid Kabir, Malini S Iyer, Joyce M Richey, Orison O Woolcott, Isaac Asare Bediako, Qiang Wu, Stella P Kim, Darko Stefanovski, Cathryn M Kolka, Isabel R Hsu, Karyn J Catalano, Jenny D Chiu, Viorica Ionut, Richard N Bergman. CB1R antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors.
American journal of physiology. Endocrinology and metabolism.
2015 Oct; 309(8):E747-58. doi:
10.1152/ajpendo.00196.2015. [PMID: 26306598] - Lola Lecru, Christophe Desterke, Stanislas Grassin-Delyle, Christos Chatziantoniou, Sophie Vandermeersch, Aurore Devocelle, Amelia Vernochet, Ninoslav Ivanovski, Catherine Ledent, Sophie Ferlicot, Meriem Dalia, Myriam Saïd, Séverine Beaudreuil, Bernard Charpentier, Aimé Vazquez, Julien Giron-Michel, Bruno Azzarone, Antoine Durrbach, Hélène François. Cannabinoid receptor 1 is a major mediator of renal fibrosis.
Kidney international.
2015 Jul; 88(1):72-84. doi:
10.1038/ki.2015.63. [PMID: 25760323] - Elisabetta Esposito, Laura Ravani, Markus Drechsler, Paolo Mariani, Catia Contado, Janne Ruokolainen, Patrizia Ratano, Patrizia Campolongo, Viviana Trezza, Claudio Nastruzzi, Rita Cortesi. Cannabinoid antagonist in nanostructured lipid carriers (NLCs): design, characterization and in vivo study.
Materials science & engineering. C, Materials for biological applications.
2015 Mar; 48(?):328-36. doi:
10.1016/j.msec.2014.12.012. [PMID: 25579930] - Stephanie Troy-Fioramonti, Laurent Demizieux, Joseph Gresti, Tania Muller, Bruno Vergès, Pascal Degrace. Acute activation of cannabinoid receptors by anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice.
Diabetes.
2015 Mar; 64(3):808-18. doi:
10.2337/db14-0721. [PMID: 25281429] - Jocelijn Meijerink, Mieke Poland, Michiel G J Balvers, Pierluigi Plastina, Carolien Lute, Jvalini Dwarkasing, Klaske van Norren, Renger F Witkamp. Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.
British journal of pharmacology.
2015 Jan; 172(1):24-37. doi:
10.1111/bph.12747. [PMID: 24780080] - Kartikkumar Navinchandra Patel, Amit Arvind Joharapurkar, Vishal Patel, Samadhan Govind Kshirsagar, Rajesh Bahekar, Brijesh Kumar Srivastava, Mukul R Jain. Cannabinoid receptor 1 antagonist treatment induces glucagon release and shows an additive therapeutic effect with GLP-1 agonist in diet-induced obese mice.
Canadian journal of physiology and pharmacology.
2014 Dec; 92(12):975-83. doi:
10.1139/cjpp-2014-0310. [PMID: 25361428] - Mariëtte R Boon, Sander Kooijman, Andrea D van Dam, Leonard R Pelgrom, Jimmy F P Berbée, Cheryl A R Visseren, Robin C van Aggele, Anita M van den Hoek, Hetty C M Sips, Marc Lombès, Louis M Havekes, Jouke T Tamsma, Bruno Guigas, Onno C Meijer, J Wouter Jukema, Patrick C N Rensen. Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2014 Dec; 28(12):5361-75. doi:
10.1096/fj.13-247643. [PMID: 25154875] - Dongmei Shi, Xi Zhan, Xiaofeng Yu, Minglei Jia, Ying Zhang, Jianfeng Yao, Xiaona Hu, Zhijun Bao. Inhibiting CB1 receptors improves lipogenesis in an in vitro non-alcoholic fatty liver disease model.
Lipids in health and disease.
2014 Nov; 13(?):173. doi:
10.1186/1476-511x-13-173. [PMID: 25406988] - Raffaele Capasso, Pierangelo Orlando, Ester Pagano, Teresa Aveta, Lorena Buono, Francesca Borrelli, Vincenzo Di Marzo, Angelo A Izzo. Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB₁ receptors and TRPV1 channels.
British journal of pharmacology.
2014 Sep; 171(17):4026-37. doi:
10.1111/bph.12759. [PMID: 24818658] - Rentian Feng, Christine A Milcarek, Xiang-Qun Xie. Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion.
BMC pharmacology & toxicology.
2014 Jun; 15(?):30. doi:
10.1186/2050-6511-15-30. [PMID: 24913620] - Akihiro Takano, Balázs Gulyás, Katarina Varnäs, Paul Brian Little, Pia K Noerregaard, Niels Ole Jensen, Christian E Elling, Christer Halldin. Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: a PET study.
Synapse (New York, N.Y.).
2014 Mar; 68(3):89-97. doi:
10.1002/syn.21721. [PMID: 24293119] - Joseph Tam, Grzegorz Godlewski, Brian J Earley, Liang Zhou, Tony Jourdan, Gergö Szanda, Resat Cinar, George Kunos. Role of adiponectin in the metabolic effects of cannabinoid type 1 receptor blockade in mice with diet-induced obesity.
American journal of physiology. Endocrinology and metabolism.
2014 Feb; 306(4):E457-68. doi:
10.1152/ajpendo.00489.2013. [PMID: 24381003] - Balapal S Basavarajappa, Shivakumar Subbanna. CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparations.
Hippocampus.
2014 Feb; 24(2):178-88. doi:
10.1002/hipo.22213. [PMID: 24123667] - Simon Nicolussi, Juan Manuel Viveros-Paredes, María Salomé Gachet, Mark Rau, Mario Eduardo Flores-Soto, Martina Blunder, Jürg Gertsch. Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice.
Pharmacological research.
2014 Feb; 80(?):52-65. doi:
10.1016/j.phrs.2013.12.010. [PMID: 24412246] - Y-F Zhang, Z-Q Yuan, D-G Song, X-H Zhou, Y-Z Wang. Effects of cannabinoid receptor 1 (brain) on lipid accumulation by transcriptional control of CPT1A and CPT1B.
Animal genetics.
2014 Feb; 45(1):38-47. doi:
10.1111/age.12078. [PMID: 23914904] - Stephan Röver, Mirjana Andjelkovic, Agnès Bénardeau, Evelyne Chaput, Wolfgang Guba, Paul Hebeisen, Susanne Mohr, Matthias Nettekoven, Ulrike Obst, Wolfgang F Richter, Christoph Ullmer, Pius Waldmeier, Matthew B Wright. 6-Alkoxy-5-aryl-3-pyridinecarboxamides, a new series of bioavailable cannabinoid receptor type 1 (CB1) antagonists including peripherally selective compounds.
Journal of medicinal chemistry.
2013 Dec; 56(24):9874-96. doi:
10.1021/jm4010708. [PMID: 24175572] - V Kumar, U Bhandari, C D Tripathi, G Khanna. Anti-obesity effect of Gymnema sylvestre extract on high fat diet-induced obesity in Wistar rats.
Drug research.
2013 Dec; 63(12):625-32. doi:
10.1055/s-0033-1349852. [PMID: 23842942] - Linda E Klumpers, Marianne Fridberg, Marieke L de Kam, Paul B Little, Niels Ole Jensen, Hendrik D Kleinloog, Christian E Elling, Joop M A van Gerven. Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects.
British journal of clinical pharmacology.
2013 Dec; 76(6):846-57. doi:
10.1111/bcp.12141. [PMID: 23601084] - Eduardo Hernández-Vázquez, Rodrigo Aguayo-Ortiz, Juan José Ramírez-Espinosa, Samuel Estrada-Soto, Francisco Hernández-Luis. Synthesis, hypoglycemic activity and molecular modeling studies of pyrazole-3-carbohydrazides designed by a CoMFA model.
European journal of medicinal chemistry.
2013 Nov; 69(?):10-21. doi:
10.1016/j.ejmech.2013.07.054. [PMID: 23995214] - Luis E Flores, María E Alzugaray, Marisa A Cubilla, María A Raschia, Héctor H Del Zotto, Carolina L Román, Angela M Suburo, Juan J Gagliardino. Islet cannabinoid receptors: cellular distribution and biological function.
Pancreas.
2013 Oct; 42(7):1085-92. doi:
10.1097/mpa.0b013e31828fd32d. [PMID: 24005231] - Maurizio Baldassarre, Ferdinando A Giannone, Lucia Napoli, Alessandra Tovoli, Carmen S Ricci, Manuel Tufoni, Paolo Caraceni. The endocannabinoid system in advanced liver cirrhosis: pathophysiological implication and future perspectives.
Liver international : official journal of the International Association for the Study of the Liver.
2013 Oct; 33(9):1298-308. doi:
10.1111/liv.12263. [PMID: 23890208] - M Baretić. Obesity drug therapy.
Minerva endocrinologica.
2013 Sep; 38(3):245-54. doi:
". [PMID: 24126545] - Wei Chen, Zhenhua Chen, Nina Xue, Zhibing Zheng, Song Li, Lili Wang. Effects of CB1 receptor blockade on monosodium glutamate induced hypometabolic and hypothalamic obesity in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2013 Aug; 386(8):721-32. doi:
10.1007/s00210-013-0875-y. [PMID: 23620336] - Alline C Campos, Zaira Ortega, Javier Palazuelos, Manoela V Fogaça, Daniele C Aguiar, Javier Díaz-Alonso, Silvia Ortega-Gutiérrez, Henar Vázquez-Villa, Fabricio A Moreira, Manuel Guzmán, Ismael Galve-Roperh, Francisco S Guimarães. The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.
The international journal of neuropsychopharmacology.
2013 Jul; 16(6):1407-19. doi:
10.1017/s1461145712001502. [PMID: 23298518] - Rita Citraro, Emilio Russo, Francesca Scicchitano, Clementina M van Rijn, Donato Cosco, Carmen Avagliano, Roberto Russo, Giuseppe D'Agostino, Stefania Petrosino, Francesca Guida, Luisa Gatta, Gilles van Luijtelaar, Sabatino Maione, Vincenzo Di Marzo, Antonio Calignano, Giovambattista De Sarro. Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.
Neuropharmacology.
2013 Jun; 69(?):115-26. doi:
10.1016/j.neuropharm.2012.11.017. [PMID: 23206503] - A N A Verty, S H Lockie, A Stefanidis, B J Oldfield. Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-induced obese mice.
International journal of obesity (2005).
2013 Feb; 37(2):279-87. doi:
10.1038/ijo.2012.35. [PMID: 22473329] - Carol A Paronis, Ganesh A Thakur, Shama Bajaj, Spyros P Nikas, V Kiran Vemuri, Alexandros Makriyannis, Jack Bergman. Diuretic effects of cannabinoids.
The Journal of pharmacology and experimental therapeutics.
2013 Jan; 344(1):8-14. doi:
10.1124/jpet.112.199331. [PMID: 23019138] - Takahiro Shimizu, Kenjiro Tanaka, Kunihiko Yokotani. Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats.
Journal of pharmacological sciences.
2013; 121(2):157-71. doi:
10.1254/jphs.12208fp. [PMID: 23386378] - Xing Xian Yu, Lynnetta M Watts, Vara Prasad Manchem, Kaushik Chakravarty, Brett P Monia, Michael L McCaleb, Sanjay Bhanot. Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.
PloS one.
2013; 8(7):e66923. doi:
10.1371/journal.pone.0066923. [PMID: 23922646] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Robert J Chorvat, Jennifer Berbaum, Kristine Seriacki, John F McElroy. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities.
Bioorganic & medicinal chemistry letters.
2012 Oct; 22(19):6173-80. doi:
10.1016/j.bmcl.2012.08.004. [PMID: 22959249] - Andrea Mastinu, Marilena Pira, Luca Pani, Gérard Aimè Pinna, Paolo Lazzari. NESS038C6, a novel selective CB1 antagonist agent with anti-obesity activity and improved molecular profile.
Behavioural brain research.
2012 Oct; 234(2):192-204. doi:
10.1016/j.bbr.2012.06.033. [PMID: 22771813] - Vidya Vaidyanathan, Raul A Bastarrachea, Paul B Higgins, V Saroja Voruganti, Subhash Kamath, Nicholas V DiPatrizio, Daniele Piomelli, Anthony G Comuzzie, Elizabeth J Parks. Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates.
American journal of physiology. Endocrinology and metabolism.
2012 Sep; 303(5):E624-34. doi:
10.1152/ajpendo.00072.2012. [PMID: 22761159] - David R Schulze, F Ivy Carroll, Lance R McMahon. Interactions between dopamine transporter and cannabinoid receptor ligands in rhesus monkeys.
Psychopharmacology.
2012 Aug; 222(3):425-38. doi:
10.1007/s00213-012-2661-9. [PMID: 22374253] - Maha M Elbatsh, M A A Moklas, C A Marsden, D A Kendall. Antidepressant-like effects of Δ⁹-tetrahydrocannabinol and rimonabant in the olfactory bulbectomised rat model of depression.
Pharmacology, biochemistry, and behavior.
2012 Aug; 102(2):357-65. doi:
10.1016/j.pbb.2012.05.009. [PMID: 22634064] - Rodrigo Rorato, Wagner Luis Reis, Beatriz de Carvalho Borges, José Antunes-Rodrigues, Lucila Leico Kagohara Elias. Cannabinoid CB₁ receptor restrains accentuated activity of hypothalamic corticotropin-releasing factor and brainstem tyrosine hydroxylase neurons in endotoxemia-induced hypophagia in rats.
Neuropharmacology.
2012 Jul; 63(1):154-60. doi:
10.1016/j.neuropharm.2011.11.009. [PMID: 22138163] - Samira G Ferreira, Filipe M Teixeira, Pedro Garção, Paula Agostinho, Catherine Ledent, Luísa Cortes, Ken Mackie, Attila Köfalvi. Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.
Neurochemistry international.
2012 Jul; 61(2):219-26. doi:
10.1016/j.neuint.2012.05.009. [PMID: 22609378] - Sandeep Singla, Rajesh Sachdeva, Jawahar L Mehta. Cannabinoids and atherosclerotic coronary heart disease.
Clinical cardiology.
2012 Jun; 35(6):329-35. doi:
10.1002/clc.21962. [PMID: 22278660] - Sawsan A Zaitone, Soha Essawy. Addition of a low dose of rimonabant to orlistat therapy decreases weight gain and reduces adiposity in dietary obese rats.
Clinical and experimental pharmacology & physiology.
2012 Jun; 39(6):551-9. doi:
10.1111/j.1440-1681.2012.05717.x. [PMID: 22524969] - Hanneke G M Wittgen, Rick Greupink, Jeroen J M W van den Heuvel, Petra H H van den Broek, Heike Dinter-Heidorn, Jan B Koenderink, Frans G M Russel. Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists.
Molecular pharmaceutics.
2012 May; 9(5):1351-60. doi:
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