zingerone (BioDeep_00000861496)

Main id: BioDeep_00000000460

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


InChI=1\C11H14O3\c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2\h5-7,13H,3-4H2,1-2H

化学式: C11H14O3 (194.0943)
中文名称: 姜油酮, 姜酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)CCC1=CC(=C(C=C1)O)OC
InChI: InChI=1S/C11H14O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-7,13H,3-4H2,1-2H3

描述信息

Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3].
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3].

同义名列表

37 个代谢物同义名

InChI=1\C11H14O3\c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2\h5-7,13H,3-4H2,1-2H; 2-(4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone; (4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone; 4-08-00-01866 (Beilstein Handbook Reference); 2-Butanone, 4-(4-hydroxy-3-methoxyphenyl)-; 4-(4-hydroxy-3-methoxy-phenyl)-butan-2-one; 4-(4-hydroxy-3-methoxy-phenyl)butan-2-one; 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone; 4-(4-hydroxy-3-methoxyphenyl)butan-2-one; 4-(3-Methoxy-4-hydroxyphenyl)-2-butanone; 4(4-Hydroxy-3-methoxyphenyl)-2-butanone; 3-Methoxy-4-hydroxy-benzylacetone; 4-Hydroxy-3-methoxybenzylacetone; 3-Methoxy-4-hydroxybenzylacetone; vanillyl acetone; EINECS 204-548-3; W312401_ALDRICH; vanillylacetone; FEMA No. 3124; ZINC00526834; [0]-Paradol; (0)-Paradol; BRN 2051099; Zingiberone; Zingherone; CCRIS 2036; ST5407498; zingerone; HSDB 1064; AI3-31837; NSC 15335; Gingerone; 122-48-5; NSC15335; LS-2368; Zingerone; Zingerone



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

47 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 BCL2, CASP3, CASP9, CAT, CYP2E1, MAPK14, MAPK8, NFE2L2, PTGS2, RELA, RUNX2, TLR4
Peripheral membrane protein 2 CYP2E1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 4 BCL2, CYP2E1, HMOX1, PTGS2
Nucleus 10 BCL2, CASP3, CASP9, HMOX1, MAPK14, MAPK8, MPO, NFE2L2, RELA, RUNX2
cytosol 11 BCL2, CASP3, CASP9, CAT, GPT, HMOX1, MAPK14, MAPK8, NFE2L2, RELA, RUNX2
centrosome 1 NFE2L2
nucleoplasm 8 CASP3, HMOX1, MAPK14, MAPK8, MPO, NFE2L2, RELA, RUNX2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 2 TLR4, TNF
Cytoplasmic side 1 HMOX1
Synapse 1 MAPK8
cell surface 2 TLR4, TNF
glutamatergic synapse 3 CASP3, MAPK14, RELA
Golgi apparatus 2 ATRN, NFE2L2
Golgi membrane 1 INS
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 MPO
plasma membrane 4 ATRN, NFE2L2, TLR4, TNF
Membrane 4 BCL2, CAT, HMOX1, TLR4
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 4 ATRN, CAT, GPT, MPO
endoplasmic reticulum 3 BCL2, HMOX1, PTGS2
extracellular space 7 ATRN, HMOX1, IL2, IL6, INS, MPO, TNF
perinuclear region of cytoplasm 2 HMOX1, TLR4
mitochondrion 4 BCL2, CASP9, CAT, MAPK14
protein-containing complex 4 BCL2, CASP9, CAT, PTGS2
intracellular membrane-bounded organelle 3 CAT, CYP2E1, MPO
Microsome membrane 2 CYP2E1, PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 ATRN, TLR4
Secreted 3 IL2, IL6, INS
extracellular region 7 CAT, IL2, IL6, INS, MAPK14, MPO, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
transcription regulator complex 2 RELA, RUNX2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TLR4, TNF
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 MPO
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
chromatin 3 NFE2L2, RELA, RUNX2
mediator complex 1 NFE2L2
phagocytic cup 2 TLR4, TNF
spindle pole 1 MAPK14
[Isoform 3]: Secreted 1 ATRN
endosome lumen 1 INS
myelin sheath 1 BCL2
azurophil granule 1 MPO
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
transport vesicle 1 INS
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
phagocytic vesicle lumen 1 MPO
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ATRN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Shahrzad Molavinia, Mehrad Nikravesh, Marzieh Pashmforoosh, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar. Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation. Neurochemical research. 2023 Oct; ?(?):. doi: 10.1007/s11064-023-04043-2. [PMID: 37864024]
  • Shahnam Shamsabadi, Yazdan Nazer, Javad Ghasemi, Erfan Mahzoon, Vafa Baradaran Rahimi, Basiru O Ajiboye, Vahid Reza Askari. Promising influences of zingerone against natural and chemical toxins: A comprehensive and mechanistic review. Toxicon : official journal of the International Society on Toxinology. 2023 Aug; 233(?):107247. doi: 10.1016/j.toxicon.2023.107247. [PMID: 37562703]
  • Devika Chopra, Vijayta D Chadha, Devinder K Dhawan. Understanding the role of zingerone on biochemical and behavioral changes in rat brain inflicted with C6 glioma cells. Journal of biochemical and molecular toxicology. 2023 Jul; ?(?):e23477. doi: 10.1002/jbt.23477. [PMID: 37477207]
  • Clarissa Garza-Cadena, Daniela Marian Ortega-Rivera, Gerson Machorro-García, Eloy Mauricio Gonzalez-Zermeño, Diego Homma-Dueñas, Maksymilian Plata-Gryl, Roberto Castro-Muñoz. A comprehensive review on Ginger (Zingiber officinale) as a potential source of nutraceuticals for food formulations: Towards the polishing of gingerol and other present biomolecules. Food chemistry. 2023 Feb; 413(?):135629. doi: 10.1016/j.foodchem.2023.135629. [PMID: 36753787]
  • Xiaoping Li, Yexuan Yao, Chengwei Yu, Teng Wei, Qinghua Xi, Jing Li, Fang Chen, Ze-Yuan Deng, Ting Luo. Modulation of PPARα-thermogenesis gut microbiota interactions in obese mice administrated with zingerone. Journal of the science of food and agriculture. 2022 Nov; ?(?):. doi: 10.1002/jsfa.12352. [PMID: 36424723]
  • Ngouana Moffo A Ivane, Fopa Kue Roméo Elysé, Suleiman A Haruna, Ngwasiri Pride, Ejoh Richard, Anuanwen Claris Foncha, Munir Abba Dandago. The anti-oxidative potential of ginger extract and its constituent on meat protein isolate under induced Fenton oxidation. Journal of proteomics. 2022 10; 269(?):104723. doi: 10.1016/j.jprot.2022.104723. [PMID: 36096434]
  • Kumud Upadhyaya, Priya Kumari Sharma, Ansab Akhtar, Sangeeta Pilkhwal Sah. Protective Effects of Zingerone Against Depression-Like Behavior and Biochemical Changes in Chronic Stressed Rats: Antioxidant Effects. Journal of medicinal food. 2022 Jun; 25(6):576-587. doi: 10.1089/jmf.2021.k.0141. [PMID: 35639359]
  • Erdinç Türk, Mehmet Güvenç, Mustafa Cellat, Ahmet Uyar, Müslüm Kuzu, Ahmet Gökhan Ağgül, Akın Kırbaş. Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats. Drug and chemical toxicology. 2022 May; 45(3):1054-1065. doi: 10.1080/01480545.2020.1804397. [PMID: 32781857]
  • Nasiru Muhammad, Busisani W Lembede, Kennedy H Erlwanger. Neonatal administration of zingerone prevents the subsequent development of high dietary fructose-induced early features of nephropathy in rats. General physiology and biophysics. 2022 Mar; 41(2):141-150. doi: 10.4149/gpb_2022008. [PMID: 35416177]
  • Nazirah Bashir, Sheikh Bilal Ahmad, Muneeb U Rehman, Showkeen Muzamil, Rahil Razak Bhat, Manzoor Ur Rahman Mir, Gamal A Shazly, Mohamed A Ibrahim, Gehan M Elossaily, Abdelrahman Y Sherif, Mohsin Kazi. Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants. Redox report : communications in free radical research. 2021 Dec; 26(1):62-70. doi: 10.1080/13510002.2021.1907518. [PMID: 33784959]
  • X Geng, H Liu, Q Yuwen, J Wang, S Zhang, X Zhang, J Sun. Protective effects of zingerone on high cholesterol diet-induced atherosclerosis through lipid regulatory signaling pathway. Human & experimental toxicology. 2021 Oct; 40(10):1732-1745. doi: 10.1177/09603271211006170. [PMID: 33845646]
  • Giovanni Schepici, Valentina Contestabile, Andrea Valeri, Emanuela Mazzon. Ginger, a Possible Candidate for the Treatment of Dementias?. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185700. [PMID: 34577171]
  • Nasiru Muhammad, Busisani Wiseman Lembede, Kennedy Honey Erlwanger. Zingerone Administered Neonatally Prevents the Subsequent Development of High Dietary Fructose-Induced Fatty Liver in Sprague Dawley Rats. Journal of medicinal food. 2021 Sep; 24(9):944-952. doi: 10.1089/jmf.2020.0189. [PMID: 33512269]
  • Tarique Anwer, Zafar Ali Alkarbi, Ali Hassan Najmi, Saeed Alshahrani, Rahimullah Siddiqui, Gyas Khan, Mohammad Firoz Alam. Modulatory effect of zingerone against STZ-nicotinamide induced type-2 diabetes mellitus in rats. Archives of physiology and biochemistry. 2021 Aug; 127(4):304-310. doi: 10.1080/13813455.2019.1637436. [PMID: 31389247]
  • N Muhammad, B W Lembede, K H Erlwanger. Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats. Journal of developmental origins of health and disease. 2021 08; 12(4):671-679. doi: 10.1017/s2040174420000525. [PMID: 32500848]
  • Niramon Utama-Ang, Sirinapa Sida, Phenphichar Wanachantararak, Arthitaya Kawee-Ai. Development of edible Thai rice film fortified with ginger extract using microwave-assisted extraction for oral antimicrobial properties. Scientific reports. 2021 07; 11(1):14870. doi: 10.1038/s41598-021-94430-y. [PMID: 34290338]
  • Insha Amin, Ishraq Hussain, Muneeb U Rehman, Bilal Ahmad Mir, Showkat Ahmad Ganaie, Sheikh Bilal Ahmad, Manzoor Ur Rahman Mir, Syed Shanaz, Showkeen Muzamil, Azher Arafah, Parvaiz Ahmad. Zingerone prevents lead-induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats. Journal of food biochemistry. 2021 03; 45(3):e13241. doi: 10.1111/jfbc.13241. [PMID: 32515504]
  • Saeed Mehrzadi, Hamidreza Khalili, Iman Fatemi, Alireza Malayeri, Amir Siahpoosh, Mehdi Goudarzi. Zingerone Mitigates Carrageenan-Induced Inflammation Through Antioxidant and Anti-inflammatory Activities. Inflammation. 2021 Feb; 44(1):186-193. doi: 10.1007/s10753-020-01320-y. [PMID: 32803664]
  • Shengqiang Qian, Huiying Fang, Lu Zheng, Mei Liu. Zingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC-3 cells. Journal of biochemical and molecular toxicology. 2021 Jan; 35(1):e22611. doi: 10.1002/jbt.22611. [PMID: 32905641]
  • Karuna Sharma, Sunil Kumar Bose, Sanjay Chhibber, Kusum Harjai. Exploring the Therapeutic Efficacy of Zingerone Nanoparticles in Treating Biofilm-Associated Pyelonephritis Caused by Pseudomonas aeruginosa in the Murine Model. Inflammation. 2020 Dec; 43(6):2344-2356. doi: 10.1007/s10753-020-01304-y. [PMID: 32948964]
  • Adil Farooq Wali, Muneeb U Rehman, Mohammad Raish, Mohsin Kazi, Padma G M Rao, Osamah Alnemer, Parvaiz Ahmad, Ajaz Ahmad. Zingerone [4-(3-Methoxy-4-hydroxyphenyl)-butan-2] Attenuates Lipopolysaccharide-Induced Inflammation and Protects Rats from Sepsis Associated Multi Organ Damage. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215127. [PMID: 33158114]
  • Sefa Kucukler, Ekrem Darendelioğlu, Cuneyt Caglayan, Adnan Ayna, Serkan Yıldırım, Fatih Mehmet Kandemir. Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis. Life sciences. 2020 Oct; 259(?):118382. doi: 10.1016/j.lfs.2020.118382. [PMID: 32898532]
  • Suk-Ling Wee, Anthony R Clarke. Male-lure type, lure dosage, and fly age at feeding all influence male mating success in Jarvis' fruit fly. Scientific reports. 2020 09; 10(1):15004. doi: 10.1038/s41598-020-72209-x. [PMID: 32929156]
  • Huseyin Gungor, Mehmet Ekici, Mehmet Onder Karayigit, Nergiz Hacer Turgut, Haki Kara, Emre Arslanbas. Zingerone ameliorates oxidative stress and inflammation in bleomycin-induced pulmonary fibrosis: modulation of the expression of TGF-β1 and iNOS. Naunyn-Schmiedeberg's archives of pharmacology. 2020 09; 393(9):1659-1670. doi: 10.1007/s00210-020-01881-7. [PMID: 32377772]
  • Soo Jean Park, Stefano G De Faveri, Jodie Cheesman, Benjamin L Hanssen, Donald N S Cameron, Ian M Jamie, Phillip W Taylor. Zingerone in the Flower of Passiflora Maliformis Attracts an Australian Fruit Fly, Bactrocera Jarvisi (Tryon). Molecules (Basel, Switzerland). 2020 Jun; 25(12):. doi: 10.3390/molecules25122877. [PMID: 32580521]
  • Ping Su, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Wang Lu. A ginger derivative, zingerone-a phenolic compound-induces ROS-mediated apoptosis in colon cancer cells (HCT-116). Journal of biochemical and molecular toxicology. 2019 Dec; 33(12):e22403. doi: 10.1002/jbt.22403. [PMID: 31714660]
  • Jing Wu, Yuqing Duan, Jie Cui, Yinping Dong, Hongyan Li, Meifang Wang, Saijun Fan, Deguan Li, Yiliang Li. Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury. Journal of radiation research. 2019 Nov; 60(6):740-746. doi: 10.1093/jrr/rrz065. [PMID: 31665488]
  • Hongyun Gan, Yaqing Zhang, Qingyun Zhou, Lierui Zheng, Xiaofeng Xie, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan. Zingerone induced caspase-dependent apoptosis in MCF-7 cells and prevents 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in experimental rats. Journal of biochemical and molecular toxicology. 2019 Oct; 33(10):e22387. doi: 10.1002/jbt.22387. [PMID: 31476248]
  • Cüneyt Çağlayan, Parham Taslimi, Yeliz Demir, Sefa Küçükler, Fatih Mehmet Kandemir, İlhami Gulçin. The effects of zingerone against vancomycin-induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes. Journal of biochemical and molecular toxicology. 2019 Oct; 33(10):e22381. doi: 10.1002/jbt.22381. [PMID: 31454121]
  • Zeinab Rafiee, Layasadat Khorsandi, Fereshteh Nejad-Dehbashi. Protective effect of Zingerone against mouse testicular damage induced by zinc oxide nanoparticles. Environmental science and pollution research international. 2019 Sep; 26(25):25814-25824. doi: 10.1007/s11356-019-05818-3. [PMID: 31270769]
  • Fatih Mehmet Kandemir, Serkan Yildirim, Cuneyt Caglayan, Sefa Kucukler, Gizem Eser. Protective effects of zingerone on cisplatin-induced nephrotoxicity in female rats. Environmental science and pollution research international. 2019 Aug; 26(22):22562-22574. doi: 10.1007/s11356-019-05505-3. [PMID: 31165450]
  • Muneeb U Rehman, Shahzada Mudasir Rashid, Saiema Rasool, Sheeba Shakeel, Bilal Ahmad, Sheikh Bilal Ahmad, Hassan Madkhali, Majid Ahmad Ganaie, Sabiya Majid, Showkat Ahmad Bhat. Zingerone (4-(4-hydroxy-3-methylphenyl)butan-2-one) ameliorates renal function via controlling oxidative burst and inflammation in experimental diabetic nephropathy. Archives of physiology and biochemistry. 2019 Jul; 125(3):201-209. doi: 10.1080/13813455.2018.1448422. [PMID: 29537332]
  • Kiran George, Nisha Susan Thomas, Raman Malathi. Modulatory Effect of Selected Dietary Phytochemicals on Delayed Rectifier K+ Current in Human Prostate Cancer Cells. The Journal of membrane biology. 2019 06; 252(2-3):195-206. doi: 10.1007/s00232-019-00070-9. [PMID: 31165179]
  • Majid Ahmad Ganaie, Abdulaziz Al Saeedan, Hassan Madhkali, Basit Lateef Jan, Tanvir Khatlani, Ishfaq Ahmad Sheikh, Muneeb U Rehman, Khalida Wani. Chemopreventive efficacy zingerone (4-[4-hydroxy-3-methylphenyl] butan-2-one) in experimental colon carcinogenesis in Wistar rats. Environmental toxicology. 2019 May; 34(5):610-625. doi: 10.1002/tox.22727. [PMID: 30720227]
  • Bong-Seon Lee, Changhun Lee, Sumin Yang, Sae-Kwang Ku, Jong-Sup Bae. Renal protective effects of zingerone in a mouse model of sepsis. BMB reports. 2019 Apr; 52(4):271-276. doi: . [PMID: 30158024]
  • Neda Sistani Karampour, Ardeshir Arzi, Anahita Rezaie, Marzieh Pashmforoosh, Fatemeh Kordi. Gastroprotective Effect of Zingerone on Ethanol-Induced Gastric Ulcers in Rats. Medicina (Kaunas, Lithuania). 2019 Mar; 55(3):. doi: 10.3390/medicina55030064. [PMID: 30862060]
  • Fatih Mehmet Kandemir, Serkan Yildirim, Sefa Kucukler, Cuneyt Caglayan, Amdia Mahamadu, Muhammet Bahaeddin Dortbudak. Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Sep; 105(?):981-991. doi: 10.1016/j.biopha.2018.06.048. [PMID: 30021393]
  • Tuba Alibakhshi, Mohammad Javad Khodayar, Layasadat Khorsandi, Mohammad Rashno, Leila Zeidooni. Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Sep; 105(?):225-232. doi: 10.1016/j.biopha.2018.05.085. [PMID: 29857302]
  • Suk-Ling Wee, Thelma Peek, Anthony R Clarke. The responsiveness of Bactrocera jarvisi (Diptera: Tephritidae) to two naturally occurring phenylbutaonids, zingerone and raspberry ketone. Journal of insect physiology. 2018 Aug; 109(?):41-46. doi: 10.1016/j.jinsphys.2018.06.004. [PMID: 29890169]
  • Ahmed F Soliman, Lobna M Anees, Doaa M Ibrahim. Cardioprotective effect of zingerone against oxidative stress, inflammation, and apoptosis induced by cisplatin or gamma radiation in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2018 08; 391(8):819-832. doi: 10.1007/s00210-018-1506-4. [PMID: 29736620]
  • Mohammad Firoz Alam, Mohammed M Safhi, Tarique Anwer, Rahimullah Siddiqui, Gyas Khan, Sivakumar Sivagurunathan Moni. Therapeutic potential of Vanillylacetone against CCl4 induced hepatotoxicity by suppressing the serum marker, oxidative stress, inflammatory cytokines and apoptosis in Swiss albino mice. Experimental and molecular pathology. 2018 08; 105(1):81-88. doi: 10.1016/j.yexmp.2018.06.001. [PMID: 29909158]
  • Vivian Boesso Oriani, Izabela Dutra Alvim, Bruno Nicolau Paulino, Fernanda Ramalho Procópio, Glaucia Maria Pastore, Míriam Dupas Hubinger. The influence of the storage temperature on the stability of lipid microparticles containing ginger oleoresin. Food research international (Ottawa, Ont.). 2018 Jul; 109(?):472-480. doi: 10.1016/j.foodres.2018.04.066. [PMID: 29803473]
  • Erdal Kaygusuzoglu, Cuneyt Caglayan, Fatih Mehmet Kandemir, Serkan Yıldırım, Sefa Kucukler, Mehmet Akif Kılınc, Yavuz Selim Saglam. Zingerone ameliorates cisplatin-induced ovarian and uterine toxicity via suppression of sex hormone imbalances, oxidative stress, inflammation and apoptosis in female wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jun; 102(?):517-530. doi: 10.1016/j.biopha.2018.03.119. [PMID: 29587238]
  • Yan Cui, Yan Shi, Yan Bao, Shulong Wang, Qiuju Hua, Yun Liu. Zingerone attenuates diabetic nephropathy through inhibition of nicotinamide adenine dinucleotide phosphate oxidase 4. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Mar; 99(?):422-430. doi: 10.1016/j.biopha.2018.01.051. [PMID: 29367111]
  • Wonhwa Lee, Mi-Hye Hwang, Yuri Lee, Jong-Sup Bae. Protective effects of zingerone on lipopolysaccharide-induced hepatic failure through the modulation of inflammatory pathways. Chemico-biological interactions. 2018 Feb; 281(?):106-110. doi: 10.1016/j.cbi.2017.12.031. [PMID: 29289488]
  • Jienny Lee, Sae Woong Oh, Seoung Woo Shin, Kyung-Woo Lee, Jae-Youl Cho, Jongsung Lee. Zingerone protects keratinocyte stem cells from UVB-induced damage. Chemico-biological interactions. 2018 Jan; 279(?):27-33. doi: 10.1016/j.cbi.2017.11.004. [PMID: 29117507]
  • Mohammed M Safhi. Nephroprotective Effect of Zingerone against CCl4-Induced Renal Toxicity in Swiss Albino Mice: Molecular Mechanism. Oxidative medicine and cellular longevity. 2018; 2018(?):2474831. doi: 10.1155/2018/2474831. [PMID: 29636837]
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