(-)-Cytisine (BioDeep_00000841815)

   


代谢物信息卡片


(-)-Cytisine

化学式: C11H14N2O (190.1106074)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2CNCC1C3=CC=CC(=O)N3C2
InChI: InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2

描述信息

同义名列表

1 个代谢物同义名

(-)-Cytisine



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet E M Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester. Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. eLife. 2022 01; 11(?):. doi: 10.7554/elife.74648. [PMID: 34982029]
  • Fangmei Chen, Xiaoying Yin, Yanqing Wang, Yixin Lv, Si Sheng, Sheng Ouyang, Youquan Zhong. Pharmacokinetics, Tissue Distribution, and Druggability Prediction of the Natural Anticancer Active Compound Cytisine N-Isoflavones Combined with Computer Simulation. Biological & pharmaceutical bulletin. 2020 Jun; 43(6):976-984. doi: 10.1248/bpb.b20-00004. [PMID: 32188833]
  • Piotr Tutka, Denis Vinnikov, Ryan J Courtney, Neal L Benowitz. Cytisine for nicotine addiction treatment: a review of pharmacology, therapeutics and an update of clinical trial evidence for smoking cessation. Addiction (Abingdon, England). 2019 11; 114(11):1951-1969. doi: 10.1111/add.14721. [PMID: 31240783]
  • Soo Hee Jeong, Janie Sheridan, Chris Bullen, David Newcombe, Natalie Walker, Malcolm Tingle. Ascending single dose pharmacokinetics of cytisine in healthy adult smokers. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Nov; 49(11):1332-1337. doi: 10.1080/00498254.2018.1557760. [PMID: 30526213]
  • Karol Wróblewski, Anna Petruczynik, Tomasz Tuzimski, Dominika Przygodzka, Grzegorz Buszewicz, Patrycjusz Kołodziejczyk, Piotr Tutka. Comparison of Various Chromatographic Systems for Analysis of Cytisine in Human Serum, Saliva and Pharmaceutical Formulation by HPLC with Diode Array, Fluorescence or Mass Spectrometry Detection. Molecules (Basel, Switzerland). 2019 Jul; 24(14):. doi: 10.3390/molecules24142580. [PMID: 31315205]
  • Soo Hee Jeong, Janie Sheridan, David Newcombe, Malcolm Tingle. Plasma concentrations of cytisine, a commercially available plant-based alkaloid, in healthy adult smokers taking recommended doses for smoking cessation. Xenobiotica; the fate of foreign compounds in biological systems. 2018 Dec; 48(12):1245-1248. doi: 10.1080/00498254.2017.1409916. [PMID: 29168931]
  • Yu-hang Wu, Zhong-bao Han, Jia-ze Ma, Yan He, Li-yan Liu, Shi-gang Xin, Zhan Yu. [Intermolecular Interactions between Cytisine and Bovine Serum Albumin A Synchronous Fluorescence Spectroscopic Analysis and Molecular Docking Research]. Guang pu xue yu guang pu fen xi = Guang pu. 2016 Mar; 36(3):765-9. doi: NULL. [PMID: 27400521]
  • Soo Hee Jeong, David Newcombe, Janie Sheridan, Malcolm Tingle. Pharmacokinetics of cytisine, an α4 β2 nicotinic receptor partial agonist, in healthy smokers following a single dose. Drug testing and analysis. 2015 Jun; 7(6):475-82. doi: 10.1002/dta.1707. [PMID: 25231024]
  • Michael J Marks, Sharon R Grady, Outi Salminen, Miranda A Paley, Charles R Wageman, J Michael McIntosh, Paul Whiteaker. α6β2*-subtype nicotinic acetylcholine receptors are more sensitive than α4β2*-subtype receptors to regulation by chronic nicotine administration. Journal of neurochemistry. 2014 Jul; 130(2):185-98. doi: 10.1111/jnc.12721. [PMID: 24661093]
  • Can Peng, Clare Stokes, Yann S Mineur, Marina R Picciotto, Chengju Tian, Christoph Eibl, Isabelle Tomassoli, Daniela Guendisch, Roger L Papke. Differential modulation of brain nicotinic acetylcholine receptor function by cytisine, varenicline, and two novel bispidine compounds: emergent properties of a hybrid molecule. The Journal of pharmacology and experimental therapeutics. 2013 Nov; 347(2):424-37. doi: 10.1124/jpet.113.206904. [PMID: 23959137]
  • Christopher I Richards, Khai Luong, Rahul Srinivasan, Stephen W Turner, Dennis A Dougherty, Jonas Korlach, Henry A Lester. Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures. Nano letters. 2012 Jul; 12(7):3690-4. doi: 10.1021/nl301480h. [PMID: 22668081]
  • Anders Ettrup, Jens D Mikkelsen, Szabolcs Lehel, Jacob Madsen, Elsebet Ø Nielsen, Mikael Palner, Daniel B Timmermann, Dan Peters, Gitte M Knudsen. 11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2011 Sep; 52(9):1449-56. doi: 10.2967/jnumed.111.088815. [PMID: 21828113]
  • H Rollema, A Shrikhande, K M Ward, F D Tingley, J W Coe, B T O'Neill, E Tseng, E Q Wang, R J Mather, R S Hurst, K E Williams, M de Vries, T Cremers, S Bertrand, D Bertrand. Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. British journal of pharmacology. 2010 May; 160(2):334-45. doi: 10.1111/j.1476-5381.2010.00682.x. [PMID: 20331614]
  • F Musshoff, B Madea. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic science international. 2009 Apr; 186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011. [PMID: 19217730]
  • Mirko Moroni, Ruud Zwart, Emanuele Sher, Bruce K Cassels, Isabel Bermudez. alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Molecular pharmacology. 2006 Aug; 70(2):755-68. doi: 10.1124/mol.106.023044. [PMID: 16720757]
  • Masahiro Ohtani, Takami Oka, Maryna Badyuk, Yingxian Xiao, Kenneth J Kellar, John W Daly. Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release. Molecular pharmacology. 2006 Mar; 69(3):899-907. doi: 10.1124/mol.105.014902. [PMID: 16332988]
  • Loredana Riganti, Cosetta Matteoni, Silvia Di Angelantonio, Andrea Nistri, Annalisa Gaimarri, Fabio Sparatore, Caterina Canu-Boido, Francesco Clementi, Cecilia Gotti. Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. British journal of pharmacology. 2005 Dec; 146(8):1096-109. doi: 10.1038/sj.bjp.0706434. [PMID: 16273122]
  • Xin Hui, Jie Gao, Xin Xie, Naoki Suto, Tsuyoshi Ogiku, Ming-Wei Wang. A robust homogeneous binding assay for alpha4beta2 nicotinic acetylcholine receptor. Acta pharmacologica Sinica. 2005 Oct; 26(10):1175-80. doi: 10.1111/j.1745-7254.2005.00202.x. [PMID: 16174432]
  • Richard W Fitch, Yumika Kaneko, Paul Klaperski, John W Daly, Gunther Seitz, Daniela Gündisch. Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors. Bioorganic & medicinal chemistry letters. 2005 Feb; 15(4):1221-4. doi: 10.1016/j.bmcl.2004.11.073. [PMID: 15686946]
  • Ali Abdel-Rahman, Anjelika M Dechkovskaia, Heena Mehta-Simmons, Jazmine M Sutton, Xiangrong Guan, Wasiuddin A Khan, Mohamed B Abou-Donia. Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty. Archives of toxicology. 2004 Aug; 78(8):467-76. doi: 10.1007/s00204-004-0560-5. [PMID: 15045467]
  • Yael Abreu-Villaça, Frederic J Seidler, Charlotte A Tate, Mandy M Cousins, Theodore A Slotkin. Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2004 May; 29(5):879-90. doi: 10.1038/sj.npp.1300401. [PMID: 14970833]
  • Thomas Boehm, Susanne Hofer, Patricia Winklehner, Bettina Kellersch, Christiane Geiger, Alexander Trockenbacher, Susanne Neyer, Heidi Fiegl, Susanne Ebner, Lennart Ivarsson, Rainer Schneider, Elisabeth Kremmer, Christine Heufler, Waldemar Kolanus. Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. The EMBO journal. 2003 Mar; 22(5):1014-24. doi: 10.1093/emboj/cdg101. [PMID: 12606567]
  • Jessie Zhang, Joe Henry Steinbach. Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates. Brain research. 2003 Jan; 959(1):98-102. doi: 10.1016/s0006-8993(02)03733-2. [PMID: 12480162]
  • David C Perry, Yingxian Xiao, Henry N Nguyen, John L Musachio, Martha I Dávila-García, Kenneth J Kellar. Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography. Journal of neurochemistry. 2002 Aug; 82(3):468-81. doi: 10.1046/j.1471-4159.2002.00951.x. [PMID: 12153472]
  • Shuang-Cheng Ma, Jiang Du, Paul Pui-Hay But, Xue-Long Deng, Yong-Wen Zhang, Vincent Eng-Choon Ooi, Hong-Xi Xu, Spencer Hon-Sun Lee, Song Fong Lee. Antiviral Chinese medicinal herbs against respiratory syncytial virus. Journal of ethnopharmacology. 2002 Feb; 79(2):205-11. doi: 10.1016/s0378-8741(01)00389-0. [PMID: 11801383]
  • Galya Abdrakhmanova, Julia Dorfman, Yingxian Xiao, Martin Morad. Protons enhance the gating kinetics of the alpha3/beta4 neuronal nicotinic acetylcholine receptor by increasing its apparent affinity to agonists. Molecular pharmacology. 2002 Feb; 61(2):369-78. doi: 10.1124/mol.61.2.369. [PMID: 11809862]
  • M E Nelson, F Wang, A Kuryatov, C H Choi, V Gerzanich, J Lindstrom. Functional properties of human nicotinic AChRs expressed by IMR-32 neuroblastoma cells resemble those of alpha3beta4 AChRs expressed in permanently transfected HEK cells. The Journal of general physiology. 2001 Nov; 118(5):563-82. doi: 10.1085/jgp.118.5.563. [PMID: 11696612]
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  • C Reavill, B Walther, I P Stolerman, B Testa. Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology. 1990 Jul; 29(7):619-24. doi: 10.1016/0028-3908(90)90022-j. [PMID: 2385332]
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