Sulbenicillin (BioDeep_00000008527)
代谢物信息卡片
化学式: C16H18N2O7S2 (414.05553979999996)
中文名称: 磺苄西林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)S(=O)(=O)O)C(=O)O)C
InChI: InChI=1S/C16H18N2O7S2/c1-16(2)11(15(21)22)18-13(20)9(14(18)26-16)17-12(19)10(27(23,24)25)8-6-4-3-5-7-8/h3-7,9-11,14H,1-2H3,(H,17,19)(H,21,22)(H,23,24,25)
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
A penicillin antibiotic having a 6beta-[phenyl(sulfo)acetamido] side-chain.
Same as: D08534
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
3 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:9322
- KEGG: C11170
- KEGGdrug: D08534
- PubChem: 39031
- PubChem: 20055036
- PubChem: 5317
- Metlin: METLIN68889
- DrugBank: DB13693
- ChEMBL: CHEMBL1256734
- ChEMBL: CHEMBL3306853
- MeSH: Sulbenicillin
- CAS: 34779-28-7
- CAS: 41744-40-5
- CAS: 58569-36-1
- PMhub: MS000022153
- MetaboLights: MTBLC9322
- PubChem: 13352
- NIKKAJI: J16.405D
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Aurijit Sarkar, Kelcey C Anderson, Glen E Kellogg. Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
European journal of medicinal chemistry.
2012 Jun; 52(?):98-110. doi:
10.1016/j.ejmech.2012.03.008
. [PMID: 22483632] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j
. [PMID: 19445515] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479
. [PMID: 18426954] - G M Pacifici. Placental transfer of antibiotics administered to the mother: a review.
International journal of clinical pharmacology and therapeutics.
2006 Feb; 44(2):57-63. doi:
10.5414/cpp44057
. [PMID: 16502764] - Y Tsuda, T Tsunoi, N Watanabe, M Ishida, H Yamada, T Itoh. Stereoselective binding and degradation of sulbenicillin in the presence of human serum albumin.
Chirality.
2001 May; 13(5):236-43. doi:
10.1002/chir.1025
. [PMID: 11317344] - T Itoh, N Watanabe, M Ishida, Y Tsuda, S Koyano, T Tsunoi, H Shimada, H Yamada. Stereoselective disposition of sulbenicillin in humans.
Antimicrobial agents and chemotherapy.
1998 Feb; 42(2):325-31. doi:
10.1128/aac.42.2.325
. [PMID: 9527780] - T Shimizu, S Souma, N Nagakura, T Masuzawa, Y Iwamoto, Y Yanagihara. Epitope analysis of aztreonam by antiaztreonam monoclonal antibodies and possible consequences in beta-lactams hypersensitivity.
International archives of allergy and immunology.
1992; 98(4):392-7. doi:
10.1159/000236216
. [PMID: 1384868] - T Yoshida. [Penetration of antibiotics into second degree burned skin in rabbits].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science.
1989 Jan; 64(1):18-30. doi:
NULL
. [PMID: 2722125] - F Fraschini, F Scaglione, E Bichisao, E Marchi, G Scarpazza, P Scarpazza, V Gaffuri Riva. Comparison between sulbenicillin and piperacillin levels in serum and in bronchial secretions--a pharmacokinetic study.
International journal of clinical pharmacology, therapy, and toxicology.
1987 Nov; 25(11):638-42. doi:
. [PMID: 3429068]
- S Ripa, F Mignini, I Patrizi, L Ferrante, M Prenna, E Falcioni. Sulbenicillin: pharmacokinetics and penetration into bronchial secretion in elderly patients.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy.
1987 Aug; 6(4):277-81. doi:
NULL
. [PMID: 3652279] - J Haginaka, J Wakai. High-performance liquid chromatographic assay of carbenicillin, ticarcillin and sulbenicillin in serum and urine using pre-column reaction with 1,2,4-triazole and mercury(II) chloride.
The Analyst.
1985 Oct; 110(10):1185-8. doi:
10.1039/an9851001185
. [PMID: 4083496] - A Suenaga, H Nakagawa, M T Huang, Y Imamura, M Otagiri, H Ichibagase. Biopharmaceutical studies on pyridinolcarbamate. V. Effect of repeated administration of pyridinolcarbamate on the renal excretion of sulbenicillin in rabbits.
Acta pharmaceutica Suecica.
1985; 22(1):45-52. doi:
NULL
. [PMID: 4024967] - X W Wang, C S Lu, Z M Zhang, C Y Wong, D K Tu, R L Zapata-Sirvent. Verdoglobinuria phenomenon in severe electrical burns.
Burns, including thermal injury.
1984 Feb; 10(3):188-92. doi:
10.1016/0305-4179(84)90025-1
. [PMID: 6426704] - K Tomita, O Matsuda, S Shinohara, T Shiigai, J Takeuchi. Sulbenicillin-induced kaliuresis in man.
The Japanese journal of physiology.
1983; 33(5):811-20. doi:
10.2170/jjphysiol.33.811
. [PMID: 6668759] - E Takeuchi, T Abe, T Shimizu, M Murase, M Tanaka, H Nogaki, A Hotta, Y Yano, Y Iyomasa. [Concentration of sulbenicillin in human serum and myocardial tissue].
The Japanese journal of antibiotics.
1982 Jul; 35(7):1716-21. doi:
. [PMID: 7176071]
- K Imagawa, M Kawasaki, I Toda, M Hayashi, A Asai, T Nomura. [A study on penetration of antibiotics into the cerebrospinal fluid after the ventriculo-peritoneal shunt (author's transl)].
The Japanese journal of antibiotics.
1982 Apr; 35(4):1072-9. doi:
. [PMID: 7097985]
- T Chiba, M Kasai. Studies on recovery of liver function of operated biliary atresia.
The Tohoku journal of experimental medicine.
1982 Apr; 136(4):439-46. doi:
10.1620/tjem.136.439
. [PMID: 7101277] - C G Ker, C F Peng, T J Huang, P C Sheen. Antibiotic concentration in bile from patients with obstructive jaundice. II: in vivo and in vitro studies of prednisolone effect on sulbenicillin excretion in bile.
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association.
1981 Dec; 80(12):1268-74. doi:
. [PMID: 6951920]
- K Bamba, M Sone. Factors affecting the quality of boar semen stored by means of dialysis.
Journal of reproduction and fertility.
1981 May; 62(1):193-7. doi:
10.1530/jrf.0.0620193
. [PMID: 7230124] - O Shiho, Y Nakagawa, K Tsuchiya. IgE antibodies for penicillins and cephalosporins in rats. II. Antigenic specificity of rat anti-penicillin-OvA IgE sera.
The Journal of antibiotics.
1981 Jan; 34(1):79-83. doi:
10.7164/antibiotics.34.79
. [PMID: 6166603] - A Montanari, L Borghi, M Canali, P Coruzzi, A Novarini, A Borghetti. The influence of renal function on the elimination kinetics of sulbenicillin in man.
International journal of clinical pharmacology, therapy, and toxicology.
1980; 18(5):225-8. doi:
. [PMID: 7390672]
- J Kataoka. [On the safety of sulbenicillin administration to infections associated with acute leukaemia (author's transl)].
The Japanese journal of antibiotics.
1979 Sep; 32(9):871-6. doi:
. [PMID: 41117]
- A Montanari, L Borghi, A Curti, M Canali, A Biggi, A Mutti, A Novarini, P Perinotto. [Role of kidney function in the pharmacokinetics of a new semisynthetic penicillin (sulbenicillin)].
La Clinica terapeutica.
1979 Apr; 89(2):163-71. doi:
NULL
. [PMID: 487714] - K Yamaoka, S Narita, T Nakagawa, T Uno. High-performance liquid chromatographic analyses of sulbenicillin and carbenicillin in human urine.
Journal of chromatography.
1979 Jan; 168(1):187-93. doi:
10.1016/s0021-9673(00)80708-6
. [PMID: 762230] - E Bertazzoni Minelli, G Benoni. [Carbenicillin and sulbenicillin. Pharmacokinetic studies in the rat].
Giornale italiano di chemioterapia.
1979 Jan; 26(1-2):173-6. doi:
NULL
. [PMID: 554807] - J Kjellander, A Lanner, R Norrby. Bacteriological and clinical studies of sulbenicillin.
Scandinavian journal of infectious diseases.
1978; 10(3):235-41. doi:
10.3109/inf.1978.10.issue-3.14
. [PMID: 362518] - K Tomiki, S Ishikawa. [Clinical evaluation of intrathoracic tissue bactericidal antibiotic level (author's transl)].
The Japanese journal of antibiotics.
1977 Jul; 30(7):511-6. doi:
NULL
. [PMID: 909140] - H Aratani, M Nakatsuka. [Fundamental studies on combination of antibiotics; especially on pharmacokinetics. I. Combination of gentamicin with sulbenicillin or cephacetrile (author's transl)].
The Japanese journal of antibiotics.
1976 Dec; 29(12):1019-34. doi:
. [PMID: 1051432]
- K Deguchi, S Oda, Y Sato, Y Ikeda, T Nakamura. [In vitro examination on antibacterial activities of broad-spectrum antibiotics against gram-negative clinical isolates (author's transl)].
The Japanese journal of antibiotics.
1975 Dec; 28(6):785-94. doi:
. [PMID: 1104913]