Mikamycin A (BioDeep_00000008587)

 

Secondary id: BioDeep_00000855541

Chemicals and Drugs


代谢物信息卡片


Virginiamycin Complex

化学式: C28H35N3O7 (525.2475)
中文名称: 蛎灰菌素A
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CC1=CC(O)CC(=O)Cc2nc(co2)C(=O)N2CCC=C2C(=O)OC(C(C)C)C(C)C=CC(=O)NCC=C1
InChI: InChI=1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5+,10-9+,18-13+/t19-,20-,26-/m1/s1

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D025361 - Streptogramins
Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by?Streptomyces virginiae, is an polyunsaturated macrocyclic lactone antibiotic and acts as a component of Virginiamycin (HY-112665)[1]. Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL. The combination of Virginiamycin M1 and Virginiamycin S1 (HY-N6680) is 0.125 μg/mL (MIC Value), which can improve the bactericidal effect 1-30 times[2].

同义名列表

7 个代谢物同义名

Pristinamycin IIA; Virginiamycin M1; Streptogramin A; Mikamycin A; Virginiamycin Complex; Ostreogrycin A; Virginiamycin M1



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 BIN3, MEFV, MSRA, MYLK, RB1CC1, RPL4, TYMS
Peripheral membrane protein 1 ATP6V1D
Endosome membrane 1 ATP6V1D
Endoplasmic reticulum membrane 2 LDAF1, RB1CC1
Cytoplasmic vesicle, autophagosome 1 MEFV
Nucleus 4 MEFV, RB1CC1, RPL4, TYMS
autophagosome 1 MEFV
cytosol 7 ATP6V1D, MEFV, MSRA, MYLK, RB1CC1, RPL4, TYMS
dendrite 1 ACVRL1
mitochondrial membrane 1 MAVS
centrosome 1 ATP6V1D
nucleoplasm 4 ATP2B1, ATP6V1D, MEFV, MSRA
Cell membrane 3 ABCB5, ACVRL1, ATP2B1
Lipid-anchor 1 MSRA
Cytoplasmic side 1 ATP6V1D
Cleavage furrow 1 MYLK
lamellipodium 2 MEFV, MYLK
Multi-pass membrane protein 5 ABCB5, ATP2B1, LDAF1, MT-CYB, SLC25A22
Synapse 2 ATP2B1, MYLK
cell surface 1 ACVRL1
glutamatergic synapse 1 ATP2B1
Golgi membrane 1 ATP6V1D
lysosomal membrane 1 ATP6V1D
mitochondrial inner membrane 4 ATP5ME, MT-CYB, SLC25A22, TYMS
neuronal cell body 1 ACVRL1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 RB1CC1
Lysosome 1 RB1CC1
plasma membrane 6 ABCB5, ACVRL1, ATP2B1, ATP6V1D, MSRA, MYLK
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ABCB5, ACVRL1, ATP2B1, ATP6V1D, MSRA, MT-CYB, RPL4
axon 1 CCK
basolateral plasma membrane 1 ATP2B1
extracellular exosome 4 ATP2B1, ATP6V1D, MSRA, RPL4
extracellular space 2 CCK, GAST
mitochondrion 6 ATP5ME, MAVS, MSRA, MT-CYB, SLC25A22, TYMS
intracellular membrane-bounded organelle 2 ATP2B1, MSRA
Single-pass type I membrane protein 1 ACVRL1
Secreted 2 CCK, GAST
extracellular region 2 CCK, GAST
Mitochondrion outer membrane 1 MAVS
Single-pass membrane protein 1 MAVS
mitochondrial outer membrane 1 MAVS
Mitochondrion matrix 1 TYMS
mitochondrial matrix 1 TYMS
Cell projection, cilium 1 ATP6V1D
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 ATP6V1D
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 RB1CC1
actin cytoskeleton 3 BIN3, MSRA, MYLK
cytoplasmic vesicle 1 MEFV
nucleolus 1 RPL4
Cytoplasmic vesicle, clathrin-coated vesicle membrane 1 ATP6V1D
clathrin-coated vesicle membrane 1 ATP6V1D
midbody 1 MSRA
Cell projection, lamellipodium 2 MEFV, MYLK
Mitochondrion inner membrane 3 MT-CYB, SLC25A22, TYMS
Cytoplasm, cytoskeleton 1 BIN3
focal adhesion 1 RPL4
microtubule 1 MEFV
Peroxisome 1 MAVS
peroxisomal membrane 1 MAVS
lateral plasma membrane 1 ATP2B1
Cell projection, ruffle 1 MEFV
ruffle 1 MEFV
cilium 1 ATP6V1D
microtubule associated complex 1 MEFV
autophagosome membrane 1 RB1CC1
cell projection 1 ATP2B1
cytoskeleton 1 BIN3
Basolateral cell membrane 1 ATP2B1
Lipid droplet 1 LDAF1
phagophore assembly site 1 RB1CC1
phagophore assembly site membrane 1 RB1CC1
specific granule membrane 1 ATP6V1D
Presynaptic cell membrane 1 ATP2B1
ubiquitin ligase complex 1 MAVS
stress fiber 1 MYLK
extrinsic component of synaptic vesicle membrane 1 ATP6V1D
immunological synapse 1 ATP2B1
respiratory chain complex III 1 MT-CYB
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
ribonucleoprotein complex 1 RPL4
[Isoform 2]: Nucleus 1 MEFV
[Isoform 1]: Cytoplasm, cytoskeleton 1 MEFV
canonical inflammasome complex 1 MEFV
Rough endoplasmic reticulum 1 RPL4
cytosolic ribosome 1 RPL4
Preautophagosomal structure 1 RB1CC1
Atg1/ULK1 kinase complex 1 RB1CC1
vacuolar proton-transporting V-type ATPase, V1 domain 1 ATP6V1D
proton-transporting V-type ATPase complex 1 ATP6V1D
proton-transporting ATP synthase complex 1 ATP5ME
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
ribosome 1 RPL4
cytosolic large ribosomal subunit 1 RPL4
photoreceptor ribbon synapse 1 ATP2B1
BMP receptor complex 1 ACVRL1


文献列表

  • Xiaoyang Wang, Mi Wang, Keyu Zhang, Ting Hou, Lifang Zhang, Chenzong Fei, Feiqun Xue, Taijun Hang. Determination of virginiamycin M1 residue in tissues of swine and chicken by ultra-performance liquid chromatography tandem mass spectrometry. Food chemistry. 2018 Jun; 250(?):127-133. doi: 10.1016/j.foodchem.2018.01.024. [PMID: 29412901]
  • Lei Li, Yawei Zhao, Lijun Ruan, Sheng Yang, Mei Ge, Weihong Jiang, Yinhua Lu. A stepwise increase in pristinamycin II biosynthesis by Streptomyces pristinaespiralis through combinatorial metabolic engineering. Metabolic engineering. 2015 May; 29(?):12-25. doi: 10.1016/j.ymben.2015.02.001. [PMID: 25708513]
  • Junling Dun, Yawei Zhao, Guosong Zheng, Hong Zhu, Lijun Ruan, Wenfang Wang, Mei Ge, Weihong Jiang, Yinhua Lu. PapR6, a putative atypical response regulator, functions as a pathway-specific activator of pristinamycin II biosynthesis in Streptomyces pristinaespiralis. Journal of bacteriology. 2015 Feb; 197(3):441-50. doi: 10.1128/jb.02312-14. [PMID: 25404695]
  • Amani D Politano, Robert G Sawyer. NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA. Current opinion in investigational drugs (London, England : 2000). 2010 Feb; 11(2):225-36. doi: . [PMID: 20112172]