Virginiamycin M1 (BioDeep_00000855541)

Main id: BioDeep_00000008587

 

Chemicals and Drugs


代谢物信息卡片


Pristinamycin IIA

化学式: C28H35N3O7 (525.247488)
中文名称: 蛎灰菌素A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C=CC(=O)NCC=CC(=CC(CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)OC1C(C)C)O)C
InChI: InChI=1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5+,10-9+,18-13+/t19-,20-,26-/m1/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D025361 - Streptogramins
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by?Streptomyces virginiae, is an polyunsaturated macrocyclic lactone antibiotic and acts as a component of Virginiamycin (HY-112665)[1]. Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL. The combination of Virginiamycin M1 and Virginiamycin S1 (HY-N6680) is 0.125 μg/mL (MIC Value), which can improve the bactericidal effect 1-30 times[2].

同义名列表

3 个代谢物同义名

Pristinamycin IIA; Virginiamycin M1; Ostreogrycin A



数据库引用编号

8 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Xiaoyang Wang, Mi Wang, Keyu Zhang, Ting Hou, Lifang Zhang, Chenzong Fei, Feiqun Xue, Taijun Hang. Determination of virginiamycin M1 residue in tissues of swine and chicken by ultra-performance liquid chromatography tandem mass spectrometry. Food chemistry. 2018 Jun; 250(?):127-133. doi: 10.1016/j.foodchem.2018.01.024. [PMID: 29412901]
  • Lei Li, Yawei Zhao, Lijun Ruan, Sheng Yang, Mei Ge, Weihong Jiang, Yinhua Lu. A stepwise increase in pristinamycin II biosynthesis by Streptomyces pristinaespiralis through combinatorial metabolic engineering. Metabolic engineering. 2015 May; 29(?):12-25. doi: 10.1016/j.ymben.2015.02.001. [PMID: 25708513]
  • Junling Dun, Yawei Zhao, Guosong Zheng, Hong Zhu, Lijun Ruan, Wenfang Wang, Mei Ge, Weihong Jiang, Yinhua Lu. PapR6, a putative atypical response regulator, functions as a pathway-specific activator of pristinamycin II biosynthesis in Streptomyces pristinaespiralis. Journal of bacteriology. 2015 Feb; 197(3):441-50. doi: 10.1128/jb.02312-14. [PMID: 25404695]
  • Amani D Politano, Robert G Sawyer. NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA. Current opinion in investigational drugs (London, England : 2000). 2010 Feb; 11(2):225-36. doi: . [PMID: 20112172]