4-Biphenylol (BioDeep_00000009771)

   


代谢物信息卡片


4-Hydroxybiphenyl

化学式: C12H10O (170.0732)
中文名称: 对羟基联苯, 4-苯基苯酚
谱图信息: 最多检出来源 Viridiplantae(not specific) 38.89%

分子结构信息

SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)O
InChI: InChI=1S/C12H10O/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,13H

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1154; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4839; ORIGINAL_PRECURSOR_SCAN_NO 4835
CONFIDENCE standard compound; INTERNAL_ID 1154; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4862; ORIGINAL_PRECURSOR_SCAN_NO 4859
CONFIDENCE standard compound; INTERNAL_ID 1154; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4882; ORIGINAL_PRECURSOR_SCAN_NO 4877
CONFIDENCE standard compound; INTERNAL_ID 1154; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4893; ORIGINAL_PRECURSOR_SCAN_NO 4890
CONFIDENCE standard compound; INTERNAL_ID 1154; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4872; ORIGINAL_PRECURSOR_SCAN_NO 4871
CONFIDENCE standard compound; INTERNAL_ID 1154; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4890; ORIGINAL_PRECURSOR_SCAN_NO 4887

同义名列表

5 个代谢物同义名

4-Hydroxybiphenyl; 4-Phenylphenol; 4-Biphenylol; 4-Hydroxybiphenyl; 4-Phenylphenol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ALB, AR, CYP2A6, CYP2B6, CYP2E1, ESRRB, HPGDS, NQO1, PGR, PLA2G12A, S100A6, S100G
Peripheral membrane protein 2 CYP2B6, CYP2E1
Endoplasmic reticulum membrane 8 CYP2A6, CYP2B6, CYP2E1, HSP90B1, SLC35A2, UGT1A1, UGT2B15, UGT2B7
Nucleus 7 ALB, AR, ESRRB, HSP90B1, NQO1, PGR, S100A6
cytosol 9 ALB, AR, ESRRB, HPGDS, HSP90B1, MYL4, NQO1, PGR, S100A6
dendrite 1 NQO1
centrosome 1 ALB
nucleoplasm 5 AR, ESRRB, HPGDS, PGR, SLC35A2
Multi-pass membrane protein 2 SLC35A2, SLC45A2
Golgi apparatus membrane 1 SLC35A2
Synapse 1 NQO1
Golgi apparatus 2 ALB, SLC35A2
Golgi membrane 1 SLC35A2
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 1 NQO1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 NQO1
plasma membrane 5 AR, IFNLR1, PGR, S100A6, UGT1A1
Membrane 9 AR, CYP2A6, HSP90B1, IFNLR1, NQO1, SLC45A2, UGT1A1, UGT2B15, UGT2B7
apical plasma membrane 1 S100G
basolateral plasma membrane 1 S100G
extracellular exosome 3 ALB, HSP90B1, S100A6
endoplasmic reticulum 4 ALB, HSP90B1, SLC35A2, UGT1A1
extracellular space 2 ALB, S100G
perinuclear region of cytoplasm 3 HSP90B1, S100A6, UGT1A1
protein-containing complex 3 ALB, AR, HSP90B1
intracellular membrane-bounded organelle 4 CYP2A6, CYP2B6, CYP2E1, HPGDS
Microsome membrane 2 CYP2B6, CYP2E1
Single-pass type I membrane protein 1 IFNLR1
Secreted 2 ALB, PLA2G12A
extracellular region 4 ALB, HSP90B1, PLA2G12A, S100A6
cytoplasmic side of plasma membrane 1 S100A6
Single-pass membrane protein 3 UGT1A1, UGT2B15, UGT2B7
mitochondrial outer membrane 1 PGR
anchoring junction 1 ALB
Melanosome membrane 1 SLC45A2
midbody 1 HSP90B1
Cytoplasm, perinuclear region 1 UGT1A1
Mitochondrion inner membrane 1 CYP2E1
focal adhesion 1 HSP90B1
collagen-containing extracellular matrix 2 HSP90B1, S100A6
nuclear speck 1 AR
ruffle 1 S100A6
ciliary basal body 1 ALB
chromatin 3 AR, ESRRB, PGR
Chromosome 1 ESRRB
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
myosin II complex 1 MYL4
nuclear envelope 1 S100A6
[Isoform 1]: Endoplasmic reticulum membrane 1 SLC35A2
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
endoplasmic reticulum lumen 2 ALB, HSP90B1
platelet alpha granule lumen 1 ALB
Sarcoplasmic reticulum lumen 1 HSP90B1
A band 1 MYL4
cytoplasmic microtubule 1 CYP2A6
condensed chromosome 1 ESRRB
endocytic vesicle lumen 1 HSP90B1
[Isoform 4]: Mitochondrion outer membrane 1 PGR
endoplasmic reticulum chaperone complex 2 HSP90B1, UGT1A1
[Isoform 2]: Golgi apparatus membrane 1 SLC35A2
cytochrome complex 1 UGT1A1
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Eliseo Herrero-Hernández, Rita Carabias-Martínez, Encarnacion Rodríguez-Gonzalo. Behavior of phenols and phenoxyacids on a bisphenol-A imprinted polymer. Application for selective solid-phase extraction from water and urine samples. International journal of molecular sciences. 2011; 12(5):3322-39. doi: 10.3390/ijms12053322. [PMID: 21686187]
  • Hong Sun, Xiao-Lin Xu, Jian-Hua Qu, Xia Hong, Yu-Bang Wang, Li-Chun Xu, Xin-Ru Wang. 4-Alkylphenols and related chemicals show similar effect on the function of human and rat estrogen receptor alpha in reporter gene assay. Chemosphere. 2008 Mar; 71(3):582-8. doi: 10.1016/j.chemosphere.2007.09.031. [PMID: 18028983]
  • Loretta Aureli, Gabriele Cruciani, Maria Candida Cesta, Roberto Anacardio, Lucio De Simone, Alessio Moriconi. Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Journal of medicinal chemistry. 2005 Apr; 48(7):2469-79. doi: 10.1021/jm049227l. [PMID: 15801837]
  • V Ivanov, V Stabnikov, W Q Zhuang, J H Tay, S T L Tay. Phosphate removal from the returned liquor of municipal wastewater treatment plant using iron-reducing bacteria. Journal of applied microbiology. 2005; 98(5):1152-61. doi: 10.1111/j.1365-2672.2005.02567.x. [PMID: 15836485]
  • Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology. 2003 Oct; 16(10):1338-58. doi: 10.1021/tx030011g. [PMID: 14565775]
  • Hiroshi Yokota, Yohko Kunimasa, Yasuko Shimoyama, Tsutomu Kobayashi, Junya Matsumoto, Akira Yuasa. Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat. Journal of biochemistry. 2002 Aug; 132(2):265-70. doi: 10.1093/oxfordjournals.jbchem.a003220. [PMID: 12153725]
  • M D Green, D J Clarke, E M Oturu, P B Styczynski, M R Jackson, B Burchell, T R Tephly. Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. Archives of biochemistry and biophysics. 1995 Oct; 322(2):460-8. doi: 10.1006/abbi.1995.1489. [PMID: 7574722]
  • M D Green, E M Oturu, T R Tephly. Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. Drug metabolism and disposition: the biological fate of chemicals. 1994 Sep; 22(5):799-805. doi: NULL. [PMID: 7835232]
  • F Chen, J K Ritter, M G Wang, O W McBride, R A Lubet, I S Owens. Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms. Biochemistry. 1993 Oct; 32(40):10648-57. doi: 10.1021/bi00091a015. [PMID: 8399210]
  • A Deng, X Yang, Y Yang, H Yang. [Study on determination of gentamycin by enhanced chemiluminescent immunoassay]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao. 1993 Mar; 24(1):101-3. doi: NULL. [PMID: 8340080]
  • T Yoshimura, S Tanaka, T Horie. Species difference and tissue distribution of uridine diphosphate-glucuronyltransferase activities toward E6080, 1-naphthol and 4-hydroxybiphenyl. Journal of pharmacobio-dynamics. 1992 Aug; 15(8):387-93. doi: 10.1248/bpb1978.15.387. [PMID: 1479538]
  • A N Sukach, A Iu Petrenko, A M Belous. [Role of albumin in the biotransformation of biphenyl by isolated rat hepatocytes]. Ukrainskii biokhimicheskii zhurnal (1978). 1991 Nov; 63(6):57-61. doi: . [PMID: 1816685]
  • G M Pacifici, L Vannucci, C Bencini, G Tusini, F Mosca. Sulphation of hydroxybiphenyls in human tissues. Xenobiotica; the fate of foreign compounds in biological systems. 1991 Sep; 21(9):1113-8. doi: 10.3109/00498259109039551. [PMID: 1788979]
  • G Powis, D J Moore, T J Wilke, K S Santone. A high-performance liquid chromatography assay for measuring integrated biphenyl metabolism by intact cells: its use with rat liver and human liver and kidney. Analytical biochemistry. 1987 Nov; 167(1):191-8. doi: 10.1016/0003-2697(87)90151-5. [PMID: 3434795]
  • F O Dorgelo, G Verver, G Wieling, R J Topp, J S Boleij, T M Pal. Urinary hydroxydiphenyl excretion of workers occupationally exposed to a mixture of diphenyl and diphenylether (Dowtherm A). International archives of occupational and environmental health. 1985; 56(2):129-34. doi: 10.1007/bf00379384. [PMID: 4055068]
  • P Paterson, J R Fry. The effect of ascorbic acid on the conjugation of 4-hydroxybiphenyl in rat isolated hepatocytes. Xenobiotica; the fate of foreign compounds in biological systems. 1983 Oct; 13(10):607-10. doi: 10.3109/00498258309052220. [PMID: 6673373]