Hydrogen cyanide (BioDeep_00000875164)

Main id: BioDeep_00000004669

 

PANOMIX_OTCML-2023


代谢物信息卡片


Hydrogen cyanide

化学式: CHN (27.0109)
中文名称: 氢氰酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C#N
InChI: InChI=1S/CHN/c1-2/h1H

描述信息

A one-carbon compound consisting of a methine group triple bonded to a nitrogen atom
D009676 - Noxae > D011042 - Poisons > D002619 - Chemical Warfare Agents
Hydrogen cyanide, also known as hydrocyanic acid or cyanide, is a member of the class of compounds known as nitriles. Nitriles are compounds having the structure RC#N; thus C-substituted derivatives of hydrocyanic acid, HC#N. Hydrogen cyanide is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Hydrogen cyanide can be found in a number of food items such as kiwi, java plum, yellow wax bean, and mamey sapote, which makes hydrogen cyanide a potential biomarker for the consumption of these food products. Hydrogen cyanide exists in all living organisms, ranging from bacteria to humans. Hydrogen cyanide is a non-carcinogenic (not listed by IARC) potentially toxic compound. Hydrogen cyanide (HCN), sometimes called prussic acid, is a chemical compound with the chemical formula HCN. It is a colorless, extremely poisonous and inflammable liquid that boils slightly above room temperature, at 25.6 °C (78.1 °F). HCN is produced on an industrial scale and is a highly valuable precursor to many chemical compounds ranging from polymers to pharmaceuticals . Antidotes to cyanide poisoning include hydroxocobalamin and sodium nitrite, which release the cyanide from the cytochrome system, and rhodanase, which is an enzyme occurring naturally in mammals that combines serum cyanide with thiosulfate, producing comparatively harmless thiocyanate. Oxygen therapy can also be administered (L97) (T3DB).

同义名列表

2 个代谢物同义名

Hydrogen cyanide; Hydrogen cyanide



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(45)

PlantCyc(7)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ANPEP, ARHGAP45, CA3, CASP3, CAT, ELANE, FST, PGP, PMP2
Peripheral membrane protein 3 ACHE, CYP1B1, HSD17B6
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 6 ACHE, CASP3, FST, MPO, PMP2, XAB2
cytosol 8 ARHGAP45, CA3, CASP3, CAT, EHHADH, ELANE, LIPE, PMP2
phagocytic vesicle 1 ELANE
nucleoplasm 3 CASP3, MPO, XAB2
Cell membrane 3 ACHE, ANPEP, LIPE
ruffle membrane 1 ARHGAP45
Early endosome membrane 1 HSD17B6
Synapse 1 ACHE
cell surface 2 ACHE, ELANE
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ACHE, ATRN
lysosomal membrane 1 ANPEP
neuromuscular junction 1 ACHE
neuronal cell body 1 CASP3
Cytoplasm, cytosol 1 LIPE
Lysosome 1 MPO
plasma membrane 4 ACHE, ANPEP, ARHGAP45, ATRN
Membrane 6 ACHE, ARHGAP45, CAT, CYP1B1, LIPE, XAB2
caveola 1 LIPE
extracellular exosome 6 ANPEP, ATRN, CAT, ELANE, MPO, PMP2
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 8 ACHE, ANPEP, ATRN, DCN, ELANE, FST, MPO, TST
lysosomal lumen 1 DCN
perinuclear region of cytoplasm 1 ACHE
mitochondrion 3 CAT, CYP1B1, TST
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 5 CAT, CYP1B1, HSD17B6, MPO, XAB2
Microsome membrane 2 CYP1B1, HSD17B6
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ATRN
Secreted 2 ACHE, DCN
extracellular region 7 ACHE, ARHGAP45, CAT, DCN, ELANE, FST, MPO
[Isoform 2]: Secreted 1 ATRN
Mitochondrion matrix 1 TST
mitochondrial matrix 2 CAT, TST
Extracellular side 1 ACHE
external side of plasma membrane 1 ANPEP
Secreted, extracellular space, extracellular matrix 1 DCN
Single-pass type II membrane protein 1 ANPEP
Cell projection, ruffle membrane 1 ARHGAP45
focal adhesion 1 CAT
Peroxisome 2 CAT, EHHADH
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, EHHADH
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 DCN, ELANE
secretory granule 2 ELANE, MPO
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
side of membrane 1 ACHE
myelin sheath 1 PMP2
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 ARHGAP45, CAT
secretory granule membrane 1 ANPEP
Golgi lumen 1 DCN
transcription repressor complex 1 ELANE
specific granule lumen 1 ELANE
azurophil granule lumen 3 ARHGAP45, ELANE, MPO
phagocytic vesicle lumen 1 MPO
endoplasmic reticulum-Golgi intermediate compartment 1 ANPEP
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ATRN
catalytic step 2 spliceosome 1 XAB2
Prp19 complex 1 XAB2
U2-type catalytic step 2 spliceosome 1 XAB2
Cytoplasmic vesicle, phagosome 1 ELANE
post-mRNA release spliceosomal complex 1 XAB2
catalase complex 1 CAT
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Sakthi Uma Devi Eswaran, Lalitha Sundaram, Kahkashan Perveen, Najat A Bukhari, R Z Sayyed. Osmolyte-producing microbial biostimulants regulate the growth of Arachis hypogaea L. under drought stress. BMC microbiology. 2024 May; 24(1):165. doi: 10.1186/s12866-024-03320-6. [PMID: 38745279]
  • Ilia A Dereven'kov, Larissa A Maiorova, Oscar I Koifman, Denis S Salnikov. High Reactivity of Supermolecular Nanoentities of a Vitamin B12 Derivative in Langmuir-Schaefer Films Toward Gaseous Toxins. Langmuir : the ACS journal of surfaces and colloids. 2023 12; 39(48):17240-17250. doi: 10.1021/acs.langmuir.3c02317. [PMID: 38050683]
  • Irfan Ali Sabir, Muhammad Aamir Manzoor, Iftikhar Hussain Shah, Zishan Ahmad, Xunju Liu, Pravej Alam, Yuxuan Wang, Wanxia Sun, Jiyuan Wang, Ruie Liu, Songtao Jiu, Caixi Zhang. Unveiling the effect of gibberellin-induced iron oxide nanoparticles on bud dormancy release in sweet cherry (Prunus avium L.). Plant physiology and biochemistry : PPB. 2023 Nov; 206(?):108222. doi: 10.1016/j.plaphy.2023.108222. [PMID: 38016371]
  • Abhishek Anand, Laurent Falquet, Eliane Abou-Mansour, Floriane L'Haridon, Christoph Keel, Laure Weisskopf. Biological hydrogen cyanide emission globally impacts the physiology of both HCN-emitting and HCN-perceiving Pseudomonas. mBio. 2023 Aug; ?(?):e0085723. doi: 10.1128/mbio.00857-23. [PMID: 37650608]
  • Pablo Díaz-Rueda, Laura Morales de Los Ríos, Luis C Romero, Irene García. Old poisons, new signaling molecules: the case of HCN. Journal of experimental botany. 2023 Aug; ?(?):. doi: 10.1093/jxb/erad317. [PMID: 37586035]
  • Eva Arrebola, Francesca R Aprile, Claudia E Calderón, Antonio de Vicente, Francisco M Cazorla. Insecticidal features displayed by the beneficial rhizobacterium Pseudomonas chlororaphis PCL1606. International microbiology : the official journal of the Spanish Society for Microbiology. 2022 Nov; 25(4):679-689. doi: 10.1007/s10123-022-00253-w. [PMID: 35670867]
  • Reghmit Abdenaceur, Benzina-Tihar Farida, Djeziri Mourad, Hadjouti Rima, Oukali Zahia, Sahir-Halouane Fatma. Effective biofertilizer Trichoderma spp. isolates with enzymatic activity and metabolites enhancing plant growth. International microbiology : the official journal of the Spanish Society for Microbiology. 2022 Nov; 25(4):817-829. doi: 10.1007/s10123-022-00263-8. [PMID: 35854164]
  • H Myrans, R M Gleadow. Regulation of cyanogenic glucosides in wild and domesticated Eusorghum taxa. Plant biology (Stuttgart, Germany). 2022 Oct; 24(6):1084-1088. doi: 10.1111/plb.13447. [PMID: 35727820]
  • Qian Song, Xun Deng, Ruiqing Song, Xiaoshuang Song. Plant Growth-Promoting Rhizobacteria Promote Growth of Seedlings, Regulate Soil Microbial Community, and Alleviate Damping-Off Disease Caused by Rhizoctonia solani on Pinus sylvestris var. mongolica. Plant disease. 2022 Oct; 106(10):2730-2740. doi: 10.1094/pdis-11-21-2562-re. [PMID: 36094426]
  • Saba Azeem, Syed Inayatullah Agha, Neelam Jamil, Bushra Tabassum, Shan Ahmed, Asif Raheem, Nusrat Jahan, Niaz Ali, Anwar Khan. Characterization and survival of broad-spectrum biocontrol agents against phytopathogenic fungi. Revista Argentina de microbiologia. 2022 Jul; 54(3):233-242. doi: 10.1016/j.ram.2021.10.005. [PMID: 35039210]
  • Simon G Innes, James S Santangelo, Nicholas J Kooyers, Kenneth M Olsen, Marc T J Johnson. Evolution in response to climate in the native and introduced ranges of a globally distributed plant. Evolution; international journal of organic evolution. 2022 07; 76(7):1495-1511. doi: 10.1111/evo.14514. [PMID: 35589013]
  • James S Santangelo, Rob W Ness, Beata Cohan, Connor R Fitzpatrick, Simon G Innes, Sophie Koch, Lindsay S Miles, Samreen Munim, Pedro R Peres-Neto, Cindy Prashad, Alex T Tong, Windsor E Aguirre, Philips O Akinwole, Marina Alberti, Jackie Álvarez, Jill T Anderson, Joseph J Anderson, Yoshino Ando, Nigel R Andrew, Fabio Angeoletto, Daniel N Anstett, Julia Anstett, Felipe Aoki-Gonçalves, A Z Andis Arietta, Mary T K Arroyo, Emily J Austen, Fernanda Baena-Díaz, Cory A Barker, Howard A Baylis, Julia M Beliz, Alfonso Benitez-Mora, David Bickford, Gabriela Biedebach, Gwylim S Blackburn, Mannfred M A Boehm, Stephen P Bonser, Dries Bonte, Jesse R Bragger, Cristina Branquinho, Kristien I Brans, Jorge C Bresciano, Peta D Brom, Anna Bucharova, Briana Burt, James F Cahill, Katelyn D Campbell, Elizabeth J Carlen, Diego Carmona, Maria Clara Castellanos, Giada Centenaro, Izan Chalen, Jaime A Chaves, Mariana Chávez-Pesqueira, Xiao-Yong Chen, Angela M Chilton, Kristina M Chomiak, Diego F Cisneros-Heredia, Ibrahim K Cisse, Aimée T Classen, Mattheau S Comerford, Camila Cordoba Fradinger, Hannah Corney, Andrew J Crawford, Kerri M Crawford, Maxime Dahirel, Santiago David, Robert De Haan, Nicholas J Deacon, Clare Dean, Ek Del-Val, Eleftherios K Deligiannis, Derek Denney, Margarete A Dettlaff, Michelle F DiLeo, Yuan-Yuan Ding, Moisés E Domínguez-López, Davide M Dominoni, Savannah L Draud, Karen Dyson, Jacintha Ellers, Carlos I Espinosa, Liliana Essi, Mohsen Falahati-Anbaran, Jéssica C F Falcão, Hayden T Fargo, Mark D E Fellowes, Raina M Fitzpatrick, Leah E Flaherty, Pádraic J Flood, María F Flores, Juan Fornoni, Amy G Foster, Christopher J Frost, Tracy L Fuentes, Justin R Fulkerson, Edeline Gagnon, Frauke Garbsch, Colin J Garroway, Aleeza C Gerstein, Mischa M Giasson, E Binney Girdler, Spyros Gkelis, William Godsoe, Anneke M Golemiec, Mireille Golemiec, César González-Lagos, Amanda J Gorton, Kiyoko M Gotanda, Gustaf Granath, Stephan Greiner, Joanna S Griffiths, Filipa Grilo, Pedro E Gundel, Benjamin Hamilton, Joyce M Hardin, Tianhua He, Stephen B Heard, André F Henriques, Melissa Hernández-Poveda, Molly C Hetherington-Rauth, Sarah J Hill, Dieter F Hochuli, Kathryn A Hodgins, Glen R Hood, Gareth R Hopkins, Katherine A Hovanes, Ava R Howard, Sierra C Hubbard, Carlos N Ibarra-Cerdeña, Carlos Iñiguez-Armijos, Paola Jara-Arancio, Benjamin J M Jarrett, Manon Jeannot, Vania Jiménez-Lobato, Mae Johnson, Oscar Johnson, Philip P Johnson, Reagan Johnson, Matthew P Josephson, Meen Chel Jung, Michael G Just, Aapo Kahilainen, Otto S Kailing, Eunice Kariñho-Betancourt, Regina Karousou, Lauren A Kirn, Anna Kirschbaum, Anna-Liisa Laine, Jalene M LaMontagne, Christian Lampei, Carlos Lara, Erica L Larson, Adrián Lázaro-Lobo, Jennifer H Le, Deleon S Leandro, Christopher Lee, Yunting Lei, Carolina A León, Manuel E Lequerica Tamara, Danica C Levesque, Wan-Jin Liao, Megan Ljubotina, Hannah Locke, Martin T Lockett, Tiffany C Longo, Jeremy T Lundholm, Thomas MacGillavry, Christopher R Mackin, Alex R Mahmoud, Isaac A Manju, Janine Mariën, D Nayeli Martínez, Marina Martínez-Bartolomé, Emily K Meineke, Wendy Mendoza-Arroyo, Thomas J S Merritt, Lila Elizabeth L Merritt, Giuditta Migiani, Emily S Minor, Nora Mitchell, Mitra Mohammadi Bazargani, Angela T Moles, Julia D Monk, Christopher M Moore, Paula A Morales-Morales, Brook T Moyers, Miriam Muñoz-Rojas, Jason Munshi-South, Shannon M Murphy, Maureen M Murúa, Melisa Neila, Ourania Nikolaidis, Iva Njunjić, Peter Nosko, Juan Núñez-Farfán, Takayuki Ohgushi, Kenneth M Olsen, Øystein H Opedal, Cristina Ornelas, Amy L Parachnowitsch, Aaron S Paratore, Angela M Parody-Merino, Juraj Paule, Octávio S Paulo, João Carlos Pena, Vera W Pfeiffer, Pedro Pinho, Anthony Piot, Ilga M Porth, Nicholas Poulos, Adriana Puentes, Jiao Qu, Estela Quintero-Vallejo, Steve M Raciti, Joost A M Raeymaekers, Krista M Raveala, Diana J Rennison, Milton C Ribeiro, Jonathan L Richardson, Gonzalo Rivas-Torres, Benjamin J Rivera, Adam B Roddy, Erika Rodriguez-Muñoz, José Raúl Román, Laura S Rossi, Jennifer K Rowntree, Travis J Ryan, Santiago Salinas, Nathan J Sanders, Luis Y Santiago-Rosario, Amy M Savage, J F Scheepens, Menno Schilthuizen, Adam C Schneider, Tiffany Scholier, Jared L Scott, Summer A Shaheed, Richard P Shefferson, Caralee A Shepard, Jacqui A Shykoff, Georgianna Silveira, Alexis D Smith, Lizet Solis-Gabriel, Antonella Soro, Katie V Spellman, Kaitlin Stack Whitney, Indra Starke-Ottich, Jörg G Stephan, Jessica D Stephens, Justyna Szulc, Marta Szulkin, Ayco J M Tack, Ítalo Tamburrino, Tayler D Tate, Emmanuel Tergemina, Panagiotis Theodorou, Ken A Thompson, Caragh G Threlfall, Robin M Tinghitella, Lilibeth Toledo-Chelala, Xin Tong, Léa Uroy, Shunsuke Utsumi, Martijn L Vandegehuchte, Acer VanWallendael, Paula M Vidal, Susana M Wadgymar, Ai-Ying Wang, Nian Wang, Montana L Warbrick, Kenneth D Whitney, Miriam Wiesmeier, J Tristian Wiles, Jianqiang Wu, Zoe A Xirocostas, Zhaogui Yan, Jiahe Yao, Jeremy B Yoder, Owen Yoshida, Jingxiong Zhang, Zhigang Zhao, Carly D Ziter, Matthew P Zuellig, Rebecca A Zufall, Juan E Zurita, Sharon E Zytynska, Marc T J Johnson. 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  • Mingyu Li, Lu Zhao, Qiang Zhou, Longfa Fang, Dong Luo, Wenxian Liu, Iain Robert Searle, Zhipeng Liu. Transcriptome and Coexpression Network Analyses Provide In-Sights into the Molecular Mechanisms of Hydrogen Cyanide Synthesis during Seed Development in Common Vetch (Vicia sativa L.). International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042275. [PMID: 35216390]
  • Max Cowan, Birger Lindberg Møller, Sally Norton, Camilla Knudsen, Christoph Crocoll, Agnelo Furtado, Robert Henry, Cecilia Blomstedt, Roslyn M Gleadow. Cyanogenesis in the Sorghum Genus: From Genotype to Phenotype. Genes. 2022 01; 13(1):. doi: 10.3390/genes13010140. [PMID: 35052482]
  • Alba Pacheco-Moreno, Francesca L Stefanato, Jonathan J Ford, Christine Trippel, Simon Uszkoreit, Laura Ferrafiat, Lucia Grenga, Ruth Dickens, Nathan Kelly, Alexander Dh Kingdon, Liana Ambrosetti, Sergey A Nepogodiev, Kim C Findlay, Jitender Cheema, Martin Trick, Govind Chandra, Graham Tomalin, Jacob G Malone, Andrew W Truman. Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition. eLife. 2021 12; 10(?):. doi: 10.7554/elife.71900. [PMID: 34792466]
  • Liang Li, Jinhang Liu, Qin Liang, Yu Feng, Chao Wang, Shaohua Wu, Yongyu Li. Downregulation of lncRNA PpL-T31511 and Pp-miRn182 Promotes Hydrogen Cyanamide-Induced Endodormancy Release through the PP2C-H2O2 Pathway in Pear (Pyrus pyrifolia). International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111842. [PMID: 34769273]
  • Yongheng Zhong, Tao Xu, Shengyang Ji, Xiaodan Wu, Tian Zhao, Shimin Li, Peng Zhang, Kaimian Li, Baiyi Lu. Effect of ultrasonic pretreatment on eliminating cyanogenic glycosides and hydrogen cyanide in cassava. Ultrasonics sonochemistry. 2021 Oct; 78(?):105742. doi: 10.1016/j.ultsonch.2021.105742. [PMID: 34487981]
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  • Harry Myrans, Rebecca K Vandegeer, Robert J Henry, Roslyn M Gleadow. Nitrogen availability and allocation in sorghum and its wild relatives: Divergent roles for cyanogenic glucosides. Journal of plant physiology. 2021 Mar; 258-259(?):153393. doi: 10.1016/j.jplph.2021.153393. [PMID: 33667954]
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  • Akhilesh Kumar, Saurabh Singh, Arpan Mukherjee, Rajesh Prasad Rastogi, Jay Prakash Verma. Salt-tolerant plant growth-promoting Bacillus pumilus strain JPVS11 to enhance plant growth attributes of rice and improve soil health under salinity stress. Microbiological research. 2021 Jan; 242(?):126616. doi: 10.1016/j.micres.2020.126616. [PMID: 33115624]
  • Martin Ferus, Paul Rimmer, Giuseppe Cassone, Antonín Knížek, Svatopluk Civiš, Judit E Šponer, Ondřej Ivanek, Jiří Šponer, Homa Saeidfirozeh, Petr Kubelík, Roman Dudžák, Lukáš Petera, Libor Juha, Adam Pastorek, Anna Křivková, Miroslav Krůs. One-Pot Hydrogen Cyanide-Based Prebiotic Synthesis of Canonical Nucleobases and Glycine Initiated by High-Velocity Impacts on Early Earth. Astrobiology. 2020 12; 20(12):1476-1488. doi: 10.1089/ast.2020.2231. [PMID: 32955922]
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  • Sharma Deepika, Amit Mittal, David Kothamasi. HCN-producing Pseudomonas protegens CHA0 affects intraradical viability of Rhizophagus irregularis in Sorghum vulgare roots. Journal of basic microbiology. 2019 Dec; 59(12):1229-1237. doi: 10.1002/jobm.201900364. [PMID: 31642093]
  • Lenka Rucká, Martin Chmátal, Natalia Kulik, Lucie Petrásková, Helena Pelantová, Petr Novotný, Romana Příhodová, Miroslav Pátek, Ludmila Martínková. Genetic and Functional Diversity of Nitrilases in Agaricomycotina. International journal of molecular sciences. 2019 Nov; 20(23):. doi: 10.3390/ijms20235990. [PMID: 31795104]
  • Rafael Díaz-Sobac, Alma Vázquez-Luna, Eduardo Rivadeneyra-Domínguez, Juan Francisco Rodríguez-Landa, Tomás Guerrero, J Sergio Durand-Niconoff. New paths of cyanogenesis from enzymatic-promoted cleavage of β-cyanoglucosides are suggested by a mixed DFT/QTAIM approach. Journal of molecular modeling. 2019 Sep; 25(9):295. doi: 10.1007/s00894-019-4170-9. [PMID: 31478108]
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