Calcimycin (BioDeep_00000008595)

 

Secondary id: BioDeep_00000176947

natural product Chemicals and Drugs


代谢物信息卡片


4-CHLORO-2-NITROBENZYLALCOHOL

化学式: C29H37N3O6 (523.2682)
中文名称: 钙离子载体 A23187
谱图信息: 最多检出来源 Homo sapiens(COVID-19)(blood) 40.82%

分子结构信息

SMILES: CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
InChI: InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D007476 - Ionophores > D061207 - Calcium Ionophores
D049990 - Membrane Transport Modulators
C254 - Anti-Infective Agent > C258 - Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis[1][2][3][4].

同义名列表

6 个代谢物同义名

Ionophore A23187; Calcimycin; 4-CHLORO-2-NITROBENZYLALCOHOL; A-23187; Antibiotic A-23187; Calcimycin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALOX5, ANXA5, CAT, FPR1, HSPA5, PTGS1
Peripheral membrane protein 3 ALOX5, ANXA5, PTGS1
Endoplasmic reticulum membrane 2 HSPA5, PTGS1
Nucleus 2 HSPA5, PLCZ1
cytosol 6 ALOX5, ANXA5, CAT, HSPA5, PLCZ1, PRKCQ
nucleoplasm 2 ALOX5, PLCZ1
Cell membrane 3 CD8A, FPR1, TNF
Multi-pass membrane protein 2 CACNA1I, FPR1
Synapse 1 TAC1
cell surface 2 HSPA5, TNF
Golgi apparatus 1 PTGS1
Golgi membrane 1 INS
lysosomal membrane 1 EGF
neuronal cell body 2 TAC1, TNF
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 ALOX5
plasma membrane 11 CACNA1I, CD8A, EGF, F2, FPR1, HSPA5, IFNLR1, IGHE, KNG1, PRKCQ, TNF
Membrane 7 ANXA5, CACNA1I, CAT, EGF, FPR1, HSPA5, IFNLR1
axon 1 TAC1
extracellular exosome 7 ANXA5, CAT, EGF, F2, HSPA5, KNG1, PTGS1
endoplasmic reticulum 1 HSPA5
extracellular space 10 ALOX5, EGF, F2, IGHE, IL4, IL6, INS, KNG1, TAC1, TNF
perinuclear region of cytoplasm 2 ALOX5, PLCZ1
mitochondrion 2 CAT, HSPA5
protein-containing complex 2 CAT, HSPA5
intracellular membrane-bounded organelle 3 CAT, HSPA5, PTGS1
Microsome membrane 1 PTGS1
pronucleus 1 PLCZ1
Single-pass type I membrane protein 3 CD8A, IFNLR1, IGHE
Secreted 4 F2, IL4, IL6, INS
extracellular region 13 ALOX5, ANXA5, CAT, CD8A, EGF, F2, IGHE, IL4, IL6, INS, KNG1, TAC1, TNF
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 1 CAT
centriolar satellite 1 PRKCQ
photoreceptor outer segment 1 PTGS1
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 3 ANXA5, CD8A, TNF
nucleolus 1 PLCZ1
midbody 1 HSPA5
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 2 ALOX5, PLCZ1
Membrane raft 1 TNF
focal adhesion 3 ANXA5, CAT, HSPA5
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 3 ANXA5, F2, KNG1
receptor complex 1 CD8A
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS1
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
Secreted, extracellular space 1 KNG1
blood microparticle 2 F2, KNG1
[Isoform 2]: Cell membrane 1 IGHE
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Endomembrane system 1 PTGS1
endosome lumen 1 INS
Melanosome 1 HSPA5
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 2 ALOX5, CAT
secretory granule lumen 3 ALOX5, CAT, INS
secretory granule membrane 1 FPR1
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 5 F2, HSPA5, IL6, INS, KNG1
nuclear matrix 1 ALOX5
platelet alpha granule lumen 2 EGF, KNG1
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
azurophil granule membrane 1 FPR1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGF
endoplasmic reticulum-Golgi intermediate compartment 1 HSPA5
ficolin-1-rich granule membrane 1 FPR1
[Isoform 1]: Cell membrane 1 CD8A
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD8A
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
sperm head 1 PLCZ1
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSPA5
endothelial microparticle 1 ANXA5
Nucleus intermembrane space 1 ALOX5
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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