Dalfampridine (BioDeep_00000858336)
Main id: BioDeep_00000009534
Volatile Flavor Compounds
代谢物信息卡片
4-aminopyridine
化学式: C5H6N2 (94.05309559999999)
中文名称: 4-氨基吡啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN=CC=C1N
InChI: InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
描述信息
D002317 - Cardiovascular Agents > D026902 - Potassium Channel Blockers
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
N - Nervous system
Same as: D04127
同义名列表
5 个代谢物同义名
4-aminopyridine; Dalfampridine; 4-AP; 4-Aminopyridine; 4-Aminopyridine
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:34385
- KEGG: C13728
- KEGGdrug: D04127
- PubChem: 1727
- DrugBank: DB06637
- ChEMBL: CHEMBL284348
- MeSH: 4-Aminopyridine
- CAS: 286367-79-1
- CAS: 504-24-5
- PubChem: 586317
- PDB-CCD: 4AP
- NIKKAJI: J1.568G
- RefMet: 4-Aminopyridine
- KNApSAcK: 34385
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tzu-Kang Lin, Kun-Chieh Yeh, Ming-Shang Pai, Pei-Wen Hsieh, Su-Jane Wang. Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats.
European journal of pharmacology.
2024 Jan; 963(?):176280. doi:
10.1016/j.ejphar.2023.176280. [PMID: 38113967] - Cheng-Wei Lu, Tzu-Yu Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang. Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes).
Neurochemistry international.
2023 May; 167(?):105537. doi:
10.1016/j.neuint.2023.105537. [PMID: 37164158] - Serdar Sahinturk. Elabela relaxes rat pulmonary artery and trachea via BKCa, KV, and KATP channels.
Prostaglandins & other lipid mediators.
2023 Apr; 167(?):106735. doi:
10.1016/j.prostaglandins.2023.106735. [PMID: 37059294] - Pratibha Attri, Sangeeta Garg, Jatinder Kumar Ratan, Ardhendu Sekhar Giri. Silver nanoparticles from Tabernaemontana divaricate leaf extract: mechanism of action and bio-application for photo degradation of 4-aminopyridine.
Environmental science and pollution research international.
2023 Feb; 30(10):24856-24875. doi:
10.1007/s11356-021-18269-6. [PMID: 35013966] - James N Brundage, Colin P Mason, Hillary A Wadsworth, Chris S Finuf, Josh J Nelson, P Joakim W Ronström, Sara R Jones, Cody A Siciliano, Scott C Steffensen, Jordan T Yorgason. Regional and sex differences in spontaneous striatal dopamine transmission.
Journal of neurochemistry.
2022 03; 160(6):598-612. doi:
10.1111/jnc.15473. [PMID: 34265080] - Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang. An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats.
International journal of molecular sciences.
2022 Feb; 23(5):. doi:
10.3390/ijms23052641. [PMID: 35269784] - Enikő Pergel, Irén Veres, Gergely Imre Csigi, Gábor Czirják. Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910515. [PMID: 34638858] - Che-Chuan Wang, Pei-Wen Hsieh, Jinn-Rung Kuo, Su-Jane Wang. Rosmarinic Acid, a Bioactive Phenolic Compound, Inhibits Glutamate Release from Rat Cerebrocortical Synaptosomes through GABAA Receptor Activation.
Biomolecules.
2021 07; 11(7):. doi:
10.3390/biom11071029. [PMID: 34356653] - Kuan-Ming Chiu, Tzu-Yu Lin, Ming-Yi Lee, Cheng-Wei Lu, Ming-Jiuh Wang, Su-Jane Wang. Typhaneoside Suppresses Glutamate Release Through Inhibition of Voltage-Dependent Calcium Entry in Rat Cerebrocortical Nerve Terminals.
Chemical research in toxicology.
2021 05; 34(5):1286-1295. doi:
10.1021/acs.chemrestox.0c00446. [PMID: 33621091] - Kristen M Manto, Prem Kumar Govindappa, Daniele Parisi, Zara Karuman, Brandon Martinazzi, John P Hegarty, M A Hassan Talukder, John C Elfar. (4-Aminopyridine)-PLGA-PEG as a Novel Thermosensitive and Locally Injectable Treatment for Acute Peripheral Nerve Injury.
ACS applied bio materials.
2021 05; 4(5):4140-4151. doi:
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Clinical therapeutics.
2017 Jul; 39(7):1360-1370. doi:
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Neurorehabilitation and neural repair.
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Critical care medicine.
2016 Nov; 44(11):e1082-e1089. doi:
10.1097/ccm.0000000000001822. [PMID: 27270180] - Ludmila A Kasatkina. 4-Аminopyridine sequesters intracellular Ca2+ which triggers exocytosis in excitable and non-excitable cells.
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10.1016/j.jpba.2015.11.042. [PMID: 26686828] - Naotami Ueoka, Yoshiaki Hikasa. Effects in cats of atipamezole, flumazenil and 4-aminopyridine on stress-related neurohormonal and metabolic responses induced by medetomidine, midazolam and ketamine.
Journal of feline medicine and surgery.
2015 Aug; 17(8):711-8. doi:
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International journal of clinical pharmacology and therapeutics.
2015 Aug; 53(8):674-80. doi:
10.5414/cp202133. [PMID: 26152130] - Peter E Haroldsen, Donald G Musson, Boyd Hanson, Adrian Quartel, Charles A O'Neill. Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults.
Clinical therapeutics.
2015 Jul; 37(7):1555-63. doi:
10.1016/j.clinthera.2015.05.498. [PMID: 26101174] - Daniel Kantor, Michael B Chancellor, Clayton W Snell, Herbert R Henney, Adrian L Rabinowicz. Assessment of confirmed urinary tract infection in patients treated with dalfampridine for multiple sclerosis.
Postgraduate medicine.
2015 Mar; 127(2):218-22. doi:
10.1080/00325481.2015.1000229. [PMID: 25560174] - Li Li, De-Pei Li, Shao-Rui Chen, Jinjun Chen, Hongzhen Hu, Hui-Lin Pan. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition.
Molecular pharmacology.
2014 Dec; 86(6):760-72. doi:
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Annals of the New York Academy of Sciences.
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Epilepsia.
2014 Aug; 55(8):1255-63. doi:
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Planta medica.
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2014; 54(7):561-4. doi:
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2012 May; 34(5):1056-69. doi:
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Glycoconjugate journal.
2012 May; 29(4):167-72. doi:
10.1007/s10719-012-9377-2. [PMID: 22535466] - John E Casida. The greening of pesticide-environment interactions: some personal observations.
Environmental health perspectives.
2012 Apr; 120(4):487-93. doi:
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ASN neuro.
2012 Mar; 4(2):. doi:
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Neuroscience.
2012 Mar; 205(?):154-66. doi:
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The Journal of nutritional biochemistry.
2012 Mar; 23(3):278-86. doi:
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The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2012 Feb; 16(1):25-30. doi:
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PloS one.
2012; 7(2):e32006. doi:
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International journal of Alzheimer's disease.
2012; 2012(?):594137. doi:
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International journal of biological sciences.
2012; 8(2):236-48. doi:
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PloS one.
2012; 7(5):e37451. doi:
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PloS one.
2012; 7(10):e47030. doi:
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PLoS pathogens.
2012; 8(6):e1002750. doi:
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Neuroscience.
2011 Dec; 199(?):125-32. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2011 Dec; 68(24):2335-40. doi:
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Brain : a journal of neurology.
2011 Dec; 134(Pt 12):3755-74. doi:
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Fungal genetics and biology : FG & B.
2011 Dec; 48(12):1130-8. doi:
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Journal of ethnopharmacology.
2011 Nov; 138(2):432-8. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2011 Nov; 68(22):2148-54. doi:
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Journal of ethnopharmacology.
2011 Oct; 137(3):1366-72. doi:
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Journal of neurochemistry.
2011 Oct; 119(1):50-63. doi:
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Microbial pathogenesis.
2011 Sep; 51(3):203-8. doi:
10.1016/j.micpath.2011.03.011. [PMID: 21497651] - Haixin Chang, Susan S Suarez. Two distinct Ca(2+) signaling pathways modulate sperm flagellar beating patterns in mice.
Biology of reproduction.
2011 Aug; 85(2):296-305. doi:
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Magnetic resonance in chemistry : MRC.
2011 Aug; 49(8):469-76. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2011 Jul; 384(1):59-70. doi:
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Current medical research and opinion.
2011 Jul; 27(7):1415-23. doi:
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Journal of neurochemistry.
2011 May; 117(3):554-64. doi:
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Free radical biology & medicine.
2011 Apr; 50(7):866-73. doi:
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Journal of ethnopharmacology.
2011 Jan; 133(2):315-23. doi:
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Cell death & disease.
2011 Jan; 2(?):e113. doi:
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Frontiers in neurology.
2011; 2(?):71. doi:
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PloS one.
2011; 6(9):e25043. doi:
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PloS one.
2011; 6(5):e19969. doi:
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Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):428108. doi:
10.1093/ecam/nep010. [PMID: 19244295] - Sujuan Yan, Yamei Chen, Min Dong, Weizhong Song, Scott M Belcher, Hong-Sheng Wang. Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling.
PloS one.
2011; 6(9):e25455. doi:
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PloS one.
2011; 6(9):e25740. doi:
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Frontiers in cellular neuroscience.
2011; 5(?):23. doi:
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