NS-102 (BioDeep_00000009536)

   


代谢物信息卡片


5-Nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime

化学式: C12H11N3O4 (261.075)
中文名称: 6,7,8,9-四氢-5-硝基-1H-苯[g]吲哚-2,3-二酮 3-肟
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC2=C3C(=CC(=C2C1)[N+](=O)[O-])C(=C(N3)O)N=O
InChI: InChI=1S/C12H11N3O4/c16-12-11(14-17)8-5-9(15(18)19)6-3-1-2-4-7(6)10(8)13-12/h5,13,16H,1-4H2

描述信息

NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102 is a potent GluR6/7 receptor antagonist[1][2][3].

同义名列表

3 个代谢物同义名

5-Nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime; NS-102; NS-102



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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亚细胞结构定位 关联基因列表
Cytoplasm 8 BCL2, CA1, CA3, CASP3, DLG4, MAP2, MAPK10, MAPK8
Golgi apparatus, trans-Golgi network membrane 1 DLG4
Endoplasmic reticulum membrane 1 BCL2
Nucleus 8 BCL2, CASP3, FASLG, FOS, JUN, MAPK10, MAPK8, REPIN1
cytosol 11 BCL2, CA1, CA3, CASP3, DLG4, FOS, MAP2, MAP3K11, MAPK10, MAPK8, REPIN1
dendrite 4 GRIA2, GRIA4, GRIK3, MAP2
centrosome 1 MAP3K11
nucleoplasm 8 CASP3, FOS, GRIK2, GRIK5, JUN, MAPK10, MAPK8, REPIN1
RNA polymerase II transcription regulator complex 2 FOS, JUN
Cell membrane 9 DLG4, FASLG, GRIA2, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5
Lipid-anchor 2 DLG4, MAPK10
Cytoplasmic side 1 DLG4
Cell projection, axon 1 DLG4
Early endosome membrane 1 DLG4
Multi-pass membrane protein 7 GRIA2, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5
Golgi apparatus membrane 1 DLG4
Synapse 2 DLG4, MAPK8
cell junction 1 DLG4
dendritic shaft 1 MAP2
glutamatergic synapse 5 CASP3, DLG4, GRID1, GRIK2, GRIK3
Golgi membrane 1 DLG4
neuromuscular junction 1 DLG4
neuronal cell body 4 CASP3, GRIA2, GRIA4, MAP2
postsynapse 1 GRIA2
presynaptic membrane 4 GRIK1, GRIK2, GRIK3, GRIK5
synaptic vesicle 1 DLG4
Cytoplasm, cytosol 1 REPIN1
Presynapse 1 DLG4
plasma membrane 10 DLG4, FASLG, GRIA2, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5, MAPK10
terminal bouton 2 GRIK2, GRIK3
Membrane 9 BCL2, FASLG, GRIA2, GRIA4, GRIK2, GRIK3, GRIK5, MAP3K11, MAPK10
axon 3 DLG4, GRIK3, MAPK8
basolateral plasma membrane 1 DLG4
caveola 1 FASLG
extracellular exosome 3 CA1, FASLG, GRID1
endoplasmic reticulum 5 BCL2, DLG4, FOS, GRIK2, GRIK5
extracellular space 1 FASLG
lysosomal lumen 1 FASLG
perinuclear region of cytoplasm 1 FASLG
adherens junction 1 DLG4
mitochondrion 2 BCL2, MAPK10
protein-containing complex 1 BCL2
intracellular membrane-bounded organelle 1 GRIK1
postsynaptic density 4 CASP3, DLG4, GRIA2, GRIK2
Secreted 1 FASLG
extracellular region 1 FASLG
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
excitatory synapse 2 DLG4, GRIA2
hippocampal mossy fiber to CA3 synapse 2 GRIK2, GRIK5
Cytoplasmic vesicle lumen 1 FASLG
transcription regulator complex 1 JUN
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 MAP3K11
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, REPIN1
external side of plasma membrane 2 FASLG, GRIA2
Extracellular vesicle 1 GRIA4
dendritic spine 3 DLG4, GRIA2, GRIA4
perikaryon 2 GRIK2, GRIK3
neuron spine 1 DLG4
Single-pass type II membrane protein 1 FASLG
postsynaptic membrane 7 DLG4, GRIA2, GRIA4, GRID1, GRIK1, GRIK2, GRIK3
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 DLG4, MAP2
microtubule 2 MAP2, MAP3K11
GABA-ergic synapse 1 GRID1
Cell projection, dendritic spine 1 DLG4
Postsynaptic cell membrane 7 GRIA2, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5
dendrite cytoplasm 4 DLG4, GRIK2, GRIK3, MAP2
kainate selective glutamate receptor complex 4 GRIK1, GRIK2, GRIK3, GRIK5
mossy fiber rosette 1 GRIK2
neuron projection 2 DLG4, MAP2
chromatin 2 FOS, JUN
microtubule associated complex 1 MAP2
cell projection 2 GRIK2, GRIK5
Chromosome 1 REPIN1
cytoskeleton 1 DLG4
nuclear chromosome 1 JUN
AMPA glutamate receptor complex 3 DLG4, GRIA2, GRIA4
axon initial segment 1 MAP2
Cell projection, dendrite 3 DLG4, GRIA4, MAP2
euchromatin 1 JUN
Presynaptic cell membrane 2 GRIK2, GRIK5
dendritic growth cone 1 MAP2
myelin sheath 1 BCL2
synaptic membrane 1 DLG4
trans-Golgi network membrane 1 DLG4
nuclear matrix 1 FOS
cortical actin cytoskeleton 1 DLG4
endocytic vesicle membrane 3 DLG4, GRIA2, GRIA4
proximal neuron projection 1 MAP2
cerebellar mossy fiber 1 DLG4
Lysosome lumen 1 FASLG
postsynaptic density membrane 8 DLG4, GRIA2, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5
postsynaptic endocytic zone 1 GRIA2
axon hillock 1 MAP2
protein-DNA complex 1 FOS
basal dendrite 2 MAP2, MAPK8
death-inducing signaling complex 1 CASP3
transcription factor AP-1 complex 2 FOS, JUN
cortical cytoskeleton 1 DLG4
asymmetric synapse 1 GRIA2
neuron projection terminus 1 DLG4
BAD-BCL-2 complex 1 BCL2
apical distal dendrite 1 MAP2
dendritic branch 1 MAP2
dendritic filopodium 1 MAP2
distal dendrite 1 MAP2
primary dendrite 1 MAP2
proximal dendrite 1 MAP2
juxtaparanode region of axon 1 DLG4
[Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted 1 FASLG
[FasL intracellular domain]: Nucleus 1 FASLG
Golgi cis cisterna 1 DLG4


文献列表

  • T A Verdoorn, T H Johansen, J Drejer, E O Nielsen. Selective block of recombinant glur6 receptors by NS-102, a novel non-NMDA receptor antagonist. European journal of pharmacology. 1994 Sep; 269(1):43-9. doi: 10.1016/0922-4106(94)90024-8. [PMID: 7828657]