Triacetyloleandomycin (BioDeep_00000858485)

Main id: BioDeep_00000009381

 


代谢物信息卡片


Pharmakon1600-01502203

化学式: C41H67NO15 (813.4510472)
中文名称: 竹桃霉素三乙酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC(C(C(O1)OC2C(CC3(CO3)C(=O)C(C(C(C(OC(=O)C(C(C2C)OC4CC(C(C(O4)C)OC(=O)C)OC)C)C)C)OC(=O)C)C)C)OC(=O)C)N(C)C
InChI: InChI=1S/C41H67NO15/c1-19-17-41(18-49-41)38(46)23(5)34(53-27(9)43)21(3)25(7)52-39(47)24(6)35(56-32-16-31(48-14)36(26(8)51-32)54-28(10)44)22(4)33(19)57-40-37(55-29(11)45)30(42(12)13)15-20(2)50-40/h19-26,30-37,40H,15-18H2,1-14H3/t19-,20+,21-,22+,23+,24+,25+,26-,30-,31-,32-,33-,34-,35-,36-,37+,40-,41+/m0/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FA - Macrolides
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
Same as: D01322

同义名列表

3 个代谢物同义名

Pharmakon1600-01502203; TROLEANDOMYCIN; Triacetyloleandomycin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats. Drug metabolism and disposition: the biological fate of chemicals. 2015 Jul; 43(7):958-68. doi: 10.1124/dmd.115.063370. [PMID: 25870103]
  • Qi Shen, Minjuan Zuo, Li Ma, Ye Tian, Lu Wang, Huidi Jiang, Quan Zhou, Hui Zhou, Lushan Yu, Su Zeng. Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity. Chemico-biological interactions. 2014 Dec; 224(?):89-99. doi: 10.1016/j.cbi.2014.10.014. [PMID: 25451576]
  • Joseph W Polli, Elizabeth Hussey, Mark Bush, Grant Generaux, Glenn Smith, David Collins, Susan McMullen, Nancy Turner, Derek J Nunez. Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: from in vitro data to clinical study design. Xenobiotica; the fate of foreign compounds in biological systems. 2013 Jun; 43(6):498-508. doi: 10.3109/00498254.2012.739719. [PMID: 23256625]
  • Shingen Misaka, Keisuke Kawabe, Satomi Onoue, José Pablo Werba, Monica Giroli, Hiroshi Watanabe, Shizuo Yamada. Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats. Drug metabolism and pharmacokinetics. 2013; 28(6):514-8. doi: 10.2133/dmpk.dmpk-13-nt-006. [PMID: 23698259]
  • Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki. Cholesterol 25-hydroxylation activity of CYP3A. Journal of lipid research. 2011 Aug; 52(8):1509-16. doi: 10.1194/jlr.m014084. [PMID: 21576599]
  • Svein I Johannessen, Cecilie Johannessen Landmark. Antiepileptic drug interactions - principles and clinical implications. Current neuropharmacology. 2010 Sep; 8(3):254-67. doi: 10.2174/157015910792246254. [PMID: 21358975]
  • Y-F Cao, Y-Y Zhang, J Li, G-B Ge, D Hu, H-X Liu, T Huang, Y-C Wang, Z-Z Fang, D-X Sun, H Huo, J Yin, L Yang. CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems. 2010 Jan; 40(1):38-47. doi: 10.3109/00498250903366052. [PMID: 20001672]
  • Soo H Bae, Soo K Bae, Myung G Lee. Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo. The Journal of pharmacy and pharmacology. 2009 Dec; 61(12):1637-42. doi: 10.1211/jpp/61.12.0008. [PMID: 19958586]
  • Hao Chen, Michael Zientek, Mehran Jalaie, Yanhua Zhang, Christopher Bigge, Abdul Mutlib. Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes. Chemical research in toxicology. 2009 Sep; 22(9):1603-12. doi: 10.1021/tx900167y. [PMID: 19697924]
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  • Rheem A Totah, Kyle E Allen, Pamela Sheffels, Dale Whittington, Evan D Kharasch. Enantiomeric metabolic interactions and stereoselective human methadone metabolism. The Journal of pharmacology and experimental therapeutics. 2007 Apr; 321(1):389-99. doi: 10.1124/jpet.106.117580. [PMID: 17259447]
  • Joo H Lee, Eun J Kim, Jong W Kwon, Moohi Yoo, Myung G Lee. Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats. Biopharmaceutics & drug disposition. 2006 Apr; 27(3):125-31. doi: 10.1002/bdd.491. [PMID: 16400709]
  • Thomas M Polasek, John O Miners. Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate. European journal of clinical pharmacology. 2006 Mar; 62(3):203-8. doi: 10.1007/s00228-005-0091-x. [PMID: 16416302]
  • Harshvardhan N Chaobal, Evan D Kharasch. Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam. Clinical pharmacology and therapeutics. 2005 Nov; 78(5):529-39. doi: 10.1016/j.clpt.2005.08.004. [PMID: 16321619]
  • Yu C Kim, Hyun J Shim, Joo H Lee, Soon H Kim, Jong W Kwon, Won B Kim, Myung G Lee. Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous DA-8159, a new erectogenic, in rats. Biopharmaceutics & drug disposition. 2005 Sep; 26(6):233-41. doi: 10.1002/bdd.453. [PMID: 15926192]
  • Dae Y Lee, Shin J Lee, Myung G Lee. Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous torasemide in rats. International journal of pharmaceutics. 2005 Jul; 298(1):38-46. doi: 10.1016/j.ijpharm.2005.03.014. [PMID: 15890479]
  • Helén Tuvesson, Ingrid Hallin, Robert Persson, Birgitta Sparre, Per Olov Gunnarsson, Janeric Seidegård. Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator. Drug metabolism and disposition: the biological fate of chemicals. 2005 Jun; 33(6):866-72. doi: 10.1124/dmd.104.002238. [PMID: 15764719]
  • Yu-Ping Wang, Peter P Fu, Ming W Chou. Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivo. International journal of environmental research and public health. 2005 Apr; 2(1):74-9. doi: 10.3390/ijerph2005010074. [PMID: 16705803]
  • Theresa Mariero Klees, Pamela Sheffels, Ola Dale, Evan D Kharasch. Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug metabolism and disposition: the biological fate of chemicals. 2005 Mar; 33(3):303-11. doi: 10.1124/dmd.104.002709. [PMID: 15557344]
  • Evan D Kharasch, Dale Whittington, Christine Hoffer, Kevin Krudys, Keith Craig, Paolo Vicini, Pam Sheffels, Bojan Lalovic. Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. Clinical pharmacokinetics. 2005; 44(7):731-51. doi: 10.2165/00003088-200544070-00005. [PMID: 15966756]
  • Evan D Kharasch, Alysa Walker, Christine Hoffer, Pamela Sheffels. Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis. Clinical pharmacology and therapeutics. 2004 Nov; 76(5):452-66. doi: 10.1016/j.clpt.2004.07.006. [PMID: 15536460]
  • Wayne A Ray, Katherine T Murray, Sarah Meredith, Sukumar Suguna Narasimhulu, Kathi Hall, C Michael Stein. Oral erythromycin and the risk of sudden death from cardiac causes. The New England journal of medicine. 2004 Sep; 351(11):1089-96. doi: 10.1056/nejmoa040582. [PMID: 15356306]
  • Yukiko Minamiyama, Shigekazu Takemura, Shinya Toyokuni, Susumu Imaoka, Yoshihiko Funae, Kazuhiro Hirohashi, Toshikazu Yoshikawa, Shigeru Okada. CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats. Free radical biology & medicine. 2004 Sep; 37(5):703-12. doi: 10.1016/j.freeradbiomed.2004.05.022. [PMID: 15288127]
  • Evan D Kharasch, Christine Hoffer, Dale Whittington, Pamela Sheffels. Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. Clinical pharmacology and therapeutics. 2004 Sep; 76(3):250-69. doi: 10.1016/j.clpt.2004.05.003. [PMID: 15371986]
  • Pam Sheffels, Jesara L Schroeder, T Gul Altuntas, H Denny Liggitt, Evan D Kharasch. Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. Chemical research in toxicology. 2004 Sep; 17(9):1177-89. doi: 10.1021/tx049899e. [PMID: 15377151]
  • Evan D Kharasch, Dale Whittington, Christine Hoffer. Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. Anesthesiology. 2004 Sep; 101(3):729-37. doi: 10.1097/00000542-200409000-00022. [PMID: 15329598]
  • Ae K Lee, Joo H Lee, Jong W Kwon, Won B Kim, Sang G Kim, So H Kim, Myung G Lee. Pharmacokinetics of clarithromycin in rats with acute renal failure induced by uranyl nitrate. Biopharmaceutics & drug disposition. 2004 Sep; 25(6):273-82. doi: 10.1002/bdd.409. [PMID: 15334627]
  • T Gul Altuntas, Sang B Park, Evan D Kharasch. Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). Chemical research in toxicology. 2004 Mar; 17(3):435-45. doi: 10.1021/tx034254k. [PMID: 15025515]
  • Rory P Remmel, Brenda C Crews, Kevin R Kozak, Amit S Kalgutkar, Lawrence J Marnett, Amit S Algutkar. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug metabolism and disposition: the biological fate of chemicals. 2004 Jan; 32(1):113-22. doi: 10.1124/dmd.32.1.113. [PMID: 14709628]
  • Vered Stearns, Michael D Johnson, James M Rae, Alan Morocho, Antonella Novielli, Pankaj Bhargava, Daniel F Hayes, Zeruesenay Desta, David A Flockhart. Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. Journal of the National Cancer Institute. 2003 Dec; 95(23):1758-64. doi: 10.1093/jnci/djg108. [PMID: 14652237]
  • S G O'Brien, P Meinhardt, E Bond, J Beck, B Peng, C Dutreix, G Mehring, S Milosavljev, C Huber, R Capdeville, T Fischer. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. British journal of cancer. 2003 Nov; 89(10):1855-9. doi: 10.1038/sj.bjc.6601152. [PMID: 14612892]
  • Vsevolod E Kostrubsky, Stephen C Strom, Janean Hanson, Ellen Urda, Kelly Rose, James Burliegh, Philip Zocharski, Hongbo Cai, Jacqueline F Sinclair, Jasminder Sahi. Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats. Toxicological sciences : an official journal of the Society of Toxicology. 2003 Nov; 76(1):220-8. doi: 10.1093/toxsci/kfg217. [PMID: 12944587]
  • David C Evans, Desmond O'Connor, Brian G Lake, Raymond Evers, Christopher Allen, Richard Hargreaves. Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein. Drug metabolism and disposition: the biological fate of chemicals. 2003 Jul; 31(7):861-9. doi: 10.1124/dmd.31.7.861. [PMID: 12814962]
  • Camille P Granvil, Ai-Ming Yu, Guillermo Elizondo, Taro E Akiyama, Connie Cheung, Lionel Feigenbaum, Kristopher W Krausz, Frank J Gonzalez. Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. Drug metabolism and disposition: the biological fate of chemicals. 2003 May; 31(5):548-58. doi: 10.1124/dmd.31.5.548. [PMID: 12695342]
  • Andra E Ibrahim, Jennifer Feldman, Aziz Karim, Evan D Kharasch. Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. Anesthesiology. 2003 Apr; 98(4):853-61. doi: 10.1097/00000542-200304000-00011. [PMID: 12657846]
  • Nan He, Song-Lin Huang, Rong-Hua Zhu, Zhi-Rong Tan, Jie Liu, Bing Zhu, Hong-Hao Zhou. Inhibitory effect of troleandomycin on the metabolism of omeprazole is CYP2C19 genotype-dependent. Xenobiotica; the fate of foreign compounds in biological systems. 2003 Feb; 33(2):211-21. doi: 10.1080/0049825021000023996. [PMID: 12623762]
  • Sompon Wanwimolruk, Mary F Paine, Susan N Pusek, Paul B Watkins. Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?. British journal of clinical pharmacology. 2002 Dec; 54(6):643-51. doi: 10.1046/j.1365-2125.2002.01687.x. [PMID: 12492613]
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  • Mary F Paine, David A Wagner, Keith A Hoffmaster, Paul B Watkins. Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin. Clinical pharmacology and therapeutics. 2002 Nov; 72(5):524-35. doi: 10.1067/mcp.2002.128387. [PMID: 12426516]
  • Kazuto Yasuda, Lu-Bin Lan, Dominique Sanglard, Katryn Furuya, John D Schuetz, Erin G Schuetz. Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. The Journal of pharmacology and experimental therapeutics. 2002 Oct; 303(1):323-32. doi: 10.1124/jpet.102.037549. [PMID: 12235267]
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