5-Hydroxyisourate (BioDeep_00000008897)

 

Secondary id: BioDeep_00001883529

human metabolite Endogenous


代谢物信息卡片


5-hydroxy-5,7-dihydro-1H-purine-2,6,8(9H)-trione

化学式: C5H4N4O4 (184.0233)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(plant) 9.67%

分子结构信息

SMILES: C12=NC(=O)NC(=O)C1(NC(=O)N2)O
InChI: InChI=1S/C5H4N4O4/c10-2-5(13)1(6-3(11)8-2)7-4(12)9-5/h13H,(H3,6,7,8,9,10,11,12)

描述信息

5-Hydroxyisourate (CAS: 6960-30-1) belongs to the class of organic compounds known as xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety. 5-Hydroxyisourate is an extremely weak basic (essentially neutral) compound (based on its pKa). 5-Hydroxyisourate exists in all living organisms, ranging from bacteria to humans. Outside of the human body, 5-hydroxyisourate has been detected, but not quantified in, several different foods, such as soybeans, common thymes, poppies, blackcurrants, black elderberries, and rapes. This could make 5-hydroxyisourate a potential biomarker for the consumption of these foods. 5-Hydroxyisourate is the product of the oxidation of uric acid by urate oxidase.
5-Hydroxyisourate is a molecule with a formula of C5H4N4O4 and molecular weight of 184.110 g/mol. It is the product of the oxidation of uric acid by urate oxidase. 5-Hydroxyisourate is found in many foods, some of which are nance, cupuaçu, horned melon, and mentha (mint).

同义名列表

8 个代谢物同义名

5-hydroxy-5,7-dihydro-1H-purine-2,6,8(9H)-trione; 5,7-Dihydro-5-hydroxy-1H-purine-2,6,8(3H)-trione; (5S)-5,6,8-trihydroxy-5,7-dihydro-2H-purin-2-one; (5S)-5,6,8-trihydroxy-7H-purin-2-one; (S)-5-Hydroxyisouric acid; 5H-Purine-2,5,6,8-tetrol; 5-Hydroxyisouric acid; 5-Hydroxyisourate



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(3)

代谢反应

374 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(16)

WikiPathways(0)

Plant Reactome(222)

INOH(0)

PlantCyc(134)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ACSS2, CDS1, CYP2C18, FASN, PCSK9, RFK
Endoplasmic reticulum membrane 3 CDS1, CYP2C18, MOGAT1
Nucleus 3 ACSS2, CDS1, MPO
cytosol 7 AACS, ACACA, ACSS2, FASN, GDA, PLIN1, RFK
nucleoplasm 2 CDS1, MPO
Multi-pass membrane protein 4 CDS1, GDA, LAPTM4A, MOGAT1
Golgi apparatus membrane 1 ST8SIA6
cell surface 2 PCSK9, PXDN
Golgi apparatus 5 CDS1, FASN, LAPTM4A, PCSK9, ST8SIA6
Golgi membrane 1 ST8SIA6
lysosomal membrane 2 LAPTM4A, PCSK9
mitochondrial inner membrane 1 GDA
Cytoplasm, cytosol 3 AACS, ACACA, ACSS2
Lysosome 2 MPO, PCSK9
endosome 1 PCSK9
plasma membrane 3 CYP2C18, FASN, PCSK9
Membrane 5 CDS1, FASN, LAPTM4A, PLIN1, ST8SIA6
extracellular exosome 4 FASN, MPO, PXDN, TTR
endoplasmic reticulum 4 CDS1, PCSK9, PLIN1, PXDN
extracellular space 6 EDN2, MPO, PCSK9, PXDN, THPO, TTR
perinuclear region of cytoplasm 1 PCSK9
mitochondrion 3 ACACA, GDA, RFK
intracellular membrane-bounded organelle 2 CYP2C18, MPO
Microsome membrane 1 CYP2C18
Secreted 3 PCSK9, THPO, TTR
extracellular region 6 EDN2, MPO, PCSK9, PXDN, THPO, TTR
mitochondrial matrix 1 ACSS2
actin cytoskeleton 1 ACACA
Early endosome 1 PCSK9
COPII-coated ER to Golgi transport vesicle 1 PCSK9
Single-pass type II membrane protein 1 ST8SIA6
Mitochondrion inner membrane 1 GDA
extracellular matrix 1 PXDN
basement membrane 1 PXDN
PML body 1 CDS1
collagen-containing extracellular matrix 1 PXDN
secretory granule 1 MPO
Late endosome 1 PCSK9
Late endosome membrane 1 LAPTM4A
fibrillar center 1 ACACA
Endomembrane system 1 LAPTM4A
Lipid droplet 1 PLIN1
Melanosome 1 FASN
azurophil granule 1 MPO
endoplasmic reticulum lumen 1 PCSK9
azurophil granule lumen 2 MPO, TTR
phagocytic vesicle lumen 1 MPO
endolysosome membrane 1 PCSK9
extrinsic component of external side of plasma membrane 1 PCSK9
Secreted, extracellular space, extracellular matrix, basement membrane 1 PXDN
PCSK9-LDLR complex 1 PCSK9
PCSK9-AnxA2 complex 1 PCSK9
glycogen granule 1 FASN
[PXDN active fragment]: Secreted, extracellular space, extracellular matrix 1 PXDN


文献列表

  • Andrea E Steuer, Dominique Kamber, Thomas Kraemer. Evaluation of endogenous urinary biomarkers for indirect detection of urine adulteration attempts by five different chemical adulterants in mass spectrometry methods. Drug testing and analysis. 2019 May; 11(5):638-648. doi: 10.1002/dta.2539. [PMID: 30408836]
  • Kentaro Kasai, Norihito Nishiyama, Kiyoshi Yamauchi. Molecular and thyroid hormone binding properties of lamprey transthyretins: The role of an N-terminal histidine-rich segment in hormone binding with high affinity. Molecular and cellular endocrinology. 2018 10; 474(?):74-88. doi: 10.1016/j.mce.2018.02.012. [PMID: 29499210]
  • Kiyoshi Yamauchi, Kentaro Kasai. Sequential Molecular Events of Functional Trade-Offs in 5-Hydroxyisourate Hydrolase Before and After Gene Duplication Led to the Evolution of Transthyretin During Chordate Diversification. Journal of molecular evolution. 2018 08; 86(7):457-469. doi: 10.1007/s00239-018-9858-4. [PMID: 30056594]
  • Shunsuke Suzuki, Kentaro Kasai, Norihito Nishiyama, Akinori Ishihara, Kiyoshi Yamauchi. Characteristics of the brown hagfish Paramyxine atami transthyretin: Metal ion-dependent thyroid hormone binding. General and comparative endocrinology. 2017 08; 249(?):1-14. doi: 10.1016/j.ygcen.2017.02.011. [PMID: 28242306]
  • Flavia C Meotti, Guy N L Jameson, Rufus Turner, D Tim Harwood, Samantha Stockwell, Martin D Rees, Shane R Thomas, Anthony J Kettle. Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation. The Journal of biological chemistry. 2011 Apr; 286(15):12901-11. doi: 10.1074/jbc.m110.172460. [PMID: 21266577]
  • Camila Matiollo, Javier Vernal, Gabriela Ecco, Jean Borges Bertoldo, Guilherme Razzera, Emanuel M de Souza, Fábio O Pedrosa, Hernán Terenzi. A transthyretin-related protein is functionally expressed in Herbaspirillum seropedicae. Biochemical and biophysical research communications. 2009 Oct; 387(4):712-6. doi: 10.1016/j.bbrc.2009.07.094. [PMID: 19632197]
  • Robert Terkeltaub. Gout. Novel therapies for treatment of gout and hyperuricemia. Arthritis research & therapy. 2009; 11(4):236. doi: 10.1186/ar2738. [PMID: 19664185]
  • Lisa Cammalleri, Mariano Malaguarnera. Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout. International journal of medical sciences. 2007 Mar; 4(2):83-93. doi: 10.7150/ijms.4.83. [PMID: 17396159]
  • Ileana Ramazzina, Claudia Folli, Andrea Secchi, Rodolfo Berni, Riccardo Percudani. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. Nature chemical biology. 2006 Mar; 2(3):144-8. doi: 10.1038/nchembio768. [PMID: 16462750]
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