Calcimycin (BioDeep_00000008595)
Secondary id: BioDeep_00000176947
natural product Chemicals and Drugs
代谢物信息卡片
4-CHLORO-2-NITROBENZYLALCOHOL
化学式: C29H37N3O6 (523.2682222000001)
中文名称: 钙离子载体 A23187
谱图信息:
最多检出来源 Homo sapiens(blood) 25%
分子结构信息
SMILES: CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
InChI: InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D007476 - Ionophores > D061207 - Calcium Ionophores
D049990 - Membrane Transport Modulators
C254 - Anti-Infective Agent > C258 - Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis[1][2][3][4].
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:3305
- ChEBI: CHEBI:107643
- KEGG: C11309
- PubChem: 40486
- PubChem: 11957499
- PubChem: 1959
- Metlin: METLIN68980
- ChEMBL: CHEMBL1434752
- ChEMBL: CHEMBL1256686
- MeSH: Calcimycin
- CAS: 52665-69-7
- CAS: 79646-37-0
- CAS: 1212378-76-1
- MoNA: CCMSLIB00003739947
- PMhub: MS000022226
- PubChem: 13484
- NIKKAJI: J22.635A
- RefMet: Calcimycin
- medchemexpress: HY-N6687
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 1969 Streptomyces chartreusis:
- 1969 Streptomyces chartreusis: 10.1128/AAC.01130-10
- 1883 Streptomyces: 10.1021/JA00813A047
- 1969 Streptomyces chartreusis:
- 1969 Streptomyces chartreusis: 10.1128/AAC.01130-10
- 1883 Streptomyces: 10.1021/JA00813A047
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hyun-Su Lee, Eun-Nam Kim, Gil-Saeng Jeong. Oral administration of Helianthus annuus leaf extract ameliorates atopic dermatitis by modulation of T cell activity in vivo.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
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Scientific reports.
2022 07; 12(1):13082. doi:
10.1038/s41598-022-17023-3. [PMID: 35906274] - Sarah L Millington-Burgess, Matthew T Harper. Maintaining flippase activity in procoagulant platelets is a novel approach to reducing thrombin generation.
Journal of thrombosis and haemostasis : JTH.
2022 04; 20(4):989-995. doi:
10.1111/jth.15641. [PMID: 35034417] - Ruifen Ren, Hao Zhou, Lingling Zhang, Xueru Jiang, Yan Liu. Ca2+ participates in programmed cell death by modulating ROS during pollen cryopreservation.
Plant cell reports.
2022 Apr; 41(4):1043-1057. doi:
10.1007/s00299-022-02836-3. [PMID: 35190883] - Barbara B North, Mary B Weitzel, Donald P Waller, William X Birch, Kenneth A Feathergill, Lynn A Birch, Christopher J De Jonge, Gail S Prins. Evaluation of the novel vaginal contraceptive agent PPCM in preclinical studies using sperm hyaluronan binding and acrosome status assays.
Andrology.
2022 02; 10(2):367-376. doi:
10.1111/andr.13110. [PMID: 34542939] - Na-Ra Han, Seong-Gyu Ko, Phil-Dong Moon, Hi-Joon Park. Chloroquine attenuates thymic stromal lymphopoietin production via suppressing caspase-1 signaling in mast cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111835. doi:
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2021 09; 9(5):1631-1651. doi:
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Prostaglandins & other lipid mediators.
2014 Oct; 113-115(?):52-61. doi:
10.1016/j.prostaglandins.2014.08.003. [PMID: 25175316] - Min-Ho Kim, Jun-Ho Seo, Hyung-Min Kim, Hyun-Ja Jeong. Zinc oxide nanoparticles, a novel candidate for the treatment of allergic inflammatory diseases.
European journal of pharmacology.
2014 Sep; 738(?):31-9. doi:
10.1016/j.ejphar.2014.05.030. [PMID: 24877691] - Dipti Mangal, Cornelius E Uboh, Lawrence R Soma, Ying Liu. Inhibitory effect of triamcinolone acetonide on synthesis of inflammatory mediators in the equine.
European journal of pharmacology.
2014 Aug; 736(?):1-9. doi:
10.1016/j.ejphar.2014.04.013. [PMID: 24751711] - Carrie D Fischer, Stephanie C Duquette, Bernard S Renaux, Troy D Feener, Douglas W Morck, Morley D Hollenberg, Merlyn J Lucas, Andre G Buret. Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.
Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4298-307. doi:
10.1128/aac.02813-14. [PMID: 24820086] - Syed Faisal Zaidi, Ji-Hyun Kim, Yashiro Tomoe, Khan Usmanghani, Makoto Kadowaki. Effect of Pakistani medicinal plants on IgE/antigen- and ionophore-induced mucosal mast cells degranulation.
Pakistan journal of pharmaceutical sciences.
2014 Jul; 27(4 Suppl):1041-8. doi:
. [PMID: 25016264] - Eri Fukunaga, Yumi Hirao, Ikuko Ogata-Ikeda, Yumiko Nishimura, Hakaru Seo, Yasuo Oyama. Bisabololoxide A, one of the constituents in German chamomile extract, attenuates cell death induced by calcium overload.
Phytotherapy research : PTR.
2014 May; 28(5):685-91. doi:
10.1002/ptr.5041. [PMID: 23873581] - Na-Ra Han, Sang Woo Kang, Phil-Dong Moon, Jae-Bum Jang, Hyung-Min Kim, Hyun-Ja Jeong. Genuine traditional Korean medicine, Naju Jjok (Chung-Dae, Polygonum tinctorium) improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesional skin.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Mar; 21(4):453-60. doi:
10.1016/j.phymed.2013.09.021. [PMID: 24200496] - Takayuki Suzuki, Jun Suzuki, Shigekazu Nagata. Functional swapping between transmembrane proteins TMEM16A and TMEM16F.
The Journal of biological chemistry.
2014 Mar; 289(11):7438-47. doi:
10.1074/jbc.m113.542324. [PMID: 24478309] - Lital Sever, Nguyen T K Vo, Niels C Bols, Brian Dixon. Rainbow trout (Oncorhynchus mykiss) contain two calnexin genes which encode distinct proteins.
Developmental and comparative immunology.
2014 Feb; 42(2):211-9. doi:
10.1016/j.dci.2013.09.005. [PMID: 24060503] - Viachaslau Barodka, Joy G Mohanty, Asif K Mustafa, Lakshmi Santhanam, Aoibhinn Nyhan, Anil K Bhunia, Gautam Sikka, Daniel Nyhan, Dan E Berkowitz, Joseph M Rifkind. Nitroprusside inhibits calcium-induced impairment of red blood cell deformability.
Transfusion.
2014 Feb; 54(2):434-44. doi:
10.1111/trf.12291. [PMID: 23781865] - Hyun-A Oh, Myong-Jo Kim, Tae-Yong Shin, Hyung-Min Kim, Hyun-Ja Jeong. The antiallergic mechanisms of Citrus sunki and bamboo salt (K-ALL) in an allergic rhinitis model.
Experimental biology and medicine (Maywood, N.J.).
2014 Jan; 239(1):83-93. doi:
10.1177/1535370213505826. [PMID: 24131540] - Xiao-Feng Lai, Hua-Di Qin, Lei-Lei Guo, Zi-Guo Luo, Jing Chang, Chun-Chang Qin. Hypercholesterolemia increases the production of leukotriene B4 in neutrophils by enhancing the nuclear localization of 5-lipoxygenase.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2014; 34(5):1723-32. doi:
10.1159/000366373. [PMID: 25428728] - Yicun Wu, Jin Dai, Weilin Zhang, Rong Yan, Yiwen Zhang, Changgeng Ruan, Kesheng Dai. Arsenic trioxide induces apoptosis in human platelets via C-Jun NH2-terminal kinase activation.
PloS one.
2014; 9(1):e86445. doi:
10.1371/journal.pone.0086445. [PMID: 24466103] - Ruzica Livaja Koshiar, Sofia Somajo, Eva Norström, Björn Dahlbäck. Erythrocyte-derived microparticles supporting activated protein C-mediated regulation of blood coagulation.
PloS one.
2014; 9(8):e104200. doi:
10.1371/journal.pone.0104200. [PMID: 25136857] - Hyo-Hyun Park, Sun-Gun Kim, Young Na Park, Jiean Lee, Youn Ju Lee, Na-Young Park, Kyu-Tae Jeong, Eunkyung Lee. Suppressive effects of britanin, a sesquiterpene compound isolated from Inulae flos, on mast cell-mediated inflammatory responses.
The American journal of Chinese medicine.
2014; 42(4):935-47. doi:
10.1142/s0192415x14500591. [PMID: 25004884] - Y S Oh, H S Ahn, M C Gye. Fucosyl neoglycoprotein binds to mouse epididymal spermatozoa and inhibits sperm binding to the egg zona pellucida.
Andrologia.
2013 Dec; 45(6):363-8. doi:
10.1111/and.12024. [PMID: 22998388] - Asuman Mutlu, Armen V Gyulkhandanyan, John Freedman, Valery Leytin. Concurrent and separate inside-out transition of platelet apoptosis and activation markers to the platelet surface.
British journal of haematology.
2013 Nov; 163(3):377-84. doi:
10.1111/bjh.12529. [PMID: 24033315] - Hee Joe Lee, Hye-Sook Seo, Gyung-Jun Kim, Chan Yong Jeon, Jong Hyeong Park, Bo-Hyoung Jang, Sun-Ju Park, Yong-Cheol Shin, Seong-Gyu Ko. Houttuynia cordata Thunb inhibits the production of pro-inflammatory cytokines through inhibition of the NFκB signaling pathway in HMC-1 human mast cells.
Molecular medicine reports.
2013 Sep; 8(3):731-6. doi:
10.3892/mmr.2013.1585. [PMID: 23846481] - Lixia Gou, Qiulin Wu, Shuangjun Lin, Xiangmei Li, Jingdan Liang, Xiufen Zhou, Derong An, Zixin Deng, Zhijun Wang. Mutasynthesis of pyrrole spiroketal compound using calcimycin 3-hydroxy anthranilic acid biosynthetic mutant.
Applied microbiology and biotechnology.
2013 Sep; 97(18):8183-91. doi:
10.1007/s00253-013-4882-1. [PMID: 23666477] - Mario Meola, Ilaria Petrucci, Adamasco Cupisti. Ultrasound in clinical setting of secondary hyperparathyroidism.
Journal of nephrology.
2013 Sep; 26(5):848-55. doi:
10.5301/jn.5000219. [PMID: 23042437] - Ana Hurtado de Llera, David Martin-Hidalgo, Joan E Rodriguez-Gil, M Cruz Gil, Luis J Garcia-Marin, M Julia Bragado. AMP-activated kinase, AMPK, is involved in the maintenance of plasma membrane organization in boar spermatozoa.
Biochimica et biophysica acta.
2013 Sep; 1828(9):2143-51. doi:
10.1016/j.bbamem.2013.05.026. [PMID: 23747367] - Hiroyuki Nakamura, Yuta Moriyama, Tomohiko Makiyama, Shunsuke Emori, Hisahiro Yamashita, Risa Yamazaki, Toshihiko Murayama. Lactosylceramide interacts with and activates cytosolic phospholipase A2α.
The Journal of biological chemistry.
2013 Aug; 288(32):23264-72. doi:
10.1074/jbc.m113.491431. [PMID: 23801329] - R W Kirby, A Martelli, V Calderone, N G McKay, K Lawson. Large conductance Ca(2+)-activated K(+) channel (BKCa) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects.
Bioorganic & medicinal chemistry.
2013 Jul; 21(14):4186-91. doi:
10.1016/j.bmc.2013.05.003. [PMID: 23707646] - Gianni Francesco Guidetti, Daria Manganaro, Alessandra Consonni, Ilaria Canobbio, Cesare Balduini, Mauro Torti. Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca(2+)-dependent activation of platelet Rap1b GTPase.
The Biochemical journal.
2013 Jul; 453(1):115-23. doi:
10.1042/bj20130131. [PMID: 23600630] - Liancheng Liu, Cong Wang, Juan'e Dong, Hui Su, Zequn Zhuo, Yaxin Xue. [Effect of calcium on medium alkalinization induced by salicylic acid in Salvia miltiorrhiza suspension cultures].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2013 Jul; 29(7):986-97. doi:
. [PMID: 24195365] - Jianbo Yang, Varsha Singh, Boyoung Cha, Tian-E Chen, Rafiquel Sarker, Rakhilya Murtazina, Shi Jin, Nicholas C Zachos, George H Patterson, C Ming Tse, Olga Kovbasnjuk, Xuhang Li, Mark Donowitz. NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.
The Journal of biological chemistry.
2013 Jun; 288(23):16960-16974. doi:
10.1074/jbc.m113.470799. [PMID: 23612977] - Jun Suzuki, Toshihiro Fujii, Takeshi Imao, Kenji Ishihara, Hiroshi Kuba, Shigekazu Nagata. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.
The Journal of biological chemistry.
2013 May; 288(19):13305-16. doi:
10.1074/jbc.m113.457937. [PMID: 23532839] - Joon-Ho Keum, Ok-Hwa Kang, Sung-Bae Kim, Su-Hyun Mun, Yun-Soo Seo, Ma-Ryong Kim, Jung-Rae Rho, Young-Seob Lee, Chung-Berm Park, Young-Guk Kim, Yong-Il Kim, Sin-Hee Han, Dong-Yeul Kwon. The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells.
Chinese journal of integrative medicine.
2013 May; 19(5):380-6. doi:
10.1007/s11655-013-1448-0. [PMID: 23494327] - Tsuneaki Omae, Taiji Nagaoka, Ichiro Tanano, Akitoshi Yoshida. Homocysteine inhibition of endothelium-dependent nitric oxide-mediated dilation of porcine retinal arterioles via enhanced superoxide production.
Investigative ophthalmology & visual science.
2013 Mar; 54(3):2288-95. doi:
10.1167/iovs.12-11082. [PMID: 23425693] - Takuya Matsui, Chihiro Ito, Hiroshi Furukawa, Tadashi Okada, Masataka Itoigawa. Lansiumamide B and SB-204900 isolated from Clausena lansium inhibit histamine and TNF-α release from RBL-2H3 cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2013 Mar; 62(3):333-41. doi:
10.1007/s00011-012-0586-8. [PMID: 23324895] - Daiana M Vota, Romina E Maltaneri, Shirley D Wenker, Alcira B Nesse, Daniela C Vittori. Differential erythropoietin action upon cells induced to eryptosis by different agents.
Cell biochemistry and biophysics.
2013 Mar; 65(2):145-57. doi:
10.1007/s12013-012-9408-4. [PMID: 22903352] - I Barrier-Battut, C Bonnet, A Giraudo, C Dubois, M Caillaud, M Vidament. Removal of seminal plasma enhances membrane stability on fresh and cooled stallion spermatozoa.
Reproduction in domestic animals = Zuchthygiene.
2013 Feb; 48(1):64-71. doi:
10.1111/j.1439-0531.2012.02026.x. [PMID: 22524671] - Donatella Vizza, Anna Perri, Danilo Lofaro, Giuseppina Toteda, Simona Lupinacci, Francesca Leone, Paolo Gigliotti, Teresa Papalia, Renzo Bonofiglio. Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells.
PloS one.
2013; 8(11):e80113. doi:
10.1371/journal.pone.0080113. [PMID: 24244623] - Steffen Nyegaard, Valerie A Novakovic, Jan T Rasmussen, Gary E Gilbert. Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells.
PloS one.
2013; 8(10):e77143. doi:
10.1371/journal.pone.0077143. [PMID: 24194865] - Rob van Zwieten, Andrea E Bochem, Petra M Hilarius, Robin van Bruggen, Ferry Bergkamp, G Kees Hovingh, Arthur J Verhoeven. The cholesterol content of the erythrocyte membrane is an important determinant of phosphatidylserine exposure.
Biochimica et biophysica acta.
2012 Dec; 1821(12):1493-500. doi:
10.1016/j.bbalip.2012.08.008. [PMID: 22960544] - Inna Freikman, Israel Ringel, Eitan Fibach. Shedding of phosphatidylserine from developing erythroid cells involves microtubule depolymerization and affects membrane lipid composition.
The Journal of membrane biology.
2012 Dec; 245(12):779-87. doi:
10.1007/s00232-012-9478-7. [PMID: 22825717] - Yuri Choi, Myung Suk Kim, Jae-Kwan Hwang. Inhibitory effects of panduratin A on allergy-related mediator production in rat basophilic leukemia mast cells.
Inflammation.
2012 Dec; 35(6):1904-15. doi:
10.1007/s10753-012-9513-y. [PMID: 22864999] - Adam Wieschhaus, Anwar Khan, Asma Zaidi, Henry Rogalin, Toshihiko Hanada, Fei Liu, Lucia De Franceschi, Carlo Brugnara, Alicia Rivera, Athar H Chishti. Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology.
The Biochemical journal.
2012 Nov; 448(1):141-52. doi:
10.1042/bj20121008. [PMID: 22870887] - Iu V Karpets, Iu E Kolupaev, T O Iastreb, A P Dmitriev. [Possible pathways of heat resistance induction in plant cells by exogenous nitrogen oxide].
TSitologiia i genetika.
2012 Nov; 46(6):28-35. doi:
". [PMID: 23285747] - Juan Meng, Dawei Peng, Xuelan Zuo. [Effect of calcium ionophore A23187 plus IFN-γ on dendritic cells derived from peripheral blood mononuclear cells].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2012 Oct; 37(10):1003-7. doi:
10.3969/j.issn.1672-7347.2012.10.006. [PMID: 23117452] - Tudevdagva Gerelsaikhan, Pavan Kumar Vasa, Avinash Chander. Annexin A7 and SNAP23 interactions in alveolar type II cells and in vitro: a role for Ca(2+) and PKC.
Biochimica et biophysica acta.
2012 Oct; 1823(10):1796-806. doi:
10.1016/j.bbamcr.2012.06.010. [PMID: 22713544] - Young Sun Han, Myung-Suk Kim, Jae-Kwan Hwang. Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells.
Inflammation.
2012 Oct; 35(5):1723-31. doi:
10.1007/s10753-012-9490-1. [PMID: 22729280]