tetrapentylammonium (BioDeep_00000009597)

   


代谢物信息卡片


tetrapentylammonium

化学式: C20H44N+ (298.3474)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCC[N+](CCCCC)(CCCCC)CCCCC
InChI: InChI=1S/C20H44N/c1-5-9-13-17-21(18-14-10-6-2,19-15-11-7-3)20-16-12-8-4/h5-20H2,1-4H3/q+1

描述信息

同义名列表

2 个代谢物同义名

tetrapentylammonium; Tetrapentylammonium



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ASIC3, AXIN2, EDN1, ITPR3, TNK1
Peripheral membrane protein 1 TNK1
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 2 AXIN2, KRT76
cytosol 6 AXIN2, KCNA1, KCNA6, KRT76, PKD2L1, PRKCQ
dendrite 2 KCNA1, KCNB1
centrosome 1 AXIN2
nucleoplasm 4 ATP2B1, ITPR3, SCN5A, SCNN1G
Cell membrane 11 ASIC2, ASIC3, ATP2B1, KCNA1, KCNA6, KCNB1, KCNC1, KCNK13, PKD2L1, SCN5A, SLC22A1
Cell projection, axon 3 KCNA1, KCNB1, KCNC1
Multi-pass membrane protein 15 ASIC2, ASIC3, ATP2B1, ITPR3, KCNA1, KCNA3, KCNA6, KCNB1, KCNC1, KCNK13, PKD2L1, SCN5A, SCNN1G, SLC22A1, SLC22A2
Synapse 3 ATP2B1, KCNA1, KCNB1
cell junction 2 KCNA1, SCN5A
cell surface 5 KCNA1, KCNB1, KCNC1, PKD2L1, SCN5A
glutamatergic synapse 3 ATP2B1, KCNA1, KCNA3
neuronal cell body 3 ASIC2, ITPR3, KCNA1
presynaptic membrane 4 ATP2B1, KCNA1, KCNA3, KCNC1
sarcolemma 2 KCNB1, SCN5A
Presynapse 3 KCNA1, SLC22A1, SLC22A2
plasma membrane 18 ASIC2, ASIC3, ATP2B1, AXIN2, ITPR3, KCNA1, KCNA3, KCNA6, KCNB1, KCNC1, KCNK13, PKD2L1, PRKCQ, SCN5A, SCNN1G, SLC22A1, SLC22A2, TNK1
synaptic vesicle membrane 1 ATP2B1
Membrane 13 ASIC3, ATP2B1, ITPR3, KCNA1, KCNA3, KCNA6, KCNB1, KCNC1, PKD2L1, SCN5A, SLC22A1, SLC22A2, TNK1
apical plasma membrane 5 KCNA1, KCNB1, SCNN1G, SLC22A1, SLC22A2
axon 2 KCNA3, KCNB1
basolateral plasma membrane 3 ATP2B1, SLC22A1, SLC22A2
brush border 1 ITPR3
caveola 1 SCN5A
extracellular exosome 4 ATP2B1, KRT76, SCNN1G, SLC22A2
endoplasmic reticulum 4 ITPR3, KCNA1, PKD2L1, SCN5A
extracellular space 1 EDN1
perinuclear region of cytoplasm 4 ASIC3, KCNA3, KCNB1, SCN5A
intercalated disc 1 SCN5A
intracellular membrane-bounded organelle 3 ATP2B1, KCNA6, PKD2L1
Secreted 1 EDN1
extracellular region 1 EDN1
basal part of cell 1 EDN1
neuronal cell body membrane 2 KCNB1, KCNC1
anchoring junction 1 KCNA1
centriolar satellite 1 PRKCQ
ciliary membrane 1 PKD2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 SCNN1G
actin cytoskeleton 1 PKD2L1
dendritic spine 1 ASIC2
T-tubule 1 SCN5A
perikaryon 2 KCNA1, KCNB1
Z disc 1 SCN5A
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 2 KCNA1, PKD2L1
nucleolus 2 ITPR3, SCN5A
apical part of cell 1 ITPR3
postsynaptic membrane 4 KCNA1, KCNA3, KCNB1, KCNC1
Apical cell membrane 3 SCNN1G, SLC22A1, SLC22A2
Cell membrane, sarcolemma 1 KCNB1
Cytoplasm, perinuclear region 1 SCN5A
Membrane raft 1 KCNA3
axolemma 1 KCNC1
sarcoplasmic reticulum 1 ITPR3
intermediate filament 1 KRT76
lateral plasma membrane 4 ATP2B1, KCNB1, SCN5A, SLC22A1
nuclear outer membrane 1 ITPR3
Postsynaptic cell membrane 1 KCNB1
receptor complex 2 ITPR3, PKD2L1
cell projection 1 ATP2B1
non-motile cilium 1 PKD2L1
Basolateral cell membrane 3 ATP2B1, SLC22A1, SLC22A2
[Isoform 2]: Cell membrane 1 KCNA3
monoatomic ion channel complex 1 KCNK13
sodium channel complex 1 SCNN1G
axon initial segment 1 KCNA1
Cell projection, dendrite 2 KCNA1, KCNB1
Presynaptic cell membrane 3 ATP2B1, KCNA1, KCNC1
basal plasma membrane 2 SLC22A1, SLC22A2
Cell membrane, sarcolemma, T-tubule 1 SCN5A
potassium channel complex 1 KCNA6
voltage-gated potassium channel complex 5 KCNA1, KCNA3, KCNA6, KCNB1, KCNC1
secretory granule membrane 1 ITPR3
axon terminus 3 KCNA1, KCNA6, KCNC1
transport vesicle 1 EDN1
paranode region of axon 1 KCNA1
postsynaptic density membrane 1 ASIC2
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
calyx of Held 3 KCNA1, KCNA3, KCNC1
calcium channel complex 1 PKD2L1
platelet dense tubular network membrane 1 ITPR3
Synapse, synaptosome 1 KCNB1
Basal cell membrane 2 SLC22A1, SLC22A2
Lateral cell membrane 2 KCNB1, SLC22A1
postsynaptic specialization membrane 1 KCNB1
[Isoform 1]: Cell membrane 1 KCNA3
dendrite membrane 2 KCNB1, KCNC1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
keratin filament 1 KRT76
Cell projection, cilium membrane 1 PKD2L1
voltage-gated sodium channel complex 1 SCN5A
cholinergic synapse 1 KCNB1
transport vesicle membrane 1 ITPR3
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
proximal dendrite 1 KCNB1
photoreceptor ribbon synapse 1 ATP2B1
juxtaparanode region of axon 1 KCNA1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3


文献列表

  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Waleed Elsayed Ahmed Ellawatty, Yusuke Masuo, Ken-Ichi Fujita, Erina Yamazaki, Hiroo Ishida, Hiroshi Arakawa, Noritaka Nakamichi, Ramadan Abdelwahed, Yasutsuna Sasaki, Yukio Kato. Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib. Drug metabolism and disposition: the biological fate of chemicals. 2018 01; 46(1):33-40. doi: 10.1124/dmd.117.076554. [PMID: 29089306]
  • Vivian Massmann, Bayram Edemir, Eberhard Schlatter, Rouvier Al-Monajjed, Saliha Harrach, Philipp Klassen, Svenja K Holle, Aleksandra Sindic, Marina Dobrivojevic, Hermann Pavenstädt, Giuliano Ciarimboli. The organic cation transporter 3 (OCT3) as molecular target of psychotropic drugs: transport characteristics and acute regulation of cloned murine OCT3. Pflugers Archiv : European journal of physiology. 2014 Mar; 466(3):517-27. doi: 10.1007/s00424-013-1335-8. [PMID: 23982114]
  • Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L Silver, Norihisa Ishiwata, Yukio Kato. Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent. Drug metabolism and disposition: the biological fate of chemicals. 2011 Jun; 39(6):1088-96. doi: 10.1124/dmd.110.037960. [PMID: 21422191]
  • Martijn J Wilmer, Moin A Saleem, Rosalinde Masereeuw, Lan Ni, Thea J van der Velden, Frans G Russel, Peter W Mathieson, Leo A Monnens, Lambertus P van den Heuvel, Elena N Levtchenko. Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters. Cell and tissue research. 2010 Feb; 339(2):449-57. doi: 10.1007/s00441-009-0882-y. [PMID: 19902259]
  • Xiao-Qing Dai, Alkarim Ramji, Yan Liu, Qiang Li, Edward Karpinski, Xing-Zhen Chen. Inhibition of TRPP3 channel by amiloride and analogs. Molecular pharmacology. 2007 Dec; 72(6):1576-85. doi: 10.1124/mol.107.037150. [PMID: 17804601]
  • Min-Koo Choi, Qing-Ri Jin, Hyo-Eon Jin, Chang-Koo Shim, Doo-Yeoun Cho, Jae-Gook Shin, Im-Sook Song. Effects of tetraalkylammonium compounds with different affinities for organic cation transporters on the pharmacokinetics of metformin. Biopharmaceutics & drug disposition. 2007 Dec; 28(9):501-10. doi: 10.1002/bdd.576. [PMID: 17876861]
  • Jürgen Biermann, Detlef Lang, Valentin Gorboulev, Hermann Koepsell, Aleksandra Sindic, Rita Schröter, Aurelija Zvirbliene, Hermann Pavenstädt, Eberhard Schlatter, Giuliano Ciarimboli. Characterization of regulatory mechanisms and states of human organic cation transporter 2. American journal of physiology. Cell physiology. 2006 Jun; 290(6):C1521-31. doi: 10.1152/ajpcell.00622.2005. [PMID: 16394027]
  • Xiao-Qing Dai, Edward Karpinski, Xing-Zhen Chen. Permeation and inhibition of polycystin-L channel by monovalent organic cations. Biochimica et biophysica acta. 2006 Feb; 1758(2):197-205. doi: 10.1016/j.bbamem.2006.01.020. [PMID: 16564495]
  • Thorsten Keller, Marco Elfeber, Valentin Gorboulev, Helmut Reiländer, Hermann Koepsell. Purification and functional reconstitution of the rat organic cation transporter OCT1. Biochemistry. 2005 Sep; 44(36):12253-63. doi: 10.1021/bi050676c. [PMID: 16142924]
  • Shinghua Ding, Lindsey Ingleby, Christopher A Ahern, Richard Horn. Investigating the putative glycine hinge in Shaker potassium channel. The Journal of general physiology. 2005 Sep; 126(3):213-26. doi: 10.1085/jgp.200509287. [PMID: 16103276]
  • Georgia I Anyatonwu, Barbara E Ehrlich. Organic cation permeation through the channel formed by polycystin-2. The Journal of biological chemistry. 2005 Aug; 280(33):29488-93. doi: 10.1074/jbc.m504359200. [PMID: 15961385]
  • Rebecca S Lam, Andrew R Shaw, Marek Duszyk. Membrane cholesterol content modulates activation of BK channels in colonic epithelia. Biochimica et biophysica acta. 2004 Dec; 1667(2):241-8. doi: 10.1016/j.bbamem.2004.11.004. [PMID: 15581861]
  • Dallas Bednarczyk, Sean Ekins, James H Wikel, Stephen H Wright. Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Molecular pharmacology. 2003 Mar; 63(3):489-98. doi: 10.1124/mol.63.3.489. [PMID: 12606755]
  • Xiaohong Zhang, Kristen K Evans, Stephen H Wright. Molecular cloning of rabbit organic cation transporter rbOCT2 and functional comparisons with rbOCT1. American journal of physiology. Renal physiology. 2002 Jul; 283(1):F124-33. doi: 10.1152/ajprenal.00367.2001. [PMID: 12060594]
  • D H Sweet, D S Miller, J B Pritchard. Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. The Journal of biological chemistry. 2001 Nov; 276(45):41611-9. doi: 10.1074/jbc.m108472200. [PMID: 11553644]
  • Y Urakami, M Okuda, S Masuda, M Akazawa, H Saito, K Inui. Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharmaceutical research. 2001 Nov; 18(11):1528-34. doi: 10.1023/a:1013070128668. [PMID: 11758759]
  • M J Dresser, A T Gray, K M Giacomini. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1). The Journal of pharmacology and experimental therapeutics. 2000 Mar; 292(3):1146-52. doi: NULL. [PMID: 10688634]
  • V Gorboulev, C Volk, P Arndt, A Akhoundova, H Koepsell. Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate. Molecular pharmacology. 1999 Dec; 56(6):1254-61. doi: 10.1124/mol.56.6.1254. [PMID: 10570053]
  • L Zhang, M E Schaner, K M Giacomini. Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). The Journal of pharmacology and experimental therapeutics. 1998 Jul; 286(1):354-61. doi: NULL. [PMID: 9655880]
  • V Gorboulev, J C Ulzheimer, A Akhoundova, I Ulzheimer-Teuber, U Karbach, S Quester, C Baumann, F Lang, A E Busch, H Koepsell. Cloning and characterization of two human polyspecific organic cation transporters. DNA and cell biology. 1997 Jul; 16(7):871-81. doi: 10.1089/dna.1997.16.871. [PMID: 9260930]
  • K H DeSilva, F B Vest, H T Karnes. Pyrene sulphonyl chloride as a reagent for quantitation of oestrogens in human serum using HPLC with conventional and laser-induced fluorescence detection. Biomedical chromatography : BMC. 1996 Nov; 10(6):318-24. doi: 10.1002/(sici)1099-0801(199611)10:6<318::aid-bmc604>3.0.co;2-y. [PMID: 8949914]
  • C E Groves, S H Wright. Tetrapentylammonium (TPeA): slowly dissociating inhibitor of the renal peritubular organic cation transporter. Biochimica et biophysica acta. 1995 Mar; 1234(1):37-42. doi: 10.1016/0005-2736(94)00256-o. [PMID: 7880858]
  • D Gründemann, V Gorboulev, S Gambaryan, M Veyhl, H Koepsell. Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 1994 Dec; 372(6506):549-52. doi: 10.1038/372549a0. [PMID: 7990927]
  • A M Lisi, R Kazlauskas, G J Trout. Diuretic screening in human urine by gas chromatography-mass spectrometry: use of a macroreticular acrylic copolymer for the efficient removal of the coextracted phase-transfer reagent after derivatization by direct extractive alkylation. Journal of chromatography. 1992 Oct; 581(1):57-63. doi: 10.1016/0378-4347(92)80447-x. [PMID: 1430008]
  • A Tinker, A R Lindsay, A J Williams. Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel. Biophysical journal. 1992 May; 61(5):1122-32. doi: 10.1016/s0006-3495(92)81922-7. [PMID: 1318091]
  • J Iwata, T Suga. Direct determination of four sulfates and seven glucuronides of 17-oxosteroids in urine by fluorescence "high-performance" liquid chromatography. Clinical chemistry. 1989 May; 35(5):794-9. doi: . [PMID: 2720972]
  • K Ensing, R A de Zeeuw. Radioreceptor assay for oxyphenonium. European journal of respiratory diseases. Supplement. 1984; 135(?):143-6. doi: NULL. [PMID: 6428927]
  • K Shiba, Y Umezawa, T Watanabe, S Ogawa, S Fujiwara. Thin-layer potentiometric analysis of lipid antigen-antibody reaction by tetrapentylammonium (TPA+) ion loaded liposomes and TPA+ ion selective electrode. Analytical chemistry. 1980 Sep; 52(11):1610-3. doi: 10.1021/ac50061a018. [PMID: 7435981]
  • A Ashford. [Effects of adrenergic blockade on adipose tissue lipolysis provoked in cats and humans by intravenous perfusion of isoprenaline]. La Nouvelle presse medicale. 1975 Dec; 4(46 Suppl):3265-7. doi: . [PMID: 3767]