Angiotensin IV (BioDeep_00000802245)

Main id: BioDeep_00000001498

 


代谢物信息卡片


Angiotensin II, 1-des-asn-2-arg

化学式: C40H54N8O8 (774.4064)
中文名称: 血管紧张素 IV
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)N
InChI: InChI=1S/C40H54N8O8/c1-5-24(4)34(47-35(50)29(44-37(52)33(41)23(2)3)18-26-13-15-28(49)16-14-26)38(53)45-30(20-27-21-42-22-43-27)39(54)48-17-9-12-32(48)36(51)46-31(40(55)56)19-25-10-7-6-8-11-25/h6-8,10-11,13-16,21-24,29-34,49H,5,9,12,17-20,41H2,1-4H3,(H,42,43)(H,44,52)(H,45,53)(H,46,51)(H,47,50)(H,55,56)/t24-,29-,30-,31-,32-,33-,34-/m0/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

3 个代谢物同义名

Angiotensin II, 1-des-asn-2-arg; Angiotensin IV; Angiotensin IV



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACE, ANPEP, ANXA4, CA1, DNPEP, FAS, LNPEP, MTOR, TNK1
Peripheral membrane protein 3 ANXA4, MTOR, TNK1
Endoplasmic reticulum membrane 1 MTOR
Nucleus 6 ANXA4, DNPEP, FOS, MET, MTOR, NLE1
cytosol 7 CA1, DNPEP, FAS, FOS, LNPEP, MTOR, SLC2A4
dendrite 1 MTOR
nuclear body 2 FAS, MET
phagocytic vesicle 1 MTOR
trans-Golgi network 1 SLC2A4
nucleoplasm 4 FOS, MET, MTOR, NLE1
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 5 ACE, ANPEP, FAS, LNPEP, SLC2A4
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 1 SLC2A4
Golgi apparatus membrane 1 MTOR
cell surface 3 ANXA4, FAS, MET
Golgi apparatus 1 FAS
Golgi membrane 2 INS, MTOR
lysosomal membrane 3 ANPEP, LNPEP, MTOR
postsynapse 1 MET
sarcolemma 1 SLC2A4
Lysosome 2 ACE, MTOR
Presynapse 1 SLC2A4
endosome 1 ACE
plasma membrane 11 ACE, ANPEP, ANXA4, FAS, KNG1, LNPEP, MET, REN, RNPEP, SLC2A4, TNK1
Membrane 10 ACE, ANXA4, FAS, HGF, LNPEP, MET, MTOR, REN, SLC2A4, TNK1
extracellular exosome 9 ACE, AGT, ANPEP, ANXA4, CA1, FAS, KNG1, RNPEP, SLC2A4
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 FOS
extracellular space 9 ACE, AGT, ANPEP, HGF, INS, KNG1, LNPEP, REN, RNPEP
perinuclear region of cytoplasm 3 ANXA4, LNPEP, SLC2A4
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 ACE, FAS
Secreted 5 ACE, AGT, INS, REN, RNPEP
extracellular region 8 ACE, AGT, HGF, INS, KNG1, MET, REN, RNPEP
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 1 MET
mitochondrial outer membrane 1 MTOR
nuclear membrane 1 ANXA4
external side of plasma membrane 4 ACE, ANPEP, FAS, SLC2A4
multivesicular body 1 SLC2A4
T-tubule 1 SLC2A4
cytoplasmic vesicle 1 ANXA4
nucleolus 1 NLE1
apical part of cell 1 REN
clathrin-coated pit 1 SLC2A4
Single-pass type II membrane protein 2 ANPEP, LNPEP
Cytoplasm, perinuclear region 1 SLC2A4
Membrane raft 2 FAS, SLC2A4
sarcoplasmic reticulum 1 SLC2A4
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 3 AGT, ANXA4, KNG1
receptor complex 1 MET
Zymogen granule membrane 1 ANXA4
chromatin 1 FOS
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
Nucleus, nucleolus 1 NLE1
blood microparticle 3 AGT, DNPEP, KNG1
sperm midpiece 1 ACE
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, SLC2A4
endosome lumen 1 INS
Cytoplasmic vesicle membrane 2 LNPEP, SLC2A4
Melanosome 1 FAS
basal plasma membrane 2 ACE, MET
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
secretory granule lumen 1 INS
secretory granule membrane 1 ANPEP
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, KNG1
nuclear matrix 1 FOS
platelet alpha granule lumen 2 HGF, KNG1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
vesicle membrane 2 ANXA4, SLC2A4
endoplasmic reticulum-Golgi intermediate compartment 1 ANPEP
protein-DNA complex 1 FOS
CD95 death-inducing signaling complex 1 FAS
death-inducing signaling complex 1 FAS
[Isoform 1]: Cell membrane 1 FAS
Cytoplasmic vesicle, phagosome 1 MTOR
transcription factor AP-1 complex 1 FOS
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
insulin-responsive compartment 1 SLC2A4
glycogen granule 1 FAS
early endosome lumen 1 LNPEP


文献列表

  • Ana Belén Segarra, Germán Domínguez-Vías, José Redondo, Magdalena Martínez-Cañamero, Manuel Ramírez-Sánchez, Isabel Prieto. Hypothalamic Renin-Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet. Nutrients. 2021 Jan; 13(2):. doi: 10.3390/nu13020480. [PMID: 33572630]
  • A V Morgun, V V Salmin, E B Boytsova, O L Lopatina, A B Salmina. Molecular Mechanisms of Proteins - Targets for SARS-CoV-2 (Review). Sovremennye tekhnologii v meditsine. 2021; 12(6):98-108. doi: 10.17691/stm2020.12.6.11. [PMID: 34796023]
  • Wen-Wu Bai, Hao Wang, Chun-Hua Gao, Ke-Yin Liu, Bing-Xiu Guo, Fan Jiang, Ming-Xiang Zhang, Chen Li, Wei-Dong Qin. Continuous Infusion of Angiotensin IV Protects against Acute Myocardial Infarction via the Inhibition of Inflammation and Autophagy. Oxidative medicine and cellular longevity. 2021; 2021(?):2860488. doi: 10.1155/2021/2860488. [PMID: 34950416]
  • Erkan Cure, Tevfik Bulent Ilcol, Medine Cumhur Cure. Angiotensin II, III, and IV may be important in the progression of COVID-19. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2020 Oct; 21(4):1470320320972019. doi: 10.1177/1470320320972019. [PMID: 33169633]
  • F K Suessenbach, B B Burckhardt. Levels of angiotensin peptides in healthy and cardiovascular/renal-diseased paediatric population-an investigative review. Heart failure reviews. 2019 09; 24(5):709-723. doi: 10.1007/s10741-019-09797-y. [PMID: 31104255]
  • Jürgen M Bohlender, Jürg Nussberger, Hendrik Tevaearai, Hans Imboden. Angiotensinergic Innervation of the Human Right Atrium: Implications for Cardiac Reflexes. American journal of hypertension. 2018 01; 31(2):188-196. doi: 10.1093/ajh/hpx163. [PMID: 28985343]
  • M Slamkova, S Zorad, K Krskova. Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity. Endocrine regulations. 2016 Oct; 50(4):229-240. doi: 10.1515/enr-2016-0025. [PMID: 27941178]
  • Caroline C Benoist, Leen H Kawas, Mingyan Zhu, Katherine A Tyson, Lori Stillmaker, Suzanne M Appleyard, John W Wright, Gary A Wayman, Joseph W Harding. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. The Journal of pharmacology and experimental therapeutics. 2014 11; 351(2):390-402. doi: 10.1124/jpet.114.218735. [PMID: 25187433]
  • Yunki Y Yau, Rupert W L Leong, Sean Shin, Sonia Bustamante, Russell Pickford, Leila Hejazi, Beth Campbell, Valerie C Wasinger. Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases. Discovery medicine. 2014 Sep; 18(98):113-24. doi: . [PMID: 25227752]
  • Arndt Manzel, Oliver Domenig, Bjoern Ambrosius, Agnes Kovacs, Johannes Stegbauer, Marko Poglitsch, Dominik N Mueller, Ralf Gold, Ralf A Linker. Angiotensin IV is induced in experimental autoimmune encephalomyelitis but fails to influence the disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2014 Sep; 9(4):533-43. doi: 10.1007/s11481-014-9548-y. [PMID: 24854706]
  • Alexandros Nikolaou, Isabelle Van den Eynde, Dirk Tourwé, Georges Vauquelin, Géza Tóth, Jayapal Reddy Mallareddy, Marko Poglitsch, Jo A Van Ginderachter, Patrick M L Vanderheyden. [3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase. European journal of pharmacology. 2013 Feb; 702(1-3):93-102. doi: 10.1016/j.ejphar.2013.01.026. [PMID: 23376157]
  • Mitsuru Ohishi, Koichi Yamamoto, Hiromi Rakugi. Angiotensin (1-7) and other angiotensin peptides. Current pharmaceutical design. 2013; 19(17):3060-4. doi: 10.2174/1381612811319170013. [PMID: 23176220]
  • Frédéric Lancien, Marty Wong, Ali Al Arab, Nagi Mimassi, Yoshio Takei, Jean-Claude Le Mével. Central ventilatory and cardiovascular actions of angiotensin peptides in trout. American journal of physiology. Regulatory, integrative and comparative physiology. 2012 Aug; 303(3):R311-20. doi: 10.1152/ajpregu.00145.2012. [PMID: 22696574]
  • María Jesús Ramírez-Expósito, María del Pilar Carrera-González, María Dolores Mayas, Basilio Dueñas, Julia Martínez-Ferrol, José Manuel Martínez-Martos. Neoadjuvant chemotherapy modifies serum angiotensinase activities in women with breast cancer. Maturitas. 2012 May; 72(1):79-83. doi: 10.1016/j.maturitas.2012.02.007. [PMID: 22424590]
  • Rui Yang, Ilse Smolders, Alain G Dupont. Blood pressure and renal hemodynamic effects of angiotensin fragments. Hypertension research : official journal of the Japanese Society of Hypertension. 2011 Jun; 34(6):674-83. doi: 10.1038/hr.2011.24. [PMID: 21412242]
  • M Siebelmann, J Wensing, E J Verspohl. The impact of ANG II and IV on INS-1 cells and on blood glucose and plasma insulin. Journal of receptor and signal transduction research. 2010 Aug; 30(4):234-45. doi: 10.3109/10799893.2010.487491. [PMID: 20524779]
  • B J Yamamoto, P D Elias, J A Masino, B D Hudson, A T McCoy, Z J Anderson, M D Varnum, M F Sardinia, J W Wright, J W Harding. The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. The Journal of pharmacology and experimental therapeutics. 2010 Apr; 333(1):161-73. doi: 10.1124/jpet.109.161711. [PMID: 20086056]
  • Rui Yang, Thomas Walther, Florian Gembardt, Ilse Smolders, Patrick Vanderheyden, Anthony L Albiston, Siew Yeen Chai, Alain G Dupont. Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated. Journal of hypertension. 2010 Mar; 28(3):487-94. doi: 10.1097/hjh.0b013e3283343250. [PMID: 19907343]
  • Yasushi Numaguchi, Masakazu Ishii, Ryuji Kubota, Yasuhiro Morita, Koji Yamamoto, Tadashi Matsushita, Kenji Okumura, Toyoaki Murohara. Ablation of angiotensin IV receptor attenuates hypofibrinolysis via PAI-1 downregulation and reduces occlusive arterial thrombosis. Arteriosclerosis, thrombosis, and vascular biology. 2009 Dec; 29(12):2102-8. doi: 10.1161/atvbaha.109.195057. [PMID: 19745198]
  • E I Pevtsova, S M Tolpygo, M F Obukhova, A V Kotov. Complexes of angiotensin IV with functionally different proteins in the regulation of drinking behavior and hemodynamics in rats. Bulletin of experimental biology and medicine. 2009 Nov; 148(5):738-41. doi: 10.1007/s10517-010-0805-7. [PMID: 20396781]
  • A G Dupont, R Yang, I Smolders, P Vanderheyden. IRAP and AT(1) receptor mediated effects of angiotensin IV. Journal of internal medicine. 2009 Mar; 265(3):401-3; author reply 404. doi: 10.1111/j.1365-2796.2008.02027.x. [PMID: 19207373]
  • Yayoi Kikuchi, Hiroko Saika, Keizo Yuasa, Masami Nagahama, Akihiko Tsuji. Isolation and biochemical characterization of two forms of RD21 from cotyledons of daikon radish (Raphanus sativus). Journal of biochemistry. 2008 Dec; 144(6):789-98. doi: 10.1093/jb/mvn132. [PMID: 18838434]
  • Rui Yang, Ilse Smolders, Dimitri De Bundel, Renaud Fouyn, Mathias Halberg, Heidi Demaegdt, Patrick Vanderheyden, Alain G Dupont. Brain and peripheral angiotensin II type 1 receptors mediate renal vasoconstrictor and blood pressure responses to angiotensin IV in the rat. Journal of hypertension. 2008 May; 26(5):998-1007. doi: 10.1097/hjh.0b013e3282f5ed58. [PMID: 18398343]
  • Michelle G Wallis, Miles F Lankford, Susanna R Keller. Vasopressin is a physiological substrate for the insulin-regulated aminopeptidase IRAP. American journal of physiology. Endocrinology and metabolism. 2007 Oct; 293(4):E1092-102. doi: 10.1152/ajpendo.00440.2007. [PMID: 17684103]
  • A Fintha, A Sebe, A Masszi, T Terebessy, T Huszár, L Rosivall, I Mucsi. Angiotensin II activates plasminogen activator inhibitor-I promoter in renal tubular epithelial cells via the AT1 receptor. Acta physiologica Hungarica. 2007 Mar; 94(1-2):19-30. doi: 10.1556/aphysiol.94.2007.1-2.4. [PMID: 17444273]
  • Rajash K Handa. Biphasic actions of angiotensin IV on renal blood flow in the rat. Regulatory peptides. 2006 Sep; 136(1-3):23-9. doi: 10.1016/j.regpep.2006.04.008. [PMID: 16780972]
  • Xiao C Li, Duncan J Campbell, Mitsuru Ohishi, Shao Yuan, Jia L Zhuo. AT1 receptor-activated signaling mediates angiotensin IV-induced renal cortical vasoconstriction in rats. American journal of physiology. Renal physiology. 2006 May; 290(5):F1024-33. doi: 10.1152/ajprenal.00221.2005. [PMID: 16380463]
  • María Pilar Carrera, María Jesús Ramírez-Expósito, Basilio Dueñas, María Dolores Mayas, María Jesús García, Susana De la Chica, Pedro Cortés, María Ruíz-Sanjuan, José Manuel Martínez-Martos. Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea. Anticancer research. 2006 Mar; 26(2A):1011-4. doi: . [PMID: 16619500]
  • A B Segarra, M Ramírez, I Banegas, F Hermoso, F Vargas, F Vives, F Alba, M de Gasparo, I Prieto. Influence of thyroid disorders on kidney angiotensinase activity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2006 Jan; 38(1):48-52. doi: 10.1055/s-2006-924978. [PMID: 16477541]
  • Gunter Wolf. [The renin-angiotensin-aldosterone system -- more complex as previously thought]. Medizinische Klinik (Munich, Germany : 1983). 2005 Aug; 100(8):471-7. doi: 10.1007/s00063-005-1071-8. [PMID: 16096728]
  • Bernard R Chaitman, Alla Y Ivleva, Marek Ujda, Jacque H F Lenis, Csaba Toth, David M Stieber, Leonardo H Reisin, Andreas M Pangerl, Julie B Friedman, John H Lawrence. Antianginal efficacy of omapatrilat in patients with chronic angina pectoris. The American journal of cardiology. 2005 Jun; 95(11):1283-9. doi: 10.1016/j.amjcard.2005.01.069. [PMID: 15904630]
  • Andrzej Mogielnicki, Ewa Chabielska, Robert Pawlak, Janusz Szemraj, Wlodzimierz Buczko. Angiotensin II enhances thrombosis development in renovascular hypertensive rats. Thrombosis and haemostasis. 2005 Jun; 93(6):1069-76. doi: 10.1160/th04-10-0701. [PMID: 15968390]
  • Alan Daugherty, Debra L Rateri, Hong Lu, Tadashi Inagami, Lisa A Cassis. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation. 2004 Dec; 110(25):3849-57. doi: 10.1161/01.cir.0000150540.54220.c4. [PMID: 15596561]
  • S Y Chai, R Fernando, G Peck, S-Y Ye, F A O Mendelsohn, T A Jenkins, A L Albiston. The angiotensin IV/AT4 receptor. Cellular and molecular life sciences : CMLS. 2004 Nov; 61(21):2728-37. doi: 10.1007/s00018-004-4246-1. [PMID: 15549174]
  • Heidi Demaegdt, Patrick Vanderheyden, Jean-Paul De Backer, Sabrina Mosselmans, Hilde Laeremans, Minh Tam Le, Veerle Kersemans, Yvette Michotte, Georges Vauquelin. Endogenous cystinyl aminopeptidase in Chinese hamster ovary cells: characterization by [125I]Ang IV binding and catalytic activity. Biochemical pharmacology. 2004 Sep; 68(5):885-92. doi: 10.1016/j.bcp.2004.05.047. [PMID: 15294451]
  • Ronni R Plovsing, Christian Wamberg, Niels C F Sandgaard, Jane A Simonsen, Niels-Henrik Holstein-Rathlou, Poul Flemming Hoilund-Carlsen, Peter Bie. Effects of truncated angiotensins in humans after double blockade of the renin system. American journal of physiology. Regulatory, integrative and comparative physiology. 2003 Nov; 285(5):R981-91. doi: 10.1152/ajpregu.00263.2003. [PMID: 12869368]
  • Christian Wamberg, Ronni R Plovsing, Niels C F Sandgaard, Peter Bie. Effects of different angiotensins during acute, double blockade of the renin system in conscious dogs. American journal of physiology. Regulatory, integrative and comparative physiology. 2003 Nov; 285(5):R971-80. doi: 10.1152/ajpregu.00262.2003. [PMID: 12869367]
  • Johannes Stegbauer, Oliver Vonend, Vitus Oberhauser, Lars Christian Rump. Effects of angiotensin-(1-7) and other bioactive components of the renin-angiotensin system on vascular resistance and noradrenaline release in rat kidney. Journal of hypertension. 2003 Jul; 21(7):1391-9. doi: 10.1097/00004872-200307000-00030. [PMID: 12817189]
  • Rebecca A Lew, Tomris Mustafa, Siying Ye, Sharon G McDowall, Siew Yeen Chai, Anthony L Albiston. Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP). Journal of neurochemistry. 2003 Jul; 86(2):344-50. doi: 10.1046/j.1471-4159.2003.01852.x. [PMID: 12871575]
  • Christian T Abrahamsen, Mark A Pullen, Christine G Schnackenberg, Eugene T Grygielko, Richard M Edwards, Nicholas J Laping, David P Brooks. Effects of angiotensins II and IV on blood pressure, renal function, and PAI-1 expression in the heart and kidney of the rat. Pharmacology. 2002 Sep; 66(1):26-30. doi: 10.1159/000063252. [PMID: 12169762]
  • William F van Rodijnen, Ton A van Lambalgen, Michiel H van Wijhe, Geert-Jan Tangelder, Piet M Ter Wee. Renal microvascular actions of angiotensin II fragments. American journal of physiology. Renal physiology. 2002 Jul; 283(1):F86-92. doi: 10.1152/ajprenal.00121.2001. [PMID: 12060590]
  • J L Mehta, D Y Li, H Yang, M K Raizada. Angiotensin II and IV stimulate expression and release of plasminogen activator inhibitor-1 in cultured human coronary artery endothelial cells. Journal of cardiovascular pharmacology. 2002 Jun; 39(6):789-94. doi: 10.1097/00005344-200206000-00003. [PMID: 12021572]
  • Kazuyuki Sakata, Roberts Pawlak, Tetumei Urano, Akikazu Takada. Effects of a long-term pharmacological interruption of the renin-angiotensin system on the fibrinolytic system in essential hypertension. Pathophysiology of haemostasis and thrombosis. 2002 Mar; 32(2):67-75. doi: 10.1159/000065078. [PMID: 12214151]
  • M Ruiz-Ortega, O Lorenzo, M Rupérez, V Esteban, Y Suzuki, S Mezzano, J J Plaza, J Egido. Role of the renin-angiotensin system in vascular diseases: expanding the field. Hypertension (Dallas, Tex. : 1979). 2001 Dec; 38(6):1382-7. doi: 10.1161/hy1201.100589. [PMID: 11751722]
  • T A Hamilton, R K Handa, J W Harding, J W Wright. A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat. Peptides. 2001 Jun; 22(6):935-44. doi: 10.1016/s0196-9781(01)00405-3. [PMID: 11390024]
  • J K Chen, J Zimpelmann, R C Harris, K D Burns. Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells. American journal of physiology. Renal physiology. 2001 Jun; 280(6):F980-8. doi: 10.1152/ajprenal.2001.280.6.f980. [PMID: 11352837]
  • L Gesualdo, G Grandaliano, F P Schena. Angiotensin IV and renal diseases. Contributions to nephrology. 2001; ?(135):63-71. doi: 10.1159/000060157. [PMID: 11705292]
  • O von Bohlen und Halbach, D Albrecht. Identification of angiotensin IV binding sites in the mouse brain by a fluorescent binding study. Neuroendocrinology. 2000 Oct; 72(4):218-23. doi: 10.1159/000054590. [PMID: 11070425]
  • R K Handa, J W Harding, S M Simasko. Characterization and function of the bovine kidney epithelial angiotensin receptor subtype 4 using angiotensin IV and divalinal angiotensin IV as receptor ligands. The Journal of pharmacology and experimental therapeutics. 1999 Dec; 291(3):1242-9. doi: NULL. [PMID: 10565848]
  • Y Kakinuma, F Sugiyama, K Taniguchi, H Horiguchi, T Ogata, K Murakami, K Yagami, A Fukamizu. Developmental stage-specific involvement of angiotensin in murine nephrogenesis. Pediatric nephrology (Berlin, Germany). 1999 Nov; 13(9):792-9. doi: 10.1007/s004670050703. [PMID: 10603124]
  • A Hus-Citharel, J M Gasc, S Zini, J Marchetti, B Roques, P Corvol, C Llorens-Cortes. Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron. Kidney international. 1999 Sep; 56(3):850-9. doi: 10.1046/j.1523-1755.1999.00634.x. [PMID: 10469354]
  • L Gesualdo, E Ranieri, R Monno, M R Rossiello, M Colucci, N Semeraro, G Grandaliano, F P Schena, M Ursi, G Cerullo. Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells. Kidney international. 1999 Aug; 56(2):461-70. doi: 10.1046/j.1523-1755.1999.00578.x. [PMID: 10432384]
  • S M Fitzgerald, R G Evans, G Bergström, W P Anderson. Renal hemodynamic responses to intrarenal infusion of ligands for the putative angiotensin IV receptor in anesthetized rats. Journal of cardiovascular pharmacology. 1999 Aug; 34(2):206-11. doi: 10.1097/00005344-199908000-00005. [PMID: 10445671]
  • J H Zhang, J M Hanesworth, M F Sardinia, J A Alt, J W Wright, J W Harding. Structural analysis of angiotensin IV receptor (AT4) from selected bovine tissues. The Journal of pharmacology and experimental therapeutics. 1999 May; 289(2):1075-83. doi: NULL. [PMID: 10215690]
  • Y Shibasaki, Y Mori, Y Tsutumi, H Masaki, K Sakamoto, S Murasawa, K Maruyama, Y Moriguchi, Y Tanaka, T Iwasaka, M Inada, H Matsubara. Differential kinetics of circulating angiotensin IV and II after treatment with angiotensin II type 1 receptor antagonist and their plasma levels in patients with chronic renal failure. Clinical nephrology. 1999 Feb; 51(2):83-91. doi: NULL. [PMID: 10069643]
  • Y Kakinuma, H Hama, F Sugiyama, K Yagami, K Goto, K Murakami, A Fukamizu. Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nature medicine. 1998 Sep; 4(9):1078-80. doi: 10.1038/2070. [PMID: 9734405]
  • R K Handa, L T Krebs, J W Harding, S E Handa. Angiotensin IV AT4-receptor system in the rat kidney. The American journal of physiology. 1998 02; 274(2):F290-9. doi: 10.1152/ajprenal.1998.274.2.f290. [PMID: 9486224]
  • I Garreau, D Chansel, S Vandermeersch, I Fruitier, J M Piot, R Ardaillou. Hemorphins inhibit angiotensin IV binding and interact with aminopeptidase N. Peptides. 1998; 19(8):1339-48. doi: 10.1016/s0196-9781(98)00075-8. [PMID: 9809647]
  • D Chansel, R Ardaillou. [Active metabolites derived from angiotensin II]. Nephrologie. 1998; 19(7):427-32. doi: . [PMID: 9857379]
  • J W Wright, J W Harding. Important role for angiotensin III and IV in the brain renin-angiotensin system. Brain research. Brain research reviews. 1997 Sep; 25(1):96-124. doi: 10.1016/s0165-0173(97)00019-2. [PMID: 9370053]
  • Y Kakinuma, H Hama, F Sugiyama, K Goto, K Murakami, A Fukamizu. Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neuroscience letters. 1997 Sep; 232(3):167-70. doi: 10.1016/s0304-3940(97)00605-8. [PMID: 9310306]
  • L T Krebs, E A Kramár, J M Hanesworth, M F Sardinia, A E Ball, J W Wright, J W Harding. Characterization of the binding properties and physiological action of divalinal-angiotensin IV, a putative AT4 receptor antagonist. Regulatory peptides. 1996 Dec; 67(2):123-30. doi: 10.1016/s0167-0115(96)00121-8. [PMID: 8958583]
  • S Czekalski, D Chansel, S Vandermeersch, P Ronco, R Ardaillou. Evidence for angiotensin IV receptors in human collecting duct cells. Kidney international. 1996 Oct; 50(4):1125-31. doi: 10.1038/ki.1996.419. [PMID: 8887269]
  • R Ardaillou, D Chansel. [Angiotensin IV, a new component of the renin-angiotensin system, which acts on kidney cells]. Bulletin de l'Academie nationale de medecine. 1996 Feb; 180(2):475-86; discussion 486. doi: NULL. [PMID: 8705385]
  • N Dulin, Z T Madhun, C H Chang, L Berti-Mattera, D Dickens, J G Douglas. Angiotensin IV receptors and signaling in opossum kidney cells. The American journal of physiology. 1995 Nov; 269(5 Pt 2):F644-52. doi: 10.1152/ajprenal.1995.269.5.f644. [PMID: 7503230]
  • H Matsufuji, T Matsui, S Ohshige, T Kawasaki, K Osajima, Y Osajima. Antihypertensive effects of angiotensin fragments in SHR. Bioscience, biotechnology, and biochemistry. 1995 Aug; 59(8):1398-401. doi: 10.1271/bbb.59.1398. [PMID: 7549089]
  • J W Wright, L T Krebs, J W Stobb, J W Harding. The angiotensin IV system: functional implications. Frontiers in neuroendocrinology. 1995 Jan; 16(1):23-52. doi: 10.1006/frne.1995.1002. [PMID: 7768321]
  • J W Harding, J W Wright, G N Swanson, J M Hanesworth, L T Krebs. AT4 receptors: specificity and distribution. Kidney international. 1994 Dec; 46(6):1510-2. doi: 10.1038/ki.1994.432. [PMID: 7699992]
  • J Terui, K Tamoto, J Sudo. Proteinuric potentials of angiotensin II, [des-Asp1]-angiotensin II, and [des-Asp1, des-Arg2]-angiotensin II in rats. Biological & pharmaceutical bulletin. 1994 Nov; 17(11):1516-8. doi: 10.1248/bpb.17.1516. [PMID: 7703976]
  • A V Miller-Wing, J M Hanesworth, M F Sardinia, K L Hall, J W Wright, R C Speth, K L Grove, J W Harding. Central angiotensin IV binding sites: distribution and specificity in guinea pig brain. The Journal of pharmacology and experimental therapeutics. 1993 Sep; 266(3):1718-26. doi: . [PMID: 8371170]
  • T Kono, A Taniguchi, H Imura, F Oseko, M C Khosla. Biological activities of angiotensin II-(1-6)-hexapeptide and angiotensin II-(1-7)-heptapeptide in man. Life sciences. 1986 Apr; 38(16):1515-9. doi: 10.1016/0024-3205(86)90565-5. [PMID: 3702589]
  • . . . . doi: . [PMID: 27038740]
  • . . . . doi: . [PMID: 9493859]