Robustine (BioDeep_00000008287)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Furo(2,3-b)quinolin-8-ol, 4-methoxy-

化学式: C12H9NO3 (215.0582)
中文名称: 4-甲氧基呋喃并[2,3-B]喹啉-8-醇
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 57.67%

分子结构信息

SMILES: COC1=C2C=COC2=NC3=C1C=CC=C3O
InChI: InChI=1S/C12H9NO3/c1-15-11-7-3-2-4-9(14)10(7)13-12-8(11)5-6-16-12/h2-6,14H,1H3

描述信息

A quinoline alkaloid that is furo[2,3-b]quinoline substituted by a methoxy and a hydroxy group at positions 4 and 8 respectively.
Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1].
Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1].

同义名列表

3 个代谢物同义名

Robustine; Furo(2,3-b)quinolin-8-ol, 4-methoxy-; Robustine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

PlantCyc(0)

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62 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACO1, CARS2, EGFR, G3BP1, NMD3, SMAD6, ZNF385A
Peripheral membrane protein 2 ATP6V1E1, RASA4
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 CD4, EGFR
Nucleus 7 EGFR, FLG, G3BP1, NMD3, RNGTT, SMAD6, ZNF385A
cytosol 7 ACO1, ATP6V1E1, FLG, G3BP1, RASA4, SMAD6, ZNF385A
dendrite 1 ZNF385A
nuclear body 1 SMAD6
nucleoplasm 4 NMD3, RNGTT, SMAD6, ZNF385A
Cell membrane 4 CD4, CD8A, EGFR, RASA4
lamellipodium 1 ANGPTL3
ruffle membrane 1 EGFR
Cytoplasmic granule 1 FLG
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 2 ANGPTL3, EGFR
glutamatergic synapse 2 EGFR, FLG
Golgi apparatus 3 ACO1, ANGPTL3, SMAD6
Golgi membrane 1 EGFR
lysosomal membrane 1 ATP6V1E1
neuronal cell body 1 ZNF385A
postsynapse 1 FLG
Cytoplasm, cytosol 3 ACO1, G3BP1, RASA4
endosome 2 ATP6V1E1, EGFR
plasma membrane 8 ATP6V1E1, BTC, CD4, CD8A, EGFR, FLG, IGHE, RASA4
synaptic vesicle membrane 1 ATP6V1E1
Membrane 6 BTC, EGFR, FLG, G3BP1, NMD3, SMAD6
apical plasma membrane 2 ATP6V1E1, EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 2 ACO1, ATP6V1E1
endoplasmic reticulum 1 ACO1
extracellular space 7 AMH, ANGPTL3, BTC, EGFR, IGHE, IL4, IL5
perinuclear region of cytoplasm 1 EGFR
mitochondrion 2 ACO1, CARS2
protein-containing complex 2 EGFR, SMAD6
Single-pass type I membrane protein 4 CD4, CD8A, EGFR, IGHE
Secreted 4 AMH, ANGPTL3, IL4, IL5
extracellular region 8 AMH, ANGPTL3, BTC, CD8A, FLG, IGHE, IL4, IL5
[Isoform 2]: Secreted 1 CD8A
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP6V1E1
nuclear membrane 1 EGFR
external side of plasma membrane 2 CD4, CD8A
perikaryon 1 G3BP1
cytoplasmic vesicle 1 FLG
nucleolus 2 NMD3, ZNF385A
Cytoplasmic vesicle, clathrin-coated vesicle membrane 1 ATP6V1E1
clathrin-coated vesicle membrane 1 ATP6V1E1
Early endosome 2 ANGPTL3, CD4
Apical cell membrane 1 ATP6V1E1
Cell projection, lamellipodium 1 ANGPTL3
Membrane raft 2 CD4, EGFR
focal adhesion 2 EGFR, G3BP1
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 2 ANGPTL3, FLG
receptor complex 3 CD8A, EGFR, FLG
chromatin 2 SMAD6, ZNF385A
IgE immunoglobulin complex 1 IGHE
cytoplasmic ribonucleoprotein granule 1 FLG
Nucleus, nucleolus 1 ZNF385A
[Isoform 2]: Cell membrane 1 IGHE
microvillus 1 ATP6V1E1
Cornified envelope 1 FLG
Cell projection, dendrite 1 ZNF385A
Cytoplasm, Stress granule 1 G3BP1
cytoplasmic stress granule 1 G3BP1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
plasma membrane raft 1 CD8A
endoplasmic reticulum lumen 1 CD4
clathrin-coated endocytic vesicle membrane 3 BTC, CD4, EGFR
ribonucleoprotein complex 1 G3BP1
heteromeric SMAD protein complex 1 SMAD6
Cytoplasm, Cytoplasmic ribonucleoprotein granule 1 G3BP1
[Isoform 1]: Cell membrane 1 CD8A
vacuolar proton-transporting V-type ATPase, V1 domain 1 ATP6V1E1
[Isoform 3]: Cell membrane 1 IGHE
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
T cell receptor complex 2 CD4, CD8A
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
keratohyalin granule 1 FLG
proton-transporting two-sector ATPase complex 1 ATP6V1E1
proton-transporting two-sector ATPase complex, catalytic domain 1 ATP6V1E1


文献列表

  • Jih-Jung Chen, Tzu-Ying Wang, Tsong-Long Hwang. Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae. Journal of natural products. 2008 Feb; 71(2):212-7. doi: 10.1021/np070594k. [PMID: 18211005]