alfaxalone (BioDeep_00000009590)
代谢物信息卡片
3-Hydroxypregnane-11,20-dione
化学式: C21H32O3 (332.23513219999995)
中文名称: 阿法沙龙
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)C1CCC2C1(CC(=O)C3C2CCC4C3(CCC(C4)O)C)C
InChI: InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
D018377 - Neurotransmitter Agents > D000081227 - Neurosteroids
同义名列表
3 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34531
- KEGG: C13803
- KEGGdrug: D07282
- PubChem: 104845
- Metlin: METLIN69710
- DrugBank: DB11371
- ChEMBL: CHEMBL190279
- CAS: 23930-19-0
- PMhub: MS000023385
- PubChem: 854048
- PDB-CCD: EY4
- NIKKAJI: J3.157G
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kayla Hasse, Amanda Crawford, Daniel Gustafson, Sangeeta Rao, Eric Klaphake, Matthew Johnston. PLASMA CONCENTRATION AND PHARMACODYNAMICS OF INTRAMUSCULAR ADMINISTRATION OF ALFAXALONE IN INDIAN PEAFOWL (PAVO CRISTATUS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2022 Mar; 53(1):108-115. doi:
10.1638/2020-0220. [PMID: 35339155] - Ciara A Barr, Fabio Alvarado, Yu-Mei Chang, Jie Luo, Oliver A Garden. The impact of alfaxalone, propofol and ketamine on canine peripheral blood lymphocyte cytotoxicity in vitro.
Research in veterinary science.
2021 May; 136(?):182-184. doi:
10.1016/j.rvsc.2021.02.019. [PMID: 33676156] - I D Yozova, H Sano, K Weidgraaf, E J Candy, J F Cockrem. A randomized cross-over trial assessing salivary and urinary cortisol concentrations after alfaxalone and propofol administration in healthy cats.
Domestic animal endocrinology.
2021 01; 74(?):106557. doi:
10.1016/j.domaniend.2020.106557. [PMID: 33039929] - Gareth E Zeiler, Andrea Fuller, Eva Rioja, Peter Kamerman, Roxanne K Buck, Friederike Pohlin, Brighton T Dzikiti. Development of a severity scoring system for acute haemorrhage in anaesthetized domestic cats: the CABSS score.
Veterinary anaesthesia and analgesia.
2020 Jul; 47(4):499-508. doi:
10.1016/j.vaa.2019.11.008. [PMID: 32507719] - Pedro Marín, Eliseo Belda, Francisco G Laredo, Crhystian A Torres, Verónica Hernandis, Elisa Escudero. Pharmacokinetics and sedative effects of alfaxalone with or without dexmedetomidine in rabbits.
Research in veterinary science.
2020 Apr; 129(?):6-12. doi:
10.1016/j.rvsc.2019.12.015. [PMID: 31901533] - Colin S Goodchild, Juliet M Serrao, John W Sear, Brian J Anderson. Pharmacokinetic and Pharmacodynamic Analysis of Alfaxalone Administered as a Bolus Intravenous Injection of Phaxan in a Phase 1 Randomized Trial.
Anesthesia and analgesia.
2020 03; 130(3):704-714. doi:
10.1213/ane.0000000000004204. [PMID: 31124836] - Tamara N Kruse, Kristen M Messenger, Andrew S Bowman, Turi K Aarnes, Thomas E Wittum, Mark Flint. Pharmacokinetics and pharmacodynamics of alfaxalone after a single intramuscular or intravascular injection in mallard ducks (Anas platyrhynchos).
Journal of veterinary pharmacology and therapeutics.
2019 Nov; 42(6):713-721. doi:
10.1111/jvp.12804. [PMID: 31435964] - Bruno H Pypendop, Linda S Barter, Peter J Pascoe, M G Ranasinghe, Kirby Pasloske. Hemodynamic effects of subclinical, clinical and supraclinical plasma alfaxalone concentrations in cats.
Veterinary anaesthesia and analgesia.
2019 Sep; 46(5):597-604. doi:
10.1016/j.vaa.2019.05.004. [PMID: 31303447] - Julie A Balko, Dana M Lindemann, Matthew C Allender, Sathya K Chinnadurai. Evaluation of the anesthetic and cardiorespiratory effects of intramuscular alfaxalone administration and isoflurane in budgerigars (Melopsittacus undulatus) and comparison with manual restraint.
Journal of the American Veterinary Medical Association.
2019 06; 254(12):1427-1435. doi:
10.2460/javma.254.12.1427. [PMID: 31149875] - Ai Wakuno, Motoki Aoki, Asuka Kushiro, Naomi Mae, Tatsuya Maeda, Yosuke Yamazaki, Yohei Minamijima, Shun-Ichi Nagata, Minoru Ohta. Clinical pharmacokinetics and pharmacodynamics of intravenous alfaxalone in young Thoroughbred horses premedicated with medetomidine and midazolam.
The Veterinary record.
2019 03; 184(13):411. doi:
10.1136/vr.105070. [PMID: 30926700] - Katherine J Bennett, Reza Seddighi, Kaitlin A Moorhead, Kristin Messenger, Sherry K Cox, Xiaocun Sun, Kirby Pasloske, Bruno H Pypendop, Thomas J Doherty. Effect of fentanyl on the induction dose and minimum infusion rate of alfaxalone preventing movement in dogs.
Veterinary anaesthesia and analgesia.
2019 Mar; 46(2):173-181. doi:
10.1016/j.vaa.2018.10.006. [PMID: 30554890] - Wendy A Goodwin, Kirby Pasloske, Helen L Keates, Millaganamada Gedara Ranasinghe, Solomon Woldeyohannes, Nigel Perkins. Alfaxalone for total intravenous anaesthesia in horses.
Veterinary anaesthesia and analgesia.
2019 Mar; 46(2):188-199. doi:
10.1016/j.vaa.2018.09.047. [PMID: 30713053] - Hirotaka Tokushige, Asuka Kushiro, Atsushi Okano, Tatsuya Maeda, Hideki Ito, Ai Wakuno, Shun-Ichi Nagata, Minoru Ohta. Clinical evaluation of constant rate infusion of alfaxalone-medetomidine combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery.
Acta veterinaria Scandinavica.
2018 Sep; 60(1):50. doi:
10.1186/s13028-018-0406-4. [PMID: 30180855] - Bruno H Pypendop, M G Ranasinghe, Kirby Pasloske. Pharmacokinetics of alfaxalone infusions, context-sensitive half-time and recovery times in male neutered cats.
Veterinary anaesthesia and analgesia.
2018 Sep; 45(5):630-639. doi:
10.1016/j.vaa.2018.06.003. [PMID: 30057008] - D Rodrigo-Mocholí, E Escudero, E Belda, F G Laredo, V Hernandis, P Marín. Pharmacokinetics and effects of alfaxalone after intravenous and intramuscular administration to cats.
New Zealand veterinary journal.
2018 Jul; 66(4):172-177. doi:
10.1080/00480169.2018.1455541. [PMID: 29562829] - Bruno H Pypendop, M G Ranasinghe, Kirby Pasloske. Comparison of two intravenous anesthetic infusion regimens for alfaxalone in cats.
Veterinary anaesthesia and analgesia.
2018 Jul; 45(4):459-466. doi:
10.1016/j.vaa.2018.03.003. [PMID: 29853416] - K Pasloske, M G Ranasinghe, S Sauer, J Hare. The bioequivalence of a single intravenous administration of the anesthetic alfaxalone in cyclodextrin versus alfaxalone in cyclodextrin plus preservatives in cats.
Journal of veterinary pharmacology and therapeutics.
2018 Jun; 41(3):437-446. doi:
10.1111/jvp.12485. [PMID: 29352472] - Bruno H Pypendop, Kristine T Siao, M G Ranasinghe, Kirby Pasloske. Effective plasma alfaxalone concentration to produce immobility in male neutered cats.
Veterinary anaesthesia and analgesia.
2018 May; 45(3):269-277. doi:
10.1016/j.vaa.2017.10.006. [PMID: 29415861] - Franz Josef Söbbeler, Inés Carrera, Kirby Pasloske, Millagahamada Gedara Ranasinghe, Patrick Kircher, Sabine Beate Rita Kästner. Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS).
BMC veterinary research.
2018 Mar; 14(1):69. doi:
10.1186/s12917-018-1396-1. [PMID: 29506576] - Inga-Catalina Cruz-Benedetti, Isabelle Bublot, Thibault Ribas, Isabelle Fourel, Claus Vogl, Claire Dubois, Mathilde Milani, Keila Kazue Ida, Karine Portier. Pharmacokinetics of intramuscular alfaxalone and its echocardiographic, cardiopulmonary and sedative effects in healthy dogs.
PloS one.
2018; 13(9):e0204553. doi:
10.1371/journal.pone.0204553. [PMID: 30248146] - Pavel Y Savechenkov, David C Chiara, Rooma Desai, Alexander T Stern, Xiaojuan Zhou, Alexis M Ziemba, Andrea L Szabo, Yinghui Zhang, Jonathan B Cohen, Stuart A Forman, Keith W Miller, Karol S Bruzik. Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.
European journal of medicinal chemistry.
2017 Aug; 136(?):334-347. doi:
10.1016/j.ejmech.2017.04.043. [PMID: 28505538] - Rachel C Bennett, Kati M Salla, Marja R Raekallio, Mika Scheinin, Outi M Vainio. Effects of the α2-adrenoceptor agonist medetomidine on the distribution and clearance of alfaxalone during coadministration by constant rate infusion in dogs.
American journal of veterinary research.
2017 Aug; 78(8):956-964. doi:
10.2460/ajvr.78.8.956. [PMID: 28738010] - Kirk A Muñoz, Sheilah A Robertson, Deborah V Wilson. Alfaxalone alone or combined with midazolam or ketamine in dogs: intubation dose and select physiologic effects.
Veterinary anaesthesia and analgesia.
2017 Jul; 44(4):766-774. doi:
10.1016/j.vaa.2017.01.004. [PMID: 28756063] - Kate L White, Stuart Paine, John Harris. A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion.
Veterinary anaesthesia and analgesia.
2017 Jul; 44(4):865-875. doi:
10.1016/j.vaa.2017.01.001. [PMID: 28318987] - Colin S Goodchild, Juliet M Serrao, Anton Kolosov, Ben J Boyd. Alphaxalone Reformulated: A Water-Soluble Intravenous Anesthetic Preparation in Sulfobutyl-Ether-β-Cyclodextrin.
Anesthesia and analgesia.
2015 May; 120(5):1025-1031. doi:
10.1213/ane.0000000000000559. [PMID: 25517195] - Jean-Loup Rault, Kate Plush, Tamara Yawno, Pieter Langendijk. Allopregnanolone and social stress: regulation of the stress response in early pregnancy in pigs.
Stress (Amsterdam, Netherlands).
2015; 18(5):569-77. doi:
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Neuropharmacology.
2014 Oct; 85(?):342-8. doi:
10.1016/j.neuropharm.2014.05.031. [PMID: 24880086] - Andrea Schwarz, Karin Kalchofner, Julia Palm, Stephanie Picek, Sonja Hartnack, Regula Bettschart-Wolfensberger. Minimum infusion rate of alfaxalone for total intravenous anaesthesia after sedation with acepromazine or medetomidine in cats undergoing ovariohysterectomy.
Veterinary anaesthesia and analgesia.
2014 Sep; 41(5):480-90. doi:
10.1111/vaa.12144. [PMID: 24575797] - C Lau, M G Ranasinghe, I Shiels, H Keates, K Pasloske, M C Bellingham. Plasma pharmacokinetics of alfaxalone after a single intraperitoneal or intravenous injection of Alfaxan(®) in rats.
Journal of veterinary pharmacology and therapeutics.
2013 Oct; 36(5):516-20. doi:
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Anesthesiology.
2013 Jun; 118(6):1417-25. doi:
10.1097/aln.0b013e318289bcd3. [PMID: 23407108] - Wendy Goodwin, Helen Keates, Kirby Pasloske, Martin Pearson, Ben Sauer, Millagahamada G Ranasinghe. Plasma pharmacokinetics and pharmacodynamics of alfaxalone in neonatal foals after an intravenous bolus of alfaxalone following premedication with butorphanol tartrate.
Veterinary anaesthesia and analgesia.
2012 Sep; 39(5):503-10. doi:
10.1111/j.1467-2995.2012.00734.x. [PMID: 22642499] - Joanne N Michou, Elizabeth A Leece, Jacqueline C Brearley. Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dogs.
Veterinary anaesthesia and analgesia.
2012 May; 39(3):275-81. doi:
10.1111/j.1467-2995.2012.00709.x. [PMID: 22414225] - Nilufar Foadi, Igor Pilawski, Vanessa Buchholz, Jeanne de la Roche, Florian Wegner, Andreas Leffler, Jörg Ahrens, Sabine Kästner. Interaction of alfaxalone with the neuronal and the skeletal muscle sodium channel.
Pharmacology.
2012; 89(5-6):295-302. doi:
10.1159/000337737. [PMID: 22538831] - Wendy A Goodwin, Helen L Keates, Kirby Pasloske, Martin Pearson, Ben Sauer, Millaganamada Gedara Ranasinghe. The pharmacokinetics and pharmacodynamics of the injectable anaesthetic alfaxalone in the horse.
Veterinary anaesthesia and analgesia.
2011 Sep; 38(5):431-8. doi:
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Molecular vision.
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Psychoneuroendocrinology.
2009 Dec; 34 Suppl 1(?):S59-66. doi:
10.1016/j.psyneuen.2009.05.020. [PMID: 19541427] - K Pasloske, B Sauer, N Perkins, T Whittem. Plasma pharmacokinetics of alfaxalone in both premedicated and unpremedicated Greyhound dogs after single, intravenous administration of Alfaxan at a clinical dose.
Journal of veterinary pharmacology and therapeutics.
2009 Oct; 32(5):510-3. doi:
10.1111/j.1365-2885.2009.01070.x. [PMID: 19754921] - T Whittem, K S Pasloske, M C Heit, M G Ranasinghe. The pharmacokinetics and pharmacodynamics of alfaxalone in cats after single and multiple intravenous administration of Alfaxan at clinical and supraclinical doses.
Journal of veterinary pharmacology and therapeutics.
2008 Dec; 31(6):571-9. doi:
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Methods in molecular biology (Clifton, N.J.).
2007; 400(?):587-600. doi:
10.1007/978-1-59745-519-0_39. [PMID: 17951761] - Pierre J Ferré, Kirby Pasloske, Ted Whittem, Millagahamanda G Ranasinghe, Qiang Li, Hervé P Lefebvre. Plasma pharmacokinetics of alfaxalone in dogs after an intravenous bolus of Alfaxan-CD RTU.
Veterinary anaesthesia and analgesia.
2006 Jul; 33(4):229-36. doi:
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British journal of anaesthesia.
2004 May; 92(5):704-11. doi:
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The Journal of pharmacology and experimental therapeutics.
2003 Nov; 307(2):765-75. doi:
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Anesthesia and analgesia.
2002 Dec; 95(6):1661-6, table of contents. doi:
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The Journal of pharmacology and experimental therapeutics.
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European journal of pharmacology.
2002 Aug; 449(1-2):85-90. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
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The Journal of pharmacy and pharmacology.
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Molecular pharmacology.
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Biochimica et biophysica acta.
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Anesthesia and analgesia.
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Pharmacology, biochemistry, and behavior.
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Journal of medicinal chemistry.
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The Journal of endocrinology.
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British journal of anaesthesia.
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The Journal of endocrinology.
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Biochemistry.
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The Journal of endocrinology.
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Anaesthesia and intensive care.
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