3-Isobutyl-1-methylxanthine (BioDeep_00000858620)

   

Volatile Flavor Compounds


代谢物信息卡片


3-Isobutyl-1-methylxanthine

化学式: C10H14N4O2 (222.1116704)
中文名称: 3-异丁基-1-甲基黄嘌呤(IBMX)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
InChI: InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)

描述信息

D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors

同义名列表

2 个代谢物同义名

3-Isobutyl-1-methylxanthine; IBMX



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cody Aplin, Richard A Cerione. Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6. The Journal of biological chemistry. 2023 Dec; 300(2):105608. doi: 10.1016/j.jbc.2023.105608. [PMID: 38159849]
  • Junjie Yue, Caiting Sun, Jinyuan Tang, Qiyuan Zhang, Mengjie Lou, Hongwen Sun, Lianying Zhang. Downregulation of miRNA-155-5p contributes to the adipogenic activity of 2-ethylhexyl diphenyl phosphate in 3T3-L1 preadipocytes. Toxicology. 2023 Feb; 487(?):153452. doi: 10.1016/j.tox.2023.153452. [PMID: 36764644]
  • Toshio Kaneda, Farida Ifadotunnikmah, Alfarius Eko Nugroho, Sae Koshikawa, Sasaki Tadahiro, Yusuke Hirasawa, Hiroshi Morita. Calofolic Acid-A from Calophyllum scriblitifolium Bark Has Vasorelaxant Activity via Indirect PKA Activation Caused by PI-3 Kinase Inhibition in Rat Vascular Smooth Muscle Cells. Journal of natural products. 2022 09; 85(9):2192-2198. doi: 10.1021/acs.jnatprod.2c00502. [PMID: 35983865]
  • Yong Pu, Elvis Ticiani, Anita A Waye, Kunzhe Dong, Huanmin Zhang, Almudena Veiga-Lopez. Sex-specific extracellular matrix remodeling during early adipogenic differentiation by gestational bisphenol A exposure. Chemosphere. 2022 Sep; 302(?):134806. doi: 10.1016/j.chemosphere.2022.134806. [PMID: 35504463]
  • Andrea Svoradová, Andrej Baláži, Peter Chrenek. Effect of selected natural and synthetic substances on rabbit reproduction-A mini review. Journal of animal physiology and animal nutrition. 2022 May; 106(3):622-629. doi: 10.1111/jpn.13641. [PMID: 34542913]
  • Zeltzin Ceja-Galicia, Diana Calderón-DuPont, Alberto Daniel, Luz María Chiu, Andrea Díaz-Villaseñor. Leptin and adiponectin synthesis and secretion in mature 3T3-L1 adipocytes are differentially down-regulated by arsenic and palmitic acid exposure throughout different stages of adipogenesis. Life sciences. 2022 Feb; 291(?):120262. doi: 10.1016/j.lfs.2021.120262. [PMID: 34968464]
  • Hyejin Ko, Seungchan An, Sungjin Ahn, In Guk Park, Junpyo Gong, Seok Young Hwang, Soyeon Oh, Min Won Ki, Sun Hee Jin, Won Jun Choi, Minsoo Noh. Sunscreen filter octocrylene is a potential obesogen by acting as a PPARγ partial agonist. Toxicology letters. 2022 Feb; 355(?):141-149. doi: 10.1016/j.toxlet.2021.12.001. [PMID: 34864131]
  • Lu Guo, Sun Young Park, He Mi Kang, Nam Jun Kang, Dae Youn Hwang, Young-Whan Choi. Edible Vitalmelon Fruit Extract Inhibits Adipogenesis and Ameliorates High-Fat Diet-Induced Obesity. BioMed research international. 2022; 2022(?):2369650. doi: 10.1155/2022/2369650. [PMID: 36193302]
  • Annanda Lyra Ribeiro, Letícia Werzel Bassai, Anny Waloski Robert, Thiago Neves Machado, Arandi Ginane Bezerra, Cintia Delai da Silva Horinouchi, Alessandra Melo de Aguiar. Bismuth-based nanoparticles impair adipogenic differentiation of human adipose-derived mesenchymal stem cells. Toxicology in vitro : an international journal published in association with BIBRA. 2021 Dec; 77(?):105248. doi: 10.1016/j.tiv.2021.105248. [PMID: 34560244]
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  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Christine E Stephens, Jonathan M Whittamore, Marguerite Hatch. The role of NHE3 (Slc9a3) in oxalate and sodium transport by mouse intestine and regulation by cAMP. Physiological reports. 2021 04; 9(7):e14828. doi: 10.14814/phy2.14828. [PMID: 33904662]
  • Kyeong Won Lee, Young Jun An, Janet Lee, Jung-Hyun Lee, Hyung-Soon Yim. α-Poly-L-lysine functions as an adipogenic inducer in 3T3-L1 preadipocytes. Amino acids. 2021 Apr; 53(4):587-596. doi: 10.1007/s00726-020-02932-2. [PMID: 33743070]
  • Liliya V Vasileva, Martina S Savova, Daniel Tews, Martin Wabitsch, Milen I Georgiev. Rosmarinic acid attenuates obesity and obesity-related inflammation in human adipocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Mar; 149(?):112002. doi: 10.1016/j.fct.2021.112002. [PMID: 33476690]
  • Zafer Sahin, Sevde Nur Biltekin, Leyla Yurttas, Barkin Berk, Yağmur Özhan, Hande Sipahi, Zhan-Guo Gao, Kenneth A Jacobson, Şeref Demirayak. Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition. European journal of medicinal chemistry. 2021 Feb; 212(?):113125. doi: 10.1016/j.ejmech.2020.113125. [PMID: 33422981]
  • Won Seok Choi, Hyun Sik Kang, Hong Jo Kim, Wang Tae Lee, Uy Dong Sohn, Ji-Yun Lee. Vinpocetine alleviates lung inflammation via macrophage inflammatory protein-1β inhibition in an ovalbumin-induced allergic asthma model. PloS one. 2021; 16(4):e0251012. doi: 10.1371/journal.pone.0251012. [PMID: 33914833]
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  • Eunkuk Park, Chang Gun Lee, Junho Kim, Subin Yeo, Ji Ae Kim, Chun Whan Choi, Seon-Yong Jeong. Antiobesity Effects of Gentiana lutea Extract on 3T3-L1 Preadipocytes and a High-Fat Diet-Induced Mouse Model. Molecules (Basel, Switzerland). 2020 May; 25(10):. doi: 10.3390/molecules25102453. [PMID: 32466183]
  • Karuna Rasineni, Jacy L Kubik, Kurt L Knight, Lukas Hall, Carol A Casey, Kusum K Kharbanda. Ghrelin regulates adipose tissue metabolism: Role in hepatic steatosis. Chemico-biological interactions. 2020 May; 322(?):109059. doi: 10.1016/j.cbi.2020.109059. [PMID: 32171850]
  • Hye Ju Han, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Seul Ki Yoo, Ho Jin Heo. Anti-Melanogenic Effect of Ethanolic Extract of Sorghum bicolor on IBMX-Induced Melanogenesis in B16/F10 Melanoma Cells. Nutrients. 2020 Mar; 12(3):. doi: 10.3390/nu12030832. [PMID: 32245029]
  • Jordi Blanco, Laia Guardia-Escote, Miquel Mulero, Pia Basaure, Judit Biosca-Brull, Maria Cabré, Maria Teresa Colomina, José L Domingo, Domènec J Sánchez. Obesogenic effects of chlorpyrifos and its metabolites during the differentiation of 3T3-L1 preadipocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Mar; 137(?):111171. doi: 10.1016/j.fct.2020.111171. [PMID: 32017950]
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  • Jhih-Wei Hsu, Szu-Ching Yeh, Feng-Yuan Tsai, Hsin-Wei Chen, Tsui-Chun Tsou. Fibroblast growth factor 21 secretion enhances glucose uptake in mono(2-ethylhexyl)phthalate-treated adipocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2019 Sep; 59(?):246-254. doi: 10.1016/j.tiv.2019.04.021. [PMID: 31009676]
  • Hsin-Hsueh Shen, Chien-Yi Yang, Ching-Wen Kung, Shu-Ying Chen, Hong-Min Wu, Pao-Yun Cheng, Kwok-Keung Lam, Yen-Mei Lee. Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3 T3-L1 cells. Journal of biomedical science. 2019 Aug; 26(1):62. doi: 10.1186/s12929-019-0556-3. [PMID: 31470850]
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  • Wen Qi, Liting Zhou, Tianye Zhao, Shuang Ding, Qi Xu, Xu Han, Yaming Zhao, Xinyue Song, Tianyang Zhao, Xiaohan Zhang, Lin Ye. Effect of the TYK-2/STAT-3 pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate. Molecular and cellular endocrinology. 2019 03; 484(?):52-58. doi: 10.1016/j.mce.2019.01.012. [PMID: 30660700]
  • Enrico D'Aniello, Tariq Fellous, Fabio Arturo Iannotti, Alessandra Gentile, Marco Allarà, Francesca Balestrieri, Roy Gray, Pietro Amodeo, Rosa Maria Vitale, Vincenzo Di Marzo. Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach. Biochimica et biophysica acta. General subjects. 2019 03; 1863(3):586-597. doi: 10.1016/j.bbagen.2019.01.002. [PMID: 30611848]
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