Catalposide (BioDeep_00000000924)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-((4-hydroxybenzoyl)oxy)-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a-beta,6-beta,6a-alpha))-

化学式: C22H26O12 (482.1424)
中文名称: 梓苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 55.81%

分子结构信息

SMILES: C1=COC(C2C1C(C3C2(O3)CO)OC(=O)C4=CC=C(C=C4)O)OC5C(C(C(C(O5)CO)O)O)O
InChI: InChI=1S/C22H26O12/c23-7-12-14(26)15(27)16(28)21(31-12)33-20-13-11(5-6-30-20)17(18-22(13,8-24)34-18)32-19(29)9-1-3-10(25)4-2-9/h1-6,11-18,20-21,23-28H,7-8H2/t11-,12-,13-,14-,15+,16-,17+,18+,20+,21+,22-/m1/s1

描述信息

Catalposide is a glycoside.

同义名列表

10 个代谢物同义名

[(1S,2S,4S,5S,6R)-2-(hydroxymethyl)-10-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-5-yl] 4-hydroxybenzoate; Catalposide; beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-((4-hydroxybenzoyl)oxy)-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a-beta,6-beta,6a-alpha))-; 1a(S)alpha,1bbeta,2beta,5abeta,6beta,6aalpha-Hexahydro-6-((4-hydroxybenzoyl)oxy)-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl beta-D-glucopyranoside; Hydroxybenzoyl catalpol; EINECS 229-789-1; 6736-85-2; C09775; Catalposide; Catalposide



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 AIMP2, MAPK8, NFKB1, SULT1A1, SULT1E1
Peripheral membrane protein 1 GORASP1
Endoplasmic reticulum membrane 4 HMOX1, UGT1A10, UGT1A6, UGT1A9
Mitochondrion membrane 1 ABCG2
Nucleus 6 AIMP2, HMOX1, JUND, MAPK8, NFKB1, PPARA
cytosol 6 AIMP2, HMOX1, MAPK8, NFKB1, SULT1A1, SULT1E1
mitochondrial membrane 1 ABCG2
nucleoplasm 6 ABCG2, HMOX1, JUND, MAPK8, NFKB1, PPARA
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 5 ABCG2, SLC22A1, SLCO1B1, SLCO1B3, TNF
Cytoplasmic side 2 GORASP1, HMOX1
Multi-pass membrane protein 6 ABCG2, SLC22A1, SLC22A6, SLC22A8, SLCO1B1, SLCO1B3
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell surface 1 TNF
Golgi apparatus 1 GORASP1
Golgi membrane 1 GORASP1
neuronal cell body 1 TNF
Cytoplasm, cytosol 2 AIMP2, SULT1E1
Presynapse 1 SLC22A1
plasma membrane 7 ABCG2, SLC22A1, SLC22A6, SLC22A8, SLCO1B1, SLCO1B3, TNF
Membrane 10 ABCG2, AIMP2, HMOX1, SLC22A1, SLC22A6, SLCO1B1, SLCO1B3, UGT1A10, UGT1A6, UGT1A9
apical plasma membrane 3 ABCG2, SLC22A1, SLC22A8
axon 1 MAPK8
basolateral plasma membrane 5 SLC22A1, SLC22A6, SLC22A8, SLCO1B1, SLCO1B3
caveola 1 SLC22A6
extracellular exosome 2 SLC22A6, SLC22A8
endoplasmic reticulum 4 HMOX1, UGT1A10, UGT1A6, UGT1A9
extracellular space 3 CXCL8, HMOX1, TNF
perinuclear region of cytoplasm 1 HMOX1
mitochondrion 1 NFKB1
protein-containing complex 1 SLC22A6
intracellular membrane-bounded organelle 1 UGT1A6
Secreted 1 CXCL8
extracellular region 3 CXCL8, NFKB1, TNF
Single-pass membrane protein 3 UGT1A10, UGT1A6, UGT1A9
mitochondrial outer membrane 1 HMOX1
transcription regulator complex 2 JUND, NFKB1
nuclear membrane 1 SULT1E1
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 ABCG2, SLC22A1
Membrane raft 2 ABCG2, TNF
cis-Golgi network 1 GORASP1
lateral plasma membrane 2 SLC22A1, SLC22A8
chromatin 3 JUND, NFKB1, PPARA
phagocytic cup 1 TNF
brush border membrane 1 ABCG2
Basolateral cell membrane 5 SLC22A1, SLC22A6, SLC22A8, SLCO1B1, SLCO1B3
basal plasma membrane 4 SLC22A1, SLC22A6, SLCO1B1, SLCO1B3
secretory granule lumen 1 NFKB1
transcription repressor complex 1 JUND
specific granule lumen 1 NFKB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
Basal cell membrane 4 SLC22A1, SLC22A6, SLCO1B1, SLCO1B3
Lateral cell membrane 1 SLC22A1
external side of apical plasma membrane 1 ABCG2
basal dendrite 1 MAPK8
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yun-Seo Kil, Seong Min Kim, Unwoo Kang, Hae Young Chung, Eun Kyoung Seo. Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata. Journal of natural products. 2017 08; 80(8):2240-2251. doi: 10.1021/acs.jnatprod.7b00139. [PMID: 28787158]
  • Yan-Fei Liu, Guo-Ru Shi, Xin Wang, Chun-Lei Zhang, Yan Wang, Ruo-Yun Chen, De-Quan Yu. Bioactive Iridoid Glycosides from the Whole Plants of Rehmannia chingii. Journal of natural products. 2016 Feb; 79(2):428-33. doi: 10.1021/acs.jnatprod.5b01126. [PMID: 26859776]
  • Hyeon-Uk Jeong, Mihwa Kwon, Yongnam Lee, Ji Seok Yoo, Dae Hee Shin, Im-Sook Song, Hye Suk Lee. Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide. Drug design, development and therapy. 2015; 9(?):643-53. doi: 10.2147/dddt.s75400. [PMID: 25653502]
  • Ji Hae Lee, Hee-jin Jun, Minh-Hien Hoang, Yaoyao Jia, Xiang Hua Han, Dong-Ho Lee, Hak-Ju Lee, Bang Yeon Hwang, Sung-Joon Lee. Catalposide is a natural agonistic ligand of peroxisome proliferator-activated receptor-α. Biochemical and biophysical research communications. 2012 Jun; 422(4):568-72. doi: 10.1016/j.bbrc.2012.05.025. [PMID: 22583896]
  • Eun Jeong Park, Sei-Ryang Oh, Hyeong-Kyu Lee, Hye Suk Lee. Liquid chromatography-mass spectrometry for the simultaneous determination of the catalpol-related iridoid glucosides, verproside, isovanilloylcatalpol, catalposide and 6-O-veratroyl catalpol in rat plasma. Biomedical chromatography : BMC. 2009 Sep; 23(9):980-6. doi: 10.1002/bmc.1211. [PMID: 19353737]
  • Vaclav Diopan, Petr Babula, Violetta Shestivska, Vojtech Adam, Milan Zemlicka, Margita Dvorska, Jaromir Hubalek, Libuse Trnkova, Ladislav Havel, Rene Kizek. Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide. Journal of pharmaceutical and biomedical analysis. 2008 Sep; 48(1):127-33. doi: 10.1016/j.jpba.2008.05.025. [PMID: 18597965]
  • Sang-Wook Kim, Suck-Chei Choi, Eun-Young Choi, Kyoung-Suk Kim, Jae-Min Oh, Hyun-Ju Lee, Hyun-Mee Oh, Soonhag Kim, Berm-Seok Oh, Ku-Chan Kimm, Moo-Hyung Lee, Geom-Seog Seo, Tae-Hyeon Kim, Hyun-Cheol Oh, Won-Hong Woo, Youn-Seok Kim, Hyun-Ock Pae, Do-Sim Park, Hun-Taeg Chung, Chang-Duk Jun. Catalposide, a compound isolated from catalpa ovata, attenuates induction of intestinal epithelial proinflammatory gene expression and reduces the severity of trinitrobenzene sulfonic Acid-induced colitis in mice. Inflammatory bowel diseases. 2004 Sep; 10(5):564-72. doi: 10.1097/00054725-200409000-00010. [PMID: 15472516]
  • M Deane Bowers. Hostplant suitability and defensive chemistry of the Catalpa sphinx, Ceratomia catalpae. Journal of chemical ecology. 2003 Oct; 29(10):2359-67. doi: 10.1023/a:1026234716785. [PMID: 14682517]
  • S J An, H O Pae, G S Oh, B M Choi, S Jeong, S I Jang, H Oh, T O Kwon, C E Song, H T Chung. Inhibition of TNF-alpha, IL-1beta, and IL-6 productions and NF-kappa B activation in lipopolysaccharide-activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). International immunopharmacology. 2002 Jul; 2(8):1173-81. doi: 10.1016/s1567-5769(02)00085-1. [PMID: 12349954]
  • R B DUFF, J S BACON, C M MUNDIE, V C FARMER, J D RUSSELL, A R FORRESTER. CATALPOL AND METHYLCATALPOL: NATURALLY OCCURRING GLYCOSIDES IN PLANTAGO AND BUDDLEIA SPECIES. The Biochemical journal. 1965 Jul; 96(?):1-5. doi: 10.1042/bj0960001. [PMID: 14343132]