BROMOBENZENE (BioDeep_00000008454)

   

Volatile Flavor Compounds natural product


代谢物信息卡片


BROMOBENZENE

化学式: C6H5Br (155.957459)
中文名称: 溴苯
谱图信息: 最多检出来源 Macaca mulatta(otcml) 20.33%

分子结构信息

SMILES: Brc1ccccc1
InChI: InChI=1S/C6H5Br/c7-6-4-2-1-3-5-6/h1-5H

描述信息

The simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30degreeC; b.p.760 156degreeC), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis.

同义名列表

3 个代谢物同义名

BROMOBENZENE; Bromobenzene; Bromobenzene



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hiroki Yoshioka, Sarah Tominaga, Mai Nishikawa, Yasuro Shinohara, Makoto Nakao, Masae Yoshikawa, Tohru Maeda, Nobuhiko Miura. Different Renal Chronotoxicity of Bromobenzene and Its Intermediate Metabolites in Mice. Biological & pharmaceutical bulletin. 2021; 44(1):150-153. doi: 10.1248/bpb.b20-00694. [PMID: 33390544]
  • Venkat R Pannala, Shanea K Estes, Mohsin Rahim, Irina Trenary, Tracy P O'Brien, Chiyo Shiota, Richard L Printz, Jaques Reifman, Masakazu Shiota, Jamey D Young, Anders Wallqvist. Toxicant-Induced Metabolic Alterations in Lipid and Amino Acid Pathways Are Predictive of Acute Liver Toxicity in Rats. International journal of molecular sciences. 2020 Nov; 21(21):. doi: 10.3390/ijms21218250. [PMID: 33158035]
  • Venkat R Pannala, Shanea K Estes, Mohsin Rahim, Irina Trenary, Tracy P O'Brien, Chiyo Shiota, Richard L Printz, Jaques Reifman, Tatsuya Oyama, Masakazu Shiota, Jamey D Young, Anders Wallqvist. Mechanism-based identification of plasma metabolites associated with liver toxicity. Toxicology. 2020 08; 441(?):152493. doi: 10.1016/j.tox.2020.152493. [PMID: 32479839]
  • Priya Josson Akkara, Evan Prince Sabina. Pre-treatment with Beta Carotene Gives Protection Against Nephrotoxicity Induced by Bromobenzene via Modulation of Antioxidant System, Pro-inflammatory Cytokines and Pro-apoptotic Factors. Applied biochemistry and biotechnology. 2020 Feb; 190(2):616-633. doi: 10.1007/s12010-019-03111-0. [PMID: 31407161]
  • B Claire McDyre, Mohamed Diwan M AbdulHameed, Matthew G Permenter, William E Dennis, Christine E Baer, Jason M Koontz, Molly H Boyle, Anders Wallqvist, John A Lewis, Danielle L Ippolito. Comparative Proteomic Analysis of Liver Steatosis and Fibrosis after Oral Hepatotoxicant Administration in Sprague-Dawley Rats. Toxicologic pathology. 2018 02; 46(2):202-223. doi: 10.1177/0192623317747549. [PMID: 29378501]
  • Haoan Zhao, Ni Cheng, Liangliang He, Guoxia Peng, Qingqing Liu, Tianchen Ma, Wei Cao. Hepatoprotective Effects of the Honey of Apis cerana Fabricius on Bromobenzene-Induced Liver Damage in Mice. Journal of food science. 2018 Feb; 83(2):509-516. doi: 10.1111/1750-3841.14021. [PMID: 29337369]
  • Hiroki Yoshioka, Tsunemasa Nonogaki, Nobuyuki Fukuishi, Yasuro Shinohara, Gi-Wook Hwang, Katsumi Ohtani, Nobuhiko Miura. Chronotoxicity of bromobenzene-induced hepatic injury in mice. The Journal of toxicological sciences. 2017; 42(2):251-258. doi: 10.2131/jts.42.251. [PMID: 28321051]
  • Mahima Vedi, Evan Prince Sabina. Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation. Cell biology and toxicology. 2016 10; 32(5):373-90. doi: 10.1007/s10565-016-9340-2. [PMID: 27250656]
  • Yongrui He, Xian-En Zhao, Shuyun Zhu, Na Wei, Jing Sun, Yubi Zhou, Shu Liu, Zhiqiang Liu, Guang Chen, Yourui Suo, Jinmao You. In situ derivatization-ultrasound-assisted dispersive liquid-liquid microextraction for the determination of neurotransmitters in Parkinson's rat brain microdialysates by ultra high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2016 Aug; 1458(?):70-81. doi: 10.1016/j.chroma.2016.06.059. [PMID: 27372412]
  • Hiroki Yoshioka, Shiori Fukaya, Nobuyuki Fukuishi, Akito Nagatsu, Tsunemasa Nonogaki, Satomi Onosaka. Bromobenzene-induced lethal toxicity in mouse is prevented by pretreatment with zinc sulfate. Chemico-biological interactions. 2016 Jul; 254(?):117-23. doi: 10.1016/j.cbi.2016.06.002. [PMID: 27270452]
  • Udhaya Lavinya Baskaran, Sherry Joseph Martin, Rasool Mahaboobkhan, Sabina Evan Prince. Protective role of Triphala, an Indian traditional herbal formulation, against the nephrotoxic effects of bromobenzene in Wistar albino rats. Journal of integrative medicine. 2015 Mar; 13(2):115-21. doi: 10.1016/s2095-4964(15)60165-0. [PMID: 25797642]
  • Mahima Vedi, Mahaboobkhan Rasool, Evan Prince Sabina. Protective effect of administration of Withania somifera against bromobenzene induced nephrotoxicity and mitochondrial oxidative stress in rats. Renal failure. 2014 Aug; 36(7):1095-103. doi: 10.3109/0886022x.2014.918812. [PMID: 24845808]
  • Mujeeb Khan, Merajuddin Khan, Mufsir Kuniyil, Syed Farooq Adil, Abdulrahman Al-Warthan, Hamad Z Alkhathlan, Wolfgang Tremel, Muhammad Nawaz Tahir, Mohammed Rafiq H Siddiqui. Biogenic synthesis of palladium nanoparticles using Pulicaria glutinosa extract and their catalytic activity towards the Suzuki coupling reaction. Dalton transactions (Cambridge, England : 2003). 2014 Jun; 43(24):9026-31. doi: 10.1039/c3dt53554a. [PMID: 24619034]
  • Xuping Wang, Lei Yang, Xiaolan Yang, Yanhua Tian. In vitro and in vivo antioxidant and antimutagenic activities of polyphenols extracted from hops (Humulus lupulus L.). Journal of the science of food and agriculture. 2014 Jun; 94(8):1693-700. doi: 10.1002/jsfa.6534. [PMID: 24338210]
  • Qing Zhu, Junping Hu, Wei-Qing Han, Fan Zhang, Pin-Lan Li, Zhengchao Wang, Ningjun Li. Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats. American journal of hypertension. 2014 Jan; 27(1):107-13. doi: 10.1093/ajh/hpt207. [PMID: 24190904]
  • Darol E Dodd, Linda J Pluta, Mark A Sochaski, Deborah A Banas, Russell S Thomas. Subchronic hepatotoxicity evaluation of bromobenzene in Fischer 344 rats. Journal of applied toxicology : JAT. 2013 May; 33(5):370-7. doi: 10.1002/jat.2732. [PMID: 22407932]
  • M A Hamed, N S El-Rigal, S A Ali. Effects of black seed oil on resolution of hepato-renal toxicity induced bybromobenzene in rats. European review for medical and pharmacological sciences. 2013 Mar; 17(5):569-81. doi: . [PMID: 23543440]
  • Shingo Okubo, Makoto Miyamoto, Kenji Takami, Masayuki Kanki, Atsushi Ono, Noriyuki Nakatsu, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani. Identification of novel liver-specific mRNAs in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Mar; 132(1):21-31. doi: 10.1093/toxsci/kfs340. [PMID: 23288050]
  • Wei Gao, Xian Li, Xin-Ling Wang, Jing Yang, Xue-Fen Wu. 4-[(2-Bromo-benzyl-idene)amino]-3-(pyridin-4-yl)-1H-1,2,4-triazole-5(4H)-thione. Acta crystallographica. Section E, Structure reports online. 2012 Jul; 68(Pt 7):o1996. doi: 10.1107/s1600536812024439. [PMID: 22807827]
  • Yeon-Kyeong Yun, Hyun-Kyung Kim, Jun-Ran Kim, Kumnara Hwang, Young-Joon Ahn. Contact and fumigant toxicity of Armoracia rusticana essential oil, allyl isothiocyanate and related compounds to Dermatophagoides farinae. Pest management science. 2012 May; 68(5):788-94. doi: 10.1002/ps.2327. [PMID: 22102526]
  • Sylvie Mavel, Zoya Mincheva, Nathalie Méheux, Yvan Carcenac, Denis Guilloteau, Mohamed Abarbri, Patrick Emond. QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT). Bioorganic & medicinal chemistry. 2012 Feb; 20(4):1388-95. doi: 10.1016/j.bmc.2012.01.014. [PMID: 22300887]
  • Vadde Ramakrishna, Sriram Gopi, Oruganti H Setty. Protective effect of Hemidesmus indicus L. R. Br. against bromobenzene-induced mitochondrial dysfunction in rat kidney. The American journal of Chinese medicine. 2012; 40(3):567-80. doi: 10.1142/s0192415x12500437. [PMID: 22745071]
  • Sung Young Kim, Sang Chul Park. Physiological antioxidative network of the bilirubin system in aging and age-related diseases. Frontiers in pharmacology. 2012; 3(?):45. doi: 10.3389/fphar.2012.00045. [PMID: 22457648]
  • O Hussein, J Zidan, K Abu Jabal, I Shams, S Szvalb, M Grozovski, I Bersudsky, R Karry, M Aviram. Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic Fatty liver disease. International journal of hepatology. 2012; 2012(?):265305. doi: 10.1155/2012/265305. [PMID: 22536512]
  • Manal A Hamed, Sanaa A Ali, Nagy Saba El-Rigal. Therapeutic potential of ginger against renal injury induced by carbon tetrachloride in rats. TheScientificWorldJournal. 2012; 2012(?):840421. doi: 10.1100/2012/840421. [PMID: 22566780]
  • Marek Banasik, Todd Stedeford, Robert P Strosznajder, Masanori Takehashi, Seigo Tanaka, Kunihiro Ueda. Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride. Journal of enzyme inhibition and medicinal chemistry. 2011 Dec; 26(6):883-9. doi: 10.3109/14756366.2011.557315. [PMID: 21395487]
  • Suzanne Geenen, Cristina Guallar-Hoyas, Filippos Michopoulos, J Gerry Kenna, Kyle L Kolaja, Hans V Westerhoff, Paul Thomas, Ian D Wilson. HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium. Journal of pharmaceutical and biomedical analysis. 2011 Nov; 56(3):655-63. doi: 10.1016/j.jpba.2011.06.001. [PMID: 21752568]
  • Mahadevappa Paramesha, Chapeyil K Ramesh, Venkatarangaiah Krishna, Yelegara S Ravi Kumar, Karur M M Parvathi. Hepatoprotective and in vitro antioxidant effect of Carthamus tinctorious L, var Annigeri-2-, an oil-yielding crop, against CCl(4) -induced liver injury in rats. Pharmacognosy magazine. 2011 Oct; 7(28):289-97. doi: 10.4103/0973-1296.90406. [PMID: 22262931]
  • Heibatullah Kalantari, Mohammadtaha Jalali, Amir Jalali, Abobakr Salimi, Foad Alhalvachi, Balazs Varga, Bela Juhasz, Anita Jakab, Adam Kemeny-Beke, Rudolf Gesztelyi, Arpad Tosaki, Judit Zsuga. Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice. Human & experimental toxicology. 2011 Oct; 30(10):1710-5. doi: 10.1177/0960327110396532. [PMID: 21247991]
  • Heibatullah Kalantari, Mohammadtaha Jalali, Amir Jalali, Masood Mahdavinia, Abobakr Salimi, Bela Juhasz, Arpad Tosaki, Rudolf Gesztelyi. Protective effect of Cassia fistula fruit extract against bromobenzene-induced liver injury in mice. Human & experimental toxicology. 2011 Aug; 30(8):1039-44. doi: 10.1177/0960327110386256. [PMID: 20930029]
  • Ayodele Morakinyo, Bolanle Iranloye, Olufeyisipe Adegoke. Calcium antagonists modulate oxidative stress and acrosomal reaction in rat spermatozoa. Archives of medical science : AMS. 2011 Aug; 7(4):613-8. doi: 10.5114/aoms.2011.24130. [PMID: 22291796]
  • James D McCluskey, Dmytro Sava, Stephen C Harbison, Carlos A Muro-Cacho, Johnson T Giffe, Xu Ping, Raymond D Harbison. Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model. International journal of critical illness and injury science. 2011 Jul; 1(2):97-103. doi: 10.4103/2229-5151.84788. [PMID: 22229131]
  • Poonam Yadav, Nalini V Purohit. Synthesis and biological evaluation of some novel 3,4-disubstituted isocoumarins. Indian journal of pharmaceutical sciences. 2011 Mar; 73(2):171-8. doi: 10.4103/0250-474x.91586. [PMID: 22303060]
  • Dana M van Bemmel, Paolo Boffetta, Linda M Liao, Sonja I Berndt, Idan Menashe, Meredith Yeager, Stephen Chanock, Sara Karami, David Zaridze, Vsevolod Matteev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko, Marie Navratilova, Neonilia Szeszenia-Dabrowska, Dana Mates, Alena Slamova, Nathaniel Rothman, Summer S Han, Philip S Rosenberg, Paul Brennan, Wong-Ho Chow, Lee E Moore. Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead. PloS one. 2011; 6(7):e20432. doi: 10.1371/journal.pone.0020432. [PMID: 21799727]
  • Shyam Biswas, Markus Tonigold, Manfred Speldrich, Paul Kögerler, Matthias Weil, Dirk Volkmer. Syntheses and magnetostructural investigations on Kuratowski-type homo- and heteropentanuclear coordination compounds [MZn4Cl4(L)6] (M(II) = Zn, Fe, Co, Ni, or Cu; L = 5,6-dimethyl-1,2,3-benzotriazolate) represented by the nonplanar K(3,3) graph. Inorganic chemistry. 2010 Aug; 49(16):7424-34. doi: 10.1021/ic100749k. [PMID: 20690751]
  • Sriram Gopi, Oruganti H Setty. Protective effect of Phyllanthus fraternus against bromobenzene induced mitochondrial dysfunction in rat liver mitochondria. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Aug; 48(8-9):2170-5. doi: 10.1016/j.fct.2010.05.024. [PMID: 20488219]
  • Mark Eggink, Maikel Wijtmans, Ansgar Kretschmer, Jeroen Kool, Henk Lingeman, Iwan J P de Esch, Wilfried M A Niessen, Hubertus Irth. Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA. Analytical and bioanalytical chemistry. 2010 May; 397(2):665-75. doi: 10.1007/s00216-010-3575-1. [PMID: 20238107]
  • S Gopi, O H Setty. Beneficial effect of the administration of Hemidesmus indicus against bromobenzene induced oxidative stress in rat liver mitochondria. Journal of ethnopharmacology. 2010 Jan; 127(1):200-3. doi: 10.1016/j.jep.2009.09.043. [PMID: 19799985]
  • A S El-Sharaky, A A Newairy, M A Kamel, S M Eweda. Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009 Jul; 47(7):1584-90. doi: 10.1016/j.fct.2009.04.005. [PMID: 19371770]
  • Shinobu Kitazume, Ritsuko Oka, Kazuko Ogawa, Satoshi Futakawa, Yoshiaki Hagiwara, Hajime Takikawa, Michio Kato, Akinori Kasahara, Eiji Miyoshi, Naoyuki Taniguchi, Yasuhiro Hashimoto. Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo. Glycobiology. 2009 May; 19(5):479-87. doi: 10.1093/glycob/cwp003. [PMID: 19150807]
  • Jun Toyohara, Muneyuki Sakata, Jin Wu, Masatomo Ishikawa, Keiichi Oda, Kenji Ishii, Masaomi Iyo, Kenji Hashimoto, Kiichi Ishiwata. Preclinical and the first clinical studies on [11C]CHIBA-1001 for mapping alpha7 nicotinic receptors by positron emission tomography. Annals of nuclear medicine. 2009 May; 23(3):301-9. doi: 10.1007/s12149-009-0240-x. [PMID: 19337782]
  • Bor-Ru Lin, Chia-Jung Yu, Wang-Chuan Chen, Hsuan-Shu Lee, Huei-Min Chang, Yen-Chih Lee, Chiang-Ting Chien, Chau-Fong Chen. Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling. Journal of biomedical science. 2009 Mar; 16(?):35. doi: 10.1186/1423-0127-16-35. [PMID: 19317920]
  • Kelly W Hall, Carlos Muro-Cacho, Alison Abritis, Giffe T Johnson, Raymond D Harbison. Attenuation of bromobenzene-induced hepatotoxicity by poly(ADP-ribose) polymerase inhibitors. Research communications in molecular pathology and pharmacology. 2009 201; 122-123(1-6):79-95. doi: . [PMID: 22032092]
  • Kelly W Hall, Carlos Muro-Cacho, Alison Abritis, Giffe T Johnson, Raymond D Harbison. Attenuation of bromobenzene-induced hepatotoxicity by poly(ADP-ribose) polymerase inhibitors. Research communications in molecular pathology and pharmacology. 2009 201; 122-123(?):79-95. doi: . [PMID: 25022032]
  • Hazem A H Kataya, Alaaeldin A Hamza. Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats. Evidence-based complementary and alternative medicine : eCAM. 2008 Sep; 5(3):281-7. doi: 10.1093/ecam/nem029. [PMID: 18830445]
  • Laura E Randle, Chris E P Goldring, Craig A Benson, Peter N Metcalfe, Neil R Kitteringham, B Kevin Park, Dominic P Williams. Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. Toxicology. 2008 Jan; 243(3):249-60. doi: 10.1016/j.tox.2007.10.011. [PMID: 18078705]
  • Jong Moon Hur, Jong Won Choi, Jong Cheol Park. Effects of methanol extract of Alisma orientale rhizome and its major component, alisol B 23-acetate, on hepatic drug metabolizing enzymes in rats treated with bromobenzene. Archives of pharmacal research. 2007 Dec; 30(12):1543-9. doi: 10.1007/bf02977323. [PMID: 18254241]
  • Wan-Fu Yue, Guang-Li Li, Jian-Mei Liu, Jian-Tong Sun, Hong-Xiang Sun, Xing-Hua Li, Xiao-Feng Wu, Yun-Gen Miao. Anti-oxidation and immune responses in mice upon exposure to manganese superoxide dismutase expressed in silkworm larvae, Bombyx mori L. Cell biology international. 2007 Sep; 31(9):974-8. doi: 10.1016/j.cellbi.2007.03.007. [PMID: 17452112]
  • Willem G E J Schoonen, Cathelijne P A M Kloks, Jan-Peter H T M Ploemen, Martin J Smit, Pieter Zandberg, G Jean Horbach, Jan-Remt Mellema, Carol Thijssen-Vanzuylen, Albert C Tas, Joop H J van Nesselrooij, Jack T W E Vogels. Uniform procedure of (1)H NMR analysis of rat urine and toxicometabonomics Part II: comparison of NMR profiles for classification of hepatotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2007 Jul; 98(1):286-97. doi: 10.1093/toxsci/kfm077. [PMID: 17420222]
  • Willem G E J Schoonen, Cathelijne P A M Kloks, Jan-Peter H T M Ploemen, G Jean Horbach, Martin J Smit, Pieter Zandberg, Jan-Remt Mellema, Carol Thijssen-van Zuylen, Albert C Tas, Joop H J van Nesselrooij, Jack T W E Vogels. Sensitivity of (1)H NMR analysis of rat urine in relation to toxicometabonomics. Part I: dose-dependent toxic effects of bromobenzene and paracetamol. Toxicological sciences : an official journal of the Society of Toxicology. 2007 Jul; 98(1):271-85. doi: 10.1093/toxsci/kfm076. [PMID: 17420223]
  • J Todd Auman, Jeff Chou, Kevin Gerrish, Qihong Huang, Supriya Jayadev, Kerry Blanchard, Richard S Paules. Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue. Environmental health perspectives. 2007 Apr; 115(4):572-8. doi: 10.1289/ehp.9396. [PMID: 17450226]
  • Rafael Izquierdo, Luis Astudillo, Jaime A Rodríguez, Cristina Theoduloz, José A Palenzuela, Guillermo Schmeda-Hirschmann. Gastroprotective effect and cytotoxicity of labdenamides. Planta medica. 2007 Apr; 73(4):310-7. doi: 10.1055/s-2007-967153. [PMID: 17410517]
  • Yoshichika Kawai, Sayaka Takeda, Junji Terao. Lipidomic analysis for lipid peroxidation-derived aldehydes using gas chromatography-mass spectrometry. Chemical research in toxicology. 2007 Jan; 20(1):99-107. doi: 10.1021/tx060199e. [PMID: 17226932]
  • Michael Winkler, Wolfram Sander. Generation and reactivity of the phenyl cation in cryogenic argon matrices: monitoring the reactions with nitrogen and carbon monoxide directly by IR spectroscopy. The Journal of organic chemistry. 2006 Aug; 71(17):6357-67. doi: 10.1021/jo0603678. [PMID: 16901116]
  • Nigel J Waters, Catherine J Waterfield, R Duncan Farrant, Elaine Holmes, Jeremy K Nicholson. Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis. Journal of proteome research. 2006 Jun; 5(6):1448-59. doi: 10.1021/pr060024q. [PMID: 16739996]
  • Sharmilee P Sawant, Ankur V Dnyanmote, Mayurranjan S Mitra, Jaya Chilakapati, Alan Warbritton, John R Latendresse, Harihara M Mehendale. Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss-Webster mice. The Journal of pharmacology and experimental therapeutics. 2006 Feb; 316(2):507-19. doi: 10.1124/jpet.105.094326. [PMID: 16207833]
  • Jong Cheol Park, Won Dong Han, Jeong Ro Park, Seong Hee Choi, Jong Won Choi. Changes in hepatic drug metabolizing enzymes and lipid peroxidation by methanol extract and major compound of Orostachys japonicus. Journal of ethnopharmacology. 2005 Dec; 102(3):313-8. doi: 10.1016/j.jep.2005.06.023. [PMID: 16081232]
  • Keiichi Minami, Toshiro Saito, Masatoshi Narahara, Hiroyuki Tomita, Hirokazu Kato, Hisashi Sugiyama, Miki Katoh, Miki Nakajima, Tsuyoshi Yokoi. Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Sep; 87(1):296-305. doi: 10.1093/toxsci/kfi235. [PMID: 15976192]
  • Wilbert H M Heijne, Diana Jonker, Rob H Stierum, Ben van Ommen, John P Groten. Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure. Mutation research. 2005 Aug; 575(1-2):85-101. doi: 10.1016/j.mrfmmm.2005.02.003. [PMID: 15878777]
  • Naotaka Kuroda, Sumika Sugihara, Yohko Sugihara, Mitsuhiro Wada, Naoya Kishikawa, Yoshihito Ohba, Kenichiro Nakashima. Fluorescence labeling method for aryl halides with 4-(4,5-diphenyl-1H-imidazol-2-yl)phenylboronic acid based on Suzuki coupling reaction. Journal of chromatography. A. 2005 Feb; 1066(1-2):119-25. doi: 10.1016/j.chroma.2005.01.047. [PMID: 15794562]
  • Figen Esen, Tulin Erdem, Damla Aktan, Mukadder Orhan, Mehmet Kaya, Haluk Eraksoy, Nahit Cakar, Lutfi Telci. Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study. Critical care (London, England). 2005 Feb; 9(1):R18-23. doi: 10.1186/cc3004. [PMID: 15693962]
  • Wilbert H M Heijne, Robert-Jan A N Lamers, Peter J van Bladeren, John P Groten, Joop H J van Nesselrooij, Ben van Ommen. Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis. Toxicologic pathology. 2005; 33(4):425-33. doi: 10.1080/01926230590958146. [PMID: 16036859]
  • Guido Steiner, Laura Suter, Franziska Boess, Rodolfo Gasser, Maria Cristina de Vera, Silvio Albertini, Stefan Ruepp. Discriminating different classes of toxicants by transcript profiling. Environmental health perspectives. 2004 Aug; 112(12):1236-48. doi: 10.1289/txg.7036. [PMID: 15345370]
  • Hector C Keun, Timothy M D Ebbels, Mary E Bollard, Olaf Beckonert, Henrik Antti, Elaine Holmes, John C Lindon, Jeremy K Nicholson. Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles. Chemical research in toxicology. 2004 May; 17(5):579-87. doi: 10.1021/tx034212w. [PMID: 15144214]
  • Sonica Pawa, Shakir Ali. Liver necrosis and fulminant hepatic failure in rats: protection by oxyanionic form of tungsten. Biochimica et biophysica acta. 2004 Apr; 1688(3):210-22. doi: 10.1016/j.bbadis.2003.12.004. [PMID: 15062871]
  • Marina Tinel, Alain Berson, Nathalie Vadrot, Véronique Descatoire, Alain Grodet, Gérard Feldmann, Jean Paul Thénot, Dominique Pessayre. Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice. Hepatology (Baltimore, Md.). 2004 Mar; 39(3):655-66. doi: 10.1002/hep.20094. [PMID: 14999684]
  • Kun-Young Park, Geun-Ok Jung, Kyung-Tae Lee, Jongwon Choi, Moo-Young Choi, Gab-Tae Kim, Hyun-Ju Jung, Hee-Juhn Park. Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. Journal of ethnopharmacology. 2004 Jan; 90(1):73-9. doi: 10.1016/j.jep.2003.09.043. [PMID: 14698512]
  • S O Kachula, O O Pentiuk. [Effect of starvation and acetone on the enzyme systems of biotransformation and toxicity of xenobiotics--CYP2E1 substrates in rats]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2004 Jan; 76(1):114-22. doi: . [PMID: 15909426]
  • Masaya Kawase, Noritaka Kagaya, Soh-Ichiro Akamatsu, Akiko Kamiyoshi, Shin-Ichi Muto, Yoh-Ichi Tagawa, Kiyohito Yagi. Liver protection by bis(maltolato)zinc(II) complex. Experimental animals. 2004 Jan; 53(1):1-9. doi: 10.1538/expanim.53.1. [PMID: 14993734]
  • Jong Cheol Park, Sang Chul Kim, Jong Moon Hur, Seong Hee Choi, Kab Yeon Lee, Jong Won Choi. Anti-hepatotoxic effects of Rosa rugosa root and its compound, rosamultin, in rats intoxicated with bromobenzene. Journal of medicinal food. 2004; 7(4):436-41. doi: 10.1089/jmf.2004.7.436. [PMID: 15671686]
  • Terry R Van Vleet, Rick G Schnellmann. Toxic nephropathy: environmental chemicals. Seminars in nephrology. 2003 Sep; 23(5):500-8. doi: 10.1016/s0270-9295(03)00094-9. [PMID: 13680539]
  • Kartik Shankar, Vishal S Vaidya, Udayan M Apte, Jose E Manautou, Martin J J Ronis, Thomas J Bucci, Harihara M Mehendale. Type 1 diabetic mice are protected from acetaminophen hepatotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2003 Jun; 73(2):220-34. doi: 10.1093/toxsci/kfg059. [PMID: 12700423]
  • Jong Moon Hur, Ju Gwon Park, Ki Ho Yang, Jong Cheol Park, Jeong Ro Park, Soon Sil Chun, Jae Sue Choi, Jong Won Choi. Effect of methanol extract of Zanthoxylum piperitum leaves and of its compound, protocatechuic acid, on hepatic drug metabolizing enzymes and lipid peroxidation in rats. Bioscience, biotechnology, and biochemistry. 2003 May; 67(5):945-50. doi: 10.1271/bbb.67.945. [PMID: 12834269]
  • Kenji Matsuno, Michio Ichimura, Takao Nakajima, Keiko Tahara, Shigeki Fujiwara, Hiroshi Kase, Junko Ushiki, Neill A Giese, Anjali Pandey, Robert M Scarborough, Nathalie A Lokker, Jin-Chen Yu, Junko Irie, Eiji Tsukuda, Shin-ichi Ide, Shoji Oda, Yuji Nomoto. Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. Journal of medicinal chemistry. 2002 Jul; 45(14):3057-66. doi: 10.1021/jm010428o. [PMID: 12086491]
  • Kun-Young Park, Geun-Ok Jung, Jongwon Choi, Kyung-Tae Lee, Hee-Juhn Park. Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana. Archives of pharmacal research. 2002 Jun; 25(3):320-4. doi: 10.1007/bf02976633. [PMID: 12135104]
  • Paul S Giffen, Chris R Pick, Mark A Price, Ann Williams, Malcolm J York. Alpha-glutathione S-transferase in the assessment of hepatotoxicity--its diagnostic utility in comparison with other recognized markers in the Wistar Han rat. Toxicologic pathology. 2002 May; 30(3):365-72. doi: 10.1080/01926230252929945. [PMID: 12051554]
  • Yakov M Koen, Robert P Hanzlik. Identification of seven proteins in the endoplasmic reticulum as targets for reactive metabolites of bromobenzene. Chemical research in toxicology. 2002 May; 15(5):699-706. doi: 10.1021/tx0101898. [PMID: 12018992]
  • Ao Zhang, Guochun Zhou, Alexander Hoepping, Jayanta Mukhopadhyaya, Kenneth M Johnson, Mei Zhang, Alan P Kozikowski. Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors. Journal of medicinal chemistry. 2002 Apr; 45(9):1930-41. doi: 10.1021/jm0105373. [PMID: 11960503]
  • Jong Cheol Park, Ju Gwon Park, Hyun Joo Kim, Jong Moon Hur, Jong Ho Lee, Nak Ju Sung, Shin Kyo Chung, Jong Won Choi. Effects of extract from Angelica keiskei and its component, cynaroside, on the hepatic bromobenzene-metabolizing enzyme system in rats. Phytotherapy research : PTR. 2002 Mar; 16 Suppl 1(?):S24-7. doi: 10.1002/ptr.783. [PMID: 11933135]
  • C Kadarian, A M Broussalis, J Miño, P Lopez, S Gorzalczany, G Ferraro, C Acevedo. Hepatoprotective activity of Achyrocline satureioides(Lam) D. C. Pharmacological research. 2002 Jan; 45(1):57-61. doi: 10.1006/phrs.2001.0904. [PMID: 11820863]
  • Guangming Zhang, Inez Hua. The impact of particulates on the aqueous sonication of bromobenzene. Chemosphere. 2002 Jan; 46(1):59-66. doi: 10.1016/s0045-6535(01)00079-0. [PMID: 11806533]
  • M J Bartosiewicz, D Jenkins, S Penn, J Emery, A Buckpitt. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. The Journal of pharmacology and experimental therapeutics. 2001 Jun; 297(3):895-905. doi: NULL. [PMID: 11356909]
  • H Wang, R Peng, D Wu, S Li. [Serum glutathione S-transferase in bromobenzene-induced acute hepato-toxicity in mice]. Wei sheng yan jiu = Journal of hygiene research. 2001 May; 30(3):135-7. doi: NULL. [PMID: 12525079]
  • M D Maines, J F Ewing, T J Huang, N Panahian. Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1. The Journal of pharmacology and experimental therapeutics. 2001 Mar; 296(3):1091-7. doi: . [PMID: 11181945]
  • Y H Chung, J A Kim, B C Song, I H Song, M S Koh, H C Lee, E Yu, Y S Lee, D J Suh. Isocitrate dehydrogenase as a marker of centrilobular hepatic necrosis in the experimental model of rats. Journal of gastroenterology and hepatology. 2001 Mar; 16(3):328-32. doi: 10.1046/j.1440-1746.2001.02447.x. [PMID: 11339426]
  • A Lupp, M Tralls, U Fuchs, W Klinger. Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of different cytotoxins on cytochrome P450 mediated monooxygenase functions and on oxidative state. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2001 Feb; 52(6):529-38. doi: 10.1016/s0940-2993(01)80011-7. [PMID: 11256755]
  • J A Szymańska, J K Piotrowski. Hepatotoxicity of monobromobenzene and hexabromobenzene: effects of repeated dosage in rats. Chemosphere. 2000 Nov; 41(10):1689-96. doi: 10.1016/s0045-6535(00)00064-3. [PMID: 11057697]
  • S G Wong, J W Card, W J Racz. The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity. Toxicology letters. 2000 Aug; 116(3):171-81. doi: 10.1016/s0378-4274(00)00218-6. [PMID: 10996478]
  • R C Lind, A J Gandolfi. Hepatoprotection by dimethyl sulfoxide. II. Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 1999 Nov; 51(6):537-43. doi: 10.1016/s0940-2993(99)80134-1. [PMID: 10661812]
  • R S Wang, T Nakajima, T Honma. Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferases in chemically induced liver damage in rat. Industrial health. 1999 Oct; 37(4):440-8. doi: 10.2486/indhealth.37.440. [PMID: 10547960]
  • R C Lind, A J Gandolfi. Hepatoprotection by dimethyl sulfoxide. I. Protection when given twenty-four hours after chloroform or bromobenzene. Toxicologic pathology. 1999 May; 27(3):342-7. doi: 10.1177/019262339902700310. [PMID: 10356711]
  • T Mizutani, Y Miyamoto. Modulation of halobenzene-induced hepatotoxicity by DT-diaphorase modulators, butylated hydroxyanisole and dicoumarol: evidence for possible involvement of quinone metabolites in the toxicity of halobenzenes. Toxicology letters. 1999 Mar; 105(1):25-30. doi: 10.1016/s0378-4274(98)00376-2. [PMID: 10092053]
  • B H Wang, K A Zuzel, K Rahman, D Billington. Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices. Toxicology. 1999 Feb; 132(2-3):215-25. doi: 10.1016/s0300-483x(99)00004-9. [PMID: 10433384]
  • J E Manautou, V M Silva, G E Hennig, H E Whiteley. Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice. Toxicology. 1998 May; 127(1-3):1-10. doi: 10.1016/s0300-483x(98)00013-4. [PMID: 9699788]
  • B H Wang, K A Zuzel, K Rahman, D Billington. Protective effects of aged garlic extract against bromobenzene toxicity to precision cut rat liver slices. Toxicology. 1998 Apr; 126(3):213-22. doi: 10.1016/s0300-483x(98)00018-3. [PMID: 9674969]
  • J A Szymańska. Hepatotoxicity of brominated benzenes: relationship between chemical structure and hepatotoxic effects in acute intoxication of mice. Archives of toxicology. 1998; 72(2):97-103. doi: 10.1007/s002040050474. [PMID: 9456081]
  • W F Salminen, R Voellmy, S M Roberts. Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction. Toxicology and applied pharmacology. 1997 Dec; 147(2):247-58. doi: 10.1006/taap.1997.8290. [PMID: 9439720]
  • M Karbowski, C Kurono, Y Nishizawa, Y Horie, T Soji, T Wakabayashi. Induction of megamitochondria by some chemicals inducing oxidative stress in primary cultured rat hepatocytes. Biochimica et biophysica acta. 1997 Nov; 1349(3):242-50. doi: 10.1016/s0005-2760(97)00140-9. [PMID: 9434138]
  • M I Thabrew, R D Hughes, I G McFarlane. Screening of hepatoprotective plant components using a HepG2 cell cytotoxicity assay. The Journal of pharmacy and pharmacology. 1997 Nov; 49(11):1132-5. doi: 10.1111/j.2042-7158.1997.tb06055.x. [PMID: 9401951]