Azacitidine (BioDeep_00000858354)
Main id: BioDeep_00000001604
代谢物信息卡片
Azacitidine
化学式: C8H12N4O5 (244.08076619999997)
中文名称: 5-氮胞苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc(N)nc2=O)O1)O)O)O
InChI: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BC - Pyrimidine analogues
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2083 - DNA Methyltransferase Inhibitor
C274 - Antineoplastic Agent > C132686 - Demethylating Agent
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes[1][2]. 5-Azacytidine induces cell autophagy[4].
同义名列表
4 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:2038
- KEGGdrug: D03021
- PubChem: 9444
- DrugBank: DB00928
- ChEMBL: CHEMBL1489
- MeSH: Azacitidine
- CAS: 1401238-97-8
- CAS: 320-67-2
- RefMet: Azacitidine
- medchemexpress: HY-10586
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 67365 - Streptomyces sparsogenes: 10.1016/S0021-9673(01)83861-9
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ziyi Hao, Yingying Fei, Juan Chen, Sailan Huang, Li Wang, Youhuan Yu, Meiru Bian, Yejun Si, Xingxia Zhang, Xiaotian Yang, Bing Zhang, Yan Wan, Yanming Zhang, Guoqiang Lin. Combination of venetoclax and azacitidine in relapsed/refractory acute B-cell lymphoblastic leukemia: a case series from a single center.
Hematology (Amsterdam, Netherlands).
2024 Dec; 29(1):2344998. doi:
10.1080/16078454.2024.2344998. [PMID: 38666535] - Cuiping Ma, Haiyan Lang, Yuhan Chen, Lu Yang, Chong Wang, Lizhen Han, Xinyi Chen, Wei Ma. Azacitidine combined with venetoclax alleviates AML-MR with TP53 mutation in SDS: a case report and literature review.
Anti-cancer drugs.
2024 Jul; 35(6):548-555. doi:
10.1097/cad.0000000000001594. [PMID: 38502829] - Shuai Jiang, Wen-Yan Li, Bei-Bei Gao, Qin-Shi Zhao. Lycocasine A, a Lycopodium Alkaloid from Lycopodiastrum casuarinoides and Its Acid-Sensing Ion Channel 1a Inhibitory Activity.
Molecules (Basel, Switzerland).
2024 Apr; 29(7):. doi:
10.3390/molecules29071581. [PMID: 38611859] - Lan Luo, Xiaoqing Wang, Ji Luo, Shuai Zheng, Ninghan Gong, Yuan He, Qian Xi, Jiao Chen, Tao Jiang, Ling Zhong. Acute undifferentiated leukemia with undifferentiated myeloid sarcoma: Case report and literature review.
Medicine.
2024 Jan; 103(4):e36948. doi:
10.1097/md.0000000000036948. [PMID: 38277531] - Xiaoling Ma, Ningxin Jiang, Jingxian Fu, Yuping Li, Lijun Zhou, Ling Yuan, Ying Wang, Yongqing Li. A cytosine analogue 5-azacitidine improves the accumulation of licochalcone A in licorice Glycyrrhiza inflata.
Journal of plant physiology.
2023 Nov; 292(?):154145. doi:
10.1016/j.jplph.2023.154145. [PMID: 38091890] - Rajat Pant, Shaheen Wasil Kabeer, Shivam Sharma, Vinod Kumar, Debarun Patra, Durba Pal, Kulbhushan Tikoo. Pharmacological inhibition of DNMT1 restores macrophage autophagy and M2 polarization in western diet-induced Nonalcoholic fatty liver disease.
The Journal of biological chemistry.
2023 May; ?(?):104779. doi:
10.1016/j.jbc.2023.104779. [PMID: 37142224] - Evandro Alexandre Fortini, Diego Silva Batista, Sérgio Heitor Sousa Felipe, Tatiane Dulcineia Silva, Ludmila Nayara Freitas Correia, Letícia Monteiro Farias, Daniele Vidal Faria, Vitor Batista Pinto, Claudete Santa-Catarina, Vanildo Silveira, Clelia De-la-Peña, Eduardo Castillo-Castro, Wagner Campos Otoni. Physiological, epigenetic, and proteomic responses in Pfaffia glomerata growth in vitro under salt stress and 5-azacytidine.
Protoplasma.
2023 Mar; 260(2):467-482. doi:
10.1007/s00709-022-01789-4. [PMID: 35788779] - Seung Hee Choi, Woo Seok Ahn, Myoung Hui Lee, Da Mon Jin, Areum Lee, Eun Yee Jie, Su Ji Ju, Sung Ju Ahn, Suk Weon Kim. Effects of TSA, NaB, Aza in Lactuca sativa L. protoplasts and effect of TSA in Nicotiana benthamiana protoplasts on cell division and callus formation.
PloS one.
2023; 18(2):e0279627. doi:
10.1371/journal.pone.0279627. [PMID: 36827385] - Mohammad Aijaz Ahmad, Samina Jam Nazeer Ahmad, Adnan Noor Shah, Jam Nazeer Ahmad, Shakil Ahmed, Wahidah H Al-Qahtani, Hamada AbdElgawad, Anis Ali Shah. Study of genetic modifications of flower development and methylation status in phytoplasma infected Brassica (Brassica rapa L.).
Molecular biology reports.
2022 Dec; 49(12):11359-11369. doi:
10.1007/s11033-022-07743-0. [PMID: 35916993] - Bin Xie, Feng Peng, Fengping He, Yixing Cheng, Jiangtao Cheng, Zhibing Zhou, Wei Mao. DNA methylation influences the CTCF-modulated transcription of RASSF1A in lung cancer cells.
Cell biology international.
2022 Nov; 46(11):1900-1914. doi:
10.1002/cbin.11868. [PMID: 35989484] - Xiao-Ying Cai, Na Li, Yong Li, Rui-Jia Zhang, Ping Lin, Ling Liu, Hao-Yu Ye, Wen-Shuang Wu, Min Zhao. An epigenetic modifier enhances the generation of anti-phytopathogenic compounds from the endophytic fungus Chaetomium globosporum of Euphorbia humifusa.
Phytochemistry.
2022 Nov; 203(?):113426. doi:
10.1016/j.phytochem.2022.113426. [PMID: 36084856] - Veronika Kosová, Vít Latzel, Věroslava Hadincová, Zuzana Münzbergová. Effect of DNA methylation, modified by 5-azaC, on ecophysiological responses of a clonal plant to changing climate.
Scientific reports.
2022 10; 12(1):17262. doi:
10.1038/s41598-022-22125-z. [PMID: 36241768] - Congmeng Lin, Yongxin Xie, Wenwen Huang, Dayi Lin, Luhui Lin. 5-Aza-dC promotes T-cell acute lymphoblastic leukemia cell invasion via downregulation of DNMT1 and upregulation of MMP-2 and MMP-9.
Experimental hematology.
2022 10; 114(?):43-53.e2. doi:
10.1016/j.exphem.2022.07.301. [PMID: 35908628] - Wei Zhou, Min-Min Chen, Hui-Ling Liu, Zi-Lin Si, Wen-Hui Wu, Hong Jiang, Lin-Xiao Wang, Nosratola D Vaziri, Xiao-Fei An, Ke Su, Cheng Chen, Ning-Hua Tan, Zhi-Hao Zhang. Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho.
Acta pharmacologica Sinica.
2022 Oct; 43(10):2609-2623. doi:
10.1038/s41401-022-00898-3. [PMID: 35347248] - Yang-Jie Zhang, Ran Xie, Jie Jiang, Li Zhai, Cong-Hui Yang, Jing Zhang, Xi Wang, Dong-Xue Chen, Hua-Tao Niu, Long Chen. 5‑Aza‑dC suppresses melanoma progression by inhibiting GAS5 hypermethylation.
Oncology reports.
2022 07; 48(1):. doi:
10.3892/or.2022.8334. [PMID: 35593315] - Félix Juan Martínez-Rivas, Rosario Blanco-Portales, Francisco Javier Molina-Hidalgo, José Luis Caballero, Leonardo Perez de Souza, Saleh Alseekh, Alisdair R Fernie, Juan Muñoz-Blanco, Antonio Rodríguez-Franco. Azacytidine arrests ripening in cultivated strawberry (Fragaria × ananassa) by repressing key genes and altering hormone contents.
BMC plant biology.
2022 Jun; 22(1):278. doi:
10.1186/s12870-022-03670-1. [PMID: 35672704] - Bo-Cheng Yang, Meng-Shiou Lee, Ming-Kuem Lin, Wen-Te Chang. 5-Azacytidine increases tanshinone production in Salvia miltiorrhiza hairy roots through epigenetic modulation.
Scientific reports.
2022 06; 12(1):9349. doi:
10.1038/s41598-022-12577-8. [PMID: 35672334] - Sankalp Arora, Carl Zainaldin, Srilakshmi Bathini, Udita Gupta, Sarah Worth, Kimo Bachiashvili, Ravi Bhatia, Kelly Godby, Omer Jamy, Sravanti Rangaraju, Barry Diamond, Josh D Oliver, Donna Salzman, Antonio Di Stasi, Pankit Vachhani. Tumor lysis syndrome and infectious complications during treatment with venetoclax combined with azacitidine or decitabine in patients with acute myeloid leukemia.
Leukemia research.
2022 06; 117(?):106844. doi:
10.1016/j.leukres.2022.106844. [PMID: 35487134] - Jonathan Wong, Emily Gruber, Belinda Maher, Mark Waltham, Zahra Sabouri-Thompson, Ian Jong, Quinton Luong, Sidney Levy, Beena Kumar, Daniella Brasacchio, Wendy Jia, Joan So, Hugh Skinner, Alexander Lewis, Simon J Hogg, Stephin Vervoort, Carmen DiCorleto, Micheleine Uhe, Jeanette Gamgee, Stephen Opat, Gareth P Gregory, Galina Polekhina, John Reynolds, Eliza A Hawkes, Gajan Kailainathan, Robin Gasiorowski, Lev M Kats, Jake Shortt. Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma.
Leukemia.
2022 06; 36(6):1654-1665. doi:
10.1038/s41375-022-01571-8. [PMID: 35459873] - Cheng-Bo Xu, Bin Liao, Hai-Ying Fu, Yan Qi, Jian-Zhen Shen. [Effect of miR-203/CREB1 Signaling Regulation Mediated by DNA Methylation on the Proliferation and Apoptosis of Multiple Myeloma Cells].
Zhongguo shi yan xue ye xue za zhi.
2022 Jun; 30(3):790-796. doi:
10.19746/j.cnki.issn.1009-2137.2022.03.021. [PMID: 35680807] - Ai Wei, Qi Gao, Fang Chen, Xiaobo Zhu, Xingren Chen, Lijun Zhang, Xin Su, Jinghong Dai, Yi Shi, Wangsen Cao. Inhibition of DNA methylation de-represses peroxisome proliferator-activated receptor-γ and attenuates pulmonary fibrosis.
British journal of pharmacology.
2022 04; 179(7):1304-1318. doi:
10.1111/bph.15655. [PMID: 34378791] - Chun Tong, Fang Ye, Ning-Ning Li, Huan Wang, Ya-Nan Shu, Ling Wang, Li-Nan Zhang. [Efficacy and Safety of Different Dosages of Decitabine in the Treatment of High-Risk Patients with Myelodysplastic Syndrome].
Zhongguo shi yan xue ye xue za zhi.
2021 Dec; 29(6):1845-1850. doi:
10.19746/j.cnki.issn.1009-2137.2021.06.026. [PMID: 34893121] - Krzysztof Mądry, Karol Lis, Andrzej Tukiendorf, Paweł Szwedyk, Katarzyna Kapelko-Słowik, Edyta Subocz, Aleksandra Gołos, Wioletta Makowska, Anna Masternak, Anna Kopińska, Magdalena Czemerska, Sara Zawadzka-Leska, Patrycja Rusicka, Joanna Drozd-Sokołowska, Elżbieta Wiater, Jadwiga Hołojda, Bartłomiej Pogłódek, Piotr Centkowski, Anna Waszczuk-Gajda, Rafał Machowicz, Janusz Hałka, Tomasz Czerw, Grzegorz Basak, Jadwiga Dwilewicz-Trojaczek. Low serum albumin level deteriorates prognosis in azacitidine-treated myelodysplastic syndromes patients - results of the PALG study 'PolAZA'.
Hematology (Amsterdam, Netherlands).
2021 Dec; 26(1):556-564. doi:
10.1080/16078454.2021.1956182. [PMID: 34384334] - Monika Krzewska, Ewa Dubas, Gabriela Gołębiowska, Anna Nowicka, Agnieszka Janas, Kamil Zieliński, Ewa Surówka, Przemysław Kopeć, Przemysław Mielczarek, Iwona Żur. Comparative proteomic analysis provides new insights into regulation of microspore embryogenesis induction in winter triticale (× Triticosecale Wittm.) after 5-azacytidine treatment.
Scientific reports.
2021 11; 11(1):22215. doi:
10.1038/s41598-021-01671-y. [PMID: 34782682] - Fatemeh Ravanrouy, Ali Niazi, Ali Moghadam, Seyed Mohsen Taghavi. MAP30 transgenic tobacco lines: from silencing to inducing.
Molecular biology reports.
2021 Oct; 48(10):6719-6728. doi:
10.1007/s11033-021-06662-w. [PMID: 34420140] - Ke-Ke Luo, Xiao-Hua Ou, Wen-Jing Deng, Xiao-Hua Liu, Meng-Ling He, Hong-Yi Zhang, Han-Jing Yan. [Effects of 5-azacytidine on DNA methylation and index components in patchouliol-type Pogostemon cablin].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Aug; 46(16):4117-4123. doi:
10.19540/j.cnki.cjcmm.20210527.101. [PMID: 34467722] - Charlotte M Niemeyer, Christian Flotho, Daniel B Lipka, Jan Starý, Claudia Rössig, André Baruchel, Thomas Klingebiel, Concetta Micalizzi, Gérard Michel, Karsten Nysom, Susana Rives, Markus Schmugge Liner, Marco Zecca, Maximilian Schönung, Irith Baumann, Peter Nöllke, Bouchra Benettaib, Noha Biserna, Jennifer Poon, Mathew Simcock, Meera Patturajan, Daniel Menezes, Allison Gaudy, Marry M van den Heuvel-Eibrink, Franco Locatelli. Response to upfront azacitidine in juvenile myelomonocytic leukemia in the AZA-JMML-001 trial.
Blood advances.
2021 07; 5(14):2901-2908. doi:
10.1182/bloodadvances.2020004144. [PMID: 34297046] - Zengqiang Li, Yali Hu, Mengmeng Chang, Muhammad Haneef Kashif, Meiqiong Tang, Dengjie Luo, Shan Cao, Hai Lu, Wenxian Zhang, Zhen Huang, Jiao Yue, Peng Chen. 5-azacytidine pre-treatment alters DNA methylation levels and induces genes responsive to salt stress in kenaf (Hibiscus cannabinus L.).
Chemosphere.
2021 May; 271(?):129562. doi:
10.1016/j.chemosphere.2021.129562. [PMID: 33453481] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Vahideh Yari, Zeynab Roein, Atefeh Sabouri. Exogenous 5-azaCitidine accelerates flowering and external GA3 increases ornamental value in Iranian Anemone accessions.
Scientific reports.
2021 04; 11(1):7478. doi:
10.1038/s41598-021-86940-6. [PMID: 33820923] - Haiying Cheng, Yiyu Zou, Chirag D Shah, Ni Fan, Tushar D Bhagat, Rasim Gucalp, Mimi Kim, Amit Verma, Bilal Piperdi, Simon D Spivack, Balazs Halmos, Roman Perez-Soler. First-in-human study of inhaled Azacitidine in patients with advanced non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands).
2021 04; 154(?):99-104. doi:
10.1016/j.lungcan.2021.02.015. [PMID: 33636454] - Masahiro Akimoto, Aki Sakurai, Yuriko Nishiyama-Fujita, Chisako Ito, Yoshinobu Aisa, Tomonori Nakazato. The prognostic value of the Fibrinogen-Albumin Ratio Index in patients with myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes treated with azacitidine.
Annals of hematology.
2021 Apr; 100(4):953-957. doi:
10.1007/s00277-021-04440-z. [PMID: 33521864] - Yuxi Zhang, Tao Zhang, Fuhui Si, Xueting Wang, Chunying Liu, Yanchao Yuan, Weirong Feng, Shupeng Gai. Changes of DNA Methylation Patterns Reveal Epigenetic Modification of Dormancy Release-Related Genes Is Induced by Chilling in Tree Peony.
DNA and cell biology.
2021 Apr; 40(4):606-617. doi:
10.1089/dna.2020.6142. [PMID: 33493084] - Senem Maral, Murat Albayrak, Osman Sahin, Hacer Berna Afacan Ozturk, Unsal Han, Mesude Falay. Synchronous detection of multiple myeloma and acute myeloid leukemia: A diagnostic and therapeutic challenge.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2021 Mar; 27(2):464-469. doi:
10.1177/1078155220932352. [PMID: 33620259] - Shuhua Shan, Yang Lu, Xiaoli Zhang, Jiangying Shi, Hanqing Li, Zhuoyu Li. Inhibitory effect of bound polyphenol from foxtail millet bran on miR-149 methylation increases the chemosensitivity of human colorectal cancer HCT-8/Fu cells.
Molecular and cellular biochemistry.
2021 Feb; 476(2):513-523. doi:
10.1007/s11010-020-03906-4. [PMID: 33011952] - C Willekens, R Rahme, M Duchmann, V Vidal, V Saada, S Broutin, J Delahousse, A Renneville, A Marceau, E Clappier, M Uzunov, J Rossignol, L Pascal, L Simon, J B Micol, F Pasquier, E Raffoux, C Preudhomme, C Quivoron, R Itzykson, V Penard-Lacronique, A Paci, P Fenaux, E C Attar, M Frattini, T Braun, L Ades, S De Botton. Effects of azacitidine in 93 patients with IDH1/2 mutated acute myeloid leukemia/myelodysplastic syndromes: a French retrospective multicenter study.
Leukemia & lymphoma.
2021 02; 62(2):438-445. doi:
10.1080/10428194.2020.1832661. [PMID: 33043739] - Costantine Albany, Zeeshan Fazal, Ratnakar Singh, Emmanuel Bikorimana, Nabil Adra, Nasser H Hanna, Lawrence H Einhorn, Susan M Perkins, George E Sandusky, Brock C Christensen, Harold Keer, Fang Fang, Kenneth P Nephew, Michael J Spinella. A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer.
Cancer medicine.
2021 01; 10(1):156-163. doi:
10.1002/cam4.3583. [PMID: 33135391] - Xirong Lu, Yuyi Li, Wei Yang, Minghao Tao, Yanmiao Dai, Jinkang Xu, Qianfei Xu. Inhibition of NF-κB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.
Journal of biochemical and molecular toxicology.
2021 Jan; 35(1):e22621. doi:
10.1002/jbt.22621. [PMID: 32894642] - Jack Khouri, Beth M Faiman, Dale Grabowski, Reda Z Mahfouz, Shahper N Khan, Wei Wei, Jason Valent, Robert Dean, Christy Samaras, Babal K Jha, Hillard Lazarus, Erica L Campagnaro, Ehsan Malek, Janice Reed, Mary Ann Karam, Kimberly Hamilton, Sherry Fada, Matt Kalaycio, Hien Liu, Ronald Sobecks, Yogen Saunthararajah, Yap Chew, Mohammed Orloff, Frederic J Reu. DNA methylation inhibition in myeloma: Experience from a phase 1b study of low-dose continuous azacitidine in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma.
Seminars in hematology.
2021 01; 58(1):45-55. doi:
10.1053/j.seminhematol.2020.12.004. [PMID: 33509443] - Susanne Ghandili, Susanne Pfefferle, Kevin Roedl, Piet Sonnemann, Panagiotis Karagiannis, Olaf Boenisch, Stefan Kluge, Stefan Schmiedel, Harald Ittrich, Holger Rohde, Marc Lütgehetmann, Katja Weisel, Carsten Bokemeyer, Dominic Wichmann, Walter Fiedler, Dominik Jarczak, Franziska Modemann. Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients.
Blood advances.
2020 12; 4(23):5936-5941. doi:
10.1182/bloodadvances.2020002543. [PMID: 33275765] - Vishwanath Bhat Deepika, Manik Vohra, Sumit Mishra, Kavita Dorai, Padmalatha Rai, Kapaettu Satyamoorthy, Thokur Sreepathy Murali. DNA demethylation overcomes attenuation of colchicine biosynthesis in an endophytic fungus Diaporthe.
Journal of biotechnology.
2020 Nov; 323(?):33-41. doi:
10.1016/j.jbiotec.2020.07.019. [PMID: 32745507] - Miroslav Pribyl, Sona Hubackova, Alena Moudra, Marketa Vancurova, Helena Polackova, Tomas Stopka, Anna Jonasova, Radka Bokorova, Ota Fuchs, Jan Stritesky, Barbora Salovska, Jiri Bartek, Zdenek Hodny. Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes.
Molecular oncology.
2020 10; 14(10):2403-2419. doi:
10.1002/1878-0261.12768. [PMID: 32696549] - Vasileios Papadopoulos, Panagiotis T Diamantopoulos, Sotirios G Papageorgiou, Menelaos Papoutselis, George Vrachiolias, Vassiliki Pappa, Athanasios G Galanopoulos, Theodoros P Vassilakopoulos, Eleftheria Hatzimichael, Panagiotis Zikos, Helen A Papadaki, Anthi Bouchla, Panayiotis Panayiotidis, Aekaterini Megalakaki, Maria Papaioannou, Konstantinos Liapis, George Dryllis, Dimitris Tsokanas, Alexandra Kourakli, Argiris Symeonidis, Nora-Athina Viniou, Ioannis Kotsianidis. Estimated glomerular filtration rate independently predicts outcome of azacitidine therapy in higher-risk Myelodysplastic syndromes. Results from 536 patients of the Hellenic National Registry of Myelodysplastic and Hypoplastic syndromes.
Hematological oncology.
2020 Oct; 38(4):541-553. doi:
10.1002/hon.2756. [PMID: 32495951] - Ana María Hurtado López, Tzu Hua Chen-Liang, María Zurdo, Salvador Carrillo-Tornel, Joaquín Panadero, Eduardo José Salido, Victor Beltrán, Begoña Muiña, MariLuz Amigo, Noelia Navarro-Villamor, Rosa Cifuentes, Inés Calabria, Ana Isabel Antón, Raúl Teruel, Manuel Muro, Vicente Vicente, Andrés Jerez. Cancer testis antigens in myelodysplastic syndromes revisited: a targeted RNA-seq approach.
Oncoimmunology.
2020 10; 9(1):1824642. doi:
10.1080/2162402x.2020.1824642. [PMID: 33101773] - Pedro Osorio-Montalvo, Clelia De-la-Peña, Carlos Oropeza, Geovanny Nic-Can, Iván Córdova-Lara, Eduardo Castillo-Castro, Luis Sáenz-Carbonell. A peak in global DNA methylation is a key step to initiate the somatic embryogenesis of coconut palm (Cocos nucifera L).
Plant cell reports.
2020 Oct; 39(10):1345-1357. doi:
10.1007/s00299-020-02568-2. [PMID: 32789543] - Jeroen Roosendaal, Hilde Rosing, Luc Lucas, Abadi Gebretensae, Alwin D R Huitema, Marloes G van Dongen, Jos H Beijnen, Aram Oganesian. Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer.
Investigational new drugs.
2020 08; 38(4):1085-1095. doi:
10.1007/s10637-019-00854-9. [PMID: 31605293] - Soumaya Zlitni, Alex Bishara, Eli L Moss, Ekaterina Tkachenko, Joyce B Kang, Rebecca N Culver, Tessa M Andermann, Ziming Weng, Christina Wood, Christine Handy, Hanlee P Ji, Serafim Batzoglou, Ami S Bhatt. Strain-resolved microbiome sequencing reveals mobile elements that drive bacterial competition on a clinical timescale.
Genome medicine.
2020 05; 12(1):50. doi:
10.1186/s13073-020-00747-0. [PMID: 32471482] - Benjamin K Tomlinson, Molly M Gallogly, Donna M Kane, Leland Metheny, Hillard M Lazarus, Basem M William, Michael D Craig, Mark J Levis, Brenda W Cooper. A Phase II Study of Midostaurin and 5-Azacitidine for Untreated Elderly and Unfit Patients With FLT3 Wild-type Acute Myelogenous Leukemia.
Clinical lymphoma, myeloma & leukemia.
2020 04; 20(4):226-233.e1. doi:
10.1016/j.clml.2019.10.018. [PMID: 32085993] - Anna Nowicka, Barbara Tokarz, Jana Zwyrtková, Eva Dvořák Tomaštíková, Klára Procházková, Ugur Ercan, Andreas Finke, Wilfried Rozhon, Brigitte Poppenberger, Miroslav Otmar, Igor Niezgodzki, Marcela Krečmerová, Ingo Schubert, Ales Pecinka. Comparative analysis of epigenetic inhibitors reveals different degrees of interference with transcriptional gene silencing and induction of DNA damage.
The Plant journal : for cell and molecular biology.
2020 04; 102(1):68-84. doi:
10.1111/tpj.14612. [PMID: 31733119] - Andrea Hrustincova, Zdenek Krejcik, David Kundrat, Katarina Szikszai, Monika Belickova, Pavla Pecherkova, Jiri Klema, Jitka Vesela, Monika Hruba, Jaroslav Cermak, Tereza Hrdinova, Matyas Krijt, Jan Valka, Anna Jonasova, Michaela Dostalova Merkerova. Circulating Small Noncoding RNAs Have Specific Expression Patterns in Plasma and Extracellular Vesicles in Myelodysplastic Syndromes and Are Predictive of Patient Outcome.
Cells.
2020 03; 9(4):. doi:
10.3390/cells9040794. [PMID: 32224889] - Luke Browne, Alayna Mead, Courtney Horn, Kevin Chang, Zeynep A Celikkol, Claudia L Henriquez, Feiyang Ma, Eric Beraut, Rachel S Meyer, Victoria L Sork. Experimental DNA Demethylation Associates with Changes in Growth and Gene Expression of Oak Tree Seedlings.
G3 (Bethesda, Md.).
2020 03; 10(3):1019-1028. doi:
10.1534/g3.119.400770. [PMID: 31941723] - Kirk E Cahill, Yasmin H Karimi, Theodore G Karrison, Nitin Jain, Margaret Green, Howard Weiner, Noreen Fulton, Sabah Kadri, Lucy A Godley, Andrew S Artz, Hongtao Liu, Michael J Thirman, Michelle M Le Beau, Megan E McNerney, Jeremy Segal, Richard A Larson, Wendy Stock, Olatoyosi Odenike. A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia.
Blood advances.
2020 02; 4(4):599-606. doi:
10.1182/bloodadvances.2019000795. [PMID: 32074275] - Yuxi Zhang, Fuhui Si, Yanyan Wang, Chunying Liu, Tao Zhang, Yanchao Yuan, Shupeng Gai. Application of 5-azacytidine induces DNA hypomethylation and accelerates dormancy release in buds of tree peony.
Plant physiology and biochemistry : PPB.
2020 Feb; 147(?):91-100. doi:
10.1016/j.plaphy.2019.12.010. [PMID: 31855819] - Yeliz Demir, Cüneyt Türkeş, Şükrü Beydemir. Molecular Docking Studies and Inhibition Properties of Some Antineoplastic Agents against Paraoxonase-I.
Anti-cancer agents in medicinal chemistry.
2020; 20(7):887-896. doi:
10.2174/1871520620666200218110645. [PMID: 32067621] - Hideki Nishimura, Eiko Himi, Chang-Ho Eun, Hidekazu Takahashi, Qian Qian, Kazuo Tsugane, Masahiko Maekawa. Transgenerational activation of an autonomous DNA transposon, Dart1-24, by 5-azaC treatment in rice.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik.
2019 Dec; 132(12):3347-3355. doi:
10.1007/s00122-019-03429-7. [PMID: 31583438] - Xiaoshuo Wang, Hong Ao, Minyan Song, Lijing Bai, Weiyong He, Chuduan Wang, Ying Yu. Identification of DNA methylation regulated novel host genes relevant to inhibition of virus replication in porcine PK15 cell using double stranded RNA mimics and DNA methyltransferase inhibitor.
Genomics.
2019 12; 111(6):1464-1473. doi:
10.1016/j.ygeno.2018.09.020. [PMID: 30315899] - Trace M Jones, Claudia Espitia, Wei Wang, Steffan T Nawrocki, Jennifer S Carew. Moving beyond hydroxychloroquine: the novel lysosomal autophagy inhibitor ROC-325 shows significant potential in preclinical studies.
Cancer communications (London, England).
2019 11; 39(1):72. doi:
10.1186/s40880-019-0418-0. [PMID: 31706349] - B-C Dong, J Meng, F-H Yu. Effects of parental light environment on growth and morphological responses of clonal offspring.
Plant biology (Stuttgart, Germany).
2019 Nov; 21(6):1083-1089. doi:
10.1111/plb.13001. [PMID: 31054216] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Linn Gillberg, Andreas D Ørskov, Ammar Nasif, Hitoshi Ohtani, Zachary Madaj, Jakob W Hansen, Nicolas Rapin, Johanne B Mogensen, Minmin Liu, Inge H Dufva, Jens Lykkesfeldt, Petra Hajkova, Peter A Jones, Kirsten Grønbæk. Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.
Clinical epigenetics.
2019 10; 11(1):143. doi:
10.1186/s13148-019-0739-5. [PMID: 31623675] - Francis Mussai, Rachel Wheat, Evgenia Sarrou, Sarah Booth, Victoria Stavrou, Livingstone Fultang, Tracey Perry, Pamela Kearns, Paul Cheng, Karen Keeshan, Charles Craddock, Carmela De Santo. Targeting the arginine metabolic brake enhances immunotherapy for leukaemia.
International journal of cancer.
2019 10; 145(8):2201-2208. doi:
10.1002/ijc.32028. [PMID: 30485425] - Xin Li, Qian Yu. PON1 hypermethylation is associated with progression of renal cell carcinoma.
Journal of cellular and molecular medicine.
2019 10; 23(10):6646-6657. doi:
10.1111/jcmm.14537. [PMID: 31400051] - Zeen Tong, Usha Yerramilli, Sylvia Yao, James D Young, Matthew Hoffmann, Sekhar Surapaneni. In vitro inhibition of human nucleoside transporters and uptake of azacitidine by an isocitrate dehydrogenase-2 inhibitor enasidenib and its metabolite AGI-16903.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Oct; 49(10):1229-1236. doi:
10.1080/00498254.2018.1539783. [PMID: 30394160] - Guochun Chen, Huihui Chen, Shuyu Ren, Ming Xia, Jiefu Zhu, Yu Liu, Lei Zhang, Luosheng Tang, Lin Sun, Hong Liu, Zheng Dong. Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease.
Kidney international.
2019 08; 96(2):409-420. doi:
10.1016/j.kint.2019.02.020. [PMID: 31101365] - Qiang Zhao, Yanli Du, Hetong Wang, Hilary J Rogers, Cuimei Yu, Wan Liu, Mingzhe Zhao, Futi Xie. 5-Azacytidine promotes shoot regeneration during Agrobacterium-mediated soybean transformation.
Plant physiology and biochemistry : PPB.
2019 Aug; 141(?):40-50. doi:
10.1016/j.plaphy.2019.05.014. [PMID: 31128562] - Panagiotis T Diamantopoulos, Ioannis Kotsianidis, Argiris Symeonidis, Vassiliki Pappa, Athanasios Galanopoulos, Dimitrios Gogos, Stamatios Karakatsanis, Helen Papadaki, Aikaterini Palla, Eleftheria Hatzimichael, Maria Dimou, Sotirios Papageorgiou, Sosana Delimpasis, Maria Papaioannou, Menelaos Papoutselis, Alexandra Kourakli, Dimitrios Tsokanas, Achilles Anagnostopoulos, Christos K Kontos, Panayiotis Panayiotidis, Nora-Athina Viniou. Chronic myelomonocytic leukemia treated with 5-azacytidine - results from the Hellenic 5-Azacytidine Registry: proposal of a new risk stratification system.
Leukemia & lymphoma.
2019 07; 60(7):1721-1730. doi:
10.1080/10428194.2018.1540783. [PMID: 30424699] - Yanxia Zhao, Qun Wang, Shi Wang, Xiaoman Liu, Jae-HyuK Yu, Weifa Zheng, Xiuguo Zhang. Disturbance in biosynthesis of arachidonic acid impairs the sexual development of the onion blight pathogen Stemphylium eturmiunum.
Current genetics.
2019 Jun; 65(3):759-771. doi:
10.1007/s00294-019-00930-w. [PMID: 30649584] - Jia Sun, Lester W Young, Megan A House, Ketema Daba, Helen M Booker. Photoperiod sensitivity of Canadian flax cultivars and 5-azacytidine treated early flowering derivative lines.
BMC plant biology.
2019 May; 19(1):177. doi:
10.1186/s12870-019-1763-5. [PMID: 31046671] - Romana Bacova, Borivoj Klejdus, Pavel Ryant, Natalia Cernei, Vojtech Adam, Dalibor Huska. The effects of 5-azacytidine and cadmium on global 5-methylcytosine content and secondary metabolites in the freshwater microalgae Chlamydomonas reinhardtii and Scenedesmus quadricauda.
Journal of phycology.
2019 04; 55(2):329-342. doi:
10.1111/jpy.12819. [PMID: 30506677] - Zili Zhang, Jian Wang, Fei Liu, Liang Yuan, Mingjing Ding, Lingdan Chen, Jili Yuan, Kai Yang, Jing Qian, Wenju Lu. Non-inflammatory emphysema induced by NO2 chronic exposure and intervention with demethylation 5-Azacytidine.
Life sciences.
2019 Mar; 221(?):121-129. doi:
10.1016/j.lfs.2019.02.022. [PMID: 30763575] - Jeroen Roosendaal, Kai Wang, Hilde Rosing, Luc Lucas, Abadi Gebretensae, Aram Oganesian, Jan H M Schellens, Jos H Beijnen, Zhongping John Lin. Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Mar; 1109(?):132-141. doi:
10.1016/j.jchromb.2019.01.011. [PMID: 30754019] - Hongjie Xie, Yuli Sun, Biao Cheng, Siming Xue, Dan Cheng, Linli Liu, Lingchao Meng, Sheng Qiang. Variation in ICE1 Methylation Primarily Determines Phenotypic Variation in Freezing Tolerance in Arabidopsis thaliana.
Plant & cell physiology.
2019 Jan; 60(1):152-165. doi:
10.1093/pcp/pcy197. [PMID: 30295898] - Courtney L Jones, Brett M Stevens, Angelo D'Alessandro, Julie A Reisz, Rachel Culp-Hill, Travis Nemkov, Shanshan Pei, Nabilah Khan, Biniam Adane, Haobin Ye, Anna Krug, Dominik Reinhold, Clayton Smith, James DeGregori, Daniel A Pollyea, Craig T Jordan. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Cancer cell.
2018 11; 34(5):724-740.e4. doi:
10.1016/j.ccell.2018.10.005. [PMID: 30423294] - Pedro Osorio-Montalvo, Luis Sáenz-Carbonell, Clelia De-la-Peña. 5-Azacytidine: A Promoter of Epigenetic Changes in the Quest to Improve Plant Somatic Embryogenesis.
International journal of molecular sciences.
2018 Oct; 19(10):. doi:
10.3390/ijms19103182. [PMID: 30332727] - Kamel Laribi, Delphine Bolle, Mustapha Alani, Habib Ghnaya, Saga Le Bourdelles, Anne Besançon, Jonathan Farhi, Nathalie Denizon, Alix Baugier de Materre. Prognostic impact of elevated pretreatment serum ferritin in patients with high-risk MDS treated with azacitidine.
Experimental hematology.
2018 09; 65(?):34-37. doi:
10.1016/j.exphem.2018.05.006. [PMID: 29883686] - S Podlipnik, F Guijarro, A Combalia, J To-Figueras, C Badenas, D Costa, M Rozman, S Jorge, P Aguilera, A Gaya. Acquired erythropoietic uroporphyria secondary to myelodysplastic syndrome with chromosome 3 alterations: a case report.
The British journal of dermatology.
2018 08; 179(2):486-490. doi:
10.1111/bjd.15927. [PMID: 28865079] - Ying-Tzu Huang, Ting-Shuan Wu, Chuan-Chen Lu, Feng-Yih Yu, Biing-Hui Liu. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells.
Toxicology letters.
2018 Jul; 291(?):129-137. doi:
10.1016/j.toxlet.2018.03.032. [PMID: 29655784] - Alexander Betekhtin, Anna Milewska-Hendel, Lukasz Chajec, Magdalena Rojek, Katarzyna Nowak, Jolanta Kwasniewska, Elzbieta Wolny, Ewa Kurczynska, Robert Hasterok. 5-Azacitidine Induces Cell Death in a Tissue Culture of Brachypodium distachyon.
International journal of molecular sciences.
2018 Jun; 19(6):. doi:
10.3390/ijms19061806. [PMID: 29921802] - Lauren B Levine, Julianna Vf Roddy, Miryoung Kim, Junan Li, Gary Phillips, Alison R Walker. A comparison of toxicities in acute myeloid leukemia patients with and without renal impairment treated with decitabine.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2018 Jun; 24(4):290-298. doi:
10.1177/1078155217702213. [PMID: 28345491] - Xin Du, Yue-Yun Lai, Zhijian Xiao, Ting Liu, Yu Hu, Aining Sun, Xiao Li, Zhi-Xiang Shen, Jie Jin, Li Yu, Eric Laille, Qian Dong, Stephen Songer, C L Beach. Efficacy, safety and pharmacokinetics of subcutaneous azacitidine in Chinese patients with higher risk myelodysplastic syndromes: Results from a multicenter, single-arm, open-label phase 2 study.
Asia-Pacific journal of clinical oncology.
2018 Jun; 14(3):270-278. doi:
10.1111/ajco.12835. [PMID: 29282890] - Jiantang Zhu, Linlin Fang, Jiaqi Yu, Ying Zhao, Fanguo Chen, Guangmin Xia. 5-Azacytidine treatment and TaPBF-D over-expression increases glutenin accumulation within the wheat grain by hypomethylating the Glu-1 promoters.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik.
2018 Mar; 131(3):735-746. doi:
10.1007/s00122-017-3032-z. [PMID: 29214328] - Wenjin Xi, Xu Chen, Jinbo Sun, Wei Wang, Yi Huo, Guoxu Zheng, Jieheng Wu, Yufang Li, Angang Yang, Tao Wang. Combined Treatment with Valproic Acid and 5-Aza-2'-Deoxycytidine Synergistically Inhibits Human Clear Cell Renal Cell Carcinoma Growth and Migration.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Feb; 24(?):1034-1043. doi:
10.12659/msm.906020. [PMID: 29457966] - Simon Limbrecht Mogensen, Martin Krøyer Rasmussen, Niels Oksbjerg, Jette Feveile Young, Jens Rolighed Larsen. In vitro differentiation of progenitor cells isolated from juvenile pig hearts - expression of relevant gene and protein markers.
Scandinavian cardiovascular journal : SCJ.
2018 Feb; 52(1):34-42. doi:
10.1080/14017431.2017.1409432. [PMID: 29179587] - João Heitor C Manfrão-Netto, Thiago M Mello-de-Sousa, Astrid R Mach-Aigner, Robert L Mach, Marcio J Poças-Fonseca. The DNA-methyltransferase inhibitor 5-aza-2-deoxycytidine affects Humicola grisea enzyme activities and the glucose-mediated gene repression.
Journal of basic microbiology.
2018 Feb; 58(2):144-153. doi:
10.1002/jobm.201700415. [PMID: 29193198] - Nourhen Mnasri, Maya Mamarbachi, Bruce G Allen, Gaétan Mayer. 5-Azacytidine engages an IRE1α-EGFR-ERK1/2 signaling pathway that stabilizes the LDL receptor mRNA.
Biochimica et biophysica acta. Gene regulatory mechanisms.
2018 Jan; 1861(1):29-40. doi:
10.1016/j.bbagrm.2017.11.010. [PMID: 29208426] - Pinar Yilgor Huri, Justin Morrissette-McAlmon, Warren L Grayson. Myogenic Differentiation of ASCs Using Biochemical and Biophysical Induction.
Methods in molecular biology (Clifton, N.J.).
2018; 1773(?):123-135. doi:
10.1007/978-1-4939-7799-4_10. [PMID: 29687385] - Yukio Kobayashi, Wataru Munakata, Michinori Ogura, Toshiki Uchida, Masafumi Taniwaki, Tsutomu Kobayashi, Fumika Shimada, Masataka Yonemura, Fumiko Matsuoka, Takeshi Tajima, Kimikazu Yakushijin, Hironobu Minami. Phase I study of panobinostat and 5-azacitidine in Japanese patients with myelodysplastic syndrome or chronic myelomonocytic leukemia.
International journal of hematology.
2018 Jan; 107(1):83-91. doi:
10.1007/s12185-017-2327-9. [PMID: 28905323] - Yasmin M Abaza, Tapan M Kadia, Elias J Jabbour, Marina Y Konopleva, Gautam Borthakur, Alessandra Ferrajoli, Zeev Estrov, William G Wierda, Ana Alfonso, Toh Han Chong, Charles Chuah, Liang-Piu Koh, Boon-Cher Goh, Julie E Chang, Daniel E Durkes, Maria Cielo Foudray, Hagop M Kantarjian, Xiao Qin Dong, Guillermo Garcia-Manero. Phase 1 dose escalation multicenter trial of pracinostat alone and in combination with azacitidine in patients with advanced hematologic malignancies.
Cancer.
2017 Dec; 123(24):4851-4859. doi:
10.1002/cncr.30949. [PMID: 28841236] - Yue-Qin Huang, Xue-Ya Zhang, Shi-Xin Wu, Xi-Zhe Guo, Jing-Xin Pan. [Curative Effect of Decitabine Combined with IAG Regimen for Senile Patients with Myelodysplastic Syndrome (MDS) Transformed Acute Myeloid Leukemia].
Zhongguo shi yan xue ye xue za zhi.
2017 Dec; 25(6):1641-1646. doi:
10.7534/j.issn.1009-2137.2017.06.011. [PMID: 29262890] - Chunyuan Guo, Lirong Pei, Xiao Xiao, Qingqing Wei, Jian-Kang Chen, Han-Fei Ding, Shuang Huang, Guoping Fan, Huidong Shi, Zheng Dong. DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8.
Kidney international.
2017 11; 92(5):1194-1205. doi:
10.1016/j.kint.2017.03.038. [PMID: 28709638] - Rohit Singh, Vikas Kumar, Sonali S Bharate, Ram A Vishwakarma. Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis.
Bioorganic & medicinal chemistry.
2017 10; 25(20):5513-5521. doi:
10.1016/j.bmc.2017.08.011. [PMID: 28843845] - Jidi Xu, Xia Wang, Hongbo Cao, Haidan Xu, Qiang Xu, Xiuxin Deng. Dynamic changes in methylome and transcriptome patterns in response to methyltransferase inhibitor 5-azacytidine treatment in citrus.
DNA research : an international journal for rapid publication of reports on genes and genomes.
2017 Oct; 24(5):509-522. doi:
10.1093/dnares/dsx021. [PMID: 28575160] - Wen-Chien Chou, Su-Peng Yeh, Liang-Tsai Hsiao, Sheng-Fung Lin, Yeu-Chin Chen, Tsai-Yun Chen, Eric Laille, Anoula Galettis, Qian Dong, Steve Songer, C L Beach. Efficacy, safety, and pharmacokinetics of subcutaneous azacitidine in Taiwanese patients with higher-risk myelodysplastic syndromes.
Asia-Pacific journal of clinical oncology.
2017 Oct; 13(5):e430-e439. doi:
10.1111/ajco.12659. [PMID: 28124500] - Feng Jin, Jose Thaiparambil, Sri Ramya Donepudi, Venkatrao Vantaku, Danthasinghe Waduge Badrajee Piyarathna, Suman Maity, Rashmi Krishnapuram, Vasanta Putluri, Franklin Gu, Preeti Purwaha, Salil Kumar Bhowmik, Chandrashekar R Ambati, Friedrich-Carl von Rundstedt, Florian Roghmann, Sebastian Berg, Joachim Noldus, Kimal Rajapakshe, Daniel Gödde, Stephan Roth, Stephan Störkel, Stephan Degener, George Michailidis, Benny Abraham Kaipparettu, Balasubramanyam Karanam, Martha K Terris, Shyam M Kavuri, Seth P Lerner, Farrah Kheradmand, Cristian Coarfa, Arun Sreekumar, Yair Lotan, Randa El-Zein, Nagireddy Putluri. Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer.
Cancer prevention research (Philadelphia, Pa.).
2017 Oct; 10(10):588-597. doi:
10.1158/1940-6207.capr-17-0198. [PMID: 28851690] - Elias Jabbour, Nicholas J Short, Guillermo Montalban-Bravo, Xuelin Huang, Carlos Bueso-Ramos, Wei Qiao, Hui Yang, Chong Zhao, Tapan Kadia, Gautam Borthakur, Naveen Pemmaraju, Koji Sasaki, Zeev Estrov, Jorge Cortes, Farhad Ravandi, Yesid Alvarado, Rami Komrokji, Mikkael A Sekeres, David P Steensma, Amy DeZern, Gail Roboz, Hagop Kantarjian, Guillermo Garcia-Manero. Randomized phase 2 study of low-dose decitabine vs low-dose azacitidine in lower-risk MDS and MDS/MPN.
Blood.
2017 09; 130(13):1514-1522. doi:
10.1182/blood-2017-06-788497. [PMID: 28774880] - Beenu Thakral, Sa A Wang. 'Hof' in pronormoblasts: pure erythroid leukemia mimicking plasma cell myeloma.
Blood.
2017 09; 130(13):1600. doi:
10.1182/blood-2017-07-796466. [PMID: 28963106] - Robert Molokie, Donald Lavelle, Michel Gowhari, Michael Pacini, Lani Krauz, Johara Hassan, Vinzon Ibanez, Maria A Ruiz, Kwok Peng Ng, Philip Woost, Tomas Radivoyevitch, Daisy Pacelli, Sherry Fada, Matthew Rump, Matthew Hsieh, John F Tisdale, James Jacobberger, Mitch Phelps, James Douglas Engel, Santhosh Saraf, Lewis L Hsu, Victor Gordeuk, Joseph DeSimone, Yogen Saunthararajah. Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.
PLoS medicine.
2017 Sep; 14(9):e1002382. doi:
10.1371/journal.pmed.1002382. [PMID: 28880867] - Istvan Arany, Samuel Hall, Amir Faisal, Mehul Dixit. Nicotine Exposure Augments Renal Toxicity of 5-aza-cytidine Through p66shc: Prevention by Resveratrol.
Anticancer research.
2017 08; 37(8):4075-4079. doi:
10.21873/anticanres.11793. [PMID: 28739690] - Dimitrij Tyč, Eva Nocarová, Lenka Sikorová, Lukáš Fischer. 5-Azacytidine mediated reactivation of silenced transgenes in potato (Solanum tuberosum) at the whole plant level.
Plant cell reports.
2017 Aug; 36(8):1311-1322. doi:
10.1007/s00299-017-2155-7. [PMID: 28510781]