Selfotel (BioDeep_00000009540)

   


代谢物信息卡片


4-(phosphonomethyl)piperidine-2-carboxylic acid

化学式: C7H14NO5P (223.06095639999998)
中文名称: 塞福太
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CNC(CC1CP(=O)(O)O)C(=O)O
InChI: InChI=1S/C7H14NO5P/c9-7(10)6-3-5(1-2-8-6)4-14(11,12)13/h5-6,8H,1-4H2,(H,9,10)(H2,11,12,13)

描述信息

D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
C26170 - Protective Agent > C1509 - Neuroprotective Agent
Same as: D02410

同义名列表

3 个代谢物同义名

CGS 19755; Selfotel; 4-(phosphonomethyl)piperidine-2-carboxylic acid



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Veronica Musante, Maria Summa, Rodrigo A Cunha, Maurizio Raiteri, Anna Pittaluga. Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. Journal of neurochemistry. 2011 May; 117(3):516-27. doi: 10.1111/j.1471-4159.2011.07223.x. [PMID: 21348870]
  • Xiao-Qiao Dong, Song-Bin Yang, Fang-Long Zhu, Qing-Wei Lv, Guo-Hai Zhang, Hang-Bin Huang. Resistin is associated with mortality in patients with traumatic brain injury. Critical care (London, England). 2010; 14(5):R190. doi: 10.1186/cc9307. [PMID: 21029428]
  • Janusz Stazka, Piotr Luchowski, Ewa M Urbanska. Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid. European journal of pharmacology. 2005 Jul; 517(3):217-23. doi: 10.1016/j.ejphar.2005.04.048. [PMID: 15961072]
  • Olov Nilsson, Stig O P Jacobsson, Christopher J Fowler. Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2003 Nov; 136(3):245-51. doi: 10.1016/s1532-0456(03)00228-x. [PMID: 14659458]
  • J Jolkkonen, K Puurunen, J Koistinaho, R Kauppinen, A Haapalinna, L Nieminen, J Sivenius. Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia. European journal of pharmacology. 1999 May; 372(1):31-6. doi: 10.1016/s0014-2999(99)00186-7. [PMID: 10374712]
  • S D Hess, L P Daggett, C Deal, C C Lu, E C Johnson, G Veliçelebi. Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors. Journal of neurochemistry. 1998 Mar; 70(3):1269-79. doi: 10.1046/j.1471-4159.1998.70031269.x. [PMID: 9489750]
  • M A Yenari, T E Bell, A N Kotake, M Powell, G K Steinberg. Dose escalation safety and tolerance study of the competitive NMDA antagonist selfotel (CGS 19755) in neurosurgery patients. Clinical neuropharmacology. 1998 Jan; 21(1):28-34. doi: . [PMID: 9579282]
  • B Knoche, S Milosavljev, S Gropper, L A Brunner, M L Powell. Enantioselective determination of selfotel in human urine by high-performance liquid chromatography on a chiral stationary phase after derivatization with 9-fluorenylmethyl chloroformate. Journal of chromatography. B, Biomedical sciences and applications. 1997 Aug; 695(2):355-63. doi: 10.1016/s0378-4347(97)00196-5. [PMID: 9300872]
  • M J Hayes, L Khemani, M L Powell. Quantitative determination of the NMDA antagonist cis-4-phosphonomethyl-2-piperidine carboxylic acid (CGS 19755) in human plasma using capillary gas chromatography/mass spectrometry. Biological mass spectrometry. 1994 Sep; 23(9):555-61. doi: 10.1002/bms.1200230905. [PMID: 7948048]
  • M J Hogan, A Gjedde, A M Hakim. In vivo distribution of CGS-19755 within brain in a model of focal cerebral ischemia. Journal of neurochemistry. 1992 Jan; 58(1):186-91. doi: 10.1111/j.1471-4159.1992.tb09294.x. [PMID: 1727429]
  • W F Hood, R P Compton, J B Monahan. N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site. Journal of neurochemistry. 1990 Mar; 54(3):1040-6. doi: 10.1111/j.1471-4159.1990.tb02355.x. [PMID: 1968086]