8-Br-cGMP (BioDeep_00000009598)
代谢物信息卡片
2-amino-8-bromo-9-(2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphorin-6-yl)-3H-purin-6-one
化学式: C10H11BrN5O7P (422.9579)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(not specific) 50%
分子结构信息
SMILES: C1C2C(C(C(O2)N3C4=C(C(=O)NC(=N4)N)N=C3Br)O)OP(=O)(O1)O
InChI: InChI=1S/C10H11BrN5O7P/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18)
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:64108
- ChEBI: CHEBI:93924
- KEGG: C13817
- PubChem: 135419186
- PubChem: 135526720
- Metlin: METLIN69715
- ChEMBL: CHEMBL1741141
- CAS: 31356-94-2
- PMhub: MS000023397
- PubChem: 854062
- PDB-CCD: 6J7
- NIKKAJI: J314.094F
- KNApSAcK: 64108
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mayumi Ikeda, Yu Ishima, Victor T G Chuang, Tsuyoshi Ikeda, Ryo Kinoshita, Hiroshi Watanabe, Tatsuhiro Ishida, Masaki Otagiri, Toru Maruyama. Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition.
Nitric oxide : biology and chemistry.
2017 Sep; 69(?):28-34. doi:
10.1016/j.niox.2017.04.005. [PMID: 28414103] - Julia Dolinina, Kristinn Sverrisson, Anna Rippe, Carl M Öberg, Bengt Rippe. Nitric oxide synthase inhibition causes acute increases in glomerular permeability in vivo, dependent upon reactive oxygen species.
American journal of physiology. Renal physiology.
2016 11; 311(5):F984-F990. doi:
10.1152/ajprenal.00152.2016. [PMID: 27681559] - Peng Zhang, Ai-Qin Mao, Chun-Yuan Sun, Xiao-Dong Zhang, Qiong-Xi Pan, Dan-Tong Yang, Jian Jin, Chun-Lei Tang, Zhen-Yu Yang, Xiao-Qiang Yao, Xiao-Jie Lu, Xin Ma. Translocation of PKG1α acts on TRPV4-C1 heteromeric channels to inhibit endothelial Ca(2+) entry.
Acta pharmacologica Sinica.
2016 Sep; 37(9):1199-207. doi:
10.1038/aps.2016.43. [PMID: 27397542] - Qi-Fei Gao, Li-Li Gu, Hui-Qin Wang, Cui-Fang Fei, Xiang Fang, Jamshaid Hussain, Shu-Jing Sun, Jing-Yun Dong, Hongtao Liu, Yong-Fei Wang. Cyclic nucleotide-gated channel 18 is an essential Ca2+ channel in pollen tube tips for pollen tube guidance to ovules in Arabidopsis.
Proceedings of the National Academy of Sciences of the United States of America.
2016 Mar; 113(11):3096-101. doi:
10.1073/pnas.1524629113. [PMID: 26929345] - Zhenwei Shi, Feng Fu, Liming Yu, Wenjuan Xing, Feifei Su, Xiangyan Liang, Ru Tie, Lele Ji, Miaozhang Zhu, Jun Yu, Haifeng Zhang. Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms.
American journal of physiology. Heart and circulatory physiology.
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FEBS letters.
2014 Mar; 588(6):1008-15. doi:
10.1016/j.febslet.2014.01.062. [PMID: 24530500] - Jisheng Li, Honglei Jia, Jue Wang. cGMP and ethylene are involved in maintaining ion homeostasis under salt stress in Arabidopsis roots.
Plant cell reports.
2014 Mar; 33(3):447-59. doi:
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Plant physiology.
2013 Oct; 163(2):578-90. doi:
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Plant physiology and biochemistry : PPB.
2013 Sep; 70(?):142-9. doi:
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American journal of physiology. Renal physiology.
2013 Mar; 304(5):F543-52. doi:
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Cellular signalling.
2013 Mar; 25(3):630-8. doi:
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The Plant cell.
2013 Feb; 25(2):558-71. doi:
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Plant molecular biology.
2013 Jan; 81(1-2):27-40. doi:
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The Journal of biological chemistry.
2011 Jan; 286(4):2461-8. doi:
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Kidney international.
2010 Oct; 78(7):650-9. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Jan; 25(1):48-54. doi:
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Brain research bulletin.
2009 Dec; 80(6):428-32. doi:
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Platelets.
2009 Dec; 20(8):555-65. doi:
10.3109/09537100903337419. [PMID: 19874215] - Biguang Tuo, Guorong Wen, Yalin Zhang, Xuemei Liu, Xue Wang, Xiaoqiang Liu, Hui Dong. Involvement of phosphatidylinositol 3-kinase in cAMP- and cGMP-induced duodenal epithelial CFTR activation in mice.
American journal of physiology. Cell physiology.
2009 Sep; 297(3):C503-15. doi:
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Molecular brain.
2009 Aug; 2(?):26. doi:
10.1186/1756-6606-2-26. [PMID: 19656393] - Thejass Punathil, Santosh K Katiyar. Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2.
Molecular carcinogenesis.
2009 Mar; 48(3):232-242. doi:
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Journal of pharmacological sciences.
2009 Jan; 109(1):110-8. doi:
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American journal of physiology. Heart and circulatory physiology.
2009 Jan; 296(1):H195-201. doi:
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The Journal of surgical research.
2008 Nov; 150(1):66-73. doi:
10.1016/j.jss.2008.01.009. [PMID: 18468638] - Theresa A John, Basil O Ibe, J Usha Raj. Regulation of endothelial nitric oxide synthase: involvement of protein kinase G 1 beta, serine 116 phosphorylation and lipid structures.
Clinical and experimental pharmacology & physiology.
2008 Feb; 35(2):148-58. doi:
10.1111/j.1440-1681.2007.04801.x. [PMID: 17892503] - Tobias Schulz, Udo Schumacher, Peter Prehm. Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP.
The Journal of biological chemistry.
2007 Jul; 282(29):20999-1004. doi:
10.1074/jbc.m700915200. [PMID: 17540771] - John J Peluso, Xiufang Liu, Jonathan Romak. Progesterone maintains basal intracellular adenosine triphosphate levels and viability of spontaneously immortalized granulosa cells by promoting an interaction between 14-3-3sigma and ATP synthase beta/precursor through a protein kinase G-dependent mechanism.
Endocrinology.
2007 May; 148(5):2037-44. doi:
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Journal of atherosclerosis and thrombosis.
2006 Dec; 13(6):286-94. doi:
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Anesthesiology.
2006 Nov; 105(5):976-83. doi:
10.1097/00000542-200611000-00019. [PMID: 17065892] - Yih-Jer Wu, Mark Bond, Graciela B Sala-Newby, Andrew C Newby. Altered S-phase kinase-associated protein-2 levels are a major mediator of cyclic nucleotide-induced inhibition of vascular smooth muscle cell proliferation.
Circulation research.
2006 May; 98(9):1141-50. doi:
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Nitric oxide : biology and chemistry.
2006 May; 14(3):200-11. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2006 Mar; 290(3):G535-42. doi:
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Regulatory peptides.
2005 Dec; 132(1-3):1-8. doi:
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The Journal of pharmacology and experimental therapeutics.
2005 Jul; 314(1):9-15. doi:
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Experimental physiology.
2005 Jul; 90(4):577-86. doi:
10.1113/expphysiol.2004.029611. [PMID: 15833757] - Muriel André, Hélia Latado, Emanuela Felley-Bosco. Inducible nitric oxide synthase-dependent stimulation of PKGI and phosphorylation of VASP in human embryonic kidney cells.
Biochemical pharmacology.
2005 Feb; 69(4):595-602. doi:
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Arteriosclerosis, thrombosis, and vascular biology.
2004 Aug; 24(8):1403-8. doi:
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International journal for parasitology.
2004 Jul; 34(8):909-14. doi:
10.1016/j.ijpara.2004.04.003. [PMID: 15217729] - Roberto Rodriguez, Bruno Molino, Harvey R Weiss, Peter M Scholz. Negative metabolic and coronary flow effects of decreases in cAMP and increases in cGMP in control and renal hypertensive rabbit hearts.
Journal of applied physiology (Bethesda, Md. : 1985).
2004 Jul; 97(1):439-45. doi:
10.1152/japplphysiol.01115.2003. [PMID: 14990553] - Xiao-Hong Jin, Helen E McGrath, John J Gildea, Helmy M Siragy, Robin A Felder, Robert M Carey. Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G.
Hypertension (Dallas, Tex. : 1979).
2004 May; 43(5):1133-9. doi:
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Hypertension (Dallas, Tex. : 1979).
2004 Apr; 43(4):866-71. doi:
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Hypertension (Dallas, Tex. : 1979).
2004 Feb; 43(2):286-91. doi:
10.1161/01.hyp.0000112421.18551.1e. [PMID: 14718358] - Gursev S Dhaunsi, Pinar T Ozand. Nitric oxide promotes mitogen-induced dna synthesis in human dermal fibroblasts through cGMP.
Clinical and experimental pharmacology & physiology.
2004 Jan; 31(1-2):46-9. doi:
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Nephron. Experimental nephrology.
2004; 96(2):e59-66. doi:
10.1159/000076405. [PMID: 14988593] - Joseph Zimpelmann, Ningjun Li, Kevin D Burns. Nitric oxide inhibits superoxide-stimulated urea permeability in the rat inner medullary collecting duct.
American journal of physiology. Renal physiology.
2003 Dec; 285(6):F1160-7. doi:
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Experimental neurology.
2003 Dec; 184(2):846-56. doi:
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Plant cell reports.
2003 Sep; 22(2):85-95. doi:
10.1007/s00299-003-0673-y. [PMID: 12879261] - Charles Henry Cottart, Valérie Nivet-Antoine, Louis Do, Ghassan Al-Massarani, Geneviéve Descamps, François Xavier-Galen, Jean-Pierre Clot. Hepatic cytoprotection by nitric oxide and the cGMP pathway after ischaemia-reperfusion in the rat.
Nitric oxide : biology and chemistry.
2003 Sep; 9(2):57-63. doi:
10.1016/j.niox.2003.09.003. [PMID: 14623171] - John M Hawdon, Bennett Datu. The second messenger cyclic GMP mediates activation in Ancylostoma caninum infective larvae.
International journal for parasitology.
2003 Jul; 33(8):787-93. doi:
10.1016/s0020-7519(03)00088-2. [PMID: 12865078] - El-Sayed Akool, Hartmut Kleinert, Farid M A Hamada, Mohamed H Abdelwahab, Ulrich Förstermann, Josef Pfeilschifter, Wolfgang Eberhardt. Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.
Molecular and cellular biology.
2003 Jul; 23(14):4901-16. doi:
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Brain research.
2003 Apr; 968(1):35-43. doi:
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American journal of physiology. Renal physiology.
2003 Jan; 284(1):F175-81. doi:
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American journal of physiology. Heart and circulatory physiology.
2002 Dec; 283(6):H2458-65. doi:
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Gastroenterology.
2002 Oct; 123(4):1291-303. doi:
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American journal of physiology. Cell physiology.
2002 Sep; 283(3):C752-61. doi:
10.1152/ajpcell.00501.2001. [PMID: 12176732] - Najma Begum, Oana A Sandu, Noreen Duddy. Negative regulation of rho signaling by insulin and its impact on actin cytoskeleton organization in vascular smooth muscle cells: role of nitric oxide and cyclic guanosine monophosphate signaling pathways.
Diabetes.
2002 Jul; 51(7):2256-63. doi:
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The Journal of biological chemistry.
2002 May; 277(20):17758-64. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2002 May; 282(5):R1436-42. doi:
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Metabolism: clinical and experimental.
2002 Feb; 51(2):175-9. doi:
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Biochemical pharmacology.
2002 Jan; 63(2):199-206. doi:
10.1016/s0006-2952(01)00873-5. [PMID: 11841794] - Tobias Polte, Anke Hemmerle, Georg Berndt, Nina Grosser, Aida Abate, Henning Schröder. Atrial natriuretic peptide reduces cyclosporin toxicity in renal cells: role of cGMP and heme oxygenase-1.
Free radical biology & medicine.
2002 Jan; 32(1):56-63. doi:
10.1016/s0891-5849(01)00761-4. [PMID: 11755317] - T Riediger, H A Schmid, T Lutz, E Simon. Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP.
American journal of physiology. Regulatory, integrative and comparative physiology.
2001 Dec; 281(6):R1833-43. doi:
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Pflugers Archiv : European journal of physiology.
2001 Nov; 443(2):306-13. doi:
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The Journal of biological chemistry.
2001 Sep; 276(36):33741-6. doi:
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Archives of biochemistry and biophysics.
2001 Sep; 393(1):97-105. doi:
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