H-Dab.HBr (BioDeep_00000875166)

Main id: BioDeep_00000001361

 

PANOMIX_OTCML-2023


代谢物信息卡片


L-2,4-Diaminobutyric acid

化学式: C4H10N2O2 (118.0742)
中文名称: L-2,4-二氨基丁酸氢溴酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CN)C(C(=O)O)N
InChI: InChI=1S/C4H10N2O2/c5-2-1-3(6)4(7)8/h3H,1-2,5-6H2,(H,7,8)/t3-/m0/s1

描述信息

A 2,4-diaminobutyric acid that has S-configuration.
2,4-diaminobutyric acid, also known as L-2,4-diaminobutanoate or alpha,gamma-diaminobutyrate, is a member of the class of compounds known as L-alpha-amino acids. L-alpha-amino acids are alpha amino acids which have the L-configuration of the alpha-carbon atom. 2,4-diaminobutyric acid is soluble (in water) and a moderately acidic compound (based on its pKa). 2,4-diaminobutyric acid can be synthesized from butyric acid. 2,4-diaminobutyric acid is also a parent compound for other transformation products, including but not limited to, N(4)-acetyl-L-2,4-diaminobutyric acid, (2S)-2-acetamido-4-aminobutanoic acid, and L-alpha-amino-gamma-oxalylaminobutyric acid. 2,4-diaminobutyric acid can be found in a number of food items such as caraway, chia, atlantic herring, and chayote, which makes 2,4-diaminobutyric acid a potential biomarker for the consumption of these food products. 2,4-diaminobutyric acid can be found primarily in blood and urine. Moreover, 2,4-diaminobutyric acid is found to be associated with alzheimers disease.
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

同义名列表

5 个代谢物同义名

L-2,4-Diaminobutyric acid; H-Dab.HBr; L-2,4-Diaminobutanoate; L-DABA; L-2,4-Diaminobutanoate



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 CASP3, CAT, CRYM, DAB1, NOS1, NOS2, NOS3, ODC1, TYR
Peripheral membrane protein 4 DAP3, HSD17B6, MBP, NOS1
Nucleus 7 CASP3, CRYM, MBP, NOS1, NOS2, NOS3, TBX3
cytosol 10 ADGRG2, CASP3, CAT, CRYM, DAB1, MBP, NOS1, NOS2, NOS3, ODC1
nucleoplasm 7 CASP3, CD2, DAP3, NOS1, NOS2, NOS3, TBX3
Cell membrane 4 CD2, DAP3, SLC38A4, SLC6A1
Cytoplasmic side 1 MBP
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 3 ADGRG2, SLC38A4, SLC6A1
Synapse 3 DAP3, MBP, NOS1
cell surface 4 ADGRG2, CD2, MBP, SLC6A1
glutamatergic synapse 3 CASP3, DAB1, DAP3
Golgi apparatus 2 CD2, NOS3
Golgi membrane 1 NOS3
mitochondrial inner membrane 2 DAP3, OTC
neuromuscular junction 1 DAP3
neuronal cell body 3 CASP3, MBP, SLC6A1
presynaptic membrane 1 SLC6A1
sarcolemma 1 NOS1
Cytoplasm, cytosol 1 NOS2
Lysosome 1 TYR
Presynapse 1 SLC6A1
plasma membrane 10 ADGRG2, CD2, DAP3, ICAM3, MBP, NOS1, NOS2, NOS3, SLC38A4, SLC6A1
Membrane 5 ADGRG2, CAT, ICAM3, SLC38A4, SLC6A1
apical plasma membrane 1 ADGRG2
axon 1 SLC6A1
caveola 1 NOS3
extracellular exosome 5 ADGRG2, CAT, CRYM, ICAM3, MBP
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
perinuclear region of cytoplasm 5 DAB1, NOS1, NOS2, NOS3, TYR
mitochondrion 6 ABAT, CAT, CRYM, DAP3, NOS1, OTC
protein-containing complex 4 CAT, CD2, MBP, NOS1
intracellular membrane-bounded organelle 4 CAT, DAB1, HSD17B6, TYR
Microsome membrane 1 HSD17B6
postsynaptic density 3 CASP3, DAP3, NOS1
Single-pass type I membrane protein 3 CD2, ICAM3, TYR
extracellular region 3 CAT, CD2, MBP
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion matrix 1 OTC
mitochondrial matrix 3 ABAT, CAT, OTC
photoreceptor inner segment 1 NOS1
external side of plasma membrane 1 CD2
dendritic spine 1 NOS1
Melanosome membrane 1 TYR
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
cell-cell junction 1 CD2
Golgi-associated vesicle 1 TYR
postsynaptic membrane 1 SLC6A1
Apical cell membrane 1 ADGRG2
Cell membrane, sarcolemma 1 NOS1
Cytoplasm, perinuclear region 2 NOS1, NOS2
Membrane raft 1 NOS1
focal adhesion 1 CAT
GABA-ergic synapse 1 SLC6A1
Peroxisome 2 CAT, NOS2
sarcoplasmic reticulum 1 NOS1
Peroxisome matrix 1 CAT
peroxisomal matrix 3 CAT, CRYM, NOS2
peroxisomal membrane 1 CAT
Cell projection, dendritic spine 1 NOS1
collagen-containing extracellular matrix 1 MBP
cilium 1 TBX3
chromatin 1 TBX3
cell periphery 2 MBP, NOS1
cytoskeleton 2 NOS1, NOS3
[Isoform 3]: Nucleus 1 MBP
Cell projection, microvillus membrane 1 SLC38A4
microvillus membrane 1 SLC38A4
Melanosome 1 TYR
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
myelin sheath 1 MBP
ficolin-1-rich granule lumen 2 CAT, MBP
secretory granule lumen 1 CAT
endocytic vesicle membrane 1 NOS3
transport vesicle 1 MBP
postsynaptic specialization 1 DAP3
ribonucleoprotein complex 1 DAP3
death-inducing signaling complex 1 CASP3
mitochondrial ribosome 1 DAP3
mitochondrial small ribosomal subunit 1 DAP3
cholinergic synapse 1 DAP3
ribosome 1 DAP3
compact myelin 1 MBP
internode region of axon 1 MBP
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
[Bone marrow proteoglycan]: Secreted 1 MBP
Myelin membrane 1 MBP
small ribosomal subunit 1 DAP3
4-aminobutyrate transaminase complex 1 ABAT


文献列表

  • Sea-Yong Kim, Per Hedberg, Monika Winder, Sara Rydberg. Evidence of 2,4-diaminobutyric acid (DAB) production as a defense mechanism in diatom Thalassiosira pseudonana. Aquatic toxicology (Amsterdam, Netherlands). 2022 Aug; 249(?):106210. doi: 10.1016/j.aquatox.2022.106210. [PMID: 35665646]
  • Kate Samardzic, Joel R Steele, Jake P Violi, Anne Colville, Simon M Mitrovic, Kenneth J Rodgers. Toxicity and bioaccumulation of two non-protein amino acids synthesised by cyanobacteria, β-N-Methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB), on a crop plant. Ecotoxicology and environmental safety. 2021 Jan; 208(?):111515. doi: 10.1016/j.ecoenv.2020.111515. [PMID: 33099142]
  • Le-Ni Sun, Dan-Dan Pan, Xiang-Wei Wu, En-Dong Yang, Ri-Mao Hua, Qing X Li. Leucobacter triazinivorans sp. nov., a s-triazine herbicide prometryn-degrading bacterium isolated from sludge. International journal of systematic and evolutionary microbiology. 2018 Jan; 68(1):204-210. doi: 10.1099/ijsem.0.002483. [PMID: 29139349]
  • Peter B Nunn, Geoffrey A Codd. Metabolic solutions to the biosynthesis of some diaminomonocarboxylic acids in nature: Formation in cyanobacteria of the neurotoxins 3-N-methyl-2,3-diaminopropanoic acid (BMAA) and 2,4-diaminobutanoic acid (2,4-DAB). Phytochemistry. 2017 Dec; 144(?):253-270. doi: 10.1016/j.phytochem.2017.09.015. [PMID: 29059579]
  • Yong Li, Wei Fang, Shou-Jiang Xie, Xuqi Yang, Lai-Fa Wang. Leucobacter corticis sp. nov., isolated from symptomatic bark of Populus × euramericana canker. International journal of systematic and evolutionary microbiology. 2017 Jul; 67(7):2248-2252. doi: 10.1099/ijsem.0.001934. [PMID: 28699860]
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  • Jian-Rong Huang, Hong Ming, Shuai Li, Xiao-Lin Meng, Jian-Xin Zhang, Thi-Nhan Khieu, Zhong Tang, Wen-Jun Li, Guo-Xing Nie. Agromyces insulae sp. nov., an actinobacterium isolated from a soil sample. International journal of systematic and evolutionary microbiology. 2016 May; 66(5):2002-2007. doi: 10.1099/ijsem.0.000978. [PMID: 26883212]
  • Wei-An Lai, Shih-Yao Lin, Asif Hameed, Yi-Han Hsu, You-Cheng Liu, Hsuan-Ru Huang, Fo-Ting Shen, Chiu-Chung Young. Leucobacter zeae sp. nov., isolated from the rhizosphere of maize (Zea mays L.). International journal of systematic and evolutionary microbiology. 2015 Dec; 65(12):4734-4742. doi: 10.1099/ijsem.0.000640. [PMID: 26420495]
  • Juan Du, Hina Singh, Jung-Eun Yang, Chang Shik Yin, MooChang Kook, Hongshan Yu, Tae-Hoo Yi. Pseudoclavibacter terrae sp. nov. isolated from rhizosphere soil of Ophiopogon japonicus. International journal of systematic and evolutionary microbiology. 2015 Nov; 65(11):4202-4207. doi: 10.1099/ijsem.0.000560. [PMID: 26311346]
  • Audrey Combes, Saïda El Abdellaoui, Jérome Vial, Emmeline Lagrange, Valérie Pichon. Development of an analytical procedure for quantifying the underivatized neurotoxin β-N-methylamino-L-alanine in brain tissues. Analytical and bioanalytical chemistry. 2014 Jul; 406(19):4627-36. doi: 10.1007/s00216-014-7872-y. [PMID: 24858470]
  • Maitham Ahmed Al-Sammak, Kyle D Hoagland, David Cassada, Daniel D Snow. Co-occurrence of the cyanotoxins BMAA, DABA and anatoxin-a in Nebraska reservoirs, fish, and aquatic plants. Toxins. 2014 Jan; 6(2):488-508. doi: 10.3390/toxins6020488. [PMID: 24476710]
  • Maitham Ahmed Al-Sammak, Kyle D Hoagland, Daniel D Snow, David Cassada. Methods for simultaneous detection of the cyanotoxins BMAA, DABA, and anatoxin-a in environmental samples. Toxicon : official journal of the International Society on Toxinology. 2013 Dec; 76(?):316-25. doi: 10.1016/j.toxicon.2013.10.015. [PMID: 24140919]
  • Maria Hoernke, Christian Schwieger, Andreas Kerth, Alfred Blume. Binding of cationic pentapeptides with modified side chain lengths to negatively charged lipid membranes: Complex interplay of electrostatic and hydrophobic interactions. Biochimica et biophysica acta. 2012 Jul; 1818(7):1663-72. doi: 10.1016/j.bbamem.2012.03.001. [PMID: 22433675]
  • Jin-Ha Lee, Sang-Seob Lee. Leucobacter margaritiformis sp. nov., isolated from bamboo extract. Current microbiology. 2012 May; 64(5):441-8. doi: 10.1007/s00284-012-0089-4. [PMID: 22349954]
  • Sathiyaraj Srinivasan, Hyun Sook Kim, Myung Kyum Kim, Myungjin Lee. Pseudoclavibacter caeni sp. nov., isolated from sludge of a sewage disposal plant. International journal of systematic and evolutionary microbiology. 2012 Apr; 62(Pt 4):786-790. doi: 10.1099/ijs.0.028951-0. [PMID: 21571937]
  • Hang-Yeon Weon, Rangasamy Anandham, Tomohiko Tamura, Moriyuki Hamada, Soo-Jin Kim, Yi-Seul Kim, Ken-Ichiro Suzuki, Soon-Wo Kwon. Leucobacter denitrificans sp. nov., isolated from cow dung. Journal of microbiology (Seoul, Korea). 2012 Feb; 50(1):161-5. doi: 10.1007/s12275-012-1324-1. [PMID: 22367952]
  • Ji-Hyun Yun, Seong Woon Roh, Min-Soo Kim, Mi-Ja Jung, Eun-Jin Park, Kee-Sun Shin, Young-Do Nam, Jin-Woo Bae. Leucobacter salsicius sp. nov., from a salt-fermented food. International journal of systematic and evolutionary microbiology. 2011 Mar; 61(Pt 3):502-506. doi: 10.1099/ijs.0.021360-0. [PMID: 20363927]
  • Adak Nasiripourdori, Valérie Taly, Thomas Grutter, Antoine Taly. From toxins targeting ligand gated ion channels to therapeutic molecules. Toxins. 2011 03; 3(3):260-93. doi: 10.3390/toxins3030260. [PMID: 22069709]
  • E Martin, N Lodders, U Jäckel, P Schumann, P Kämpfer. Leucobacter aerolatus sp. nov., from the air of a duck barn. International journal of systematic and evolutionary microbiology. 2010 Dec; 60(Pt 12):2838-2842. doi: 10.1099/ijs.0.021303-0. [PMID: 20081017]
  • G S N Reddy, Suman Pradhan, Ruth Manorama, S Shivaji. Cryobacterium roopkundense sp. nov., a psychrophilic bacterium isolated from glacial soil. International journal of systematic and evolutionary microbiology. 2010 Apr; 60(Pt 4):866-870. doi: 10.1099/ijs.0.011775-0. [PMID: 19661491]
  • Thomas Krüger, Bettina Mönch, Steven Oppenhäuser, Bernd Luckas. LC-MS/MS determination of the isomeric neurotoxins BMAA (beta-N-methylamino-L-alanine) and DAB (2,4-diaminobutyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius. Toxicon : official journal of the International Society on Toxinology. 2010 Feb; 55(2-3):547-57. doi: 10.1016/j.toxicon.2009.10.009. [PMID: 19825383]
  • Undine Behrendt, Andreas Ulrich, Peter Schumann. Leucobacter tardus sp. nov., isolated from the phyllosphere of Solanum tuberosum L. International journal of systematic and evolutionary microbiology. 2008 Nov; 58(Pt 11):2574-8. doi: 10.1099/ijs.0.2008/001065-0. [PMID: 18984695]
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