Dalfampridine (BioDeep_00000858336)
Main id: BioDeep_00000009534
代谢物信息卡片
4-aminopyridine
化学式: C5H6N2 (94.05309559999999)
中文名称: 4-氨基吡啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN=CC=C1N
InChI: InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
描述信息
D002317 - Cardiovascular Agents > D026902 - Potassium Channel Blockers
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
N - Nervous system
Same as: D04127
同义名列表
3 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:34385
- KEGG: C13728
- KEGGdrug: D04127
- PubChem: 1727
- DrugBank: DB06637
- ChEMBL: CHEMBL284348
- MeSH: 4-Aminopyridine
- CAS: 286367-79-1
- CAS: 504-24-5
- PubChem: 586317
- PDB-CCD: 4AP
- NIKKAJI: J1.568G
- RefMet: 4-Aminopyridine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tzu-Kang Lin, Kun-Chieh Yeh, Ming-Shang Pai, Pei-Wen Hsieh, Su-Jane Wang. Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats.
European journal of pharmacology.
2024 Jan; 963(?):176280. doi:
10.1016/j.ejphar.2023.176280. [PMID: 38113967] - Cheng-Wei Lu, Tzu-Yu Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang. Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes).
Neurochemistry international.
2023 May; 167(?):105537. doi:
10.1016/j.neuint.2023.105537. [PMID: 37164158] - Serdar Sahinturk. Elabela relaxes rat pulmonary artery and trachea via BKCa, KV, and KATP channels.
Prostaglandins & other lipid mediators.
2023 Apr; 167(?):106735. doi:
10.1016/j.prostaglandins.2023.106735. [PMID: 37059294] - Pratibha Attri, Sangeeta Garg, Jatinder Kumar Ratan, Ardhendu Sekhar Giri. Silver nanoparticles from Tabernaemontana divaricate leaf extract: mechanism of action and bio-application for photo degradation of 4-aminopyridine.
Environmental science and pollution research international.
2023 Feb; 30(10):24856-24875. doi:
10.1007/s11356-021-18269-6. [PMID: 35013966] - James N Brundage, Colin P Mason, Hillary A Wadsworth, Chris S Finuf, Josh J Nelson, P Joakim W Ronström, Sara R Jones, Cody A Siciliano, Scott C Steffensen, Jordan T Yorgason. Regional and sex differences in spontaneous striatal dopamine transmission.
Journal of neurochemistry.
2022 03; 160(6):598-612. doi:
10.1111/jnc.15473. [PMID: 34265080] - Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang. An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats.
International journal of molecular sciences.
2022 Feb; 23(5):. doi:
10.3390/ijms23052641. [PMID: 35269784] - Enikő Pergel, Irén Veres, Gergely Imre Csigi, Gábor Czirják. Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910515. [PMID: 34638858] - Che-Chuan Wang, Pei-Wen Hsieh, Jinn-Rung Kuo, Su-Jane Wang. Rosmarinic Acid, a Bioactive Phenolic Compound, Inhibits Glutamate Release from Rat Cerebrocortical Synaptosomes through GABAA Receptor Activation.
Biomolecules.
2021 07; 11(7):. doi:
10.3390/biom11071029. [PMID: 34356653] - Kuan-Ming Chiu, Tzu-Yu Lin, Ming-Yi Lee, Cheng-Wei Lu, Ming-Jiuh Wang, Su-Jane Wang. Typhaneoside Suppresses Glutamate Release Through Inhibition of Voltage-Dependent Calcium Entry in Rat Cerebrocortical Nerve Terminals.
Chemical research in toxicology.
2021 05; 34(5):1286-1295. doi:
10.1021/acs.chemrestox.0c00446. [PMID: 33621091] - Kristen M Manto, Prem Kumar Govindappa, Daniele Parisi, Zara Karuman, Brandon Martinazzi, John P Hegarty, M A Hassan Talukder, John C Elfar. (4-Aminopyridine)-PLGA-PEG as a Novel Thermosensitive and Locally Injectable Treatment for Acute Peripheral Nerve Injury.
ACS applied bio materials.
2021 05; 4(5):4140-4151. doi:
10.1021/acsabm.0c01566. [PMID: 34142019] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Nicolas J Guehl, Ramesh Neelamegam, Yu-Peng Zhou, Sung-Hyun Moon, Maeva Dhaynaut, Georges El Fakhri, Marc D Normandin, Pedro Brugarolas. Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[11C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS.
ACS chemical neuroscience.
2021 02; 12(4):756-765. doi:
10.1021/acschemneuro.0c00791. [PMID: 33539063] - Jeppe Seamus Bayley, Jesper Givskov Sørensen, Martin Moos, Vladimír Koštál, Johannes Overgaard. Cold acclimation increases depolarization resistance and tolerance in muscle fibers from a chill-susceptible insect, Locusta migratoria.
American journal of physiology. Regulatory, integrative and comparative physiology.
2020 10; 319(4):R439-R447. doi:
10.1152/ajpregu.00068.2020. [PMID: 32847398] - Jyosna Doniparthi, Jeevana Jyothi B. Novel tamarind seed gum-alginate based multi-particulates for sustained release of dalfampridine using response surface methodology.
International journal of biological macromolecules.
2020 Feb; 144(?):725-741. doi:
10.1016/j.ijbiomac.2019.11.203. [PMID: 31843610] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Na Wang, Ying-Hong Hu, Li-Da Su. Potassium channels-mediated electrophysiologic responses are inhibited by cytosolic phospholipase A2α ablation.
Neuroreport.
2018 Jan; 29(1):59-64. doi:
10.1097/wnr.0000000000000933. [PMID: 29112675] - Pegah Hashemi, Hasan Bagheri, Abbas Afkhami, Salimeh Amidi, Tayyebeh Madrakian. Graphene nanoribbon/FePt bimetallic nanoparticles/uric acid as a novel magnetic sensing layer of screen printed electrode for sensitive determination of ampyra.
Talanta.
2018 Jan; 176(?):350-359. doi:
10.1016/j.talanta.2017.08.046. [PMID: 28917761] - Juan Gu, Xin Tian, Wei Wang, Qin Yang, Peijia Lin, Yuanlin Ma, Yan Xiong, Demei Xu, Yanke Zhang, Yong Yang, Shanshan Lu, Zijun Lin, Jing Luo, Fei Xiao, Xuefeng Wang. Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 46(1):160-177. doi:
10.1159/000488419. [PMID: 29587280] - Steven J Kehl. A Model of the Block of Voltage-Gated Potassium Kv4.2 Ionic Currents by 4-Aminopyridine.
The Journal of pharmacology and experimental therapeutics.
2017 11; 363(2):184-195. doi:
10.1124/jpet.117.243097. [PMID: 28864468] - Esther S Kim. Fampridine Prolonged Release: A Review in Multiple Sclerosis Patients with Walking Disability.
Drugs.
2017 Sep; 77(14):1593-1602. doi:
10.1007/s40265-017-0808-z. [PMID: 28864863] - Peter E Haroldsen, Zlatko Sisic, Joe Datt, Donald G Musson, Gary Ingenito. Acetylator Status Impacts Amifampridine Phosphate (Firdapse™) Pharmacokinetics and Exposure to a Greater Extent Than Renal Function.
Clinical therapeutics.
2017 Jul; 39(7):1360-1370. doi:
10.1016/j.clinthera.2017.05.353. [PMID: 28641995] - Anil Sindhurakar, Asht M Mishra, Disha Gupta, Jennifer F Iaci, Tom J Parry, Jason B Carmel. Clinically Relevant Levels of 4-Aminopyridine Strengthen Physiological Responses in Intact Motor Circuits in Rats, Especially After Pyramidal Tract Injury.
Neurorehabilitation and neural repair.
2017 04; 31(4):387-396. doi:
10.1177/1545968316688800. [PMID: 28107804] - E O Sanya, A O Soladoye, O O Desalu, P M Kolo, L A Olatunji, J K Olarinoye. Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2017 Mar; 31(2):115-119. doi:
. [PMID: 28262846] - Han-Bin Chen, Jiang-Tao Zhou, Yu-Hong Liu, Zhen-Biao Zhang, Ya-Xian Zhan, Zi-Ren Su, Hui-Fang Zeng. Synthesis of pogostone by one-step.
Journal of Asian natural products research.
2017 Feb; 19(2):172-175. doi:
10.1080/10286020.2016.1184253. [PMID: 27243631] - Zen-Kong Dai, Chang-Ling Kao, Su-Ling Hsieh, Ing-Jun Chen, Bin-Nan Wu. Restoration of uridine 5'-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cells.
The Kaohsiung journal of medical sciences.
2016 Dec; 32(12):607-613. doi:
10.1016/j.kjms.2016.09.008. [PMID: 27914611] - Abdelouahab Bellou, Suleiman Al-Hammadi, Elhadi H Aburawi, Subramanian Dhanasekaran, Abderrahim Nemmar, Abderrahim Oulhaj, Mohamed Shafiuallah, Moufida Zerrouki, Javed Yasin, Leila Bellou, Seth L Alper, Sirine Bellou, Elsadig Kazzam. 4-Aminopyridine, A Blocker of Voltage-Dependent K+ Channels, Restores Blood Pressure and Improves Survival in the Wistar Rat Model of Anaphylactic Shock.
Critical care medicine.
2016 Nov; 44(11):e1082-e1089. doi:
10.1097/ccm.0000000000001822. [PMID: 27270180] - Ludmila A Kasatkina. 4-Аminopyridine sequesters intracellular Ca2+ which triggers exocytosis in excitable and non-excitable cells.
Scientific reports.
2016 10; 6(?):34749. doi:
10.1038/srep34749. [PMID: 27703262] - Florencia Ardon, Ross D Markello, Lian Hu, Zarah I Deutsch, Chih-Kuan Tung, Mingming Wu, Susan S Suarez. Dynamics of Bovine Sperm Interaction with Epithelium Differ Between Oviductal Isthmus and Ampulla.
Biology of reproduction.
2016 10; 95(4):90. doi:
10.1095/biolreprod.116.140632. [PMID: 27605344] - A Suneetha, Rajeswari K Raja. Comparison of LC-UV and LC-MS methods for simultaneous determination of teriflunomide, dimethyl fumarate and fampridine in human plasma: application to rat pharmacokinetic study.
Biomedical chromatography : BMC.
2016 Sep; 30(9):1371-7. doi:
10.1002/bmc.3694. [PMID: 26849839] - María Alcaide, Stavros Papaioannou, Andrew Taylor, Ladislav Fekete, Leonid Gurevich, Vladimir Zachar, Cristian Pablo Pennisi. Resistance to protein adsorption and adhesion of fibroblasts on nanocrystalline diamond films: the role of topography and boron doping.
Journal of materials science. Materials in medicine.
2016 May; 27(5):90. doi:
10.1007/s10856-016-5696-3. [PMID: 26975747] - Hashem Haghdoost-Yazdi, Hossein Piri, Ayda Faraji, Negin Fraidouni, Tahereh Dargahi, Marzieh Mahmudi, Mahmud Alipour Heidari. Pretreatment with potassium channel blockers of 4-aminopyridine and tetraethylammonium attenuates behavioural symptoms of Parkinsonism induced by intrastriatal injection of 6-hydroxydopamine; the role of lipid peroxidation.
Neurological research.
2016 Apr; 38(4):294-300. doi:
10.1080/01616412.2015.1114290. [PMID: 27098232] - Eva Costa-Arpín, Antonio Pato, Ana Rodríguez-Regal, Luciana Midaglia, Rosa Yáñez, Delicias Muñoz, José R Lorenzo, Campo Amigo, José M Prieto. Clinical response and tolerability of fampridine in clinical practice.
Neurodegenerative disease management.
2016 Apr; 6(2):99-105. doi:
10.2217/nmt-2015-0004. [PMID: 27032814] - A Suneetha, K Raja Rajeswari. A high throughput flow gradient LC-MS/MS method for simultaneous determination of fingolimod, fampridine and prednisone in rat plasma, application to in vivo perfusion study.
Journal of pharmaceutical and biomedical analysis.
2016 Feb; 120(?):10-8. doi:
10.1016/j.jpba.2015.11.042. [PMID: 26686828] - Naotami Ueoka, Yoshiaki Hikasa. Effects in cats of atipamezole, flumazenil and 4-aminopyridine on stress-related neurohormonal and metabolic responses induced by medetomidine, midazolam and ketamine.
Journal of feline medicine and surgery.
2015 Aug; 17(8):711-8. doi:
10.1177/1098612x14556557. [PMID: 25366173] - Natsuko Ishida, Erina Kobayashi, Yuya Kondo, Ryo Matsushita, Kiyonobu Komai. Pharmacokinetics and safety of 3,4-diaminopyridine base in healthy Japanese volunteers.
International journal of clinical pharmacology and therapeutics.
2015 Aug; 53(8):674-80. doi:
10.5414/cp202133. [PMID: 26152130] - Peter E Haroldsen, Donald G Musson, Boyd Hanson, Adrian Quartel, Charles A O'Neill. Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults.
Clinical therapeutics.
2015 Jul; 37(7):1555-63. doi:
10.1016/j.clinthera.2015.05.498. [PMID: 26101174] - Daniel Kantor, Michael B Chancellor, Clayton W Snell, Herbert R Henney, Adrian L Rabinowicz. Assessment of confirmed urinary tract infection in patients treated with dalfampridine for multiple sclerosis.
Postgraduate medicine.
2015 Mar; 127(2):218-22. doi:
10.1080/00325481.2015.1000229. [PMID: 25560174] - Li Li, De-Pei Li, Shao-Rui Chen, Jinjun Chen, Hongzhen Hu, Hui-Lin Pan. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition.
Molecular pharmacology.
2014 Dec; 86(6):760-72. doi:
10.1124/mol.114.095505. [PMID: 25267719] - Andrew R Blight, Herbert R Henney, Ron Cohen. Development of dalfampridine, a novel pharmacologic approach for treating walking impairment in multiple sclerosis.
Annals of the New York Academy of Sciences.
2014 Nov; 1329(?):33-44. doi:
10.1111/nyas.12512. [PMID: 25154911] - Seda Salar, Anna Maslarova, Kristina Lippmann, Julia Nichtweiss, Itai Weissberg, Liron Sheintuch, Wolfram S Kunz, Zamir Shorer, Alon Friedman, Uwe Heinemann. Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures.
Epilepsia.
2014 Aug; 55(8):1255-63. doi:
10.1111/epi.12713. [PMID: 24995798] - Xiaomin Hou, Yu Liu, Longgang Niu, Lijuan Cui, Mingsheng Zhang. Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery.
Planta medica.
2014 Apr; 80(6):465-72. doi:
10.1055/s-0034-1368320. [PMID: 24710898] - María Teresa Frejo, Javier Del Pino, Margarita Lobo, Jimena García, Miguel Andrés Capo, María Jesús Díaz. Liver and kidney damage induced by 4-aminopyridine in a repeated dose (28 days) oral toxicity study in rats: gene expression profile of hybrid cell death.
Toxicology letters.
2014 Mar; 225(2):252-63. doi:
10.1016/j.toxlet.2013.12.016. [PMID: 24378259] - Salim Sharopov, Rongqing Chen, Haiyan Sun, Sergei N Kolbaev, Sergei Kirischuk, Heiko J Luhmann, Werner Kilb. Inhibition of different GABA transporter systems is required to attenuate epileptiform activity in the CA3 region of the immature rat hippocampus.
Epilepsy research.
2014 Feb; 108(2):182-9. doi:
10.1016/j.eplepsyres.2013.11.019. [PMID: 24359690] - Tzu-Yu Lin, Wei-Jan Huang, Chia-Chan Wu, Cheng-Wei Lu, Su-Jane Wang. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats.
PloS one.
2014; 9(2):e88644. doi:
10.1371/journal.pone.0088644. [PMID: 24520409] - Atsuko Nishikawa, Madoka Mori-Yoshimura, Tomoko Okamoto, Yasushi Oya, Tomohiko Nakata, Kinji Ohno, Miho Murata. [Beneficial effects of 3,4-diaminopyridine in a 26-year-old woman with DOK7 congenital myasthenic syndrome who was originally diagnosed with facioscapulohumeral dystrophy].
Rinsho shinkeigaku = Clinical neurology.
2014; 54(7):561-4. doi:
10.5692/clinicalneurol.54.561. [PMID: 25087557] - Emil Samara, Peter Winkle, Patricia Pardo, Herbert R Henney, Susan L Way, Eppie Brown, Angela Lee, Andrew R Blight. Pharmacokinetics of dalfampridine extended release 7.5-mg tablets in healthy subjects and individuals with mild and moderate renal impairment: an open-label study.
Journal of clinical pharmacology.
2014 Jan; 54(1):53-60. doi:
10.1002/jcph.189. [PMID: 24150835] - Scott Weir, Risa Torkin, Herbert R Henney. Pharmacokinetic profile of dalfampridine extended release: clinical relevance in patients with multiple sclerosis.
Current medical research and opinion.
2013 Dec; 29(12):1627-36. doi:
10.1185/03007995.2012.749221. [PMID: 23157467] - Stalin Kondaveeti, Dharmesh R Chejara, A K Siddhanta. A facile one-pot synthesis of a fluorescent agarose-O-naphthylacetyl adduct with slow release properties.
Carbohydrate polymers.
2013 Oct; 98(1):589-95. doi:
10.1016/j.carbpol.2013.06.046. [PMID: 23987386] - Jennifer F Iaci, Tom J Parry, Zhihong Huang, Seth P Finklestein, Jingmei Ren, Dana K Barrile, Matthew D Davenport, Rui Wu, Andrew R Blight, Anthony O Caggiano. Dalfampridine improves sensorimotor function in rats with chronic deficits after middle cerebral artery occlusion.
Stroke.
2013 Jul; 44(7):1942-50. doi:
10.1161/strokeaha.111.000147. [PMID: 23652269] - Tzu Yu Lin, Cheng Wei Lu, Shu-Kuei Huang, Su-Jane Wang. Tanshinone IIA, a constituent of Danshen, inhibits the release of glutamate in rat cerebrocortical nerve terminals.
Journal of ethnopharmacology.
2013 May; 147(2):488-96. doi:
10.1016/j.jep.2013.03.045. [PMID: 23542145] - Chun-Chi Chen, Yung-Lin Yang, Chun-Lin Ou, Chih-Hung Chou, Chih-Chuang Liaw, Po-Chiao Lin. Direct monitoring of chemical transformations by combining thin layer chromatography with nanoparticle-assisted laser desorption/ionization mass spectrometry.
The Analyst.
2013 Mar; 138(5):1379-85. doi:
10.1039/c2an36423a. [PMID: 23330148] - Tzu-Yu Lin, Yu-Wan Lin, Cheng-Wei Lu, Shu-Kuei Huang, Su-Jane Wang. Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex.
PloS one.
2013; 8(6):e67215. doi:
10.1371/journal.pone.0067215. [PMID: 23840629] - Oscar Fernandez, Thomas Berger, Hans-Peter Hartung, Norman Putzki. Historical overview of the rationale for the pharmacological use of prolonged-release fampridine in multiple sclerosis.
Expert review of clinical pharmacology.
2012 Nov; 5(6):649-65. doi:
10.1586/ecp.12.59. [PMID: 23146002] - Vannina G Marrachelli, José M Centeno, Ignacio Miranda, María Castelló-Ruiz, María C Burguete, Teresa Jover-Mengual, Juan B Salom, Germán Torregrosa, Francisco J Miranda, Enrique Alborch. Diabetes impairs the atrial natriuretic peptide relaxant action mediated by potassium channels and prostacyclin in the rabbit renal artery.
Pharmacological research.
2012 Nov; 66(5):392-400. doi:
10.1016/j.phrs.2012.07.008. [PMID: 22898325] - Dongfeng Wei, Yanxia Wei, Weidong Cheng, Lifeng Zhang. Sulfated modification, characterization and antitumor activities of Radix hedysari polysaccharide.
International journal of biological macromolecules.
2012 Nov; 51(4):471-6. doi:
10.1016/j.ijbiomac.2012.06.004. [PMID: 22705472] - Lei Xu, Sui-Ping Huang. Effect of the ginsenoside Rb1 on the spontaneous contraction of intestinal smooth muscle in mice.
World journal of gastroenterology.
2012 Oct; 18(38):5462-9. doi:
10.3748/wjg.v18.i38.5462. [PMID: 23082064] - Yongjie Wang, Bailin Cong, Jihong Shen, Shenghao Liu, Feng Liu, Nengfei Wang, Xiaohang Huang. Molecular cloning and functional analysis of a voltage-gated potassium channel in lymphocytes from sea perch, Lateolabrax japonicus.
Fish & shellfish immunology.
2012 Sep; 33(3):605-13. doi:
10.1016/j.fsi.2012.05.024. [PMID: 22651989] - Laura Medina-Ceja, Flavio Sandoval-García, Alberto Morales-Villagrán, Silvia J López-Pérez. Rapid compensatory changes in the expression of EAAT-3 and GAT-1 transporters during seizures in cells of the CA1 and dentate gyrus.
Journal of biomedical science.
2012 Aug; 19(?):78. doi:
10.1186/1423-0127-19-78. [PMID: 22931236] - Rita de C V de A F Da Silva, Sandra Crestani, Priscila de Souza, Aline A Boligon, Margareth L Athayde, Adair R S Santos, Maria Consuelo Andrade Marques, Cândida A L Kassuya, José Eduardo Da Silva-Santos. Endothelium-dependent and independent vasorelaxation induced by an n-butanolic fraction of bark of Scutia buxifolia Reiss (Rhamanaceae).
Journal of ethnopharmacology.
2012 Jun; 141(3):997-1004. doi:
10.1016/j.jep.2012.03.045. [PMID: 22783552] - Junlong Wang, Baotang Zhao, Xiaofang Wang, Jian Yao, Ji Zhang. Structure and antioxidant activities of sulfated guar gum: homogeneous reaction using DMAP/DCC catalyst.
International journal of biological macromolecules.
2012 Jun; 50(5):1201-6. doi:
10.1016/j.ijbiomac.2012.03.009. [PMID: 22484325] - Huey-Chuan Shih, Ling-Ling Yang. Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle.
Pharmaceutical biology.
2012 Jun; 50(6):760-5. doi:
10.3109/13880209.2011.631930. [PMID: 22471999] - François Senejoux, Corinne Girard, Haji Akber Aisa, Mahinur Bakri, Parhat Kerram, Alain Berthelot, Françoise Bévalot, Céline Demougeot. Vasorelaxant and hypotensive effects of a hydroalcoholic extract from the fruits of Nitraria sibirica Pall. (Nitrariaceae).
Journal of ethnopharmacology.
2012 Jun; 141(2):629-34. doi:
10.1016/j.jep.2011.08.012. [PMID: 21864668] - David R Cornblath, E Jay Bienen, Andrew R Blight. The safety profile of dalfampridine extended release in multiple sclerosis clinical trials.
Clinical therapeutics.
2012 May; 34(5):1056-69. doi:
10.1016/j.clinthera.2012.03.007. [PMID: 22497693] - Dongfeng Wei, Weidong Cheng, Yanxia Wei, Lifeng Zhang. Phosphorylated modification and in vitro antioxidant activity of Radix Hedysari polysaccharide.
Glycoconjugate journal.
2012 May; 29(4):167-72. doi:
10.1007/s10719-012-9377-2. [PMID: 22535466] - John E Casida. The greening of pesticide-environment interactions: some personal observations.
Environmental health perspectives.
2012 Apr; 120(4):487-93. doi:
10.1289/ehp.1104405. [PMID: 22472325] - Robert Zorec, Alfonso Araque, Giorgio Carmignoto, Philip G Haydon, Alexei Verkhratsky, Vladimir Parpura. Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route.
ASN neuro.
2012 Mar; 4(2):. doi:
10.1042/an20110061. [PMID: 22313347] - D Ehrlich, M Pirchl, C Humpel. Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats.
Neuroscience.
2012 Mar; 205(?):154-66. doi:
10.1016/j.neuroscience.2011.12.054. [PMID: 22244974] - Eui-Baek Byun, Sachiko Korematsu, Teruaki Ishikawa, Taichi Nishizuka, Shunji Ohshima, Tomomasa Kanda, Toshiro Matsui. Apple procyanidins induce hyperpolarization of rat aorta endothelial cells via activation of K+ channels.
The Journal of nutritional biochemistry.
2012 Mar; 23(3):278-86. doi:
10.1016/j.jnutbio.2010.12.005. [PMID: 21543207] - Hye Kyung Lee, Kyoung Hwa Lee, Eui-Sic Cho. Bile Acid Inhibition of N-type Calcium Channel Currents from Sympathetic Ganglion Neurons.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2012 Feb; 16(1):25-30. doi:
10.4196/kjpp.2012.16.1.25. [PMID: 22416216] - Sandeep Khurana, Hema Raina, Valeria Pappas, Jean-Pierre Raufman, Thomas L Pallone. Effects of deoxycholylglycine, a conjugated secondary bile acid, on myogenic tone and agonist-induced contraction in rat resistance arteries.
PloS one.
2012; 7(2):e32006. doi:
10.1371/journal.pone.0032006. [PMID: 22359652] - Dayne Beccano-Kelly, Jenni Harvey. Leptin: a novel therapeutic target in Alzheimer's disease?.
International journal of Alzheimer's disease.
2012; 2012(?):594137. doi:
10.1155/2012/594137. [PMID: 22254146] - Feifei Su, Miaoqian Shi, Zhiqiang Yan, Dongbo Ou, Juntang Li, Zifan Lu, Qiangsun Zheng. Simvastatin modulates remodeling of Kv4.3 expression in rat hypertrophied cardiomyocytes.
International journal of biological sciences.
2012; 8(2):236-48. doi:
10.7150/ijbs.8.236. [PMID: 22253567] - Yu-Guang Ma, Wen-Chao Liu, Shuo Dong, Cheng Du, Xiao-Jun Wang, Jin-Sheng Li, Xiao-Ping Xie, Li Wu, Da-Chang Ma, Zhi-Bin Yu, Man-Jiang Xie. Activation of BK(Ca) channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells.
PloS one.
2012; 7(5):e37451. doi:
10.1371/journal.pone.0037451. [PMID: 22655048] - Dong-Mei Zhang, Yong Li, Wai San Cheang, Chi Wai Lau, Shun-Ming Lin, Qian-Lan Zhang, Nan Yao, Ying Wang, Xin Wu, Yu Huang, Wen-Cai Ye. Cajaninstilbene acid relaxes rat renal arteries: roles of Ca2+ antagonism and protein kinase C-dependent mechanism.
PloS one.
2012; 7(10):e47030. doi:
10.1371/journal.pone.0047030. [PMID: 23056567] - Veronica Jimenez, Roberto Docampo. Molecular and electrophysiological characterization of a novel cation channel of Trypanosoma cruzi.
PLoS pathogens.
2012; 8(6):e1002750. doi:
10.1371/journal.ppat.1002750. [PMID: 22685407] - J Fahanik-Babaei, A Eliassi, R Saghiri. How many types of large conductance Ca⁺²-activated potassium channels exist in brain mitochondrial inner membrane: evidence for a new mitochondrial large conductance Ca²⁺-activated potassium channel in brain mitochondria.
Neuroscience.
2011 Dec; 199(?):125-32. doi:
10.1016/j.neuroscience.2011.09.055. [PMID: 21996476] - Sarah McDonald, Jennifer N Clements. Dalfampridine: a new agent for symptomatic management of multiple sclerosis.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2011 Dec; 68(24):2335-40. doi:
10.2146/ajhp110134. [PMID: 22135060] - Angela Vincent. John Newsom-Davis: clinician-scientist and so much more.
Brain : a journal of neurology.
2011 Dec; 134(Pt 12):3755-74. doi:
10.1093/brain/awr284. [PMID: 22171357] - Andreia S Fernandes, A Pedro Gonçalves, Ana Castro, Telma A Lopes, Rui Gardner, N Louise Glass, Arnaldo Videira. Modulation of fungal sensitivity to staurosporine by targeting proteins identified by transcriptional profiling.
Fungal genetics and biology : FG & B.
2011 Dec; 48(12):1130-8. doi:
10.1016/j.fgb.2011.09.004. [PMID: 22001288] - Geneviève Irié-N'guessan, Pierre Champy, Gisèle Kouakou-Siransy, Armand Koffi, Brou Jérôme Kablan, Véronique Leblais. Tracheal relaxation of five Ivorian anti-asthmatic plants: role of epithelium and K⁺ channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark.
Journal of ethnopharmacology.
2011 Nov; 138(2):432-8. doi:
10.1016/j.jep.2011.09.016. [PMID: 21963567] - Herbert R Henney, Bonnie Faust, Andrew R Blight. Effect of food on the single-dose pharmacokinetics and tolerability of dalfampridine extended-release tablets in healthy volunteers.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2011 Nov; 68(22):2148-54. doi:
10.2146/ajhp110054. [PMID: 22058101] - C F Ng, C M Koon, D W S Cheung, M Y Lam, P C Leung, C B S Lau, K P Fung. The anti-hypertensive effect of Danshen (Salvia miltiorrhiza) and Gegen (Pueraria lobata) formula in rats and its underlying mechanisms of vasorelaxation.
Journal of ethnopharmacology.
2011 Oct; 137(3):1366-72. doi:
10.1016/j.jep.2011.08.006. [PMID: 21855622] - Cristina Romei, Silvia Di Prisco, Maurizio Raiteri, Luca Raiteri. Glycine release provoked by disturbed Na⁺, Na⁺ and Ca²⁺ homeostasis in cerebellar nerve endings: roles of Ca²⁺ channels, Na⁺/Ca²⁺ exchangers and GlyT2 transporter reversal.
Journal of neurochemistry.
2011 Oct; 119(1):50-63. doi:
10.1111/j.1471-4159.2011.07401.x. [PMID: 21790607] - Gabriela Prêtre, Noelia Olivera, Maia Cédola, Santiago Haase, Lucrecia Alberdi, Bibiana Brihuega, Ricardo M Gómez. Role of inducible nitric oxide synthase in the pathogenesis of experimental leptospirosis.
Microbial pathogenesis.
2011 Sep; 51(3):203-8. doi:
10.1016/j.micpath.2011.03.011. [PMID: 21497651] - Haixin Chang, Susan S Suarez. Two distinct Ca(2+) signaling pathways modulate sperm flagellar beating patterns in mice.
Biology of reproduction.
2011 Aug; 85(2):296-305. doi:
10.1095/biolreprod.110.089789. [PMID: 21389347] - Alejandra León, María Isabel Chávez, Guillermo Delgado. (1)H and DOSY NMR spectroscopy analysis of Ligusticum porteri rhizome extracts.
Magnetic resonance in chemistry : MRC.
2011 Aug; 49(8):469-76. doi:
10.1002/mrc.2767. [PMID: 21761449] - Yi Chang, Yu-Wan Lin, Su-Jane Wang. Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 Jul; 384(1):59-70. doi:
10.1007/s00210-011-0630-1. [PMID: 21541760] - Jeffrey Dunn, Andrew Blight. Dalfampridine: a brief review of its mechanism of action and efficacy as a treatment to improve walking in patients with multiple sclerosis.
Current medical research and opinion.
2011 Jul; 27(7):1415-23. doi:
10.1185/03007995.2011.583229. [PMID: 21595605] - Yunzhou Shi, Wenjing Sun, Jennifer J McBride, Ji-Xin Cheng, Riyi Shi. Acrolein induces myelin damage in mammalian spinal cord.
Journal of neurochemistry.
2011 May; 117(3):554-64. doi:
10.1111/j.1471-4159.2011.07226.x. [PMID: 21352229] - James M Flynn, Sung W Choi, Nicholas U Day, Akos A Gerencser, Alan Hubbard, Simon Melov. Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice.
Free radical biology & medicine.
2011 Apr; 50(7):866-73. doi:
10.1016/j.freeradbiomed.2010.12.030. [PMID: 21215798] - Hye Yoom Kim, Hyuncheol Oh, Xiang Li, Kyung Woo Cho, Dae Gill Kang, Ho Sub Lee. Ethanol extract of seeds of Oenothera odorata induces vasorelaxation via endothelium-dependent NO-cGMP signaling through activation of Akt-eNOS-sGC pathway.
Journal of ethnopharmacology.
2011 Jan; 133(2):315-23. doi:
10.1016/j.jep.2010.09.024. [PMID: 20932888] - E Benítez-Rangel, L García, M C Namorado, J L Reyes, A Guerrero-Hernández. Ion channel inhibitors block caspase activation by mechanisms other than restoring intracellular potassium concentration.
Cell death & disease.
2011 Jan; 2(?):e113. doi:
10.1038/cddis.2010.93. [PMID: 21368885] - Torill Berg, Jørgen Jensen. Simultaneous parasympathetic and sympathetic activation reveals altered autonomic control of heart rate, vascular tension, and epinephrine release in anesthetized hypertensive rats.
Frontiers in neurology.
2011; 2(?):71. doi:
10.3389/fneur.2011.00071. [PMID: 22131984] - Carmen Cifuentes-Diaz, Fabrice Chareyre, Marta Garcia, Jérôme Devaux, Michèle Carnaud, Grégoire Levasseur, Michiko Niwa-Kawakita, Sheila Harroch, Jean-Antoine Girault, Marco Giovannini, Laurence Goutebroze. Protein 4.1B contributes to the organization of peripheral myelinated axons.
PloS one.
2011; 6(9):e25043. doi:
10.1371/journal.pone.0025043. [PMID: 21966409] - Elena I Sinauridze, Alexey N Romanov, Irina V Gribkova, Olga A Kondakova, Stepan S Surov, Aleksander S Gorbatenko, Andrey A Butylin, Mikhail Yu Monakov, Alexey A Bogolyubov, Yuryi V Kuznetsov, Vladimir B Sulimov, Fazoyl I Ataullakhanov. New synthetic thrombin inhibitors: molecular design and experimental verification.
PloS one.
2011; 6(5):e19969. doi:
10.1371/journal.pone.0019969. [PMID: 21603576] - Peter T Dorsher, Peter M McIntosh. Acupuncture's Effects in Treating the Sequelae of Acute and Chronic Spinal Cord Injuries: A Review of Allopathic and Traditional Chinese Medicine Literature.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):428108. doi:
10.1093/ecam/nep010. [PMID: 19244295] - Sujuan Yan, Yamei Chen, Min Dong, Weizhong Song, Scott M Belcher, Hong-Sheng Wang. Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling.
PloS one.
2011; 6(9):e25455. doi:
10.1371/journal.pone.0025455. [PMID: 21980463] - Andoria Tjondrokoesoemo, Ki Ho Park, Christopher Ferrante, Shinji Komazaki, Sebastian Lesniak, Marco Brotto, Jae-Kyun Ko, Jingsong Zhou, Noah Weisleder, Jianjie Ma. Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.
PloS one.
2011; 6(9):e25740. doi:
10.1371/journal.pone.0025740. [PMID: 21984944] - Ilgam Khalilov, Geneviève Chazal, Ilona Chudotvorova, Christophe Pellegrino, Séverine Corby, Nadine Ferrand, Olena Gubkina, Romain Nardou, Roman Tyzio, Sumii Yamamoto, Thomas J Jentsch, Christian A Hübner, Jean-Luc Gaiarsa, Yehezkel Ben-Ari, Igor Medina. Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus.
Frontiers in cellular neuroscience.
2011; 5(?):23. doi:
10.3389/fncel.2011.00023. [PMID: 22065950]