Granisetronum (BioDeep_00000804031)
代谢物信息卡片
exo-Granisetron (Granisetron Impurity F)
化学式: C18H24N4O (312.195)
中文名称: 格拉司琼杂质F
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
InChI: InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:184693
- PubChem: 3510
- ChEMBL: CHEMBL289469
- ChEMBL: CHEMBL519643
- MeSH: Granisetron
- CAS: 1364914-39-5
- CAS: 1224925-64-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Min Zeng, Junxiang Li, Tingting Zheng, Xi Yan, Feng Yuan, Bingbing Xiang. Electropress Needle Stimulation for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Prospective, Randomized Controlled Trial.
Obesity surgery.
2023 09; 33(9):2831-2840. doi:
10.1007/s11695-023-06752-7. [PMID: 37507634] - Fei Liu, Liu-Lin Xiong, Ting-Ting Li, Yan-Jun Chen, Wei Ma, Qi-Jun Li, Qian Li, Ting-Hua Wang. Analgesic Effects and Adverse Reactions of Lidocaine for Patient-Controlled Intravenous Analgesia on Patients Undergoing Open Hepatectomy: A Retrospective Analysis.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses.
2023 Feb; 38(1):39-44. doi:
10.1016/j.jopan.2022.05.069. [PMID: 35989234] - Mitsuhiro Goda, Masaya Kanda, Toshihiko Yoshioka, Ami Yoshida, Yoichi Murai, Yoshito Zamami, Fuka Aizawa, Takahiro Niimura, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Masayuki Chuma, Yuki Izawa-Ishizawa, Keisuke Ishizawa. Effects of 5-HT₃ receptor antagonists on cisplatin-induced kidney injury.
Clinical and translational science.
2021 09; 14(5):1906-1916. doi:
10.1111/cts.13045. [PMID: 33982438] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ashkan Divanbeigi, Mohammad Nasehi, Salar Vaseghi, Sepideh Amiri, Mohammad-Reza Zarrindast. Tropisetron But Not Granisetron Ameliorates Spatial Memory Impairment Induced by Chronic Cerebral Hypoperfusion.
Neurochemical research.
2020 Nov; 45(11):2631-2640. doi:
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European journal of pharmacology.
2020 Sep; 883(?):173310. doi:
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Toxins.
2020 06; 12(6):. doi:
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The Journal of physiology.
2019 11; 597(21):5247-5264. doi:
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Journal of chromatographic science.
2019 Oct; 57(9):790-798. doi:
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Zhonghua yi xue za zhi.
2019 Sep; 99(33):2606-2610. doi:
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Hepatology (Baltimore, Md.).
2019 04; 69(4):1751-1767. doi:
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International journal of clinical pharmacology and therapeutics.
2019 Jan; 57(1):24-31. doi:
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The journal of medical investigation : JMI.
2019; 66(3.4):269-274. doi:
10.2152/jmi.66.269. [PMID: 31656287] - Rehab Abdelmonem, Mohamed El Nabarawi, Alshaimaa Attia. Development of novel bioadhesive granisetron hydrochloride spanlastic gel and insert for brain targeting and study their effects on rats.
Drug delivery.
2018 Nov; 25(1):70-77. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1095(?):50-58. doi:
10.1016/j.jchromb.2018.07.009. [PMID: 30053687] - André Dallmann, Ibrahim Ince, Katrin Coboeken, Thomas Eissing, Georg Hempel. A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.
Clinical pharmacokinetics.
2018 06; 57(6):749-768. doi:
10.1007/s40262-017-0594-5. [PMID: 28924743] - Guozhong Yang, Meilin He, Suohui Zhang, Man Wu, Yunhua Gao. An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron.
Drug development and industrial pharmacy.
2018 May; 44(5):808-816. doi:
10.1080/03639045.2017.1414230. [PMID: 29216752] - Mihoko Morita, Shinji Kishi, Miyuki Ookura, Yasufumi Matsuda, Katsunori Tai, Takahiro Yamauchi, Takanori Ueda. Efficacy of aprepitant for CHOP chemotherapy-induced nausea, vomiting, and anorexia.
Current problems in cancer.
2017 Nov; 41(6):419-425. doi:
10.1016/j.currproblcancer.2017.09.001. [PMID: 29061362] - Sheila A Doggrell. Granisetron in the treatment of chemotherapy-induced nausea and vomiting (CINV) - is there still a role after comparison with palonosetron?.
Expert opinion on pharmacotherapy.
2017 Jul; 18(10):1019-1026. doi:
10.1080/14656566.2017.1342809. [PMID: 28612633] - Yasmin Moustafa Ahmed, Basim Anwar Shehata Messiha, Ali Ahmed Abo-Saif. Granisetron and carvedilol can protect experimental rats againstadjuvant-induced arthritis.
Immunopharmacology and immunotoxicology.
2017 Apr; 39(2):97-104. doi:
10.1080/08923973.2017.1286502. [PMID: 28211304] - Martha L Bustos, Yang Zhao, Huijun Chen, Steve N Caritis, Raman Venkataramanan. Polymorphisms in CYP1A1 and CYP3A5 Genes Contribute to the Variability in Granisetron Clearance and Exposure in Pregnant Women with Nausea and Vomiting.
Pharmacotherapy.
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BMC anesthesiology.
2016 10; 16(1):101. doi:
10.1186/s12871-016-0254-6. [PMID: 27765010] - Steve Caritis, Yang Zhao, Hui-Jun Chen, Raman Venkataramanan. Pharmacodynamics of transdermal granisetron in women with nausea and vomiting of pregnancy.
American journal of obstetrics and gynecology.
2016 07; 215(1):93.e1-4. doi:
10.1016/j.ajog.2016.01.163. [PMID: 26812081] - Qi Shi, Wen Li, Hongjia Li, Qiqi Le, Shanshan Liu, Shaoqi Zong, Leizhen Zheng, Fenggang Hou. Prevention of cisplatin-based chemotherapy-induced delayed nausea and vomiting using triple antiemetic regimens: a mixed treatment comparison.
Oncotarget.
2016 Apr; 7(17):24402-14. doi:
10.18632/oncotarget.8255. [PMID: 27015550] - Jennyfer Cázares-Delgadillo, Adriana Ganem-Rondero, Virginia Merino, Yogeshvar N Kalia. Controlled transdermal iontophoresis for poly-pharmacotherapy: Simultaneous delivery of granisetron, metoclopramide and dexamethasone sodium phosphate in vitro and in vivo.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Mar; 85(?):31-8. doi:
10.1016/j.ejps.2016.01.027. [PMID: 26826281] - Yang Zhao, Hui-Jun Chen, Steve Caritis, Raman Venkataramanan. Development and validation of a sensitive liquid chromatographic-tandem mass spectrometric method for the simultaneous analysis of granisetron and 7-hydroxy granisetron in human plasma and urine samples: application in a clinical pharmacokinetic study in pregnant subject.
Biomedical chromatography : BMC.
2016 Feb; 30(2):149-54. doi:
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2015 Oct; 22(10):911-4. doi:
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Reproductive toxicology (Elmsford, N.Y.).
2015 Jun; 53(?):92-8. doi:
10.1016/j.reprotox.2015.02.011. [PMID: 25813292] - Howida K Ibrahim, Nevine S Abdel Malak, Sally A Abdel Halim. Formulation of Convenient, Easily Scalable, and Efficient Granisetron HCl Intranasal Droppable Gels.
Molecular pharmaceutics.
2015 Jun; 12(6):2019-25. doi:
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Clinical and experimental pharmacology & physiology.
2015 Apr; 42(4):361-8. doi:
10.1111/1440-1681.12373. [PMID: 25676798] - Hironori Nakamura, Haruko Yokoyama, Risa Takayanagi, Koichi Yoshimoto, Akihiro Nakajima, Kiyoshi Okuyama, Osamu Iwase, Yasuhiko Yamada. Theoretical evaluation of antiemetic effects of 5-HT3 receptor antagonists for prevention of vomiting induced by cisplatin.
European journal of drug metabolism and pharmacokinetics.
2015 Mar; 40(1):39-44. doi:
10.1007/s13318-014-0175-z. [PMID: 24470169] - Ying Zhou, Ji Jiang, Pei Hu, Hongyun Wang. A high-performance liquid chromatography-tandem mass spectrometry method coupled with protein precipitation for determination of granisetron in human plasma and its application to a comparative pharmacokinetic study.
Biomedical chromatography : BMC.
2014 Dec; 28(12):1597-600. doi:
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Reproductive toxicology (Elmsford, N.Y.).
2014 Nov; 49(?):43-7. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2013 May; 133(1):186-95. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):933-51. doi:
10.1124/dmd.112.050278. [PMID: 23454828] - Hironori Nakamura, Haruko Yokoyama, Koichi Yoshimoto, Akihiro Nakajima, Kiyoshi Okuyama, Osamu Iwase, Yasuhiko Yamada. Method for individualized evaluation of antiemetic effect induced by 5-HT3 receptor antagonist.
Biological & pharmaceutical bulletin.
2013; 36(5):780-7. doi:
10.1248/bpb.b12-00946. [PMID: 23459393] - Hea-Jeong Doh, Yunjin Jung, Prabagar Balakrishnan, Hyun-Jong Cho, Dae-Duk Kim. A novel lipid nanoemulsion system for improved permeation of granisetron.
Colloids and surfaces. B, Biointerfaces.
2013 Jan; 101(?):475-80. doi:
10.1016/j.colsurfb.2012.07.019. [PMID: 23010057] - Junki Endo, Hirotoshi Iihara, Maya Yamada, Koumei Yanase, Fumihiko Kamiya, Fumitaka Ito, Norihiko Funaguchi, Yasushi Ohno, Shinya Minatoguchi, Yoshinori Itoh. A randomized controlled non-inferiority study comparing the antiemetic effect between intravenous granisetron and oral azasetron based on estimated 5-HT3 receptor occupancy.
Anticancer research.
2012 Sep; 32(9):3939-47. doi:
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The Journal of pharmacology and experimental therapeutics.
2012 May; 341(2):350-9. doi:
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The Journal of pharmacology and experimental therapeutics.
2011 Oct; 339(1):125-31. doi:
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Cancer chemotherapy and pharmacology.
2011 Sep; 68(3):653-9. doi:
10.1007/s00280-010-1519-2. [PMID: 21125277] - Manish Yadav, Ajay Gupta, Puran Singhal, Pranav S Shrivastav. Development and validation of a selective and rapid LC-MS-MS method for the quantification of abacavir in human plasma.
Journal of chromatographic science.
2010 Sep; 48(8):654-62. doi:
10.1093/chromsci/48.8.654. [PMID: 20819295] - Koji Yakabi, Susumu Kurosawa, Mitsuo Tamai, Mitsutoshi Yuzurihara, Miwa Nahata, Shino Ohno, Shoki Ro, Shingo Kato, Toru Aoyama, Tomoya Sakurada, Hidehiko Takabayashi, Tomohisa Hattori. Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction.
Regulatory peptides.
2010 Apr; 161(1-3):97-105. doi:
10.1016/j.regpep.2010.02.003. [PMID: 20171995] - Jennyfer Cázares-Delgadillo, Adriana Ganem-Rondero, David Quintanar-Guerrero, Alicia C López-Castellano, Virginia Merino, Yogeshvar N Kalia. Using transdermal iontophoresis to increase granisetron delivery across skin in vitro and in vivo: effect of experimental conditions and a comparison with other enhancement strategies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2010 Mar; 39(5):387-93. doi:
10.1016/j.ejps.2010.01.008. [PMID: 20096354] - Julian Howell, Jean Smeets, Henk-Jan Drenth, David Gill. Pharmacokinetics of a granisetron transdermal system for the treatment of chemotherapy-induced nausea and vomiting.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2009 Dec; 15(4):223-31. doi:
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Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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Bioanalysis.
2009 Jun; 1(3):537-48. doi:
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The Lancet. Oncology.
2009 Feb; 10(2):115-24. doi:
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Neuropharmacology.
2009 Jan; 56(1):285-91. doi:
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Cancer chemotherapy and pharmacology.
2008 Dec; 63(1):75-83. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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The oncologist.
2007 Sep; 12(9):1151-5. doi:
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Pain.
2007 Aug; 130(3):235-248. doi:
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Indian journal of dermatology, venereology and leprology.
2007 Jul; 73(4):231-4. doi:
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Archives of pharmacal research.
2007 Jun; 30(6):778-84. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Dec; 844(2):268-77. doi:
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Journal of pharmaceutical and biomedical analysis.
2006 Oct; 42(4):464-73. doi:
10.1016/j.jpba.2006.05.001. [PMID: 16784831] - Ramakrishna V S Nirogi, Vishwottam N Kandikere, Manoj Shukla, Koteshwara Mudigonda, Santosh Maurya, Ravikumar Boosi. Quantification of granisetron in human plasma by liquid chromatography coupled to electrospray tandem mass spectrometry.
Biomedical chromatography : BMC.
2006 Sep; 20(9):888-97. doi:
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Cancer journal (Sudbury, Mass.).
2006 Jan; 12(1):69-72. doi:
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2005 May; 280(21):20476-82. doi:
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